SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF
THE SECURITIES EXCHANGE ACT OF 1934
Date of report (Date of earliest event reported): JANUARY 21, 2003
EXACT SCIENCES CORPORATION
 (Exact Name of Registrant as Specified in Its Charter)
DELAWARE
 (State or Other Jurisdiction of Incorporation)

       000-32179                                         02-0478229
------------------------                      ---------------------------------
(Commission File Number)                      (IRS Employer Identification No.)

                63 GREAT ROAD, MAYNARD, MASSACHUSETTS       01754
               ----------------------------------------   ----------
               (Address of Principal Executive Offices)   (Zip Code)	

Registrant's telephone number, including area code: (978) 897-2800
 
ITEM 5. OTHER EVENTS.
On January 21, 2003, EXACT Sciences Corporation issued a press release, a copy of which is being filed as Exhibit 99.1 to this Current Report on Form 8-K, such press release being incorporated herein by reference.
ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS
(c) Exhibits
99.1 Press Release dated January 21, 2003.
 
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
EXACT Sciences Corporation

January 22, 2003                         By: /s/ John A. McCarthy, Jr.
                                             ----------------------------------
                                             John A. McCarthy, Jr.
                                             Executive Vice President, Chief
                                             Operating Officer, Chief Financial
                                             Officer and Treasurer	

                                  EXHIBIT INDEX

EXHIBIT NUMBER    DESCRIPTION

99.1              Press Release dated January 21, 2003.	

EXHIBIT 99.1
MAYNARD, MASS. - JANUARY 21, 2003 - EXACT Sciences Corporation (NASDAQ: EXAS) announced today that it will host a conference call for its fourth quarter and year-end 2002 financial and operating results on Tuesday, January 28, 2003 at 8:30 a.m. EST. A live Webcast of the conference call can be accessed at www.exactsciences.com through the Investor Relations link. The conference call and the Webcast are open to all interested parties. An archived version of the Webcast will be available at EXACT Sciences' Web site, www.exactsciences.com, through the Investor Relations link, for one month. A replay of the conference call also will be available for 48 hours, following the completion of the live call.
EXACT Sciences will announce its fourth quarter and year-end 2002 financial and operating results on Monday, January 27, 2003, after the close of regular market trading hours. Information for the call is as follows:
Domestic callers: 888-371-9318 International callers: 973-935-2100
The conference call replay information is as follows:

Domestic callers:             877-519-4471
International callers:        973-341-3080
PIN #                         3681698	

The webcast is also being distributed over CCBN's Investor Distribution Network to both institutional and individual investors. Individual investors can listen to the call through CCBN's individual investor center at www.companyboardroom.com or by visiting any of the investor sites in CCBN's Individual Investor Network. Institutional investors can access the call via CCBN's password-protected event management site, StreetEvents (www.streetevents.com).
ABOUT EXACT SCIENCES CORPORATION
EXACT Sciences Corporation is an applied genomics company that has developed proprietary technologies that may be used for the early detection of several common cancers. EXACT Sciences has selected colorectal cancer as the first application of its technologies. Colorectal cancer is the most deadly cancer among non-smokers, and is curable if detected early. Despite the availability of colorectal cancer screening and diagnostic tests for more than 20 years, the rate of early detection of colorectal cancer remains low. EXACT Sciences believes its genomics-based technologies will enable early detection of colorectal cancer so that more people can be effectively treated. Founded in 1995, EXACT Sciences is based in Maynard, Mass. Detailed information on EXACT Sciences can be found on the World Wide Web at www.exactsciences.com.
CONTACT:
Media Contact
Amy Turner, 617/267-8223
turnera@fleishman.com
or
Investor Relations
Amy Hedison, 978/897-2800, x252
ahedison@exactsciences.com