SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G
(Amendment No. 1)

Under the Securities Exchange Act of 1934

Exact Sciences Corporation
(Name of Issuer)

Common Stock, $0.01 par value
(Title of Class of Securities)

30063P105
(CUSIP Number)

December 31, 2010
(Date of Event Which Requires Filing of this Statement)
 
Check the following box to designate the rule pursuant to which the Schedule is filed:

o	Rule 13d-1(b)	 	
x	Rule 13d-1(c)	 	
o	Rule 13d-1(d)	 	

* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

CUSIP No. 30063P105
 	 	
 	1.	Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
D. E. Shaw & Co., L.P.
13-3695715	 	
 	 	 	 	
 	2.	Check the Appropriate Box if a Member of a Group (See Instructions)	 	
 	 	(a)	o	 	
 	 	(b)	o	 	
 	 	 	 	 	
 	3.	SEC Use Only	 	
 	 	 	 	
 	4.	Citizenship or Place of Organization
Delaware	 	
 	 	 	 	
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With	5.	Sole Voting Power
-0-	 	
 	 	 	 	
 	 	 	6.	Shared Voting Power
2,616,284	 	
 	 	 	 	 	 	
 	 	 	7.	Sole Dispositive Power
-0-	 	
 	 	 	 	 	 	
 	 	 	8.	Shared Dispositive Power
2,644,084	 	
 	 	 	 	 	 	
 	9.	Aggregate Amount Beneficially Owned by Each Reporting Person
2,644,084	 	
 	 	 	 	
 	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o	 	
 	 	 	 	
 	11.	Percent of Class Represented by Amount in Row (9)
5.2%	 	
 	 	 	 	
 	12.	Type of Reporting Person (See Instructions)
IA, PN	 	

 
CUSIP No. 30063P105	 	
 	 	
 	1.	Names of Reporting Persons
I.R.S. Identification Nos. of above persons (entities only)
David E. Shaw	 	
 	 	 	 	
 	2.	Check the Appropriate Box if a Member of a Group (See Instructions)	 	
 	 	(a)	o	 	 	
 	 	(b)	o	 	 	
 	 	 	 	 	
 	3.	SEC Use Only	 	
 	 	 	 	
 	4.	Citizenship or Place of Organization
United States	 	
 	 	 	 	
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With	5.	Sole Voting Power
-0-	 	
 	 	 	 	
 	 	 	6.	Shared Voting Power
2,616,284	 	
 	 	 	 	 	 	
 	 	 	7.	Sole Dispositive Power
-0-	 	
 	 	 	 	 	 	
 	 	 	8.	Shared Dispositive Power
2,644,084	 	
 
 	9.	Aggregate Amount Beneficially Owned by Each Reporting Person
2,644,084	 	
 	 	 	 	
 	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o	 	
 	 	 	 	
 	11.	Percent of Class Represented by Amount in Row (9)
5.2%	 	
 	 	 	 	
 	12.	Type of Reporting Person (See Instructions)
IN	 	

 
 
Item 1.	 	 	
(a)	 	Name of Issuer	
 	 	Exact Sciences Corporation	
 	 	 	
(b)	 	Address of Issuer's Principal Executive Offices	
 	 	441 Charmany Drive
Madison, WI 53719	
 	 	 	
Item 2.	 	 	
(a)	 	Name of Person Filing	
 	 	D. E. Shaw & Co., L.P.
David E. Shaw	
 	 	 	
(b)	 	Address of Principal Business Office or, if none, Residence	
 	 	The business address for each reporting person is:
1166 Avenue of the Americas, 9 th Floor
New York, NY 10036	
 	 	 	
(c)	 	Citizenship	
 	 	D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware.
David E. Shaw is a citizen of the United States of America.	
 	 	 	
(d)	 	Title of Class of Securities	
 	 	Common Stock, $0.01 par value	
 	 	 	
(e)	 	CUSIP Number	
 	 	30063P105	
  
Item 3.	If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:	 	
 	 	 	
Not Applicable	 	

Item 4.	Ownership	 	
 	 	 	
As of December 31, 2010:
 
(a) Amount beneficially owned:		
 
D. E. Shaw & Co., L.P.:	2,644,084 shares
This is composed of (i) 1,413,738 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,030,630 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 199,716 shares under the management of D. E. Shaw Investment Management, L.L.C.	
 	 	
David E. Shaw:	2,644,084 shares
This is composed of (i) 1,413,738 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,030,630 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 199,716 shares under the management of D. E. Shaw Investment Management, L.L.C.	

(b) Percent of class:
 	D. E. Shaw & Co., L.P.:	5.2%	
 	David E. Shaw:	5.2%	
 
(c) Number of shares to which the person has:
 
(i)      Sole power to vote or to direct the vote:
 	D. E. Shaw & Co., L.P.:	-0- shares	
 	David E. Shaw:	-0- shares	
 
(ii)     Shared power to vote or to direct the vote:
 	D. E. Shaw & Co., L.P.:	2,616,284 shares	
 	David E. Shaw:	2,616,284 shares	
 
(iii)    Sole power to dispose or to direct the disposition of:
 	D. E. Shaw & Co., L.P.:	-0- shares	
 	David E. Shaw:	-0- shares	
 
(iv)    Shared power to dispose or to direct the disposition of:
 	D. E. Shaw & Co., L.P.:	2,644,084 shares	
 	David E. Shaw:	2,644,084 shares	
 
David E. Shaw does not own any shares directly.  By virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the manager and investment adviser of D. E. Shaw Valence Portfolios, L.L.C., the investment adviser of D. E. Shaw Oculus Portfolios, L.L.C., and the managing member of D. E. Shaw Investment Management, L.L.C., and by virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Oculus Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of 2,616,284 shares, and the shared power to dispose or direct the disposition of 2,644,084 shares, the 2,644,084 shares as described above constituting 5.2% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares.  David E. Shaw disclaims beneficial ownership of such 2,644,084 shares.
 
Item 5.	Ownership of Five Percent or Less of a Class	
Not Applicable	
 	
Item 6.	Ownership of More than Five Percent on Behalf of Another Person	
Not Applicable	
 	
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person	
Not Applicable	
 	
Item 8.	Identification and Classification of Members of the Group	
Not Applicable	
 	
Item 9.	Notice of Dissolution of Group	
Not Applicable	
	 	
Item 10.	Certification	
By signing below, each of D. E. Shaw & Co., L.P. and David E. Shaw certify that, to the best of such reporting person’s knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purposes or effect.	

 

SIGNATURE
 
After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.  A Power of Attorney, dated October 24, 2007, granted by David E. Shaw in favor of Rochelle Elias, is attached hereto.

Dated: February 14, 2011
 	 	 	
 	D. E. Shaw & Co., L.P.	

 	 
 	
 	By:   	/s/  Rochelle Elias	
 	
Rochelle Elias
Chief Compliance Officer	

 	David E. Shaw	

 	 
 	
 	By:   	/s/  Rochelle Elias	
 	
Rochelle Elias
Attorney-in-Fact for David E. Shaw	

 

Exhibit 1

POWER OF ATTORNEY
FOR CERTAIN FILINGS
UNDER THE SECURITIES EXCHANGE ACT OF 1934

I, David E. Shaw, hereby make, constitute, and appoint each of:

Anne Dinning,

Rochelle Elias,

Julius Gaudio,

John Liftin,

Louis Salkind,

Stuart Steckler,

Maximilian Stone, and

Eric Wepsic,

acting individually, as my agent and attorney-in-fact, with full power of substitution, for the purpose of, from time to time, executing in my name and/or my capacity as President of D. E. Shaw & Co., Inc. (acting for itself or as the general partner of D. E. Shaw & Co., L. P. and general partner, managing member, or manager of other entities, any of which in turn may be acting for itself or other entities) all documents, certificates, instruments, statements, other filings, and amendments to the foregoing (collectively, “documents”) determined by such person to be necessary or appropriate to comply with ownership or control-person reporting requirements imposed by any United States or non-United States governmental or regulatory authority, including without limitation Forms 3, 4, 5, and 13F and Schedules 13D and 13G required to be filed with the Securities and Exchange Commission; and delivering, furnishing, or filing any such documents to or with the appropriate governmental or regulatory authority.  Any such determination shall be conclusively evidenced by such person’s execution, delivery, furnishing, and/or filing of the applicable document.

This power of attorney shall be valid from the date hereof and replaces the power granted on February 24, 2004, which is hereby cancelled.

IN WITNESS HEREOF, I have executed this instrument as of the date set forth below.

Date:  October 24, 2007

DAVID E. SHAW, as President of
D. E. Shaw & Co., Inc.
/s/ David E. Shaw
New York , New York