FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         	UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  	OMB APPROVAL
OMB Number: 3235-0287
Expires: February 28, 2011 
Estimated average burden
hours per response... 0.5	
                      	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public
Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940	                      	

1. Name and Address of Reporting Person *

SAFEGUARD SCIENTIFICS INC	2. Issuer Name and Ticker or Trading Symbol

CLARIENT, INC [ CLRT ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      __ X __ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)	
(Last)          (First)          (Middle)

435 DEVON PARK DRIVE, BUILDING 800	3. Date of Earliest Transaction (MM/DD/YYYY)

11/20/2008		
(Street)

WAYNE, PA 19087-1945
(City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)

 	6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person	

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned	
1.Title of Security
(Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code
(Instr. 8)	4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)	5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)	
			Code	V	Amount	(A) or (D)	Price				
Common Stock  	11/20/2008  	 	X	  	100000  	A	$0.01  	38982600  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	125000  	A	$0.01  	39107600  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	31250  	A	$0.01  	39138850  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	31250  	A	$0.01  	39170100  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	31250  	A	$0.01  	39201350  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	1643750  	A	$0.01  	40845100  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	550000  	A	$0.01  	41395100  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	550000  	A	$0.01  	41945100  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	550000  	A	$0.01  	42495100  	I  	SSI Delaware   (1)	
Common Stock  	11/20/2008  	 	X	  	550000  	A	$0.01  	43045100  	I  	SSI Delaware   (1)	
Common Stock  	 	 	 	  	 	 	 	3438721  	I  	Safeguard Delaware   (1)	

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)	
1. Title of Derivate Security
(Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code
(Instr. 8)	5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)	6. Date Exercisable and Expiration Date	7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)	8. Price of Derivative Security
(Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)	
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares					
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	100000   	1/17/2007  	1/17/2011  	Common Stock  	100000  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	125000   	3/7/2007  	3/7/2011  	Common Stock  	125000  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	31250   	11/14/2007  	11/14/2011  	Common Stock  	31250  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	31250   	12/17/2007  	12/17/2011  	Common Stock  	31250  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	31250   	3/5/2008  	3/5/2012  	Common Stock  	31250  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	1643750   	3/14/2008  	3/14/2013  	Common Stock  	1643750  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	550000   	6/11/2008  	6/11/2013  	Common Stock  	550000  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	550000   	7/2/2008  	7/2/2013  	Common Stock  	550000  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	550000   	9/2/2008  	9/2/2013  	Common Stock  	550000  	$0  	0  	I  	SSI Delaware   (1)	
Warrant (right to buy)  	$0.01  	11/20/2008  	 	X 	  	  	550000   	11/6/2008  	11/6/2013  	Common Stock  	550000  	$0  	0  	I  	SSI Delaware   (1)	

Explanation of Responses:	
(  1) 	Safeguard Delaware, Inc. ("SSI Delaware") and Safeguard Scientifics (Delaware), Inc. ("Safeguard Delaware") are wholly-owned subsidiaries of reporting person and the record holders of the Issuer's securities.	

Remarks:
Additional Reporting Persons (both of which are wholly owned subsidiaries of reporting person):

Safeguard Scientifics (Delaware), Inc.
Safeguard Delaware, Inc.
1105 North Market Street
Wilmington, DE 19801	

Reporting Owners	
Reporting Owner Name / Address	Relationships	
	Director	10% Owner	Officer	Other	
SAFEGUARD SCIENTIFICS INC
435 DEVON PARK DRIVE
BUILDING 800
WAYNE, PA 19087-1945		X			

Signatures		
By: Brian J. Sisko, SVP & General Counsel For: Safeguard Scientifics		11/21/2008	
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.	
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).	
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).	
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.	
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.