UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
 Washington, D.C. 20549
 SCHEDULE 13G
 Under the Securities Exchange Act of 1934
(Amendment No. _4_)*
Vical, Inc.
 (Name of Issuer)

Common Stock
 (Title of Class of Securities)

925602104
 (CUSIP Number)
with a copy to:

Austin W. Marxe         Allen B. Levithan, Esq.
527 Madison Avenue, Suite 2600          Lowenstein Sandler PC
New York, New York 10022                65 Livingston Avenue
                        Roseland, New Jersey 07068
                        (973) 597-2406	

(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
December 31, 2010
(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
____ Rule 13d-1(b)
_x__ Rule 13d-1(c)
____ Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed
to be ?filed? for the purpose of Section 18 of the Securities Exchange Act of 1934 (?Act?) or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the Notes).
Cusip No. 925602104 13G Page 2 of 6 Pages
1.Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only):
Austin W. Marxe and David M. Greenhouse

        2.      Check the Appropriate Box if a Member of a Group (See
Instructions):
        (a)     [    ]          Not Applicable
        (b)     [    ]

        3.      SEC Use Only

        4.      Source of Funds (See Instructions):  00

        5.      Check if Disclosure of Legal Proceedings Is Required Pursuant to
Items 2(d) or 2(e):
                                Not Applicable

        6.      Citizenship or Place of Organization:       United States

        Number of       7.      Sole Voting Power:      0
        Shares Beneficially     8.      Shared Voting Power:    4,612,586*
        Owned by
        Each Reporting  9.      Sole Dispositive Power: 0
        Person With     10.     Shared Dispositive Power: 4,612,586*___

        11.     Aggregate Amount Beneficially Owned by Each Reporting Person:
            4,612,586*	

12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions): Not Applicable
13. Percent of Class Represented by Amount in Row (11): 6.4%*
14. Type of Reporting Person (See Instructions): IA, IN
* This is a joint filing by Austin W. Marxe (?Marxe?) and David M. Greenhouse (?Greenhouse?). Marxe and Greenhouse share sole voting and investment power over 2,124,500 Common Shares are owned by Special Situations Fund III QP, L.P., 859,515 Common Shares are owned by Special Situations Private Equity Fund, L.P., 710,900 Common shares are owned by Special Situations Cayman Fund, L.P. and 917,671 Common shares are owned by Special Situations Life Sciences Fund, L.P. See Items 2 and 4 of this Schedule for additional information.
Page 3 of 6 Pages
Item 1. Security and Issuer:
 (a) Vical Incorporated
(b) 10390 Pacific Center Court, San Diego, CA 92121 Item 2. (a) Name of Person Filing:
The persons filing this report are Austin W. Marxe (?Marxe?) and David M. Greenhouse (?Greenhouse?), who are the controlling principals of AWM Investment Company, Inc. (?AWM?), the general partner of and investment adviser to Special Situations Cayman Fund, L.P. (?Cayman?). AWM also serves as the general partner of MGP Advisers Limited Partnership (?MGP?), the general partner of Special Situations Fund III QP, L.P. (?SSFQP?). Marxe and Greenhouse are members of MG Advisers L.L.C. (?MG?), the general partner of Special Situations Private Equity Fund, L.P. (?SSPE?). Marxe and Greenhouse are also members of LS Advisers L.L.C. (?LS?), the general partner of Special Situations Life Sciences Fund, L.P. (?Life Sciences?). AWM serves as the investment adviser to SSFQP, SSPE, and Life Sciences. (SSFQP, SSPE, and Life Sciences will hereafter be referred to as, the ?Funds?). The principal business of each Fund is to invest in equity and equity-related securities and other securities of any kind or nature.
(b) Address of Principal Business Office or, if none, Residence:
The principal business address for Marxe and Greenhouse is 527 Madison Avenue, Suite 2600, New York, NY 10022.
(c) Citizenship:
Austin W. Marxe and David M. Greenhouse are United States citizens.
(d) Title of Class of Securities: Common Stock
(e) CUSIP Number: 925602104.
Item 3. If this statement is filed pursuant to $240.13d-1(b) or 240.13d-
 2(b), check whether the person filing is a: Not Applicable
(a) ( ) Broker or Dealer registered under section 15 of the Act;
(b) ( ) Bank as defined in section 3(a) (6) of the Act;
(c) ( ) Insurance Company as defined in section 3(a) (19) of the Act;
(d) ( ) Investment Company registered under section 8 of the Investment Company Act of 1940;
(e) ( ) An Investment Adviser in accordance with $240.13d -1(b)(I)(ii)(E);
(f) ( ) An employee benefit plan or endowment fund in accordance with $240.13d-1(b)(I)(ii)(F);
Page 4 of 6 Pages
(g) ( ) A parent holding company or control person in accordance with $240.13d-
1(b)(1)(ii)(G);
(h) ( ) A savings association as defined in Section 3(b) of the Federal Deposit Insurance
Act;
(i) ( ) A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940;
(j) ( ) Group, in accordance with $240.13d-1(b)(1)(ii)(J).
Item 4. Ownership:
(a) Amount Beneficially Owned: Messrs. Marxe and Greenhouse beneficially own a total of 4,612,586 Common Shares. This amount includes 859,515 Common Shares owned by SSPE, 2,124,500 Common Shares owned by SSFQP, 710,900 Common Shares owned by Cayman and 917,671 Common shares owned by Life Sciences.
(b) Percent of Class: Messrs. Marxe and Greenhouse beneficially own 6.4% of the shares outstanding. SSPE owns 1.2% of the outstanding shares, SSFQP owns 3.0% of the outstanding shares, Cayman owns 1.0% of the outstanding shares and Life Sciences owns 1.3% of the outstanding shares.
(c) Number of Shares as to which the person has:
(i) Sole power to vote or to direct the vote: 0
(ii) Shared power to vote or to direct the vote: 4,612,586
(iii) Sole power to dispose or to direct the disposition of: 0
(iv) Shared power to dispose or to direct the disposition of:
4,612,586
Item 5. Ownership of Five Percent or Less of a Class: If this statement is
being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more that five percent of the class of securities, check the following __.
Item 6.Ownership of More than Five Percent on Behalf of Another Person: Not Applicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired the Security being Reported on By the Parent Holding Company: Not Applicable.
Item 8. Identification and Classification of Members of the Group: Not
applicable
Item 9. Notices of Dissolution of Group: Not applicable.
Page 5 of 6 Pages
Item 10.Certification:
By signing below I certify that, to the best of my knowledge and belief, the securities
referred to above were acquired and are held in the ordinary course of business and were not
acquired and are not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held in connection with
or as a participant in any transaction having that purpose or effect.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 11, 2011.

                                /s/ Austin W. Marxe
                                AUSTIN W. MARXE

                                /s/David M Greenhouse
                                DAVID M. GREENHOUSE	

Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001).
Page 6 of 6 Pages
JOINT FILING AGREEMENT
Austin W. Marxe and David M. Greenhouse hereby agree that the Schedule 13G to which this agreement is attached is filed on behalf of each of them.

        /s/_Austin W. Marxe
Austin W. Marxe

        /s/_David M. Greenhouse
David M. Greenhouse	

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1319328.02