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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 10-K

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
For the fiscal year ended December 31, 2007
Commission File Number 1-1136

BRISTOL-MYERS SQUIBB COMPANY
(Exact name of registrant as specified in its charter)

 
			
Delaware	 	22-0790350	
(State or other jurisdiction
of incorporation or organization)	 	(IRS Employer
Identification No.)	
345 Park Avenue, New York, N.Y. 10154
(Address of principal executive offices)
Telephone: (212) 546-4000

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	 	Name of each exchange on which registered	
Common Stock, $0.10 Par Value	 	New York Stock Exchange	
		
$2 Convertible Preferred Stock, $1 Par Value	 	New York Stock Exchange	
Securities registered pursuant to Section 12(g) of the Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes   x     No   ¨
Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.    Yes   ¨     No   x
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   x     No   ¨
Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.   ¨
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See definitions of “accelerated filer”, “large accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer   x     Accelerated filer   ¨     Non-accelerated filer   ¨     Smaller reporting company   ¨
Indicate by check mark if the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes   ¨     No   x
The aggregate market value of the 1,978,987,106 shares of voting common equity held by non-affiliates of the registrant, computed by reference to the closing price as reported on the New York Stock Exchange, as of the last business day of the registrant’s most recently completed second fiscal quarter (June 30, 2007) was approximately $62,456,833,065. Bristol-Myers Squibb has no non-voting common equity. At February 12, 2008, there were 1,979,387,706 shares of common stock outstanding.
DOCUMENTS INCORPORATED BY REFERENCE: Portions of the Proxy Statement for the registrant’s Annual Meeting of Stockholders to be held May 6, 2008 are incorporated by reference into Part III of this Annual Report on Form 10-K.

 

Table of Contents
PART I
 
Item 1.	BUSINESS.	
General
Bristol-Myers Squibb Company (which may be referred to as Bristol-Myers Squibb, BMS or the Company) was incorporated under the laws of the State of Delaware in August 1933 under the name Bristol-Myers Company, as successor to a New York business started in 1887. In 1989, Bristol-Myers Company changed its name to Bristol-Myers Squibb Company as a result of a merger. The Company, through its divisions and subsidiaries, is engaged in the discovery, development, licensing, manufacturing, marketing, distribution and sale of pharmaceuticals and other health care related products.
Acquisitions and Divestitures
In July 2007, the Company completed the sale of the BUFFERIN* and EXCEDRIN* brands in Japan, Asia (excluding China and Taiwan) and certain Oceanic countries to Lion Corporation (Japan) for $247 million in cash. As a result of this transaction, the Company recognized a pre-tax gain of $247 million ($144 million net of tax) in the third quarter of 2007.
In October 2007, the Company completed the acquisition of Adnexus Therapeutics, Inc. (Adnexus), developer of a new therapeutic class of biologics called ADNECTINS, for a net purchase price of $415 million. In addition, in the event that certain future development and regulatory milestones are achieved, the Company is obligated under the terms of the agreement to pay the former stockholders of Adnexus up to an additional $74 million.
In December 2007, the Company entered into a definitive agreement with Avista Capital Partners L.P. (Avista) for the sale of its Medical Imaging business for a purchase price of approximately $525 million in cash, subject to customary post-closing adjustments. The closing of the transaction was completed on January 7, 2008. As a result of this transaction, the Company expects to recognize a pre-tax gain of approximately $20 million to $40 million ($30 million to $50 million loss net of tax) in the first quarter of 2008, subject to the post-closing adjustments.
Bristol-Myers Squibb Website
The Company’s internet website address is www.bms.com . The Company makes available free of charge on its website its annual, quarterly and current reports, including amendments to such reports, as soon as reasonably practicable after the Company electronically files such material with, or furnishes such material to, the U.S. Securities and Exchange Commission (SEC).
Information relating to corporate governance at Bristol-Myers Squibb, including the Company’s Standards of Business Conduct and Ethics, Code of Ethics for Senior Financial Officers, Code of Business Conduct and Ethics for Directors, (collectively, the “Codes”), Corporate Governance Guidelines, and information concerning the Company’s Executive Committee, Board of Directors, including Board Committees and Committee charters, and transactions in Bristol-Myers Squibb securities by Directors and executive officers, is available on the Company’s website at www.bms.com under the “Investors—Corporate Governance” caption and in print to any stockholder upon request. Any waivers to the Codes by directors or executive officers and any material amendment to the Code of Business Conduct and Ethics for Directors and Code of Ethics for Senior Financial Officers will be posted promptly on the Company’s website. Information relating to stockholder services, including the Company’s Dividend Reinvestment Plan and direct deposit of dividends, is available on the Company’s website at www.bms.com under the “Investors—Stockholder Services” caption.
The Company incorporates by reference certain information from parts of its proxy statement for the 2008 Annual Meeting of Stockholders. The SEC allows the Company to disclose important information by referring to it in that manner. Please refer to such information. The Company’s proxy statement for the 2008 Annual Meeting of Stockholders and 2007 Annual Report will be available on the Company’s website ( www.bms.com ) under the “Investors—SEC Filings” caption on or after March 21, 2008.
 
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Business Segments
The Company has three reportable segments—Pharmaceuticals, Nutritionals and ConvaTec (previously a component of the Other Health Care operating segment). In January 2008, the Company completed the sale of its Medical Imaging business to Avista. The results of the Medical Imaging business previously included in the former Other Health Care operating segment, are presented as part of the Company’s results from discontinued operations.
The Pharmaceuticals segment is made up of the global pharmaceutical and international consumer medicines business. The Pharmaceuticals segment accounted for 81% of the Company’s sales in 2007, 80% of the Company’s sales in 2006, and 83% of the Company’s sales in 2005. U.S. Pharmaceuticals sales accounted for 58%, 54% and 54% of total Pharmaceutical sales in 2007, 2006 and 2005, respectively, while international Pharmaceutical sales accounted for 42%, 46% and 46% of total Pharmaceutical sales in 2007, 2006 and 2005, respectively.
The other two segments – Nutritionals and ConvaTec – comprise the Company’s Health Care Group. The Nutritionals segment consists of Mead Johnson Nutritionals (Mead Johnson), primarily an infant formula and children’s nutritionals business. The ConvaTec segment consists of the ostomy, wound and skin care business. Health Care Group sales accounted for 19% of the Company’s sales in 2007, 20% of the Company’s sales in 2006, and 17% of the Company’s sales in 2005. U.S. Health Care Group sales accounted for 40%, 42% and 43% of total Health Care Group sales in 2007, 2006 and 2005, respectively, while international Health Care Group sales accounted for 60%, 58% and 57% of total Health Care Group sales in 2007, 2006 and 2005, respectively.
For additional information about these segments, see “Item 8. Financial Statements—Note 19. Segment Information.”
Pharmaceuticals Segment
The Pharmaceuticals segment competes with other worldwide research-based drug companies, smaller research companies and generic drug manufacturers. These products are sold worldwide, primarily to wholesalers, retail pharmacies, hospitals, government entities and the medical profession. The Company manufactures these products in the U.S. and Puerto Rico and in 14 foreign countries. U.S Pharmaceuticals net sales accounted for 58%, 54% and 54% of total Pharmaceuticals net sales in 2007, 2006 and 2005, respectively, while Pharmaceuticals net sales in Europe, Middle East and Africa accounted for 25%, 28% and 29% of total Pharmaceuticals net sales in 2007, 2006 and 2005, respectively. Pharmaceuticals net sales in Japan accounted for 4% of total Pharmaceuticals net sales in each of 2007, 2006 and 2005.
The Company’s key products include PLAVIX* (clopidogrel bisulfate), AVAPRO/AVALIDE* (irbesartan/irbesartan–hydrochlorothiazide), REYATAZ (atazanavir sulfate), ABILIFY* (aripiprazole), ERBITUX* (cetuximab), SPRYCEL (dasatinib), BARACLUDE (entecavir), ORENCIA (abatacept), the SUSTIVA Franchise (efavirenz) and IXEMPRA (ixabepilone).
The composition of matter patent for PLAVIX*, which expires in 2011, is currently the subject of patent litigation in the U.S. with Apotex Inc. and Apotex Corp. (Apotex) and other generic companies as well as in other less significant jurisdictions. As previously disclosed, on August 8, 2006, Apotex launched a generic clopidogrel bisulfate product that competes with PLAVIX*. The generic launch had a significant adverse impact on PLAVIX* sales, which the Company estimates to be in a range of $250 million to $350 million in 2007 and $1.2 billion to $1.4 billion in 2006. Estimated total U.S. prescription demand for clopidogrel bisulfate (branded and generic) increased 8% in 2007 compared to 2006, while estimated total U.S. prescription demand for branded PLAVIX* increased 34% in the same period. The Company believes that the supply of generic clopidogrel bisulfate that was sold into distribution channels following the Apotex at-risk launch in August 2006 has been substantially depleted. In June 2007, the U.S. District Court for the Southern District of New York (District Court) upheld the composition of matter patent for PLAVIX* and enjoined Apotex from engaging in any activity that infringes the patent, including marketing its generic product in the U.S. until after the patent expires. Apotex has appealed the District Court’s decision. The Apotex appeal date has been set for March 2008. The damages phase of the trial is on-going. For more information about the pending PLAVIX* litigation, as well as the generic launch by Apotex, see “Item 8. Financial Statements —Note 22. Legal Proceedings and Contingencies.”
 
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Products
Most of the Company’s pharmaceutical revenues come from products in the following therapeutic classes: cardiovascular; virology, including human immunodeficiency virus (HIV) infection; oncology; affective and other (psychiatric) disorders; and immunoscience.
In the pharmaceutical industry, the majority of an innovative product’s commercial value is usually realized during the period in which the product has market exclusivity. Market exclusivity is based upon patent rights and/or certain regulatory forms of exclusivity. In the U.S. and some other countries, when these patent rights and other forms of exclusivity expire and generic versions of a medicine are approved and marketed, there are often very substantial and rapid declines in the sales of the original innovative product. The Company’s business is focused on innovative pharmaceutical products, and the Company relies on patent rights and other forms of protection to maintain the market exclusivity of its products. For further discussion of patents rights and regulatory forms of exclusivity, see “—Intellectual Property and Product Exclusivity” below. For further discussion of the impact of generic competition on the Company’s business, see “—Generic Competition” below.
An increasing portion of the Company’s innovative pharmaceutical products are biological products, or biologics. Currently, generic versions of biological products cannot be approved under U.S. law. However, the law could change in the future. Even in the absence of new legislation, the U.S. Food and Drug Administration (FDA) is taking steps toward allowing generic versions of certain biologics. Competitors seeking approval of biological products must file their own safety and efficacy data, and address the challenges of biologics manufacturing, which involves more complex processes and are more costly than those of traditional pharmaceutical operations.
The chart below shows the net sales of key products in the Pharmaceuticals segment, together with the year in which the basic exclusivity loss (patent rights or data exclusivity) occurred or is currently estimated to occur in the U.S., the European Union (EU) and Japan. The Company also sells its pharmaceutical products in other countries; however, data is not provided on a country-by-country basis because individual country sales are not significant outside the U.S., the EU and Japan. In many instances, the basic exclusivity loss date listed below is the expiration date of the patent that claims the active ingredient of the drug or the method of using the drug for the approved indication. In some instances, the basic exclusivity loss date listed in the chart is the expiration date of the data exclusivity period. In situations where there is only data exclusivity without patent protection, a competitor could seek regulatory approval by submitting its own clinical trial data to obtain marketing approval prior to the expiration of data exclusivity.
The Company estimates the market exclusivity period for each of its products on a case-by-case basis for the purposes of business planning only. The length of market exclusivity for any of the Company’s products is impossible to predict with certainty because of the complex interaction between patent and regulatory forms of exclusivity and the inherent uncertainties regarding patent litigation. Although the Company provides these estimates for business planning purposes, these are not intended as an indication of how the Company’s patents might fare in any particular patent litigation brought against potential infringers. There can be no assurance that a particular product will enjoy market exclusivity for the full period of time that appears in the estimate or that the exclusivity will be limited to the estimate.
 
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Pharmaceutical Products	  	2007	  	2006	  	2005	  	Past or Currently
Estimated
Year of
U.S. Basic
Exclusivity Loss	 	 	Past or Currently
Estimated
Year of
EU Basic
Exclusivity Loss (a)	 	 	Past or Currently
Estimated
Year of
Japanese Basic
Exclusivity Loss	
Dollars in Millions	  	 	  	 	  	 	  	 	 	 	 	 	 	 	
Cardiovascular	  			  			  			  			 			 		
PLAVIX*	  	$	4,755	  	$	3,257	  	$	3,823	  	2011	 	 	2008-2013	 	 	++	
AVAPRO*/AVALIDE*	  	 	1,204	  	 	1,097	  	 	982	  	2012	 	 	2007-2013	 	 	++	
PRAVACHOL	  	 	443	  	 	1,197	  	 	2,256	  	2006	 	 	2002-2008	 	 	++	
COUMADIN	  	 	201	  	 	220	  	 	212	  	(b	)	 	(b	)	 	++	
Virology	  			  			  			  			 			 		
REYATAZ	  	 	1,124	  	 	931	  	 	696	  	2017	 	 	2017	 	 	2017	
SUSTIVA Franchise (total revenue)	  	 	956	  	 	791	  	 	680	  	2013	(c)	 	2013	(c)	 	++	
BARACLUDE	  	 	275	  	 	83	  	 	12	  	2015	 	 	2011-2016	 	 	2016	
Oncology	  			  			  			  			 			 		
ERBITUX*	  	 	692	  	 	652	  	 	413	  	2017	(d)	 	++	 	 	++	
TAXOL ® (paclitaxel)	  	 	422	  	 	563	  	 	747	  	2000	 	 	2003	 	 	2006	
SPRYCEL	  	 	158	  	 	25	  	 	—  	  	2020	 	 	2020	(e)	 	++	
IXEMPRA	  	 	15	  	 	—  	  	 	—  	  	2018	 	 	2018	 	 	++	
Affective (Psychiatric) Disorders	  			  			  			  			 			 		
ABILIFY* (total revenue)	  	 	1,660	  	 	1,282	  	 	912	  	2014	(f)	 	2014	(g)	 	++	
Immunoscience	  			  			  			  			 			 		
ORENCIA	  	 	231	  	 	89	  	 	—  	  	2016	(d)	 	2012	(h)	 	++	
Other Pharmaceuticals	  			  			  			  			 			 		
EFFERALGAN	  	 	308	  	 	266	  	 	283	  	++	 	 	N/A	 	 	++	
 
Note: The currently estimated year of basic exclusivity loss includes any statutory extensions of exclusivity that have been earned, but not those that are speculative. In some instances, there may be later-expiring patents that cover particular forms or compositions of the drug, as well as methods of manufacturing or methods of using the drug. Such patents may sometimes result in a favorable market position for the Company’s product, but product exclusivity cannot be predicted or assured. Note also that, for products filed under a Biologics License Application (BLA) in the U.S., the year of exclusivity is listed as the year of patent expiration even though there is currently not a regulatory pathway for the approval of follow-on biologic products, as described in more detail in “—Intellectual Property” and “—Product Exclusivity” below.
 
*	Indicates brand names of products which are registered trademarks not owned by the Company or its subsidiaries. Specific trademark ownership information can be found on page 152.	
 
++	The Company does not currently market the product in the jurisdiction indicated.	
 
(a)	References to the EU throughout this Form 10-K include the following current 27 member states: Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, and the United Kingdom (UK). Basic patent applications have not been filed in all 27 current member states for all of the listed products. In some instances the date of basic exclusivity loss will be different in various EU member states. In such instances, the earliest and latest dates of basic exclusivity loss are listed. For those EU countries where the basic patent was not obtained, there may be data protection available.	
 
(b)	Basic exclusivity expired before BMS acquired the product.	
 
(c)	Exclusivity period relates to SUSTIVA brand only.	
 
(d)	Biologic product approved under a BLA. In the U.S., there is currently no regulatory approval path for generic biologics.	
 
(e)	Pending application. EU patent application was not filed in Estonia, Latvia, Lithuania, Malta, Slovakia and Slovenia.	
 
(f)	The Company’s rights to commercialize aripiprazole in the U.S. terminate in 2012.	
 
(g)	The Company’s rights to commercialize aripiprazole in the EU terminate in 2014.	
 
(h)	Data exclusivity in the EU expires in 2017.	
 
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Below is a summary of the indication, intellectual property position, licensing arrangements, if any, and third-party manufacturing arrangements, if any, for each of the above products in the U.S. and, where applicable, the EU and Japan.

Cardiovascular	  		
		
PLAVIX*	  	Clopidogrel bisulfate is a platelet aggregation inhibitor, which is approved for protection against fatal or non-fatal heart attack or stroke in patients with a history of heart attack, stroke, peripheral arterial disease or acute coronary syndrome.	
		
	  	Clopidogrel bisulfate was codeveloped and is jointly marketed with Sanofi-Aventis (Sanofi). The worldwide alliance operates under the framework of two geographic territories: one in the Americas and Australia (the Company’s primary territory) and the other in Europe and Asia (Sanofi’s primary territory).	
		
	  	The composition of matter patent in the U.S. expires in 2011 (which includes a statutory patent term extension), and is currently the subject of patent litigation in the U.S. with Apotex and other generic companies, as well as in other less significant jurisdictions. The District Court has upheld the validity and enforceability of the composition of matter patent and Apotex has appealed that decision. The oral argument on the Apotex appeal date has been set for March 2008. It is not possible at this time reasonably to assess the outcome of the appeal by Apotex and/or the timing of any renewed generic competition from Apotex or potential additional generic competition from other generic pharmaceutical companies. However, if Apotex were to prevail in its appeal, the Company would expect renewed generic competition promptly thereafter. For more information about these litigation matters, as well as the generic launch by Apotex, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”	
		
	  	In the EU, regulatory data exclusivity expires in July 2008 in all the EU member countries and the key composition of matter patent expires in 2013 in the majority of the EU member countries.	
		
	  	The Company obtains its bulk requirements for clopidogrel bisulfate from Sanofi and a third party. Both the Company and Sanofi finish the product in their own facilities. For more information about the Company’s arrangements with Sanofi, see “—Strategic Alliances” below and “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
		
AVAPRO*/AVALIDE*	  	Irbesartan/irbesartan-hydrochlorothiazide is an angiotensin II receptor antagonist indicated for the treatment of hypertension and diabetic nephropathy.	
		
	  	Irbesartan was codeveloped and is jointly marketed with Sanofi. The worldwide alliance operates under the framework of two geographic territories: one in the Americas and Australia (the Company’s primary territory) and the other in Europe and Asia (Sanofi’s primary territory). In September 2006, the Company elected to terminate its copromotion of this product with Sanofi in Ireland, Sweden, Norway, Finland and Denmark.	
		
	  	The basic composition of matter patent in the U.S. expires in 2012 (including pediatric extension) and in the EU in 2013. Data exclusivity in the EU expires in August 2007 for AVAPRO* and in October 2008 for AVALIDE*.	
		
	  	Irbesartan is manufactured by both the Company and Sanofi. The Company manufactures its bulk requirements for irbesartan and finishes AVAPRO*/AVALIDE* in its own facilities. For AVALIDE*, the Company purchases bulk requirements for hydrochlorothiazide from a third party.	
		
	  	For more information about the Company’s arrangements with Sanofi, see “—Strategic Alliances” below and “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
		
PRAVACHOL	  	Pravastatin sodium is an HMG Co-A reductase inhibitor indicated as an adjunct to diet and exercise for patients with primary hypercholesterolemia, for lowering the risk of a first heart attack in people without clinically evident coronary heart disease who have elevated cholesterol, and for reducing the risk of heart attack and stroke in patients with clinically evident coronary heart disease.	
 
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	  	The Company has licensed a patent covering pravastatin, marketed by the Company in the U.S. as PRAVACHOL, from Sankyo Company, Ltd. (Sankyo) of Japan, with key provisions of the agreement expiring as exclusivity expires on a market-by-market basis. Exclusivity in the U.S. under the patent (including pediatric extension) expired in April 2006. The Company entered into a distribution agreement with Watson Pharmaceutical (Watson) in November 2005 authorizing Watson to distribute generic pravastatin sodium tablets in the U.S.	
		
	  	In December 2006, LEK D.D. (LEK), a Slovenian generic company that is wholly-owned by Novartis AG (Novartis), filed suit against the Company and Watson in the U.S. District court for the Eastern District of Texas in Marshall, Texas. LEK’s complaint alleges that the Company’s sale of PRAVACHOL and Watson’s sale of an authorized generic of PRAVACHOL infringe two patents of LEK. For more information about this litigation matter, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”	
		
	  	The composition of matter patent has expired in all countries in the EU.	
		
	  	The Company obtains its bulk requirements for pravastatin from Sankyo and finishes the product in its own facilities.	
		
COUMADIN	  	Warfarin sodium is an oral anticoagulant used predominantly in patients with atrial fibrillation or deep venous thrombosis/pulmonary embolism.	
		
	  	Market exclusivity expired in the U.S. in 1997. Basic patent protection and regulatory data protection had expired before the Company acquired COUMADIN in 2001.	
		
	  	The Company obtains its bulk requirements for warfarin from a third party and produces the majority of finished goods in its own facilities.	
		
Virology	  		
		
REYATAZ	  	Atazanavir sulfate is a protease inhibitor for the treatment of HIV. REYATAZ was launched in the U.S. in July 2003.	
		
	  	The Company developed atazanavir under a worldwide license from Novartis for which it pays a royalty based on a percentage of net sales. The Company is entitled to promote REYATAZ for use in combination with NORVIR* (ritonavir) under a Non-Exclusive License Agreement between Abbott Laboratories and the Company dated July 30, 2003, as amended, for which it pays a royalty based on a percentage of net sales.	
		
	  	Market exclusivity for REYATAZ is expected to expire in 2017 in the U.S., in the major EU member countries and Japan. Data exclusivity in the EU expires in 2014.	
		
	  	The Company manufactures its bulk requirements for atazanavir and finishes the product in its own facilities.	
		
SUSTIVA Franchise	  	Efavirenz, the active ingredient in SUSTIVA, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV. The SUSTIVA Franchise includes SUSTIVA, an antiretroviral drug used in the treatment of HIV, and as well as bulk efavirenz included in the combination therapy, ATRIPLA*, which is sold through a joint venture with Gilead Sciences, Inc. (Gilead). The Company and Gilead share responsibility for commercializing ATRIPLA* in the U.S. Gilead records 100% of ATRIPLA* revenues and consolidates the results of the joint venture in its operating results. The Company records revenue for the bulk efavirenz component of ATRIPLA* upon sales of that product by the Gilead joint venture to third-party customers. The Company’s revenue for the efavirenz component is determined by applying a percentage to ATRIPLA* revenue, which approximates revenue for the SUSTIVA brand. In Europe, the Company and Gilead share responsibility for commercializing ATRIPLA* throughout the EU and certain other European countries. Gilead will record revenues from future net sales of ATRIPLA* in most countries in Europe and the Company will record revenues at a percentage relative to the contribution represented by SUSTIVA. In December 2007, the European Commission granted marketing authorization for ATRIPLA*. For more information about the Company’s arrangement with Gilead, see “—Strategic Alliances” below and “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
 
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	  	Rights to market efavirenz in the U.S., Canada, the UK, France, Germany, Ireland, Italy and Spain are licensed from Merck & Co., Inc. for a royalty based on a percentage of net sales.	
		
	  	Market exclusivity for SUSTIVA is expected to expire in 2013 in the U.S. and in countries in the EU; the Company does not, but another company does, market efavirenz in Japan.	
		
	  	The Company obtains its bulk requirements for efavirenz from third parties and produces finished goods in its own facilities. The Company provides bulk efavirenz to Gilead, who is responsible for producing ATRIPLA* finished goods.	
		
BARACLUDE	  	Entecavir is a potent and selective inhibitor of hepatitis B virus that was approved by the FDA in March 2005 for the treatment of chronic hepatitis B infection. BARACLUDE was discovered and developed internally. It has also been approved and marketed in over 50 countries outside of the U.S. including China, Japan and the EU. The Company has learned that in China several companies have filed for clinical trial permission since the Company received approval. The Company is not aware that any of the applications for clinical trial permission in China have been approved. Due to uncertainty about China’s exclusivity laws, it is possible that one or more of these companies could receive marketing authorization from China’s health authority by 2010.	
		
	  	The Company has a composition of matter patent that expires in the U.S. in 2010. An application for a patent term extension has been approved in the U.S., which extends the patent expiration to 2015. The composition of matter patent expires in the EU between 2011 and 2016 and in Japan in 2016. A patent term extension has been approved in Japan which extends the patent expiration to 2016. Supplementary protection certificates have been requested in the EU and approved in some EU countries, extending the exclusivity for the approved product to 2016.	
		
	  	The Company manufactures its bulk requirements for entecavir and finishes the product in its own facilities.	
		
Oncology	  		
		
ERBITUX*	  	ERBITUX* (cetuximab) is an IgG1 monoclonal antibody designed to exclusively target and block the Epidermal Growth Factor Receptor (EGFR), which is expressed on the surface of certain cancer cells in multiple tumor types as well as some normal cells. ERBITUX*, a biological product, is approved for the treatment in combination with irinotecan of patients with EGFR-expressing metastatic colorectal cancer (mCRC) who had failed an irinotecan-based regimen and as monotherapy for patients who are intolerant of irinotecan. In March 2006, the FDA approved ERBITUX* for use in the treatment of squamous cell carcinoma of the head and neck. Specifically, ERBITUX* was approved for use in combination with radiation therapy, for the treatment of locally or regionally advanced squamous cell carcinoma of the head and neck and, as a single agent, for the treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck for whom prior platinum-based therapy has failed.	
		
	  	Also, in October 2007, the Company received FDA approval for a supplemental Biologics License Application (sBLA) filing to update the ERBITUX* product labeling to include overall survival data as a single agent in EGFR-expressing mCRC patients after failure of both irinotecan-based and oxaliplatin-based regimens.	
		
	  	ERBITUX* is marketed in North America by the Company under a distribution and copromotion agreement with ImClone Systems Incorporated (ImClone). The Company shares copromotion rights to ERBITUX* with Merck KGaA in Japan under a codevelopment and cocommercialization agreement signed in October 2007 among the Company, ImClone, Merck KGaA and Merck Japan. ERBITUX* is not yet marketed in Japan, although an application has been submitted with the Japanese Pharmaceuticals and Medical Devices Agency (PMDA) for the use of ERBITUX* in treating patients with advanced colorectal cancer. For a description of the Company’s alliance with ImClone, see “—Strategic Alliances” below and “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
 
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	  	In July 2007, the Company and ImClone amended the terms of their agreement for the codevelopment and copromotion of ERBITUX* in North America. Under this amendment, the companies have jointly agreed to expand the investment in the ongoing clinical development plan for ERBITUX* by up to several hundred million dollars. Development costs, up to a threshold value, will be the sole responsibility of the Company; costs in excess of this threshold will be shared by both companies according to a predetermined ratio.	
		
	  	There is no composition of matter patent that specifically claims ERBITUX*. ERBITUX* has been approved by the FDA and other health authorities for monotherapy, for which there is no use patent. The use of ERBITUX* in combination with an anti-neoplastic agent is approved by the FDA. Such combination use is claimed in a granted U.S. patent that expires in 2017. The inventorship of this use patent has been challenged by three researchers from Yeda Research and Development Company Ltd. (Yeda). In September 2006, the court granted Yeda the complete ownership of that patent. ImClone appealed the court’s decision and also filed a declaratory judgment action alleging that if the Yeda researchers remain sole inventors of the patent, the patent is invalid.	
		
	  	Pursuant to a settlement agreement executed and announced in December 2007 by ImClone, Sanofi and Yeda to end worldwide litigation related to the use patent, Sanofi and Yeda granted ImClone a worldwide license under the use patent. The settlement agreement does not change ImClone’s worldwide royalty rate for ERBITUX* sales. Under its commercial agreement with ImClone, the Company pays a royalty to ImClone on sales of ERBITUX* that is not impacted by the settlement agreement.	
		
	  	Yeda also has the right to license the use patent to others. Yeda’s license of the patent to third parties could result in product competition for ERBITUX* that might not otherwise occur. It is too early to assess whether and to what extent any such competitive impact will occur or to quantify any such impact. However, Yeda has also granted Amgen Inc. (Amgen) a license under the use patent. Amgen received FDA approval to market an EGFR-product that competes with ERBITUX*.	
		
	  	For more information about this litigation, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.” The European equivalent of this use patent has been opposed. For more information about biologics patents, see “—Intellectual Property and Product Exclusivity” below.	
		
	  	The Company obtains its finished goods requirements for cetuximab for use in North America from ImClone. ImClone manufactures bulk requirements for cetuximab in its own facilities and finishing is performed by a third party for ImClone. For a description of the Company’s supply agreement with ImClone, see “—Manufacturing and Quality Assurance” below.	
		
TAXOL ®  (paclitaxel)	  	Paclitaxel is used in the treatment of refractory ovarian cancer, first-line treatment of ovarian cancer in combination with cisplatin, second-line treatment of acquired immunodeficiency syndrome (AIDS)-related Kaposi’s Sarcoma, treatment of metastatic breast cancer after failure of combination chemotherapy, adjuvant treatment of node-positive breast cancer and in the treatment of non-small cell lung carcinoma with cisplatin.	
		
	  	The active ingredient in TAXOL ® (paclitaxel) did not have patent protection in the U.S., the EU or Japan, but did have regulatory protection in the form of data exclusivity. Data exclusivity in the U.S. expired in 1997. An initial approval for a U.S. generic version of paclitaxel was granted in 2000, revoked by the FDA in 2001 and then reinstated in 2002. Data exclusivity in the EU expired in 2003. Data exclusivity for TAXOL ® (paclitaxel) in Japan expired in 2003. A patent claiming the approved dosing and administration schedule expires in Japan in 2013. A nullity action filed in 2004 in the Japanese Patent Office invalidated this patent and the Company appealed the decision, but the invalidation decision was affirmed. Meanwhile, a generic paclitaxel was launched in Japan in 2006.	
		
	  	Paclitaxel was developed under a collaborative research and development agreement with the U.S. government. Under the agreement, the Company obtained rights to the U.S. government’s TAXOL ® (paclitaxel) data.	
		
	  	The Company manufactures its bulk requirements for paclitaxel and finishes the product in its own facilities.	
 
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SPRYCEL	  	Dasatinib is a multi-targeted tyrosine kinase inhibitor that was approved by the FDA in June 2006 for treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy including imatinib, and for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy. Dasatinib was approved in the EU in November 2006. SPRYCEL was discovered and developed internally.	
		
	  	The basic composition of matter patent protecting dasatinib in the U.S. is due to expire in April 2020, and a patent term extension has been requested, which, upon grant, would extend the patent term until June 2020. In several EU countries, the patent is pending and upon grant, would expire in April 2020 (excluding term extensions). An EU patent application was not filed in Cyprus, Estonia, Latvia, Lithuania, Malta, Netherlands, Slovakia or Slovenia. In the U.S., New Chemical Entity Protection expires in 2011, and Orphan Drug Exclusivity expires in 2013, which protects the product from generic applications for the currently approved orphan indications only.	
		
	  	The Company manufactures its bulk requirements for dasatinib and finishes the product in its own facilities.	
		
IXEMPRA	  	IXEMPRA (ixabepilone) is a microtubule inhibitor belonging to a class of antineoplastic agents, the epothilones and their analogs. In October 2007, the FDA approved ixabepilone in combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated, and in monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine. Marketing authorization is currently being sought in EU and other countries.	
		
	  	The basic composition of matter patent protecting ixabepilone in the U.S. is due to expire in May 2018, and a patent term extension has been requested which, upon grant, would extend the patent term until September 2020. A corresponding patent also has been granted in EU countries which is due to expire in June 2018 (excluding term extensions). An EU patent application was not filed in Malta. In the U.S., New Chemical Entity Protection expires in 2012.	
		
	  	Ixabepilone was developed by the Company, but is subject to a license agreement with Helmholtz Zentrum fur Infektionsforschung GmbH (HZI), relating to epothilone technologies. Under the Agreement, HZI is entitled to royalties of 0.5% of net sales in all countries in which the product is sold.	
		
	  	The Company manufactures its bulk requirements for ixabepilone in its own facilities including manufacture of the active ingredient. The drug product which comprises a pharmaceutical kit is finished by Baxter Oncology GmbH.	
		
Affective (Psychiatric) Disorders	  		
		
ABILIFY*	  	Aripiprazole is an atypical antipsychotic agent for patients with schizophrenia, acute bipolar mania and Bipolar I Disorder.	
		
	  	Aripiprazole is copromoted in the U.S. by the Company and Otsuka Pharmaceutical Co., Ltd. (Otsuka). The Company’s rights to commercialize aripiprazole in the U.S. terminate in 2012. Thereafter, Otsuka has the sole right to commercialize aripiprazole in the U.S. In Germany and Spain, the Company copromotes with an Otsuka affiliate. In the UK and France, the Company currently acts as distributor for the product and copromotes with an Otsuka affiliate. In all other European markets, the Company acts as exclusive distributor. The Company is the exclusive licensee for the product in the rest of the world, excluding Japan and certain other countries. In the U.S., Spain and Germany, the Company records alliance revenue for its contractual share of the net sales and records all expenses related to the product. Alliance revenue is recorded by the Company as net sales based upon 65% of third-party customer net sales in the copromotion countries. The Company recognizes this alliance revenue when ABILIFY* is shipped and all risks and rewards of ownership have transferred to third-party customers. In the UK, France and Italy, the Company currently records 100% of the net sales and related cost of products sold. In countries where the Company has an exclusive right to sell ABILIFY*, the Company also records 100% of the net sales and related cost of products sold. For more information about the Company’s arrangement with Otsuka, see “—Strategic Alliances” below and “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
 
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	  	The basic U.S. composition of matter patent for ABILIFY* expires in 2014 (including the granted patent term extension). In 2004, Otsuka filed with the U.S. Patent and Trademark Office (USPTO) a Request for Reexamination of a U.S. composition of matter patent, U.S. Patent No. 5,006,528 (the ‘528 Patent), covering ABILIFY*. In June 2006, the USPTO issued an Ex Parte Reexamination Certificate for the ‘528 Patent confirming the patentability of the original claims and approving additional new claims.	
		
	  	Otsuka has received formal notices from each of Teva Pharmaceuticals USA (Teva), Barr Pharmaceuticals, Inc. (Barr), Sandoz Inc. (Sandoz), Synthon Laboratories, Inc. (Synthon), Sun Pharmaceuticals Ltd. (Sun) and Apotex stating that each has filed an Abbreviated New Drug Application (aNDA) with the FDA for various dosage forms of aripiprazole, which the Company and Otsuka comarket in the U.S. as ABILIFY*. Each of the notices further states that its aNDA contains a p(IV) certification directed to ‘528 Patent, which covers aripiprazole and expires in October 2014. In addition, each of the notices purports to provide Otsuka with the respective p(IV) certification. These certifications contain various allegations regarding the enforceability of the ‘528 Patent and/or the validity and/or infringement of some or all of the claims therein. Otsuka has filed patent infringement actions based on the ‘528 Patent against Teva, Barr, Sandoz, Sun and Apotex in the U.S. District Court of New Jersey and against Synthon in the U.S. District Court for the Middle District of North Carolina. Otsuka has sole rights to enforce the ‘528 Patent.	
		
	  	A composition of matter patent is in force in Germany, the UK, France, Italy, the Netherlands, Romania, Sweden, Switzerland, Spain and Denmark. The original expiration date of 2009 has been extended to 2014 by grant of a supplemental protection certificate in all of the above countries except Romania and Denmark. Data exclusivity in the EU expires in 2014. There is no composition of matter patent in Austria, Belgium, Finland, Greece, Ireland, Luxembourg, Portugal, Latvia, Hungary, Cyprus, Czech Republic, Slovenia, Slovakia, Poland, Malta, Lithuania, Bulgaria and Estonia.	
		
	  	The Company obtains its bulk requirements for aripiprazole from Otsuka. Both Otsuka and the Company finish the product in their own facilities.	
		
Immunoscience	  		
		
ORENCIA	  	Abatacept, a biological product, is a fusion protein with novel immunosuppressive activity targeted initially at adult patients with moderate to severe rheumatoid arthritis, who have had an inadequate response to certain currently available treatments. Abatacept was approved by the FDA in December 2005 and made commercially available in the U.S. in February 2006.	
		
	  	ORENCIA was discovered and developed internally.	
		
	  	The Company has a series of patents covering abatacept and its method of use. The latest of the composition of matter patents expires in the U.S. in 2016. The Company has submitted its request for patent term extension for one of the composition of matter patents that expires in 2015, which could possibly extend the term of the patent. In the majority of the EU countries, the Company has a patent covering abatacept that expires in 2012. Data exclusivity in the EU expires in 2017. In January 2006, Repligen Corporation and the Regents of the University of Michigan filed a complaint against the Company in the U.S. District Court for the Eastern District of Texas, Marshall Division alleging that the Company’s then-anticipated sales of ORENCIA will infringe U.S. Patent No. 6,685,941. In August 2006, Zymogenetics Inc. filed a complaint against the Company in the U.S. District Court for the District of Delaware. The complaint alleges that the Company’s manufacture and sales of ORENCIA infringe U.S. Patents No. 5,843,725 and 6,018,026. For more information about these litigations, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”	
		
	  	The Company obtains bulk abatacept from a third party and from its own manufacturing facilities. The Company finishes the product in its own facilities.	
		
Other Pharmaceuticals	  		
		
EFFERALGAN	  	EFFERALGAN is a formulation of acetaminophen first introduced in 1972 and distributed as an effervescent tablet. It is indicated for the treatment of fever or mild to moderate pain for adults and children, and marketed primarily in Europe. There is no composition of matter patent in Europe for EFFERALGAN.	
 
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In addition to the products discussed above, the Company’s Pharmaceuticals segment also includes the Company’s wholly-owned UPSA Consumer Medicines business in Europe, which includes EFFERALGAN, described above, as well as ASPIRINE UPSA, DAFALGAN and FERVEX in Europe and other overseas markets.
Strategic Alliances and Arrangements
The Company enters into strategic alliances and arrangements with third parties, which give the Company rights to develop, manufacture, market and/or sell pharmaceutical products, the rights to which are owned by such third parties. The Company also enters into strategic alliances and arrangements with third parties, which give such third parties the rights to develop, manufacture, market and/or sell pharmaceutical products, the rights to which are owned by the Company. These alliances and arrangements can take many forms, including licensing arrangements, codevelopment and comarketing agreements, copromotion arrangements and joint ventures. Such alliances and arrangements reduce the risk of incurring all research and development expenses that do not lead to revenue-generating products; however, the gross margins on alliance products are generally lower, sometimes substantially so, than the gross margins on the Company’s own products that are not partnered because profits from alliance products are shared with the Company’s alliance partners. While there can be no assurance that new alliances will be formed, the Company actively pursues such arrangements and views alliances as an important complement to its own discovery and development activities.
The Company’s most significant current alliances and arrangements for the Company’s products are those with Sanofi for PLAVIX* and AVAPRO*/AVALIDE*, Otsuka for ABILIFY*, ImClone for ERBITUX* and Gilead for ATRIPLA*. The Company’s most significant alliances and arrangements for investigational compounds under development are with Medarex, Inc. (Medarex) for ipilimumab, a monoclonal antibody being investigated as an anticancer treatment, the rights to which are owned by Medarex; with AstraZeneca PLC (AstraZeneca) for saxagliptin, an oral compound discovered by the Company for the potential treatment of diabetes that is a DPP-IV inhibitor, and dapagliflozin, an oral compound discovered by the Company for the potential treatment of diabetes that is a sodium-glucose cotransporter-2 (SGLT2) inhibitor; and with Pfizer, Inc. (Pfizer) for apixaban, an anticoagulant discovered by the Company being studied for the prevention and treatment of a broad range of venous and arterial thrombotic conditions. Each of these significant alliances and arrangements are discussed in more detail below. Additionally, the Company has licensing arrangements with Novartis for REYATAZ and with HZI for IXEMPRA, a novel microtubule-stabilizing agent for the treatment of breast cancer.
In general, the Company’s strategic alliances and arrangements are for periods co-extensive with the periods of market exclusivity protection on a country-by-country basis. Based on the Company’s current expectations with respect to the expiration of market exclusivity in the Company’s significant markets, the licensing arrangements with Novartis for REYATAZ are expected to expire in 2017 in the U.S., the EU and Japan; and HZI for IXEMPRA are expected to expire in 2017 in the U.S., and on the 10th anniversary of the first commercial sale in the EU and Japan. For further discussion of market exclusivity protection, including a chart showing net sales of key products together with the year in which basic exclusivity loss occurred or is expected to occur in the U.S., the EU and Japan, see “—Products” above and “—Intellectual Property and Product Exclusivity” below.
Each of the Company’s strategic alliances and arrangements with third parties who own the rights to manufacture, market and/or sell pharmaceutical products contain customary early termination provisions typically found in agreements of this kind and are generally based on the other party’s material breach or bankruptcy (voluntary or involuntary) and product safety concerns. The amount of notice required for early termination generally ranges from immediately upon notice to 90 days after receipt of notice. Termination immediately upon notice is generally available where the other party files a voluntary bankruptcy petition or if a material safety issue arises with a product such that the medical risk/benefit is incompatible with the welfare of patients to continue to develop or commercialize this product. Termination upon 30 to 90 days notice is generally available where an involuntary bankruptcy petition has been filed (and has not been dismissed) or a material breach by the other party has occurred (and not been cured). Early termination due to product safety concerns typically arises when a product is determined to create significant risk of harm to patients due to concerns regarding the product’s efficacy or level of toxicity. The Company’s strategic alliances and arrangements typically do not otherwise contain provisions that provide the other party the right to terminate the alliance on short notice.
In general, where the other party to the Company’s strategic alliance and arrangement will continue to have exclusivity protection upon the expiration or termination of the alliance, the Company does not retain any rights to the product or to the other party’s intellectual property. The loss of rights to one or more products that are marketed and sold by the Company pursuant to strategic alliance arrangements with third parties in one or more countries or territories could be material to the Company’s results of operations and cash flows and, in the case of PLAVIX*, could be material to its financial condition and liquidity. As is customary in the pharmaceutical industry, the terms of the Company’s strategic alliances and arrangements generally are co-extensive with the exclusivity period, which is discussed above, and may vary on a country-by-country basis.
As discussed below, the Company’s strategic alliance with Otsuka expires in November 2012 in the U.S. and Puerto Rico, which is prior to the expected expiration of market exclusivity protection for ABILIFY* in 2014 in the U.S. (including a granted patent term extension).
 
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Current Marketed Products
Sanofi The Company has agreements for the codevelopment and cocommercialization of AVAPRO*/AVALIDE*, an angiotensin II receptor antagonist indicated for the treatment of hypertension and diabetic nephropathy, which is copromoted in certain countries outside the U.S. under the tradename APROVEL*/COAPROVEL* and comarketed in certain countries outside the U.S. by the Company under the tradename KARVEA*/KARVEZIDE*; and PLAVIX*, a platelet aggregation inhibitor, which is copromoted in certain countries outside the U.S. under the tradename PLAVIX* and comarketed in certain countries outside the U.S. by the Company under the tradename ISCOVER*.
The worldwide alliance operates under the framework of two geographic regions, one covering certain European and Asian countries, defined as Territory A, and one covering the U.S., Puerto Rico, Canada, Australia and certain Latin American countries, defined as Territory B. The region covering the U.S., Puerto Rico, Canada, Australia, and certain Latin American countries is managed by two separate territory agreements, one for U.S. and Puerto Rico AVAPRO*/AVALIDE* only, and a second agreement for U.S. and Puerto Rico PLAVIX* only, plus Canada, Australia, Mexico, Brazil, Colombia and Argentina for both products. Within each of Territory A and B, a Territory Partnership exists to supply product to the countries within each territory and to manage certain central expenses such as marketing, research and development and royalties. Countries within Territory A and B are structured so that the Company’s local affiliate and Sanofi either comarket separate brands (e.g., each affiliate operates independently and sells a competing brand), or copromote a single brand.
Within Territory A, the comarketing countries include Germany, Spain, Italy (irbesartan only), Greece and China (clopidogrel bisulfate only). The Company sells ISCOVER* and KARVEA*/KARVEZIDE* and Sanofi sells PLAVIX* and APROVEL*/COAPROVEL* in these countries, except China, where the Company retains the right to, but does not currently comarket ISCOVER*. The Company and Sanofi copromote PLAVIX* and APROVEL*/COAPROVEL* in France, the UK, Belgium, Netherlands, Switzerland and Portugal. In addition, the Company and Sanofi copromote PLAVIX* in Austria, Italy, Ireland, Denmark, Finland, Norway, Sweden, Turkey, Taiwan, Korea, Singapore, Malaysia and Hong Kong, and APROVEL*/COAPROVEL* in certain French export countries. Sanofi acts as the operating partner for Territory A and owns a 50.1% majority financial controlling interest in this territory. The Company’s ownership interest in this territory is 49.9%. The Company accounts for the investment in partnership entities in this territory under the equity method and records its share of the results in equity in net income of affiliates in the consolidated statement of earnings. The Company’s share of net income from these partnership entities before taxes was $526 million in 2007, $439 million in 2006 and $345 million in 2005.
Within Territory B, the Company and Sanofi copromote PLAVIX* in the U.S., Canada and Puerto Rico and AVAPRO*/AVALIDE* in Canada. The other Territory B countries, Australia, Mexico, Brazil, Colombia (clopidogrel bisulfate only) and Argentina are comarketing countries. In 2001, the Company and Sanofi modified their previous exclusive license to the Company for AVAPRO*/AVALIDE* in the U.S. and Puerto Rico to form a copromotion joint venture, as part of which the Company contributed the AVAPRO*/AVALIDE* intellectual property and Sanofi agreed to pay the Company $200 million in 2001 and $150 million in 2002. The Company accounts for these payments as a sale of an interest in a license and defers and amortizes the total amount of $350 million into other income over the expected useful life of the license, which is approximately 11 years from the date of the formation of the copromotion joint venture. The Company acts as the operating partner for Territory B and the U.S./Puerto Rico AVAPRO*/AVALIDE* Territory and owns a 50.1% majority controlling interest in these territories. As such, the Company consolidates all partnership results in these territories and records Sanofi’s share of the results as a minority interest expense, net of taxes, which was $746 million in 2007, $428 million in 2006 and $578 million in 2005.
The Company recorded sales in Territory B, the U.S./Puerto Rico AVAPRO*/AVALIDE* Territory and Territory A comarketing countries of $5,958 million in 2007, $4,355 million in 2006 and $4,805 million in 2005.
In September 2006, the Company opted out of its copromotion rights with Sanofi for APROVEL*/COAPROVEL* in Ireland, Sweden, Denmark, Finland and Norway. The Company has also opted out of its comarketing or copromotion arrangements in a number of other countries prior to 2006. The Company receives a royalty payment from Sanofi based on a percentage of Sanofi’s net sales in the opt-out countries.
The territory partnerships are governed by a series of committees with enumerated functions, powers and responsibilities. Each territory has two senior committees (Senior Committees) which have final decision making authority with respect to that territory as to the enumerated functions, powers and responsibilities within its jurisdiction.
The agreements with Sanofi expire on the later of (i) with respect to PLAVIX*, 2013 and, with respect to AVAPRO*/AVALIDE*, 2012 in the Americas and Australia and 2013 in Europe and Asia, and (ii) the expiration of all patents and other exclusivity rights in the applicable territory.
The alliance arrangements may be terminated by the Company or Sanofi, either in whole or in any affected country or Territory, depending on the circumstances, in the event of (i) voluntary or involuntary bankruptcy or insolvency, which in the case of involuntary bankruptcy continues for 60 days or an order or decree approving same continues unstayed and in effect for 30 days; (ii) a
 
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material breach of an obligation under a major alliance agreement that remains uncured for 30 days following notice of the breach except where commencement and diligent prosecution of cure has occurred within 30 days after notice; (iii) deadlocks of one of the Senior Committees which render the continued commercialization of the product impossible in a given country or Territory or, in the case of AVAPRO*/AVALIDE* in the U.S., with respect to advertising and promotion spending levels or the amount of sales force commitment; (iv) an increase in the combined cost of goods and royalty which exceeds a specified percentage of the net selling price of the product; or (v) a good faith determination by the terminating party that commercialization of a product should be terminated for reasons of patient safety.
In the case of each of these termination rights, the agreements include provisions for the termination of the relevant alliance with respect to the applicable product in the applicable country or territory or, in the case of a termination due to bankruptcy or insolvency or material breach, both products in the applicable territory. Each of these termination procedures is slightly different; however, in all events, the Company could lose all rights to either or both products, as applicable, in the relevant country or territory even in the case of a bankruptcy or insolvency or material breach where the Company is not the defaulting party.
For further discussion of the Company’s strategic alliance with Sanofi, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”
Otsuka In 1999, the Company entered into a worldwide commercialization agreement with Otsuka, to codevelop and copromote ABILIFY* for the treatment of schizophrenia and related psychiatric disorders, except in Japan, China, Taiwan, North Korea, South Korea, the Philippines, Thailand, Indonesia, Pakistan and Egypt. The Company began copromoting the product with Otsuka in the U.S. and Puerto Rico in November 2002. In June 2004, the Company received marketing approval from the European Commission. The product is currently copromoted with Otsuka in the UK, Germany, France and Spain. In the U.S., Germany and Spain, where the product is invoiced to third-party customers by the Company on behalf of Otsuka, the Company records alliance revenue for its 65% contractual share of third-party net sales and records all expenses related to the product. The Company recognizes this alliance revenue when ABILIFY* is shipped and all risks and rewards of ownership have transferred to third-party customers. In the UK, France and Italy, where the Company is presently the exclusive distributor for the product, the Company records 100% of the net sales and related cost of products sold and expenses. The Company also has an exclusive right to sell ABILIFY* in other countries in Europe, the Americas and a number of countries in Asia. In these countries the Company records 100% of the net sales and related cost of products sold.
Under the terms of the agreement, the Company purchases the product from Otsuka and performs finish manufacturing for sale by the Company or Otsuka to third-party customers. The agreement expires in November 2012 in the U.S. For the entire EU, the agreement expires in June 2014. In each other country where the Company has the exclusive right to sell ABILIFY*, the agreement expires on the later of the 10th anniversary of the first commercial sale in such country or expiration of the applicable patent in such country. Early termination is available based on the other party’s voluntary or involuntary bankruptcy, failure to make minimum payments, failure to commence the first commercial sale within three months after receipt of all necessary approvals and material breach. The amount of notice required for early termination of the strategic alliance is immediately upon notice (i) in the case of voluntary bankruptcy, (ii) where minimum payments are not made to Otsuka, or (iii) if first commercial sale has not occurred within three months after receipt of all necessary approvals, 30 days where a material breach has occurred (and not been cured or commencement of cure has not occurred within 90 days after notice of such material breach) and 90 days in the case where an involuntary bankruptcy petition has been filed (and not been dismissed). In addition, termination is available to Otsuka upon 30 days notice in the event that the Company were to challenge Otsuka’s patent rights or, on a market-by-market basis, the Company were to market a product in direct competition with ABILIFY*. Upon termination or expiration of the alliance, the Company does not retain any rights to ABILIFY*.
The Company recorded total revenue for ABILIFY* of $1,660 million in 2007, $1,282 million in 2006 and $912 million in 2005. Total milestone payments made to Otsuka under the agreement through 2007 were $217 million, of which $157 million was expensed as acquired in-process research and development in 1999. The remaining $60 million was capitalized in other intangible assets and is amortized into cost of products sold over the remaining life of the agreement in the U.S., ranging from 8 to 11 years. The Company amortized in cost of products sold $6 million in each of 2007, 2006 and 2005. The unamortized capitalized payment balance was $29 million and $35 million as of December 31, 2007 and 2006, respectively.
For further discussion of the Company’s strategic alliance with Otsuka, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”
ImClone In 2001, the Company purchased 14.4 million shares of ImClone for $70 per share, or $1,007 million, which represented approximately 19.9% of the ImClone shares outstanding just prior to the Company’s commencement of a public tender offer for those ImClone shares. ImClone is a biopharmaceutical company focused on developing targeted cancer treatments, which include growth factor blockers, cancer vaccines and anti-angiogenesis therapeutics. The equity investment in ImClone is part of a strategic agreement between the Company and ImClone that also included a commercialization arrangement expiring in September 2018 for the codevelopment and copromotion of ERBITUX*, for a series of payments originally totaling $1 billion. The Company
 
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paid ImClone a milestone payment of $200 million in 2001. In 2002, the agreement with ImClone was revised to reduce the total payments to $900 million from $1 billion. In accordance with the agreement, the Company paid ImClone $140 million in 2002, $60 million in 2003, $250 million in 2004 and $250 million in the first quarter of 2006. The 2004 payment was made upon the approval by the FDA of the BLA for ERBITUX* for use in combination with irinotecan in the treatment of patients with EGFR-expressing, mCRC who are refractory to irinotecan-based chemotherapy and for use as a single agent in the treatment of patients with EGFR-expressing, mCRC who are intolerant to irinotecan-based chemotherapy. The 2006 milestone payment was made upon FDA approval of ERBITUX* for use in the treatment of squamous cell carcinoma of the head and neck in combination with radiation or as monotherapy. The Company also has codevelopment and copromotion rights in Canada and Japan to the extent the product is commercialized in such countries. Under the agreement, covering North America, ImClone receives a distribution fee based on a flat rate of 39% of net sales in North America. The Company purchases all of its commercial requirements for bulk ERBITUX* from ImClone at a price equal to ImClone’s manufacturing cost plus 10%.
In July 2007, the Company and ImClone amended the terms of their agreement for the codevelopment and copromotion of ERBITUX* in North America. Under this amendment, the companies have jointly agreed to expand the investment in the ongoing clinical development plan for ERBITUX* by up to several hundred million dollars. Development costs, up to a threshold value, will be the sole responsibility of the Company; costs in excess of this threshold will be shared by both companies according to a predetermined ratio.
The Company shares copromotion rights to ERBITUX* with Merck KGaA in Japan under a codevelopment and cocommercialization agreement signed in October 2007 among BMS, BMKK, E.R. Squibb & Sons, LLC, ImClone, Merck KGaA and Merck Japan. ERBITUX* is not yet marketed in Japan, although the Company and ImClone submitted in February 2007 an application to the PMDA for the use of ERBITUX* in treating patients with advanced colorectal cancer.
The Company accounts for the $500 million total approval milestones paid in 2004 and 2006 as license acquisitions, and amortizes the payments into the cost of products sold over the remaining term of the agreement, which ends in 2018. The Company amortized into cost of products sold $38 million, $34 million and $17 million for 2007, 2006 and 2005, respectively. The unamortized portion of the approval payments is recorded in other intangible assets, net, in the consolidated balance sheet and was $397 million and $435 million as of December 31, 2007 and 2006, respectively.
The Company determines its equity share in ImClone’s net income or loss by eliminating from ImClone’s results the milestone revenue ImClone recognized for the $400 million in pre-approval milestone payments made by the Company from 2001 through 2003. The Company recorded net income of $7 million and $43 million in 2007 and 2006, respectively, and net loss of $5 million in 2005 for its share of ImClone’s results of operations. The Company records its share of the results in equity in net income of affiliates in the consolidated statement of earnings. The Company recorded net sales for ERBITUX* of $692 million in 2007, $652 million in 2006 and $413 million in 2005.
The Company’s recorded investment and the market value of its holdings in ImClone common stock was $114 million and approximately $619 million as of December 31, 2007, respectively, and $109 million and approximately $385 million as of December 31, 2006, respectively. The Company holds 14.4 million shares of ImClone stock, representing approximately 17% of ImClone’s shares outstanding at December 31, 2007 and 2006. On a per share basis, the carrying value of the ImClone investment and the closing market price of the ImClone shares as of December 31, 2007 were $7.92 and $43.00, respectively, compared to $7.59 and $26.76, respectively, as of December 31, 2006.
Early termination is available based on material breach and is effective 60 days after notice of the material breach (and such material breach has not been cured or commencement of cure has not occurred), or upon six months notice from the Company if there exists a significant concern regarding a regulatory or patient safety issue that would seriously impact the long-term viability of the product. Upon termination or expiration of the alliance, the Company does not retain any rights to ERBITUX*.
During 2004 and through May 2005, McKesson Corporation (McKesson), one of the Company’s wholesalers, provided warehousing, packing and shipping services for ERBITUX*. McKesson held ERBITUX* inventory on consignment and, under the Company’s revenue recognition policy, the Company recognized revenue when such inventory was shipped by McKesson to the end-users. McKesson also held inventories of ERBITUX* for its own account. Upon the divestiture of Oncology Therapeutics Network in May 2005, the Company discontinued the consignment arrangement with McKesson and McKesson no longer held inventories for its own account. Thereafter, the Company sold ERBITUX* to intermediaries (such as wholesalers and specialty oncology distributors) and shipped ERBITUX* directly to the end-users of the product who are the customers of those intermediaries. Beginning in the third quarter of 2006, the Company began expanding its distribution model to include wholesalers and distributors who hold ERBITUX* inventory. The Company recognizes revenue upon such shipment consistent with its revenue recognition policy.
For further discussion of the Company’s strategic alliance with ImClone, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”
 
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Gilead In 2004, the Company and Gilead entered into a joint venture to develop and commercialize a fixed-dose combination of the Company’s SUSTIVA and Gilead’s TRUVADA* (emtricitabine and tenofovir disoproxil fumarate) in the U.S. In July 2006, the FDA granted approval of ATRIPLA*, which is the first complete Highly Active Antiretroviral Therapy treatment product for HIV available in the U.S. in a fixed-dose combination taken once daily. Fixed-dose combinations contain multiple medicines formulated together and may help simplify HIV therapy for patients and providers. Guidelines issued by the U.S. Department of Health and Human Services list the combination of emtricitabine, tenofovir disoproxil fumarate and efavirenz as one of the preferred non-NNRTI-based treatments for use in appropriate patients that have never taken anti-HIV medicines before. In September 2006, the companies amended their agreements to commercialize ATRIPLA* in Canada. ATRIPLA* was approved by Health Canada in October 2007 and by the European Commission in December 2007 for commercialization in the 27 countries of the EU, as well as Norway and Iceland.
The Company and Gilead share responsibility for commercializing ATRIPLA* in the U.S., Canada, throughout the EU and certain other European countries, and both provide funding and field-based sales representatives in support of promotional efforts for ATRIPLA*. Gilead records 100% of ATRIPLA* revenues in the U.S., Canada and most countries in Europe. The Company records revenue for the bulk efavirenz component of ATRIPLA* upon sales of that product by the joint venture with Gilead to third-party customers. The Company’s revenue for the efavirenz component is determined by applying a percentage to ATRIPLA* revenue, which approximates revenue for the SUSTIVA brand. The Company recorded efavirenz revenues of $335 million in 2007 and $76 million in 2006 related to ATRIPLA* sales.
Gilead consolidates the results of the joint venture in their operating results and the Company accounts for its participation in the joint venture under the equity method of accounting and records its share of the joint venture results in equity in net income of affiliates in the consolidated statement of earnings. The Company recorded an equity loss on the joint venture with Gilead of $9 million in 2007, $6 million in 2006 and $4 million in 2005.
The joint venture between the Company and Gilead will continue until terminated by mutual agreement of the parties or otherwise as described below. In the event of a material breach by one party, the non-breaching party may terminate the joint venture only if both parties agree that it is both desirable and practicable to withdraw the combination product from the markets where it is commercialized. At such time as one or more generic versions of SUSTIVA appear on the market in the U.S., Gilead will have the right to terminate the joint venture and thereby acquire all the rights to the combination product, both in the U.S. and Canada; however, the Company will continue for three years to receive a percentage of the net sales based on the contribution of bulk efavirenz to ATRIPLA*, and otherwise retains all rights to SUSTIVA.
For further discussion of the Company’s strategic alliance with Gilead, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”
Investigational Compounds Under Development
Medarex In 2004, the Company entered into a worldwide collaboration and share purchase agreement with Medarex to codevelop and copromote ipilimumab, a fully human antibody currently in Phase III development for the treatment of metastatic melanoma. The agreement became effective in January 2005 after the companies received certain governmental clearances and approvals, and the receipt of consent from the U.S. Public Health Service of the sublicense to the Company of Medarex’s rights to MDX-1379 (gp100), a vaccine that is being developed in combination with ipilimumab. The FDA has granted Fast Track status to ipilimumab in combination with MDX-1379 for treatment of patients with late stage unresectable metastatic melanoma who have failed or are intolerant to first-line therapy.
In January 2005, under the terms of the agreement, the Company made a cash payment of $25 million to Medarex, which was expensed as research and development, and an additional $25 million equity investment in Medarex. Further milestone payments are expected to be made upon the successful achievement of various regulatory and sales-related stages. The Company and Medarex will also share in future development and commercialization costs. Medarex could receive up to $205 million if all regulatory milestones are met, and up to $275 million in sales-related milestones. Medarex will have an option to copromote and receive up to 45% of the profits with the Company in the U.S. The Company will receive an exclusive license outside of the U.S. and pay royalties to Medarex.

The agreement with Medarex does not expire unless and until one of the following events occurs: (1) the Company voluntarily terminates the agreement in its entirety or on a country-by-country basis by providing Medarex with six months prior written notice; (2) the Company voluntarily terminates the agreement on a product-by-product basis (but only if a second product is then in GLP toxicology studies or later) or a country-by-country basis by providing Medarex with six months prior written notice depending on the circumstances; (3) the Company terminates Medarex’s copromotion option and rights in the U.S. on 60 days written notice after the end of the second calendar year in the event Medarex provides less than 60 percent of certain performance obligations in any two out of three consecutive calendar years (such termination right to be exercised only with respect to those indications as to which Medarex failed to meet such performance obligation). Upon any such termination by the Company via any of the scenarios in (1) – (3) above, Medarex will no longer have a right to share in the profits and losses of the product for the terminated indication(s) and, instead the Company will pay Medarex royalties on net sales of the product; or (4) Medarex terminates the agreement with respect to all products on 60 days written notice if the Company provides less than 60 percent of certain performance obligations in any two out of three consecutive calendar years. Generally, upon termination in (4), the Company will assign all rights to the product to Medarex and receive a royalty thereafter on intellectual property licensed by the Company to Medarex. Medarex may also elect not to copromote a product for one or more indications in the U.S., in which event it will receive a royalty on sales of the product for such indication. If there is a material breach as to manufacturing by a party, then the other party shall be limited to termination of such party’s manufacturing rights only.
 
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AstraZeneca In January 2007, the Company entered into two worldwide (except for Japan) codevelopment and cocommercialization agreements with AstraZeneca, one for the codevelopment and cocommercialization of saxagliptin, a DPP-IV inhibitor (Saxagliptin Agreement), and one for the codevelopment and cocommercialization of dapagliflozin, a SGLT2 inhibitor (SGLT2 Agreement). Both compounds are being studied for the treatment of diabetes and were discovered by the Company. Under the terms of the agreements, the Company received from AstraZeneca an upfront payment of $100 million in January 2007, which was deferred and is being recognized over the life of the agreements into other income. The Company amortized into other income $7 million in 2007. The unamortized portion of the upfront payment was $93 million as of December 31, 2007. Milestone payments are expected to be received by the Company upon the successful achievement of various development and regulatory events, as well as sales-related milestones. Under the Saxagliptin Agreement, the Company could receive up to $300 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met. Under the SGLT2 Agreement, the Company could receive up to $350 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met. Under each agreement, the Company and AstraZeneca also share in future development and commercialization costs. The majority of development costs under the initial development plans through 2009 will be paid by AstraZeneca and any additional development costs will generally be shared equally. The Company records in research and development expenses saxagliptin and dapagliflozin development costs net of its alliance partner’s share. Under each agreement, the two companies will jointly develop the clinical and marketing strategy and share commercialization expenses and profits/losses equally on a global basis, excluding Japan, and the Company will manufacture both products and, with certain limited exceptions, record net sales.
Pfizer In April 2007, the Company and Pfizer entered into a worldwide codevelopment and cocommercialization agreement for apixaban, an anticoagulant discovered by the Company being studied for the prevention and treatment of a broad range of venous and arterial thrombotic conditions. In accordance with the terms of the agreement, Pfizer made an upfront payment of $250 million to the Company in May 2007, which was deferred and is being recognized over the life of the agreement into other income. In December 2007, the Company and Pfizer agreed to include Japan in the worldwide agreement. Pfizer made an upfront payment of $40 million in December 2007, which was deferred and is being recognized over the life of the agreement into other income. The Company amortized into other income $11 million in 2007. The unamortized portion of the upfront payments was $279 million as of December 31, 2007. Pfizer will fund 60% of all development costs effective January 1, 2007 going forward, and the Company will fund 40%. The Company records in research and development expenses apixaban development costs net of its alliance partner’s share. The Company may also receive additional payments of up to $780 million from Pfizer based on development and regulatory milestones. The companies will jointly develop the clinical and marketing strategy of apixaban, and will share commercialization expenses and profits/losses equally on a global basis.
For further information on alliances relating to products under development and drug discovery, see “—Research and Development” below.
HEALTH CARE GROUP
Nutritionals Segment
The Nutritionals segment, through Mead Johnson, manufactures, markets, distributes and sells infant formulas and other nutritional products, including the entire line of ENFAMIL products. The ENFAMIL LIPIL product is the first infant formula in the U.S. to contain the nutrients docosahexaenoic acid (DHA) and arachidonic acid (ARA). Also naturally found in breast milk, DHA and ARA are believed to support infant brain and eye development. The Company obtains these nutrients from a sole provider pursuant to a non-exclusive worldwide license and supply agreement. The supply agreement, in force until at least 2011, provides no firm guarantee of supply and pricing is subject to change pursuant to a pricing formula. The license expires beginning in 2024 on a country-by-country basis 25 years after the Company commenced sales in a country.
The Company’s Nutritionals products are generally sold by wholesalers and retailers and are promoted primarily to health care professionals. The Company also promotes Nutritionals products directly to consumers worldwide through advertising. The Company manufactures these products in the U.S. and in five foreign countries. Nutritionals sales accounted for 13% of the Company’s sales in 2007, 14% of the Company’s sales in 2006 and 12% of the Company’s sales in 2005. U.S. Nutritionals sales accounted for 44%, 46% and 49% of total Nutritionals sales in 2007, 2006 and 2005, respectively, while international Nutritionals sales accounted for 56%, 54% and 51% of total Nutritionals sales in 2007, 2006 and 2005, respectively. Approximately one-half of U.S. gross sales of infant formula are subject to rebates issued under the Women, Infants and Children (WIC) program. Sales subject to WIC rebates have much lower margins than those of non-WIC program sales.
 
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Key Nutritionals product lines and their sales are as follows:

Dollars in Millions	  	2007	  	2006	  	2005	
Infant Formulas	  	$	1,786	  	$	1,637	  	$	1,576	
ENFAMIL	  	 	1,082	  	 	1,007	  	 	992	
Toddler/Children’s Nutritionals	  	 	693	  	 	606	  	 	529	
ENFAGROW	  	 	295	  	 	262	  	 	206	
ConvaTec Segment
The ConvaTec segment manufactures, distributes and sells ostomy and modern wound and skin care products. Principal brands of ConvaTec include NATURA, SUR-FIT, ESTEEM, AQUACEL, DUODERM and FLEXI-SEAL. These products are marketed worldwide, primarily to hospitals, medical professions and medical suppliers. The Company mainly relies on an internal sales force, and sales are made through various distributors around the world. The Company manufactures these products in the U.S., the UK and the Dominican Republic.
ConvaTec sales accounted for approximately 6% of the Company’s sales in 2007, 6% of the Company’s sales in 2006 and 5% of the Company’s sales in 2005. U.S. ConvaTec sales accounted for 32%, 33% and 31% of total ConvaTec sales in 2007, 2006 and 2005, respectively, while international ConvaTec sales accounted for 68%, 67% and 69% of total ConvaTec sales in 2007, 2006 and 2005, respectively.
ConvaTec sales by business and key products are as follows:

Dollars in Millions	  	2007	  	2006	  	2005	
ConvaTec	  	$	1,155	  	$	1,048	  	$	992	
Ostomy	  	 	594	  	 	554	  	 	550	
Wound Therapeutics	  	 	488	  	 	441	  	 	416	
Productivity Transformation Initiative
The Company undertook a broad range of actions in the fourth quarter of 2007 as part of the previously announced three-year Productivity Transformation Initiative (PTI), which is reducing costs, streamlining operations and rationalizing global manufacturing. The initiative, which is on track to achieve $1.5 billion in annual cost savings and cost avoidance on a pre-tax basis by 2010, is central to the Company’s strategy to become a more nimble and flexible next generation biopharmaceutical enterprise.
Key productivity initiatives include reducing general and administrative operations by simplifying, standardizing and outsourcing, where appropriate, processes and services, rationalizing the Company’s mature brands portfolio, consolidating its global manufacturing network while eliminating complexity and enhancing profitability, simplifying its geographic footprint and implementing a more efficient go-to-market model. Specific productivity goals include reducing the number of brands in the Company’s mature products portfolio by 60 percent between 2007 and 2011, reducing the number of manufacturing facilities by more than 50 percent by the end of 2010, and reducing total headcount by approximately 10 percent between 2007 and 2010. Some positions have been eliminated in 2007, although the substantial majority of positions will be eliminated in 2008 and 2009. The Company has announced the impending closure of several manufacturing facilities, including Barceloneta, Puerto Rico and Mayaguez, Puerto Rico.
Costs associated with the implementation of the PTI are estimated to be between $0.9 billion to $1.1 billion on a pre-tax basis, with $292 million incurred in 2007 and approximately $500 million expected to be incurred in 2008. The ultimate timing of the recording of the charges cannot be predicted with certainty and will be affected by the occurrence of triggering events for expense recognition under U.S. Generally Accepted Accounting Principles (GAAP), among other factors.
 
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Sources and Availability of Raw Materials
In general, the Company purchases its raw materials, medical devices and supplies required for the production of the Company’s products in the open market. For some products, the Company purchases its raw materials, medical devices and supplies from a single source, which in certain circumstances is specified in the Company’s product registrations, thereby requiring the Company to obtain such raw materials and supplies from that particular source. The Company attempts, if possible, to mitigate raw material supply risks to the Company, through inventory management and alternative sourcing strategies. For further discussion of sourcing, see “—Manufacturing and Quality Assurance” below and discussions of particular products.
Manufacturing and Quality Assurance
To meet all expected product demand, the Company operates and manages its manufacturing network, including its third-party contract manufacturers, and the inventory related thereto, in a manner that permits the Company to improve efficiency while maintaining flexibility in its ability to reallocate manufacturing capacity. Pharmaceutical production processes are complex, highly regulated and vary widely from product to product. Given that shifting or adding manufacturing capacity can be a very lengthy process requiring significant capital and out-of-pocket expenditures and regulatory approvals, the Company maintains and operates its flexible manufacturing network, consisting of internal and external resources, that minimizes unnecessary product transfers and inefficient uses of manufacturing capacity. For further discussion of the regulatory impact on the Company’s manufacturing, see “—Government Regulation and Price Constraints” below.
Pharmaceutical manufacturing facilities require significant ongoing capital investment for both maintenance and compliance with increasing regulatory requirements. In addition, as the Company adds to its product line and realigns its focus over the next several years, the Company expects to modify its existing manufacturing network to meet complex processing standards that may be required for newly introduced products, including biologics. Biologics manufacturing involves more complex processes than those of traditional pharmaceutical operations. Although the Company does have the capacity to manufacture biologics for clinical trials and commercial launch, its capacity to manufacture larger commercial volumes is limited. As biologics become more important to the Company’s product portfolio, the Company may continue to make arrangements with third-party manufacturers, and in addition expects to make substantial investments to increase its internal capacity to produce biologics on a commercial scale. During 2006, the Board of Directors approved capital expenditures of approximately $750 million for a bulk biologics manufacturing facility in the U.S. In February 2007, the Company completed the land purchase of an 89-acre site to locate its large scale multi-product bulk biologics manufacturing facility in Devens, Massachusetts. Construction of the Devens, Massachusetts facility began in early 2007, and the facility is projected to be operationally complete by 2009. The Company expects to submit the site for regulatory approval in 2010. Commercial production of biologic compounds is anticipated to begin by 2011.
The Company relies on third parties to manufacture, or to supply it with active ingredients necessary for it to manufacture certain products, including PLAVIX*, ABILIFY*, ERBITUX*, the SUSTIVA Franchise, ORENCIA*, PRAVACHOL, COUMADIN and TAXOL ® (paclitaxel). To maintain a stable supply of these products, the Company takes a variety of actions designed to provide that there is a reasonable level of these ingredients held by the third-party supplier, the Company or both, so that the Company’s manufacturing operations are not interrupted. As an additional protection, in some cases, the Company takes steps to maintain an approved back-up source where available. For example, the Company will rely on the combined capacity of its Devens, Massachusetts, Syracuse, New York, and Manati, Puerto Rico, facilities, and the capacity available at its third-party contract manufacturers to manufacture ORENCIA* and the commercial quantities of the Company’s other investigational compounds in late-stage development should those compounds receive regulatory approval.
If the Company or any third-party manufacturer that the Company relies on for existing or future products is unable to maintain a stable supply of products, operate at sufficient capacity to meet its order requirements, comply with government regulations for manufacturing pharmaceuticals or meet the heightened processing requirements for biologics, the Company’s business performance and prospects could be negatively impacted. Additionally, if the Company or any of its third-party suppliers were to experience extended plant shutdowns or substantial unplanned increases in demand or suspension of manufacturing for regulatory reasons, the Company could experience an interruption in supply of certain products or product shortages until production could be resumed or expanded.
In connection with divestitures, licensing arrangements or distribution agreements of certain of the Company’s products, or in certain other circumstances, the Company has entered into agreements under which the Company has agreed to supply such products to third parties. In addition to liabilities that could arise from the Company’s failure to supply such products under the agreements, these arrangements could require the Company to invest in facilities for the production of non-strategic products, result in additional regulatory filings and obligations or cause an interruption in the manufacturing of its own products.
The Company’s success depends in great measure upon customer confidence in the quality of its products and in the integrity of the data that support their safety and effectiveness. Product quality arises from a total commitment to quality in all parts of the Company’s operations, including research and development, purchasing, facilities planning, manufacturing, and distribution. The Company maintains quality-assurance procedures relating to the quality and integrity of technical information and production processes.
 
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Control of production processes involves detailed specifications for ingredients, equipment and facilities, manufacturing methods, processes, packaging materials, and labeling. The Company performs tests at various stages of production processes and on the final product to ensure that the product meets all regulatory requirements and the Company’s standards. These tests may involve chemical and physical chemical analyses, microbiological testing, or a combination of these along with other analyses. Quality control is provided by business unit/site quality assurance groups that monitor existing manufacturing procedures and systems used by the Company, its subsidiaries and third-party suppliers.
Intellectual Property and Product Exclusivity
The Company owns or licenses a number of patents in the U.S. and foreign countries primarily covering its products. The Company has also developed many brand names and trademarks for products in all areas. The Company considers the overall protection of its patent, trademark, license and other intellectual property rights to be of material value and acts to protect these rights from infringement.
In the pharmaceutical industry, the majority of an innovative product’s commercial value is usually realized during the period in which the product has market exclusivity. In the U.S. and some other countries, when market exclusivity expires and generic versions of a product are approved and marketed, there can often be very substantial and rapid declines in the product’s sales. The rate of this decline varies by country and by therapeutic category. For a discussion of how generic versions of a product can impact that product’s sales, see “—Generic Competition” below.
A product’s market exclusivity is generally determined by two forms of intellectual property: patent rights held by the innovator company and any regulatory forms of exclusivity to which the innovative drug is entitled.
Patents are a key determinant of market exclusivity for most branded pharmaceuticals. Patents provide the innovator with the right to exclude others from practicing an invention related to the medicine. Patents may cover, among other things, the active ingredient(s), various uses of a drug product, pharmaceutical formulations, drug delivery mechanisms and processes for (or intermediates useful in) the manufacture of products. Protection for individual products extends for varying periods in accordance with the expiration dates of patents in the various countries. The protection afforded, which may also vary from country to country, depends upon the type of patent, its scope of coverage and the availability of meaningful legal remedies in the country.
Market exclusivity is also sometimes influenced by regulatory intellectual property rights. Many developed countries provide certain non-patent incentives for the development of medicines. For example, the U.S., the EU and Japan each provide for a minimum period of time after the approval of a new drug during which the regulatory agency may not rely upon the innovator’s data to approve a competitor’s generic copy. Regulatory intellectual property rights are also available in certain markets as incentives for research on new indications, on orphan drugs and on medicines useful in treating pediatric patients.
Regulatory intellectual property rights are independent of any patent rights that the Company may possess and can be particularly important when a drug lacks broad patent protection. However, most regulatory forms of exclusivity do not prevent a competitor from gaining regulatory approval prior to the expiration of regulatory data exclusivity on the basis of the competitor’s own safety and efficacy data on its drug, even when that drug is identical to that marketed by the innovator.
The Company estimates the likely market exclusivity period for each of its products on a case-by-case basis. It is not possible to predict the length of market exclusivity for any of the Company’s products with certainty because of the complex interaction between patent and regulatory forms of exclusivity, and inherent uncertainties concerning patent litigation. There can be no assurance that a particular product will enjoy market exclusivity for the full period of time that the Company currently estimates or that the exclusivity will be limited to the estimate. For a discussion on market exclusivity, see “—Pharmaceuticals Segment” above.
In addition to patents and regulatory forms of exclusivity, the Company also holds intellectual property in the form of trademarks on products such as ENFAMIL. Trademarks have no effect on market exclusivity for a product, but are considered to have marketing value. Worldwide, all of the Company’s important products are sold under trademarks that are considered in the aggregate to be of material importance. Trademark protection continues in some countries as long as used; in other countries, as long as registered. Registration is for fixed terms and can be renewed indefinitely.
Specific aspects of the law governing market exclusivity for pharmaceuticals vary from country to country. The following summarizes key exclusivity rules in markets representing significant Company sales:
United States
A company seeking to market an innovative pharmaceutical in the U.S. must file a complete set of safety and efficacy data to the FDA. The type of application filed depends on whether the drug is a chemical (a small molecule) or a biological product (a large molecule). If the innovative pharmaceutical is a chemical, the company files a New Drug Application (NDA). If the medicine is a biological product, a BLA is filed. The type of application filed affects regulatory exclusivity rights.
 
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A competitor seeking to launch a generic substitute of a chemical innovative drug in the U.S. must file an aNDA with the FDA. In the aNDA, the generic manufacturer needs to demonstrate only “bioequivalence” between the generic substitute and the approved NDA drug. The aNDA relies upon the safety and efficacy data previously filed by the innovator in its NDA.
Medicines approved under a NDA can receive several types of regulatory data protection. An innovative chemical pharmaceutical (also known as a new chemical entity) is entitled to five years of regulatory data protection in the U.S., during which an aNDA cannot be filed with the FDA. If an innovator’s patent is challenged, as described below, the generic manufacturer may file its aNDA after the fourth year of the five-year data protection period. A pharmaceutical drug product that contains an active ingredient that has been previously approved in a NDA, but is approved in a new formulation or for a new indication on the basis of new clinical trials, receives three years of data protection. Finally, a NDA that is designated as an Orphan Drug, which is a drug that gains an indication for treatment of a condition that occurs only rarely in the U.S., can receive seven years of exclusivity for the orphan indication. During this time period, neither NDAs nor aNDAs for the same drug product can be approved for the same orphan use.
Because a significant portion of patent life can be lost during the time it takes to obtain regulatory approval, the innovator can extend one patent to compensate the innovator for the lost patent term, at least in part. More specifically, the innovator may identify one patent, which claims the product or its approved method of use, and, depending on a number of factors, may extend the expiration date of that patent. There are two limits to these extensions. First, the maximum term a patent can be extended is five years, and second, the extension cannot cause the patent to be in effect for more than 14 years from the date of NDA approval.
A company may also earn six months of additional exclusivity for a drug where specific clinical trials are conducted at the written request of the FDA to study the use of the medicine to treat pediatric patients, and submission to the FDA is made prior to the loss of basic exclusivity. This six-month period extends most forms of exclusivity (patent and regulatory) that are listed with the FDA at the time the studies are completed and submitted to the FDA, but not against products already finally approved.
Currently, generic versions of biological products cannot be approved under U.S. law. However, the law could change in the future. Even in the absence of new legislation, the FDA is taking steps toward allowing generic versions of certain biologics. Competitors seeking approval of biological products must file their own safety and efficacy data, and address the challenges of biologics manufacturing, which involves more complex processes and are more costly than those of traditional pharmaceutical operations.
Many (but not all) innovative drugs are also covered by patents held by the NDA sponsor beyond the minimum period of regulatory exclusivity provided by U.S. law.
The innovator company is required to list certain of its patents covering the medicine with the FDA in what is commonly known as the Orange Book. Absent a successful patent challenge, the FDA cannot approve an aNDA until after the innovator’s listed patents expire. However, after the innovator has marketed its product for four years, a generic manufacturer may file an aNDA and allege that one or more of the patents listed in the Orange Book under an innovator’s NDA is either invalid or not infringed. This allegation is commonly known as a “Paragraph IV certification.” The innovator then must decide whether to file a patent infringement suit against the generic manufacturer. If one or more of the NDA-listed patents are successfully challenged, or if the innovator chooses not to sue, the first filer of a Paragraph IV certification (or first filers if more than one generic qualifies) may be entitled to a 180-day period of market exclusivity against all other generic manufacturers. From time to time, aNDAs, including Paragraph IV certifications, are filed with respect to certain of the Company’s products. The Company evaluates these aNDAs on a case-by-case basis and, where warranted, files suit against the generic manufacturer to protect its patent rights.
In the U.S., the increased likelihood of generic challenges to innovators’ intellectual property has increased the risk of loss of innovators’ market exclusivity. First, generic companies have increasingly sought to challenge innovators’ basic patents covering major pharmaceutical products. For a discussion of one such litigation related to patent challenges by generic companies, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies—PLAVIX* Litigation,” and “—Other Intellectual Property Litigation.” Second, statutory and regulatory provisions in the U.S. limit the ability of an innovator company to prevent generic drugs from being approved and launched while patent litigation is ongoing. Third, the FDA is actively considering ways to expand the use of a regulatory mechanism that allows for regulatory approval of drugs that are similar to (but not generic copies of) innovative drugs on the basis of less extensive data than is required for a full NDA. As a result of all of these developments, it is not possible to predict the length of market exclusivity for a particular Company product with certainty based solely on the expiration of the relevant patent(s) or the current forms of regulatory exclusivity. For more information about new legislation, see “—Government Regulation and Price Constraints” below.
 
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European Union
Recent pharmaceutical legislation in the EU has an impact on the procedures for authorization of pharmaceutical products in the EU under both the centralized and mutual recognition procedures. In particular, the legislation contains new data protection provisions. All products (regardless of whether they have been approved under the centralized or the mutual recognition procedures) will be subject to an “8+2+1” regime. Eight years after the innovator has received its first community authorization for a medicinal product, a generic company may file a marketing authorization application for that product with the health authorities. However, the generic company may not commercialize the product until after either 10 or 11 years have elapsed from the initial marketing authorization granted to the innovator. The possible one-year extension is available if the innovator, during the first eight years of the marketing authorization, obtains an additional indication that is of significant clinical benefit in comparison with existing treatments. There is a transitional provision for these new data protection requirements, and these provisions will apply as new marketing authorization applications are submitted under the new legislation. For those products that continue to be covered under the old law, there is a 10-year period of data protection under the centralized procedures and a period of either six or 10 years under the mutual recognition procedure (depending on the member state). Regardless of the procedure used to obtain marketing authorization approval, a company then must obtain pricing and reimbursement for the pharmaceutical product, which is typically subject to member state law. The pricing and reimbursement procedure can take months and sometimes years to obtain.
Patents on pharmaceutical products are generally enforceable in the EU. However, in contrast to the U.S., patents are not listed with regulatory authorities. Generic copies can be approved after data protection expires, regardless of whether the innovator holds patents covering its drug. Thus, it is possible that an innovator may be seeking to enforce its patents against a generic competitor that is already marketing its product. Also, the European patent system has an opposition procedure in which generic manufacturers may challenge the validity of patents covering innovator products within nine months of grant. As in the U.S., patents in the EU may be extended to compensate for the patent term lost during the regulatory review process. Such extensions are granted on a country-by-country basis.
In general, EU law treats chemically-synthesized drugs and biologically-derived drugs the same with respect to intellectual property and market exclusivity. The European Medicines Evaluation Agency (EMEA) has issued a guideline that outlines what additional information has to be provided for biosimilar products, also known as generic biologics, in order for the EMEA to review an application for marketing approval.
Japan
In Japan, medicines of new chemical entities are generally afforded eight years (previously six years before 2007) of data exclusivity for approved indications and dosage. Patents on pharmaceutical products are enforceable. Generic copies can receive regulatory approval after data exclusivity and patent expirations. As in the U.S., patents in Japan may be extended to compensate for the patent term lost during the regulatory review process.
In general, Japanese law treats chemically-synthesized and biologically-derived drugs the same with respect to intellectual property and market exclusivity.
Rest of World
In countries outside of the U.S., the EU and Japan, there is a wide variety of legal systems with respect to intellectual property and market exclusivity of pharmaceuticals. Most other developed countries utilize systems similar to either the U.S. (e.g., Canada) or the EU (e.g., Switzerland). Among developing countries, some have adopted patent laws and/or regulatory exclusivity laws, while others have not. Some developing countries have formally adopted laws in order to comply with World Trade Organization (WTO) commitments, but have not taken steps to implement these laws in a meaningful way. Enforcement of WTO obligations is a long process, and there is no assurance of the outcome. Thus, in assessing the likely future market exclusivity of the Company’s innovative drugs in developing countries, the Company takes into account not only formal legal rights but political and other factors as well.
Marketing, Distribution and Customers
The Company promotes its products in medical journals and directly to health care providers such as doctors, nurse practitioners, physician assistants, pharmacists, technologists, hospitals, Pharmacy Benefit Managers (PBMs), Managed Care Organizations (MCOs) and government agencies. The Company also markets directly to consumers in the U.S. through direct-to-consumer print, radio and television advertising. In addition, the Company sponsors general advertising to educate the public about its innovative medical research. For a discussion of the regulation of promotion and marketing of pharmaceuticals, see “—Government Regulation and Price Constraints” below.
Through the Company’s sales and marketing organizations, the Company explains the approved uses and advantages of its products to medical professionals. The Company works to gain access to health authority, PBM and MCO formularies (lists of recommended or approved medicines and other products), including Medicare Part D plans and reimbursement lists by demonstrating
 
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the qualities and treatment benefits of its products. Marketing of prescription pharmaceuticals is limited to the approved uses of the particular product, but the Company continues to develop information about its products and provides such information in response to unsolicited inquiries from doctors and other medical professionals. All drugs must complete clinical trials required by regulatory authorities to show they are safe and effective for treating one or more medical problems. A manufacturer may choose, however, to undertake additional studies, including comparative clinical trials with competitive products, to demonstrate additional advantages of a compound. Those studies can be costly and take years to complete, and the results are uncertain. Balancing these considerations makes it difficult to decide whether and when to undertake such additional studies. But, when they are successful, such studies can have a major impact on approved marketing claims and strategies.
The Company’s operations include several pharmaceutical marketing and sales organizations. Each organization markets a distinct group of products supported by a sales force and is typically based on particular therapeutic areas or physician groups. These sales forces often focus on selling new products when they are introduced, and promotion to physicians is increasingly targeted at specialists and high value primary care physicians.
The Company’s prescription pharmaceutical products are sold principally to wholesalers, but the Company also sells directly to distributors, retailers, hospitals, clinics, government agencies and pharmacies. In 2007, sales to three pharmaceutical wholesalers in the U.S., McKesson, Cardinal Health, Inc. (Cardinal) and AmerisourceBergen Corporation (AmerisourceBergen), accounted for approximately 19%, 16% and 12%, respectively, of the Company’s total net sales. In 2006, sales to McKesson, Cardinal and AmerisourceBergen accounted for approximately 19%, 16% and 11%, respectively, of the Company’s total net sales. In 2005, sales to McKesson, Cardinal and AmerisourceBergen accounted for approximately 21%, 18% and 12%, respectively, of the Company’s total net sales. Sales to these U.S. wholesalers were concentrated in the Pharmaceuticals segment.
The Company’s U.S. Pharmaceuticals business, through the Inventory Management Agreements (IMAs), has arrangements with substantially all of its direct wholesaler and distributor customers that allow the Company to monitor U.S. wholesaler inventory levels and require those wholesalers to maintain inventory levels that are no more than one month of their demand. The IMAs have a two-year term, through December 31, 2009, subject to certain termination provisions.
The Company sells ERBITUX* to intermediaries (such as wholesalers and specialty oncology distributors) and ships ERBITUX* directly to the end users of the product who are the customers of those intermediaries. The Company also sells ERBITUX* in the U.S. to other wholesalers and distributors who then hold ERBITUX* inventory. The Company recognizes revenue upon such shipment consistent with its revenue recognition policy.
For information on sales and marketing of Nutritionals and ConvaTec products, see “—Nutritionals Segment” and “—ConvaTec Segment” above.
Competition
The markets in which the Company competes are generally broad-based and highly competitive. The principal means of competition vary among product categories and business groups.
The Company’s Pharmaceuticals segment competes with other worldwide research-based drug companies, many smaller research companies with more limited therapeutic focus and generic drug manufacturers. Important competitive factors include product efficacy, safety and ease of use, price and demonstrated cost-effectiveness, marketing effectiveness, product labeling, service and research and development of new products and processes. Sales of the Company’s products can be impacted by new studies that indicate a competitor’s product has greater efficacy for treating a disease or particular form of disease than one of the Company’s products. The Company’s sales also can be impacted by additional labeling requirements relating to safety or convenience that may be imposed on its products by the FDA or by similar regulatory agencies in different countries. If competitors introduce new products and processes with therapeutic or cost advantages, the Company’s products can be subject to progressive price reductions or decreased volume of sales, or both.
To successfully compete for business with MCOs and PBMs, the Company must often demonstrate that its products offer not only medical benefits but also cost advantages as compared with other forms of care. Most new products that the Company introduces must compete with other products already on the market or products that are later developed by competitors. Manufacturers of generic pharmaceuticals typically invest far less in research and development than research-based pharmaceutical companies and therefore can price their products significantly lower than branded products. Accordingly, when a branded product loses its market exclusivity, it normally faces intense price competition from generic forms of the product. In certain countries outside the U.S., patent protection is weak or nonexistent and the Company must compete with generic versions shortly after it launches its innovative product. In addition, generic pharmaceutical companies may introduce a generic product before exclusivity has expired, and before the resolution of any related patent litigation. For a discussion of the generic launch of a clopidogrel bisulfate product that competes with PLAVIX*, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies—PLAVIX* Litigation.”
 
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Many other companies, large and small, manufacture and sell one or more products that are similar to those marketed by the Company’s Nutritionals and ConvaTec segments. Sources of competitive advantage include patents and trademarks, product quality and efficacy, brand identity, advertising and promotion, product innovation, broad distribution capabilities, customer satisfaction and price. Significant expenditures for advertising, promotion and marketing are generally required to achieve both consumer and trade acceptance of these products.
The Company believes its long-term competitive position depends upon its success in discovering and developing innovative, cost-effective products that serve unmet medical need, together with its ability to manufacture the products efficiently and to market them effectively in a highly competitive environment. There can be no assurance that the Company’s research and development efforts will result in commercially successful products or that its products or processes will not become outmoded from time to time as a result of products or processes developed by its competitors.
Managed Care Organizations
The growth of MCOs in the U.S. has been a major factor in the competitive make-up of the health care marketplace. Over half the U.S. population now participates in some version of managed care. Because of the size of the patient population covered by MCOs, marketing of prescription drugs to them and the PBMs that serve many of those organizations has become important to the Company’s business. MCOs can include medical insurance companies, medical plan administrators, health-maintenance organizations, Medicare Part D formularies, alliances of hospitals and physicians and other physician organizations. Those organizations have been consolidating into fewer, even larger entities, enhancing their purchasing strength and importance to the Company.
A major objective of MCOs is to contain and, where possible, reduce health care expenditures. They typically use formularies, volume purchases and long-term contracts to negotiate discounts from pharmaceutical providers. MCOs and PBMs typically develop formularies to reduce their cost for medications. Formularies can be based on the prices and therapeutic benefits of the available products. Due to their generally lower cost, generic medicines are often favored. The breadth of the products covered by formularies can vary considerably from one MCO to another, and many formularies include alternative and competitive products for treatment of particular medical problems. MCOs use a variety of means to encourage patients’ use of products listed on their formularies.
Exclusion of a product from a formulary can lead to its sharply reduced usage in the MCO patient population. Consequently, pharmaceutical companies compete aggressively to have their products included. Where possible, companies compete for inclusion based upon unique features of their products, such as greater efficacy, better patient ease of use or fewer side effects. A lower overall cost of therapy is also an important factor. Products that demonstrate fewer therapeutic advantages must compete for inclusion based primarily on price. The Company has been generally, although not universally, successful in having its major products included on MCO formularies.
Generic Competition
One of the biggest competitive challenges that the Company faces in the U.S. and, to a lesser extent, internationally is from generic pharmaceutical manufacturers. Upon the expiration or loss of market exclusivity on a product, the Company can lose the major portion of sales of that product in a very short period of time. In the U.S., the FDA approval process exempts generics from costly and time-consuming clinical trials to demonstrate their safety and efficacy, and allows generic manufacturers to rely on the safety and efficacy of the innovator product. Therefore, generic competitors operate without the Company’s large research and development expenses and its costs of conveying medical information about the product to the medical community. For more information about market exclusivity, see “—Intellectual Property and Product Exclusivity” above.
The rate of sales decline of a product after the expiration of exclusivity varies by country. In general, the decline in the U.S. market is more rapid than in most other developed countries. Also, the declines in developed countries tend to be more rapid than in developing countries.
The rate of sales decline after the expiration of exclusivity has also historically been influenced by product characteristics. For example, drugs that are used in a large patient population (e.g., those prescribed by primary care physicians) tend to experience more rapid declines than drugs in specialized areas of medicine (e.g., oncology). Drugs that are more complex to manufacture (e.g., sterile injectable products) usually experience a slower decline than those that are simpler to manufacture.
As noted above, MCOs that focus primarily on the immediate cost of drugs often favor generics over brand-name drugs. Many governments also encourage the use of generics as alternatives to brand-name drugs in their health care programs. Laws in the U.S. generally allow, and in many cases require, pharmacists to substitute generic drugs that have been rated under government procedures to be therapeutically equivalent to a brand-name drug. The substitution must be made unless the prescribing physician expressly forbids it. These laws and policies provide an added incentive for generic manufacturers to seek marketing approval as the automatic substitution removes the need for generic manufacturers to incur many of the sales and marketing costs, which innovators must incur.
 
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Research and Development
The Company invests heavily in research and development because it believes it is critical to its long-term competitiveness. Bristol-Myers Squibb Pharmaceutical Research and Development has major facilities in Princeton, Hopewell and New Brunswick, New Jersey and Wallingford, Connecticut. Pharmaceutical research and development is also carried out at various other facilities in the U.S. and in Belgium, Canada, the UK and India. Management continues to emphasize leadership, innovation, productivity and quality as strategies for success in Bristol-Myers Squibb Pharmaceutical Research and Development.
The Company spent $3,282 million in 2007, $2,991 million in 2006 and $2,678 million in 2005 on Company-sponsored research and development activities. The Company-sponsored pharmaceutical research and development spending includes certain payments under third-party collaborations and contracts. At the end of 2007, the Company employed approximately 8,200 people in research and development throughout the Company, including a substantial number of physicians, scientists holding graduate or postgraduate degrees and higher-skilled technical personnel.
The Company concentrates its pharmaceutical research and development efforts in the following disease areas with significant unmet medical need: Affective (psychiatric) disorders, Alzheimer’s/dementia, atherosclerosis/thrombosis, diabetes, hepatitis, HIV/AIDS, obesity, oncology, rheumatoid arthritis and related diseases and solid organ transplant. However, the Company continues to analyze and may selectively pursue promising leads in other areas. In addition to discovering and developing new molecular entities, the Company looks for ways to expand the value of existing products through new uses and formulations that can provide additional benefits to patients.
To supplement the Company’s internal efforts, the Company collaborates with independent research organizations, including educational institutions and research-based pharmaceutical and biotechnology companies, and contracts with others for the performance of research in their facilities. The Company’s drug discovery program includes many alliances and collaborative agreements. These agreements bring new products into the pipeline or help the Company remain on the cutting edge of technology in the search for novel medicines. In drug development, the Company engages the services of physicians, hospitals, medical schools and other research organizations worldwide to conduct clinical trials to establish the safety and effectiveness of new products.
Drug development is time consuming, expensive and risky. In the development of human health products, industry practice and government regulations, in the U.S. and most foreign countries, provide for the determination of effectiveness and safety of new molecular entities through preclinical tests and controlled clinical evaluation. Before a new drug may be marketed in the U.S., recorded data on preclinical and clinical experience are included in the NDA or the BLA to the FDA for the required approval. The development of certain other products is also subject to government regulations covering safety and efficacy in the U.S. and many foreign countries. There can be no assurance that a compound developed as a result of any program will obtain the regulatory approvals necessary for it to be marketed for any particular disease indication.
On average, only about one in 10,000 chemical compounds discovered by pharmaceutical industry researchers proves to be both medically effective and safe enough to become an approved medicine. The process from discovery to regulatory approval typically takes 10 years or longer. Drug candidates can fail at any stage of the process, and even late-stage product candidates sometimes fail to receive regulatory approval. The Company believes its investments in research, both internally and in collaboration with others, have been rewarded by the number of new pharmaceutical compounds and indications it has in all stages of development.
Listed below are several investigational compounds that the Company has in the later stages of development. All of these compounds are in Phase III clinical trials. Whether or not any of these investigational compounds ultimately becomes one of the Company’s marketed products depends on the results of pre-clinical and clinical studies, the competitive landscape of the potential product’s market and the manufacturing processes necessary to produce the potential product on a commercial scale, among other factors. However, as noted above, there can be no assurance that the Company will seek regulatory approval of any of these compounds or that, if such approval is sought, it will be obtained. At this stage of development, the Company cannot determine all intellectual property issues or all the patent protection that may, or may not, be available for these investigational compounds. The patent coverage highlighted below does not include potential patent term extensions.

Apixaban	  	Apixaban is an oral Factor Xa inhibitor, which is being developed internally and has recently entered Phase III clinical trials for the prevention of thromboembolic disorders. In April 2007, the Company entered into a worldwide agreement with Pfizer for the codevelopment and cocommercialization of apixaban. The Company owns an issued U.S. patent covering composition of matter and method of use of apixaban that expires in September 2022 (extended to February 2023 via patent term adjustment).	
		
Saxagliptin	  	Saxagliptin is an oral compound for the potential treatment of diabetes, which was discovered internally and is currently in Phase III clinical trials. In January 2007, the Company entered into the Saxagliptin Agreement with AstraZeneca for the codevelopment and cocommercialization of saxagliptin. A patent application covering the composition of matter has been issued and will expire in 2021 in the U.S.	
 
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Ipilimumab	  	Ipilimumab, which is being codeveloped with Medarex and is currently in Phase III clinical trials, is a monoclonal antibody being investigated as an anticancer treatment. It is in a novel class of agents intended to potentiate elements of the immunologic response. The Company owns a composition of matter patent that expires in the U.S. in 2016 and has rights to method of use patents owned by Medarex that expire in the U.S. in 2015. The Company also has rights to a Medarex composition of matter patent that expires in 2020 (extended to 2022 via patent term adjustment) and pending Medarex patent applications covering composition of matter and method of use of ipilimumab.	
		
Belatacept	  	Belatacept, a biological product, which is being developed internally and is in Phase III clinical trials, is a fusion protein with novel immunosuppressive activity targeted at prevention of solid organ transplant rejection. The Company has a composition of matter patent that expires in the U.S. in 2021.	
		
Dapagliflozin	  	Dapagliflozin is an oral compound for the potential treatment of diabetes, which was discovered internally and is currently in Phase III clinical trials. In January 2007, the Company entered into the SGLT2 Agreement with AstraZeneca for the codevelopment and cocommercialization of dapagliflozin. A patent application covering the composition of matter has been issued and will expire in 2020 in the U.S.	
In November 2007, the Company and Pierre Fabre Medicament S.A. announced the termination of the license agreement for the development of vinflunine, a chemotherapy agent under investigation for the treatment of advanced or metastatic bladder cancer and other tumor types.
The Company sometimes enters into agreements with respect to its own investigational compounds in order to share the costs and risks of development, and in some cases, facilitate their commercialization. These agreements can take many forms, including codevelopment, comarketing, copromotion and/or joint venture arrangements.
The Company’s competitors also devote substantial funds and resources to research and development. In addition, the consolidation that has occurred in the pharmaceutical industry has created companies with substantial research and development resources. The extent to which the Company’s competitors are successful in their research could result in erosion of the sales of its products and unanticipated product obsolescence.
Government Regulation and Price Constraints
The pharmaceutical industry is subject to extensive global regulation by regional, country, state and local agencies. The Federal Food, Drug, and Cosmetic Act (FDC Act), other Federal statutes and regulations, various state statutes and regulations, and laws and regulations of foreign governments govern to varying degrees the testing, approval, production, labeling, distribution, post-market surveillance, advertising, dissemination of information, and promotion of the Company’s products. The lengthy process of laboratory and clinical testing, data analysis, manufacturing, development, and regulatory review necessary for required governmental approvals is extremely costly and can significantly delay product introductions in a given market. Promotion, marketing, manufacturing and distribution of pharmaceutical products are extensively regulated in all major world markets. In addition, the Company’s operations are subject to complex Federal, state, local, and foreign environmental and occupational safety laws and regulations. The Company anticipates that the laws and regulations affecting the manufacture and sale of current products and the introduction of new products will continue to require substantial scientific and technical effort, time, expense and significant capital investment.
Of particular importance is the FDA in the U.S. It has jurisdiction over virtually all of the Company’s businesses and imposes requirements covering the testing, safety, effectiveness, manufacturing, labeling, marketing, advertising and post-marketing surveillance of the Company’s pharmaceutical products. The FDA also regulates most of the Company’s Nutritionals and ConvaTec products. In many cases, the FDA’s requirements have increased the amount of time and money necessary to develop new products and bring them to market in the U.S.
The Company’s pharmaceutical products, as well as the medical device products it sells through its ConvaTec business, are subject to pre-market approval requirements in the U.S. New drugs are approved under, and are subject to, the FDC Act and related regulations. Biological drugs are subject to both the FDC Act and the Public Health Service Act (PHS Act), and related regulations. Biological drugs are licensed under the PHS Act. Medical devices are subject to the FDC Act including Medical Device Amendments. The Company’s Nutritionals products are regulated by the FDA, primarily under the Infant Formula Act of 1980 and its amendments.

The FDA mandates that drugs be manufactured, packaged and labeled in conformity with current Good Manufacturing Practices (cGMP) established by the FDA. In complying with cGMP regulations, manufacturers must continue to expend time, money and effort in production, record keeping and quality control to ensure that the product meets applicable specifications and other requirements to ensure product safety and efficacy. The FDA periodically inspects drug manufacturing facilities to ensure compliance with applicable cGMP requirements. Failure to comply with the statutory and regulatory requirements subjects the manufacturer to possible legal or regulatory action, such as suspension of manufacturing, seizure of product or voluntary recall of a product. Adverse experiences with the use of products must be reported to the FDA and could result in the imposition of market restrictions through labeling changes or in product removal. Product approvals may be withdrawn if compliance with regulatory requirements is not maintained or if problems concerning safety or efficacy of the product occur following approval.
 
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The Federal government has extensive enforcement powers over the activities of pharmaceutical and medical device manufacturers, including authority to withdraw product approvals, commence actions to seize and prohibit the sale of unapproved or non-complying products, to halt manufacturing operations that are not in compliance with cGMPs, and to impose or seek injunctions, voluntary recalls, and civil monetary and criminal penalties. Such a restriction or prohibition on sales or withdrawal of approval of products marketed by the Company could materially adversely affect its business, financial condition and results of operations and cash flows. The Federal government has similar powers with respect to the manufacturing operations of the Nutritionals business.
Marketing authorization for the Company’s products is subject to revocation by the applicable governmental agencies. In addition, modifications or enhancements of approved products or changes in manufacturing locations are in many circumstances subject to additional FDA approvals, which may or may not be received and which may be subject to a lengthy application process.
The distribution of pharmaceutical products is subject to the Prescription Drug Marketing Act (PDMA) as part of the FDC Act, which regulates such activities at both the Federal and state level. Under the PDMA and its implementing regulations, states are permitted to require registration of manufacturers and distributors who provide pharmaceuticals even if such manufacturers or distributors have no place of business within the state. States are also permitted to adopt regulations limiting the distribution of product samples to licensed practitioners. The PDMA also imposes extensive licensing, personnel recordkeeping, packaging, quantity, labeling, product handling and facility storage and security requirements intended to prevent the sale of pharmaceutical product samples or other diversions. For discussion of recent settlement of certain investigations of drug pricing and sales and marketing activities, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”
The FDA Amendments Act of 2007 imposed additional obligations on pharmaceutical companies and delegated more enforcement authority to the FDA in the area of drug safety. Key elements of this legislation give the FDA new authority to (1) require that companies conduct post-marketing safety studies of drugs, (2) impose certain drug labeling changes relating to safety, (3) mandate risk mitigation measures such as the education of healthcare providers and the restricted distribution of medicines, (4) require companies to publicly disclose data from clinical trials and (5) pre-review television advertisements.
The marketing practices of all U.S. pharmaceutical manufacturers are subject to Federal and state health care laws that are used to protect the integrity of government health care programs. The Office of Inspector General of the U.S. Department of Health and Human Services (OIG) oversees compliance with applicable Federal laws, in connection with the payment for products by government funded programs (primarily Medicaid and Medicare). These laws include the Federal anti-kickback statute, which criminalizes the offering of something of value to induce the recommendation, order or purchase of products or services reimbursed under a government health care program. The OIG has issued a series of Guidances to segments of the health care industry, including the 2003 Compliance Program Guidance for Pharmaceutical Manufacturers (the OIG Guidance), which includes a recommendation that pharmaceutical manufacturers, at a minimum, adhere to the PhRMA Code, a voluntary industry code of marketing practices. The Company subscribes to the PhRMA Code, and has implemented a compliance program to address the requirements set forth in the OIG Guidance and the Company’s compliance with the health care laws. Failure to comply with these health care laws could subject the Company to administrative and legal proceedings, including actions by the state and Federal government agencies. Such actions could result in the imposition of civil and criminal sanctions, which may include fines, penalties and injunctive remedies, the impact of which could materially adversely affect the Company’s business, financial condition and results of operations and cash flows.
The Company is also subject to the jurisdiction of various other Federal and state regulatory and enforcement departments and agencies, such as the Federal Trade Commission, the Department of Justice and the Department of Health and Human Services in the U.S. The Company is also licensed by the U.S. Drug Enforcement Agency to procure and produce controlled substances. The Company is, therefore, subject to possible administrative and legal proceedings and actions by those organizations. Such actions may result in the imposition of civil and criminal sanctions, which may include fines, penalties and injunctive or administrative remedies.
The Company’s activities outside the U.S. are also subject to regulatory requirements governing the testing, approval, safety, effectiveness, manufacturing, labeling and marketing of the Company’s products. These regulatory requirements vary from country to country. In the EU, there are two ways that a company can obtain marketing authorization for a pharmaceutical product. The first route is the “centralized procedure.” This procedure is compulsory for certain pharmaceutical products, in particular those using biotechnological processes, but also is available for certain new chemical compounds and products. The second route to obtain marketing authorization in the EU is the “mutual recognition procedure.” Applications are made to a single member state, and if the member state approves the pharmaceutical product under a national procedure, then the applicant may submit that approval to the mutual recognition procedure of some or all other member states. As set forth above, pricing and reimbursement of the product continues to be the subject of member state law.
 
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Whether or not FDA approval or approval of the EMEA has been obtained for a product, approval of the product by comparable regulatory authorities of countries outside of the U.S. or the EU, as the case may be, must be obtained prior to marketing the product in those countries. The approval process may be more or less rigorous from country to country and the time required for approval may be longer or shorter than that required in the U.S. Approval in one country does not assure that such product will be approved in another country.
In many markets outside the U.S., the Company operates in an environment of government-mandated, cost-containment programs. Several governments have placed restrictions on physician prescription levels and patient reimbursements, emphasized greater use of generic drugs and/or enacted across-the-board price cuts as methods of cost control. Most European countries do not provide market pricing for new medicines, except the UK and Germany. Pricing freedom is limited in the UK by the operation of a profit control plan and in Germany by the operation of a reference price system. Companies also face significant delays, mainly in France, Spain, Italy and Belgium, in market access for new products, and more than two years can elapse before new medicines become available on some national markets. Additionally, member states of the EU have regularly imposed new or additional cost containment measures for pharmaceuticals. In recent years, Italy, for example, has imposed mandatory price decreases. The existence of price differentials within Europe due to the different national pricing and reimbursement laws leads to significant parallel trade flows.
In recent years, Congress and some state legislatures have considered a number of proposals and have enacted laws that could effect major changes in the health care system, either nationally or at the state level. Driven in part by budget concerns, Medicaid access and reimbursement restrictions have been implemented in some states and proposed in many others. Similar cost containment issues exist in many foreign countries where the Company does business.
Federal and state governments also have pursued direct methods to reduce the cost of drugs for which they pay. The Company participates in state government-managed Medicaid programs, as well as certain other qualifying Federal and state government programs whereby discounts and rebates are provided to participating state and local government entities. Rebates under Medicaid and related state programs reduced revenues by $169 million in 2007, $174 million in 2006 and $595 million in 2005. The decrease in 2006 as compared to 2005 was primarily due to the exclusivity loss of PRAVACHOL and lower PLAVIX* sales. The shift in patient enrollment from Medicaid to Medicare under Medicare Part D also resulted in a decrease in Medicaid rebates, which was partially offset by a corresponding increase in the Company’s managed health care rebates. The Company also participates in prime vendor programs with government entities, the most significant of which are the U.S. Department of Defense and the U.S. Department of Veterans Affairs. These entities receive minimum discounts based off a defined “non-federal average manufacturer price” for purchases. Other prime vendor programs in which the Company participates provide discounts for outpatient medicines purchased by certain Public Health Service entities and other hospitals meeting certain criteria. The Company recorded discounts related to the prime vendor programs of $662 million in 2007, $703 million in 2006 and $1,090 million in 2005.
In the U.S., governmental cost containment efforts have extended to the federally funded Special Supplemental Nutrition Program for WIC. All states participate in the WIC program and have sought and obtained rebates from manufacturers of infant formula whose products are used in the program. All states have conducted competitive bidding for infant formula contracts, which require the use of specific infant formula products by the state WIC program, unless a physician requests a non-contract formula for a WIC customer. States participating in the WIC program are required to engage in competitive bidding or to use other cost containment measures that yield savings equal to or greater than the savings generated by a competitive bidding system. Mead Johnson participates in this program and approximately half of its gross U.S. sales are subject to rebates under the WIC program. Rebates under the WIC program reduced revenues by $848 million in 2007, $872 million in 2006 and $843 million in 2005.
For further discussion of these rebates and programs, see “Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations—Results of Operations.”
Environmental Regulation
The Company’s facilities and operations are subject to extensive U.S. and foreign laws and regulations relating to environmental protection and human health and safety, including those governing discharges of pollutants into the air and water, the use, management and disposal of hazardous, radioactive and biological materials and wastes, and the cleanup of contamination. Pollution controls and permits are required for many of the Company’s operations, and these permits are subject to modification, renewal or revocation by the issuing authorities.
An environment, health and safety group within the Company monitors operations around the world, providing the Company with an overview of regulatory requirements and overseeing the implementation of Company standards for compliance. The Company also incurs operating and capital costs for such matters on an ongoing basis. The Company expended approximately $38 million, $50 million and $45 million on capital environmental projects undertaken specifically to meet environmental requirements in 2005, 2006 and 2007, respectively, and expects to spend approximately $46 million in 2008. Although the Company believes that it is in
 
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substantial compliance with applicable environmental, health and safety requirements and the permits required for its operations, the Company nevertheless could incur additional costs, including civil or criminal fines or penalties, clean-up costs, or third-party claims for property damage or personal injury, for violations or liabilities under these laws.
Many of the Company’s current and former facilities have been in operation for many years, and, over time, the Company and other operators of those facilities have generated, used, stored or disposed of substances or wastes that are considered hazardous under Federal, state and foreign environmental laws, including the U.S. Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). As a result, the soil and groundwater at or under certain of these facilities is or may be contaminated, and the Company may be required to make significant expenditures to investigate, control and remediate such contamination, and in some cases to provide compensation and/or restoration for damages to natural resources. Currently, the Company is involved in investigation and remediation at 13 current or former Company facilities. The Company has also been identified as a “potentially responsible party” (PRP) under applicable laws for environmental conditions at approximately 30 former waste disposal or reprocessing facilities operated by third parties at which investigation and/or remediation activities are ongoing.
The Company may face liability under CERCLA and other Federal, state and foreign laws for the entire cost of investigation or remediation of contaminated sites, or for natural resource damages, regardless of fault or ownership at the time of the disposal or release. In addition, at certain sites the Company bears remediation responsibility pursuant to contract obligations. Generally, at third-party operator sites involving multiple PRPs, liability has been or is expected to be apportioned based on the nature and amount of hazardous substances disposed of by each party at the site and the number of financially viable PRPs. For additional information about these matters, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”
Employees
The Company employed approximately 42,000 people at December 31, 2007.
In late 2007, the Company undertook a broad range of actions, as part of the previously announced three-year PTI. As part of this multi-year PTI, the Company is implementing a comprehensive cost reduction program that includes workforce reductions in some areas and the rationalization of some facilities. Specific productivity goals include reducing total headcount by approximately 10 percent between 2007 and 2010.
Some positions have been eliminated in 2007, although the substantial majority of positions will be eliminated in 2008 and 2009. During 2007, the Company recorded pre-tax charges of $189 million, relating to the termination benefits and other related costs for workforce reductions of approximately 2,800 manufacturing, selling and administrative personnel, across all geographic regions.
For further discussion of this initiative and 2007 restructuring activities, see “—Productivity Transformation Initiative” above and “Item 8. Financial Statements—Note 3. Restructuring.”
Foreign Operations
The Company has significant operations outside the U.S. They are conducted both through the Company’s subsidiaries and through distributors, and involve all three of the same business segments as the Company’s U.S. operations —Pharmaceuticals, Nutritionals and ConvaTec.
Revenues from operations outside the U.S. of $8.5 billion accounted for 44% of the Company’s total revenues in 2007. In 2007, revenues exceeded $500 million in each of France, Canada, Spain, Japan, Italy, Mexico and Germany. In 2006, revenues exceeded $500 million in each of France, Japan, Canada, Spain, Italy and Mexico. In 2005, revenues exceeded $500 million in each of France, Japan, Spain, Canada, Italy and Germany. No single country outside the U.S. contributed more than 10% of the Company’s total revenues in 2007, 2006 or 2005. For a geographic breakdown of net sales, see the table captioned Geographic Areas in “Item 8. Financial Statements—Note 19. Segment Information” and for further discussion of the Company’s sales by geographic area see “Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations—Geographic Areas.”
International operations are subject to certain risks, which are inherent in conducting business abroad, including, but not limited to, currency fluctuations, possible nationalization or expropriation, price and exchange controls, counterfeit, limitations on foreign participation in local enterprises and other restrictive governmental actions. The Company’s international businesses are also subject to government-imposed constraints, including laws on pricing or reimbursement for use of products.

Depending on the direction of change relative to the U.S. dollar, foreign currency values can increase or reduce the reported dollar value of the Company’s net assets and results of operations. In 2007, the change in foreign exchange rates had a net favorable impact on the growth rate of revenues. While the Company cannot predict with certainty future changes in foreign exchange rates or the effect they will have on it, the Company attempts to mitigate their impact through operational means and by using various financial instruments. See the discussions under “Item 7A. Quantitative and Qualitative Disclosures About Market Risk” and “Item 8. Financial Statements—Note 18. Financial Instruments.”
 
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Item 1A.	RISK FACTORS.	
Any of the factors described below could significantly and negatively affect the Company’s business, prospects, financial condition, operating results, or credit ratings, which could cause the trading price of the Company’s common stock to decline. Additional risks and uncertainties not presently known to the Company, or risks that the Company currently considers immaterial, may also impair the Company’s operations.
The Company faces competition from other pharmaceutical manufacturers, including from lower-priced generic products, and it is possible that the Company may lose market exclusivity of a product earlier than expected.
Competition from manufacturers of competing products, including lower-priced generic versions of the Company’s products is a major challenge, both within the United States (U.S.) and internationally. Such competition may include (i) new products developed by competitors that have lower prices or superior performance features or that are otherwise competitive with the Company’s current products; (ii) technological advances and patents attained by competitors; (iii) results of clinical studies related to the Company’s products or a competitor’s products; (iv) problems with licensors, suppliers and distributors; and (v) business combinations among the Company’s competitors and major customers.
In the pharmaceutical industry, the majority of an innovative product’s commercial value is usually realized during the period in which the product has market exclusivity. In the U.S. and some other countries, when market exclusivity expires and generic versions of a product are approved and marketed, there can often be very substantial and rapid declines in the product’s sales. The rate of this decline varies by country and by therapeutic category.
Market exclusivity for the Company’s products is based upon patent rights and/or certain regulatory forms of exclusivity. The scope of the Company’s patent rights may vary from country to country. In some countries, including in certain European Union member states, basic patent protection for the Company’s products may not exist because historically certain countries did not offer the right to obtain certain types of patents and/or the Company (or its licensors) did not file in those markets. Absent relevant patent protection for a product, once the data exclusivity period expires, generic versions of the product can be approved and marketed. In addition, prior to the expiration of data exclusivity, a competitor could seek regulatory approval by submitting its own clinical trial data to obtain marketing approval. Manufacturers of generic products are also increasingly seeking to challenge patents before they expire, and may in some cases launch a generic product before the expiration of the applicable patent(s) and/or before the final resolution of patent litigation. The length of market exclusivity for any of the Company’s products is impossible to predict with certainty and there can be no assurance that a particular product will enjoy market exclusivity for the full period of time that appears in the estimates disclosed in this Form 10-K.
For a discussion of how generic versions of a product can impact that product’s sales, see “Item 1. Business—Competition—Generic Competition” above. For more information about market exclusivity, see “Item 1. Business—Products” and “Item 1. Business—Intellectual Property and Product Exclusivity” above.
The patent infringement lawsuit with Apotex Inc. and Apotex Corp. (Apotex) involving PLAVIX* is ongoing, and there is a risk of generic competition from Apotex and from other generic pharmaceutical companies.
Although, as previously disclosed, the U.S. District Court for the Southern District of New York (District court) issued an opinion and order upholding the validity and enforceability of the U.S. Patent No. 4,847,265 relating to PLAVIX*, ruled that Apotex’s generic clopidogrel bisulfate product infringed the patent and enjoined Apotex from engaging in any activity that infringes that patent, the PLAVIX* patent infringement lawsuit is still ongoing and there is a risk that the Company could face generic competition from Apotex and from other generic pharmaceutical companies. Apotex has filed a notice of appeal with the U.S. Court of Appeals for the Federal Circuit. If Apotex were to prevail in its appeal of the District court’s decision, the Company could face renewed generic competition for PLAVIX* from Apotex promptly thereafter. Loss of market exclusivity for PLAVIX* and/or sustained generic competition would be material to the Company’s results of operations and cash flows and could be material to its financial condition and liquidity. It is not possible at this time reasonably to assess the outcomes of the appeal by Apotex of the District court’s decision, or the other PLAVIX* patent litigations or the timing of any renewed generic competition for PLAVIX* from Apotex or additional generic competition for PLAVIX* from other third-party generic pharmaceutical companies.
The Company has recorded deferred tax assets related to the U.S. foreign tax credit, research tax credit and charitable contribution carryforwards. The charitable contribution carryforwards expire in varying amounts beginning in 2009, while the foreign tax credit and research tax credit carryforwards expire in varying amounts beginning in 2012. Realization of the foreign tax credit, research tax credit and charitable contribution carryforwards is dependent on generating sufficient domestic taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized. The amount of foreign tax credit, research tax credit and charitable contribution carryforwards considered realizable, however, could be reduced in the near term if PLAVIX* is subject to either renewed or additional generic competition. If such events occur, the Company may need to record additional valuation allowances against these U.S. federal deferred tax assets. For a discussion of PLAVIX* related matters, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”
The Company may be adversely impacted by economic factors beyond its control and may incur additional impairment charges to its investment portfolio.
As of December 31, 2007, the Company had $811 million of principal invested in auction rate securities (ARS), representing interests in collateralized debt obligations supported by pools of residential and commercial mortgages or credit cards, insurance securitizations and other structured credits, including corporate bonds. Some of the underlying collateral for the ARS held by the Company consists of sub-prime mortgages. The estimated market value of the Company’s ARS holdings at December 31, 2007 was $419 million, which reflects a $392 million adjustment to the principal value of $811 million. Although the ARS continue to pay interest according to their stated terms, based on valuation models and an analysis of other-than-temporary impairment factors, the Company has recorded an impairment charge of $275 million in the fourth quarter, reflecting the portion of ARS holdings that the Company has concluded have an other-than-temporary decline in value. In addition, the Company recorded an unrealized pre-tax loss of $142 million in other comprehensive income as a reduction in shareholders’ equity, reflecting $117 million of adjustments to ARS holdings and $25 million of other marketable securities that the Company has concluded have a temporary decline in value.
The credit and capital markets have continued to deteriorate in 2008. If uncertainties in these markets continue, these markets deteriorate further or the Company experiences any additional ratings downgrades on any investments in its portfolio (including on ARS), the Company may incur additional impairments to its investment portfolio, which could negatively affect the Company’s financial condition, cash flow and reported earnings.
 
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The Company also has significant operations outside of the U.S. Revenue from operations outside of the U.S. accounted for 44% of the Company’s revenues in 2007. As such, the Company is exposed to changes in fluctuation of foreign currency exchange rates. For more information on the Company’s foreign currency exchange exposure, see “Item 7A. Quantitative and Qualitative Disclosures About Market Risk.” The Company also has significant borrowings which are exposed to changes in interest rates. At December 31, 2007, the Company had short-term borrowings and long-term debt of $6.3 billion. For more information on the Company’s interest rate exposure, see “Item 7A. Quantitative and Qualitative Disclosures About Market Risk.” The Company is also exposed to other economic factors over which the Company has no control.
The Company may experience difficulties and delays in the manufacturing and sale of its products.
The Company may experience difficulties and delays inherent in manufacturing and sale, such as (i) seizure or recalls of pharmaceutical products or forced closings of manufacturing plants; (ii) the failure to obtain, the imposition of limitations on the use of, or loss of patent and other intellectual property rights; (iii) failure of the Company or any of its vendors or suppliers to comply with Current Good Manufacturing Practices and other application regulations and quality assurance guidelines that could lead to temporary manufacturing shutdowns, product shortages and delays in product manufacturing; (iv) construction delays related to the construction of new facilities or the expansion of existing facilities, including those intended to support future demand for the Company’s biologics products; and (v) other manufacturing or distribution problems including changes in manufacturing production sites and limits to manufacturing capacity due to regulatory requirements, changes in types of products produced, such as biologics, or physical limitations that could impact continuous supply.
The Company may experience difficulties or delays in the development and commercialization of new products.
The Company may experience difficulties and delays in the development and commercialization of new products, including the inherent risks and uncertainties associated with product development, such as (i) compounds or products that may appear promising in development but fail to reach market within the expected or optimal timeframe, or fail ever to reach market, or to be approved for additional indications for any number of reasons, including efficacy or safety concerns, the delay or denial of necessary regulatory approvals and the difficulty or excessive cost to manufacture; (ii) failure to enter into or successfully implement optimal alliances where appropriate for the discovery and/or commercialization of products, or otherwise to maintain a consistent scope and variety of promising late-stage products; (iii) failure of one or more of the Company’s products to achieve or maintain commercial viability.
There are legal matters in which adverse outcomes could negatively affect the Company’s business.
The Company is currently involved in various lawsuits, claims, proceedings and government investigations, any of which can preclude or delay commercialization of products or adversely affect operations, profitability, liquidity or financial condition, including (i) intellectual property disputes; (ii) sales and marketing practices in the U.S. and internationally; (iii) adverse decisions in litigation, including product liability and commercial cases; (iv) recalls or withdrawals of pharmaceutical products or forced closings of manufacturing plants; (v) the failure to fulfill obligations under supply contracts with the government and other customers which may result in liability; (vi) product pricing and promotion matters; (vii) lawsuits and claims asserting violations of securities, antitrust, federal and state pricing and other laws; (viii) environmental, health and safety matters; and (ix) tax liabilities. There can be no assurance that there will not be an increase in scope of these matters or there will not be additional lawsuits, claims, proceedings or investigations in the future; nor is there any assurance that these matters will not have a material adverse impact on the Company.
U.S. and foreign regulations may negatively affect the Company’s sales and profit margins.
The Company could become subject to new government laws and regulations, such as (i) health care reform initiatives in the U.S. at the state and Federal level and in other countries; (ii) changes in the U.S. Food and Drug Administration (FDA) and foreign regulatory approval processes that may cause delays in approving, or preventing the approval of, new products; (iii) tax changes such as the phasing out of tax benefits heretofore available in the U.S. and certain foreign countries; (iv) new laws, regulations and judicial or other governmental decisions affecting pricing or marketing within or across jurisdictions; (v) changes in intellectual property law; and (vi) other matters such as compulsory licenses that could alter the protections afforded one or more of its products.
The Company faces increased pricing pressure in the U.S. and abroad from managed care organizations, institutional purchasers, and government agencies and programs that could negatively affect the Company’s sales and profit margins.
Pharmaceutical products are subject to increasing price pressures and other restrictions in the U.S. and worldwide, including (i) rules and practices of managed care groups and institutional and governmental purchasers, (ii) judicial decisions and governmental laws and regulations related to Medicare, Medicaid and healthcare reform, including the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, (iii) the potential impact of importation restrictions, legislative and/or regulatory changes, pharmaceutical reimbursement, Medicare Part D Formularies and product pricing in general, and (iv) other developments in technology and/or industry practices that could directly or indirectly impact the reimbursement policies and practices of third-party payers.
 
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The Company relies on third parties to meet their contractual, regulatory, and other obligations.
The Company relies on vendors, partners, including alliances with other pharmaceutical companies for the development and commercialization of products, and other third parties to meet their contractual, regulatory, and other obligations in relation to their arrangements with the Company. The failure of these parties to meet their obligations, and/or the development of significant disagreements or other factors that materially disrupt the ongoing commercial relationship and prevent optimal alignment between the partners and their activities, could have a material adverse impact on the Company.
Failure to execute the Company’s business strategy could adversely impact its growth and profitability.
As part of its strategy, the Company currently is implementing a comprehensive cost reduction program that includes workforce reductions in some areas and the rationalization of some facilities. The Company expects to incur restructuring and other charges in connection with this program in the range of $0.9 billion to $1.1 billion on a pre-tax basis over the next three years, with $292 million of those charges having been incurred in the fourth quarter of 2007 and approximately $500 million in charges expected to be incurred in 2008.
The Company may not be able to fully execute the strategic transformation of its business to attain a new period of sustainable revenue and earnings growth. The Company continues to invest in its key products and pipeline as part of a focus on addressing areas of significant unmet medical need. Failure to realize the expected cost savings in 2008, to achieve and maintain a competitive cost base, or to successfully transition the product portfolio, however, could materially and adversely affect the Company’s results of operations. In addition, the Company’s failure to hire and retain personnel with the right expertise and experience in operations that are critical to its business functions could adversely impact the execution of its business strategy. Changes in the Company’s structure, operations, revenues, costs, or efficiency resulting from acquisitions, divestitures, mergers, alliances, restructurings or other strategic initiatives, could result in greater than expected costs and other difficulties, including the need for regulatory approvals, as appropriate.
The Company is increasingly dependent on its information technology and outsourcing arrangements.
The Company is increasingly dependent on information technology systems and any significant breakdown, invasion, destruction or interruption of these systems could negatively impact operations. The Company is also increasing its dependence on third-party providers for certain services, including information technology systems. The failure of these service providers to meet their obligations and/or the development of significant disagreements or other factors that materially disrupt the Company’s ongoing relationship with these providers could negatively affect operations.
 
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Item 1B.	UNRESOLVED STAFF COMMENTS.	
None.
 
Item 2.	PROPERTIES.	
The Company’s world headquarters is located at 345 Park Avenue, New York, NY, where it leases approximately 375,000 square feet of floor space, approximately 215,000 square feet of which is sublet to others.
The Company manufactures products at 36 major worldwide locations with an aggregate floor space of approximately 11.7 million square feet. All facilities are owned by the Company. The following table illustrates the geographic location of the Company’s significant manufacturing facilities by business segment.

 	  	Total
Company	  	Pharmaceuticals	  	Nutritionals	  	ConvaTec	
United States	  	8	  	5	  	2	  	1	
Europe, Middle East and Africa	  	14	  	11	  	1	  	2	
Other Western Hemisphere	  	7	  	5	  	1	  	1	
Pacific	  	7	  	4	  	3	  	—  	
	  	 	  	 	  	 	  	 	
Total	  	36	  	25	  	7	  	4	
	  	 	  	 	  	 	  	 	
Portions of these facilities and other facilities owned or leased by the Company in the U.S. and elsewhere are used for research, administration, storage and distribution. For further information about the Company’s facilities, see “Item 1. Business—Manufacturing and Quality Assurance.”
 
Item 3.	LEGAL PROCEEDINGS.	
Information pertaining to legal proceedings can be found in “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies” and is incorporated by reference herein.
 
Item 4.	SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.	
No matters were submitted to a vote of security holders during the fourth quarter of the year ended December 31, 2007.
 
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PART IA
Executive Officers of the Registrant
Listed below is information on executive officers of the Company as of February 21, 2008. Executive officers are elected by the Board of Directors for an initial term, which continues until the first Board meeting following the next annual meeting of stockholders and thereafter are elected for a one-year term or until their successors have been elected. All executive officers serve at the pleasure of the Board of Directors.

Name and Current Position	  	Age	  	Employment History for the Past 5 Years	
			
James M. Cornelius
Chairman of the Board and Chief Executive Officer
Member of the Management Council	  	64	  	2000 to 2005 – Chief Executive Officer and Chairman of the Board, Guidant Corporation.
2005 to 2006 – Interim Chief Executive Officer and Chairman of the Board, Guidant Corporation.
2006 to 2007 –Interim Chief Executive Officer and Director of the Company.
2007 to 2008 – Chief Executive Officer and Director of the Company
2008 to present – Chairman of the Board and Chief Executive Officer of the Company.	
			
Lamberto Andreotti
Executive Vice President and President,
Worldwide Pharmaceuticals
Member of the Management Council	  	57	  	2002 to 2005 – Senior Vice President and President International, Worldwide Medicines Group, a division of the Company.
2005 to present – Executive Vice President and President, Worldwide Pharmaceuticals, a division of the Company.	
			
Stephen E. Bear
Senior Vice President, Human Resources,
Corporate Staff
Member of the Management Council	  	57	  	2001 to present – Senior Vice President, Human Resources, Corporate Staff of the Company.	
			
Andrew R. J. Bonfield
Executive Vice President and Chief Financial Officer,
Corporate Staff
Member of the Management Council	  	45	  	2002 to present – Chief Financial Officer, Corporate Staff of the Company.	
			
Joseph C. Caldarella
Vice President and Corporate Controller,
Corporate Staff	  	52	  	1998 to 2005 – Vice President, Finance, Pharmaceutical Research Institute, a division of the Company.
2005 to present – Vice President and Corporate Controller, Corporate Staff of the Company.	
			
John E. Celentano
President, Health Care Group
Member of the Management Council	  	48	  	2002 to 2005 – President, Latin America and Canada, Worldwide Medicines Group, a division of the Company.
2005 to present – President, Health Care Group, a division of the Company.	
			
Anthony C. Hooper
President, U.S. Pharmaceuticals
Member of the Management Council	  	53	  	2002 to 2004 – President, Europe, Middle East & Africa, Worldwide Medicines Group, a division of the Company.
2004 to present – President, U.S. Pharmaceuticals, Worldwide Medicines Group, a division of the Company.	
			
Sandra Leung
Senior Vice President and General Counsel
Corporate Staff
Member of the Management Council	  	47	  	2002 to 2006 – Vice President and Corporate Secretary, Corporate Staff of the Company.
2006 to 2007 – Vice President, Corporate Secretary and Acting General Counsel, Corporate Staff of the Company.
2007 to present – Senior Vice President and General Counsel, Corporate Staff of the Company.	
 
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Elliott Sigal, M.D., Ph.D.
Executive Vice President, Chief Scientific Officer
and President, Pharmaceutical Research and Development
Member of the Management Council	  	56	  	2002 to 2004 – Senior Vice President, Global Clinical and Pharmaceutical Development, Pharmaceutical Research Institute, a division of the Company.
2004 to present – Chief Scientific Officer and President, Pharmaceutical Research and Development, a division of the Company.	
			
Robert T. Zito
Senior Vice President, Corporate and Business
Communications and Chief Communications Officer
Member of the Management Council	  	54	  	1999 to 2004 – Executive Vice President, Communications, New York Stock Exchange.
2004 to present – Senior Vice President, Corporate Affairs, Corporate Staff of the Company.	
 
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PART II
 
Item 5.	MARKET FOR THE REGISTRANT’S COMMON STOCK AND OTHER STOCKHOLDER MATTERS.	
Market Prices
Bristol-Myers Squibb common and preferred stocks are traded on the New York Stock Exchange (NYSE) and were traded on the NYSE Arca, Inc, formerly the Pacific Exchange, Inc. (symbols: BMY; BMYPR). On December 1, 2006, the Company voluntarily withdrew its securities from listing on the NYSE Arca, Inc. A quarterly summary of  the high and low market prices is presented below:
Common:

 	  	2007	  	2006	
 	  	High	  	Low	  	High	  	Low	
First Quarter	  	$	29.39	  	$	25.73	  	$	25.95	  	$	21.21	
Second Quarter	  	 	32.25	  	 	27.00	  	 	25.97	  	 	23.21	
Third Quarter	  	 	32.35	  	 	26.38	  	 	26.14	  	 	20.08	
Fourth Quarter	  	 	30.35	  	 	26.52	  	 	26.41	  	 	23.93	
Preferred:

 	  	2007	  	2006	
 	  	High	  	Low	  	High	  	Low	
First Quarter	  	$	600.00	  	$	460.00	  	$	360.00	  	$	355.00	
Second Quarter	  	 	500.00	  	 	500.00	  	 	*	  	 	*	
Third Quarter	  	 	503.00	  	 	475.00	  	 	420.00	  	 	318.00	
Fourth Quarter	  	 	475.37	  	 	450.00	  	 	430.00	  	 	400.00	

*	During the second quarter of 2006, there were no trades of the Company’s preferred stock. The preferred stock pays a quarterly dividend of $.50 per share.	
Holders of Common Stock
The number of record holders of common stock at December 31, 2007 was 69,254.
The number of record holders is based upon the actual number of holders registered on the books of the Company at such date and does not include holders of shares in “street names” or persons, partnerships, associations, corporations or other entities identified in security position listings maintained by depository trust companies.
Voting Securities and Principal Holders
Reference is made to the 2008 Proxy Statement to be filed on or about March 21, 2008 with respect to voting securities and principal holders, which is incorporated herein by reference and made a part hereof in response to the information required by this Item 5.
 
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Dividends
The Board of Directors of the Company declared the following dividends per share, which were paid in 2007 and 2006 in the quarters indicated below:

 	  	Common	  	Preferred	
 	  	2007	  	2006	  	2007	  	2006	
First Quarter	  	$	.28	  	$	.28	  	$	.50	  	$	.50	
Second Quarter	  	 	.28	  	 	.28	  	 	.50	  	 	.50	
Third Quarter	  	 	.28	  	 	.28	  	 	.50	  	 	.50	
Fourth Quarter	  	 	.28	  	 	.28	  	 	.50	  	 	.50	
	  	 	 	  	 	 	  	 	 	  	 	 	
	  	$	1.12	  	$	1.12	  	$	2.00	  	$	2.00	
	  	 	 	  	 	 	  	 	 	  	 	 	
In December 2007, the Board of Directors of the Company declared a quarterly dividend of $.31 per share on the common stock of the Company and of $.50 per share on the preferred stock of the Company, which was paid on February 1, 2008 to shareholders of record as of January 4, 2008.
Unregistered Sales of Equity Securities and Use of Proceeds
The following table summarizes the surrenders of the Company’s equity securities in connection with stock option and restricted stock programs during the 12-month period ended December 31, 2007:

Period	  	Total Number
of
Shares
Purchased (a)	  	Average Price
Paid per
Share (a)	  	Total Number of
Shares Purchased as
Part of Publicly
Announced Plans or
Programs (b)	  	Approximate Dollar
Value of Shares that
May Yet Be
Purchased Under the
Plans or Programs (b)	
Dollars in Millions, except per share data	  	 	  	 	  	 	  	 	
January 1 to 31, 2007	  	11,191	  	$	26.10	  	—  	  	$2,220	
February 1 to 28, 2007	  	8,819	  	$	28.13	  	—  	  	$2,220	
March 1 to 31, 2007	  	290,683	  	$	26.91	  	—  	  	$2,220	
	  	 	  			  		  		
Three months ended March 31, 2007	  	310,693	  			  		  		

April 1 to 30, 2007	  	11,307	  	$	27.33	  	—  	  	$2,220	
May 1 to 31, 2007	  	203,148	  	$	30.16	  	—  	  	$2,220	
June 1 to 30, 2007	  	7,448	  	$	30.91	  	—  	  	$2,220	
	  	 	  			  		  		
Three months ended June 30, 2007	  	221,903	  			  		  		

July 1 to 31, 2007	  	28,362	  	$	31.56	  	—  	  	$2,220	
August 1 to 31, 2007	  	6,956	  	$	29.42	  	—  	  	$2,220	
September 1 to 30, 2007	  	31,477	  	$	28.27	  	—  	  	$2,220	
	  	 	  			  		  		
Three months ended September 30, 2007	  	66,795	  			  		  		

October 1 to 31, 2007	  	26,955	  	$	29.02	  	—  	  	$2,220	
November 1 to 30, 2007	  	12,955	  	$	29.01	  	—  	  	$2,220	
December 1 to 31, 2007	  	4,242	  	$	29.38	  	—  	  	$2,220	
	  	 	  			  		  		
Three months ended December 31, 2007	  	44,152	  			  		  		

Twelve months ended December 31, 2007	  	643,543	  			  	—  	  		

(a)	Reflects the following transactions during the 12 months ended December 31, 2007: (i) the surrender to the Company of 166,630 shares of Common Stock to pay the exercise price and to satisfy tax withholding obligations in connection with the exercise of employee stock options, and (ii) the surrender to the Company of 476,913 shares of Common Stock to satisfy tax withholding obligations in connection with the vesting of restricted stock issued to employees.	
(b)	In June 2001, the Company announced that the Board of Directors authorized the purchase of up to $14 billion of Company common stock. During the 12 months ended December 31, 2007, no shares were repurchased pursuant to this program and no purchases of any shares under this program are expected in 2008.	
 
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Performance Graph
The following performance graph compares the performance of Bristol-Myers Squibb for the periods indicated with the performance of the Standard & Poor’s 500 Stock Index (S&P 500) and the average performance of a group consisting of our peer corporations on a line-of-business basis. The corporations making up our peer companies group are Abbott Laboratories, AstraZeneca PLC, Eli Lilly and Company, GlaxoSmithKline plc, Johnson & Johnson, Merck & Co., Inc., Novartis AG, Pfizer, Inc., Sanofi-Aventis (including the performance of Aventis prior to its merger with Sanofi), Schering-Plough Corporation and Wyeth.
Total return indices reflect reinvested dividends and are weighted using beginning-period market capitalization for each of the reported time periods. We  measured our performance against this same group in the 2007 Proxy Statement.
Comparison of Five-Year Cumulative Total Return

																			
 	  	12/31/02	  	12/31/03	  	12/31/04	  	12/31/05	  	12/31/06	  	12/31/07	
Bristol-Myers Squibb	  	$	100	  	$	129	  	$	120	  	$	112	  	$	135	  	$	141	
S&P 500 Index	  	$	100	  	$	129	  	$	143	  	$	150	  	$	173	  	$	183	
Peer Group	  	$	100	  	$	113	  	$	111	  	$	114	  	$	129	  	$	131	
Assumes $100 invested on 12/31/02 in Bristol-Myers Squibb Common Stock, S&P 500 Index and Peer Companies Group Index. Values are as of December 31 of specified year assuming dividends are reinvested.
 
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Item 6.	SELECTED FINANCIAL DATA.	
Five-Year Financial Summary

Amounts in Millions, except per share data	  	2007	  	2006	  	2005	  	2004	  	2003	
Income Statement Data: (1)(2) 	  			  			  			  			  			
Net Sales	  	$	19,348	  	$	17,256	  	$	18,605	  	$	18,791	  	$	18,145	
Earning from Continuing Operations Before
Minority Interest and Income Taxes	  	 	3,534	  	 	2,400	  	 	4,304	  	 	4,210	  	 	4,529	
Net Earnings from Continuing Operations	  	 	1,968	  	 	1,422	  	 	2,842	  	 	2,213	  	 	2,978	
						
Net Earnings from Continuing Operations per Common Share:	  			  			  			  			  			
Basic	  	$	1.00	  	$	0.73	  	$	1.45	  	$	1.14	  	$	1.54	
Diluted (3)	  	$	0.99	  	$	0.73	  	$	1.44	  	$	1.12	  	$	1.53	
						
Average common shares outstanding:	  			  			  			  			  			
Basic	  	 	1,970	  	 	1,960	  	 	1,952	  	 	1,942	  	 	1,937	
Diluted (3)	  	 	1,980	  	 	1,963	  	 	1,983	  	 	1,976	  	 	1,950	
						
Dividends paid on common and preferred stock	  	$	2,213	  	$	2,199	  	$	2,186	  	$	2,174	  	$	2,169	
						
Dividends declared per Common Share	  	$	1.15	  	$	1.12	  	$	1.12	  	$	1.12	  	$	1.12	
						
Financial Position Data at December 31:	  			  			  			  			  			
						
Total Assets (4)(5)	  	$	26,172	  	$	25,575	  	$	28,138	  	$	30,435	  	$	27,448	
Cash and cash equivalents	  	 	1,801	  	 	2,018	  	 	3,050	  	 	3,680	  	 	2,549	
Marketable securities	  	 	424	  	 	1,995	  	 	2,749	  	 	3,794	  	 	3,013	
Long-term debt	  	 	4,381	  	 	7,248	  	 	8,364	  	 	8,463	  	 	8,522	
Stockholders’ Equity	  	 	10,562	  	 	9,991	  	 	11,208	  	 	10,202	  	 	9,786	

(1)	The Company recorded items that affected the comparability of results. For a discussion of these items for the years 2007, 2006 and 2005, see “Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations—Expenses;” “Item 8. Financial Statements—Note 2. Alliances and Investments;” “—Note 3. Restructuring;” “—Note 4. Acquisitions and Divestitures;” “—Note 5. Discontinued Operations and Assets Held for Sale;” “—Note 9. Cash, Cash Equivalents and Marketable Securities;” “—Note 15. Short-Term Borrowings and Long-Term Debt;” and “—Note 22. Legal Proceedings and Contingencies.”	
 
(2)	Excludes discontinued operations of Medical Imaging for years 2003 through 2007 and Oncology Therapeutics Network for years 2003 through 2005.	
 
(3)	In 2007 and 2006, the 29 million weighted-average shares issuable, as well as $38 million and $35 million, respectively, of interest expense, net of tax, on the assumed conversion of convertible debt were not included in the diluted earnings per share calculation because they were anti-dilutive.	
 
(4)	In 2006, includes the impact of the adoption of Statement of Financial Accounting Standard (SFAS) No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans—an amendment of FASB Statements No. 87, 88, 106, and 132(R). For further discussion on SFAS No. 158, see “Item 8. Financial Statements—Note 21. Pension and Other Postretirement Benefits.”	
 
(5)	In 2007, includes Medical Imaging and other assets classified as held for sale.	
 
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Item 7.	MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.	
EXECUTIVE SUMMARY
About the Company
Bristol-Myers Squibb Company (BMS, the Company or Bristol-Myers Squibb) is a global biopharmaceutical and related health care products company whose mission is to extend and enhance human life by providing the highest quality pharmaceutical and related health care products. The Company is engaged in the discovery, development, licensing, manufacturing, marketing, distribution and sale of pharmaceuticals and related health care products.
The Company has three reportable segments—Pharmaceuticals, Nutritionals and ConvaTec. The Pharmaceuticals segment consists of the global pharmaceutical/biotechnology and international consumer medicines business, which accounted for approximately 81% of the Company’s 2007 net sales. The Nutritionals segment consists of Mead Johnson Nutritionals (Mead Johnson), primarily an infant formula and children’s nutritionals business, which accounted for approximately 13% of the Company’s 2007 net sales. The ConvaTec segment consists of ostomy, wound and skin care business, which accounted for approximately 6% of the Company’s 2007 net sales and was previously included in the Other Health Care operating segment. In January 2008, the Company completed the sale of its Medical Imaging business to Avista Capital Partners L.P. (Avista). The results of the Medical Imaging business, previously included in the former Other Health Care operating segment, are presented as part of the Company’s results from discontinued operations.
2007 Financial Highlights
Worldwide net sales from continuing operations for 2007 increased 12% to $19.3 billion compared to 2006. PLAVIX* (clopidogrel bisulfate) sales grew 46%, primarily reflecting the adverse impact of generic competition from August 2006 to mid-2007, as well as strong underlying sales growth. The other key products within the Company’s Pharmaceuticals segment, including AVAPRO*/AVALIDE* (irbesartan/irbesartan-hydrochlorothiazide), REYATAZ (atazanavir sulfate), the SUSTIVA (efavirenz) Franchise and ABILIFY* (aripiprazole) experienced double digit sales growth for the year. Sales of the Company’s newer specialty and biologics medicines BARACLUDE (entecavir), ORENCIA (abatacept) and SPRYCEL (dasatinib) continue to be strong. In addition, the Company launched IXEMPRA (ixabepilone) for the treatment of metastatic or locally advanced breast cancer. Overall worldwide sales growth, however, was moderated by a significant decline in PRAVACHOL (pravastatin sodium) sales due to generic competition.
Net earnings from continuing operations were $2.0 billion in 2007 compared with $1.4 billion in 2006. The 2007 results include a $230 million charge for acquired in-process research and development related to the purchase of Adnexus Therapeutics, Inc. (Adnexus), a $292 million charge in connection with the Company’s three-year Productivity Transformation Initiative (PTI) and a $275 million impairment charge of the Company’s investment in certain auction rate securities (ARS). The 2006 results include a $353 million increase in reserves for a pricing and sales litigation settlement and $220 million in early debt retirement costs. Additionally, the Company also recorded gains on sale of product assets and properties of $273 million and $200 million in 2007 and 2006, respectively.
In December 2007, the Company announced that the Board of Directors (the Board) declared an 11 percent dividend increase, the first increase since 2002. The dividend increase will result in a quarterly dividend of thirty-one cents ($.31) per share on the Company’s Common Stock for an indicative dividend for the full year of 2008 of $1.24 per share, subject to the normal quarterly review by the Board.
Business Environment
The Company conducts its business primarily within the pharmaceutical/biotechnology industry, which is highly competitive and subject to numerous government regulations. Many competitive factors may significantly affect the Company’s sales of its products, including product efficacy, safety, price and cost-effectiveness, marketing effectiveness, product labeling, quality control and quality assurance of its manufacturing operations, and research and development of new products. To successfully compete for business in the health care industry, the Company must demonstrate that its products offer medical benefits, as well as cost advantages. Currently, most of the Company’s new product introductions compete with other products already on the market in the same therapeutic category, in addition to potential competition of new products that competitors may introduce in the future. The Company manufactures branded products, which are priced higher than generic products. Generic competition is one of the Company’s leading challenges globally.
In the pharmaceutical/biotechnology industry, the majority of an innovative product’s commercial value is usually realized during the period that the product has market exclusivity. When a product loses exclusivity, it is no longer protected by a patent and is
 
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subject to new competing products in the form of generic brands. Upon exclusivity loss, the Company can lose a major portion of that product’s sales in a short period of time. Currently, generic versions of biological products cannot be approved under U.S. law. However, the law could change in the future. Even in the absence of new legislation, the U.S. Food and Drug Administration (FDA) is taking steps toward allowing generic versions of certain biologics. Competitors seeking approval of biological products must file their own safety and efficacy data, and address the challenges of biologics manufacturing, which involves more complex processes and are more costly than those of traditional pharmaceutical operations.
Both in the U.S. and internationally, the health care industry is subject to various government-imposed regulations that authorize prices or price controls that have and will continue to have an impact on the Company’s sales. In the U.S., Congress and some state legislatures have considered a number of proposals and have enacted laws that could effect major changes in the health care system, either nationally or at the state level. Driven in part by budget concerns, Medicaid access and reimbursement restrictions have been implemented in some states and proposed in many others. In addition, the Medicare Prescription Drug Improvement and Modernization Act provides outpatient prescription drug coverage to senior citizens in the U.S. This legislation has had a modest favorable impact on the Company, as a result of an increase in the number of seniors with drug coverage. There continues to be a potential negative impact on the U.S. pharmaceutical business that could result from pricing pressures or controls. In many markets outside the U.S., the Company operates in environments of government-mandated, cost-containment programs, or under other regulatory bodies or groups that can exert downward pressure on pricing. Pricing freedom is limited in the United Kingdom (UK), for instance, by the operation of a profit control plan and in Germany by the operation of a reference price system. Companies also face significant delays in market access for new products and more than two years can elapse after drug approval before new medicines become available in some national markets.
The growth of Managed Care Organizations (MCOs) in the U.S. has played a large role in the competition that surrounds the health care industry. MCOs seek to reduce health care expenditures for participants by making volume purchases and entering into long-term contracts to negotiate discounts with various pharmaceutical providers. Because of the market potential created by the large pool of participants, marketing prescription drugs to MCOs has become an important part of the Company’s strategy. Companies compete for inclusion in a MCO formulary and the Company has generally been successful in having its major products included. The Company believes that developments in the managed care industry, including continued consolidation, have had and will continue to have a generally downward pressure on prices.
Pharmaceutical/biotechnology production processes are complex, highly regulated and vary widely from product to product. Shifting or adding manufacturing capacity can be a lengthy process requiring significant capital expenditures and regulatory approvals. Biologics manufacturing involves more complex processes than those of traditional pharmaceutical operations. As biologics become more important to the Company’s product portfolio, the Company will continue to make arrangements with third-party manufacturers, and to make substantial investments to increase its internal capacity to produce biologics on a commercial scale. One such investment is the building of a new state-of-the-art manufacturing facility for the production of biologics in Devens, Massachusetts, the construction of which began in May 2007.
The Company has maintained a competitive position in the market and strives to uphold this position, which is dependent on its success in discovering and developing innovative, cost-effective products that serve unmet medical need. Recently, several of the Company’s competitors have announced cost reduction programs in an effort to reduce their respective cost bases and increase their productivity and competitiveness. The Company has also announced a three-year PTI to reduce costs, streamline operations and rationalize global manufacturing as part of its efforts to become a more productive and competitive biopharmaceutical company.
The Company and its subsidiaries are the subject of a number of significant pending lawsuits, claims, proceedings and investigations. It is not possible at this time reasonably to assess the final outcome of these investigations or litigations. For additional discussion of legal matters, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”
Strategy
In December 2007, the Company outlined its multi-year strategy designed to transform the Company into a next-generation biopharmaceutical company. The strategy encompasses all aspects and all geographies of the business and will yield substantial cost savings and cost avoidance and increase the Company’s financial flexibility to take advantage of attractive market opportunities that may arise.
As the Company develops into a next-generation biopharmaceutical company, it will continue to invest in key growth products, including specialty and biologic medicines, and cardiovascular and metabolic drugs. The Company continues to execute its ongoing strategy for long-term growth through the scale back of assets in its profitable, though declining, mature brands and increased focus
 
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on key and new growth products, which include PLAVIX*, ABILIFY*, AVAPRO*/AVALIDE*, REYATAZ, the SUSTIVA Franchise, ERBITUX* (cetuximab), ORENCIA, BARACLUDE, SPRYCEL and IXEMPRA. The Company experienced the last of a series of major anticipated exclusivity losses in 2006 and does not expect any significant new exclusivity losses for the next several years.
In order to support the production of specialty products in the pharmaceutical portfolio, including biologics, the Company completed a land purchase in 2007 of an 89-acre site to locate its new large-scale, expandable multi-project bulk biologics manufacturing facility in Devens, Massachusetts. The Company has committed $750 million to fund the construction of the facility which began in May 2007. The facility is projected to be operationally complete in 2009, and the Company plans to submit the site for regulatory approval in 2010. Commercial production of biologic compounds is anticipated to begin in 2011. In addition, the Company expanded its Manati, Puerto Rico facility, with the expansion targeted for start-up in 2008.
The new state-of-the-art facility, as well as the expanded Manati, Puerto Rico facility, will support the filling and finishing of the Company’s sterile products and biologic compounds, including ORENCIA, the Company’s first internally discovered and developed biologic medicine, and commercial quantities of compounds currently in development should those compounds receive regulatory approval.
In keeping with its strategy, the Company invested $3.3 billion in research and development, representing a 10% growth rate over 2006. Research and development dedicated to pharmaceutical products, including milestone payments for in-licensing and development programs, was $3.1 billion compared to $2.8 billion in 2006.
Consistent with the Company’s objective to maximize the value of its non-pharmaceutical businesses, in January 2008, the Company completed the sale of its Medical Imaging business to Avista. The Company will continue to seek opportunities to maximize the value of its remaining Health Care Group businesses.
As it transitions into a next-generation biopharmaceutical company, the Company seeks to reallocate resources to enable strategic acquisitions, such as the acquisition of Adnexus in October 2007, as well as pursue partnerships and other collaborative arrangements, such as the worldwide alliance with AstraZeneca PLC (AstraZeneca) to discover, develop and commercialize saxagliptin and dapagliflozin and the two separate agreements with Pfizer Inc. (Pfizer) for the research, development and commercialization of a Pfizer discovery program and for the development and commercialization of apixaban.
Productivity Transformation Initiative
The Company undertook a broad range of actions in the fourth quarter of 2007 as part of the previously announced three-year PTI, which is reducing costs, streamlining operations and rationalizing global manufacturing. The initiative, which is on track to achieve $1.5 billion in annual cost savings and cost avoidance on a pre-tax basis by 2010, is central to the Company’s strategy to become a more nimble and flexible next generation biopharmaceutical enterprise.
Key productivity initiatives include reducing general and administrative operations by simplifying, standardizing and outsourcing, where appropriate, processes and services, rationalizing the Company’s mature brands portfolio, consolidating its global manufacturing network while eliminating complexity and enhancing profitability, simplifying its geographic footprint and implementing a more efficient go-to-market model. Specific productivity goals include reducing the number of brands in the Company’s mature products portfolio by 60 percent between 2007 and 2011, reducing the number of manufacturing facilities by more than 50 percent by the end of 2010, and reducing total headcount by approximately 10 percent between 2007 and 2010. Some positions have been eliminated in 2007, although the substantial majority of positions will be eliminated in 2008 and 2009. Among the many productivity activities across the entire organization in the fourth quarter of 2007 are the impending closure of several manufacturing facilities, including Mayaguez, Puerto Rico and Barceloneta, Puerto Rico.
Costs associated with the implementation of the PTI are estimated to be between $0.9 billion to $1.1 billion on a pre-tax basis, with $292 million incurred in 2007 and approximately $500 million expected to be incurred in 2008. The ultimate timing of the recording of the charges cannot be predicted with certainty and will be affected by the occurrence of triggering events for expense recognition under U.S. Generally Accepted Accounting Principles (GAAP), among other factors.
 
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New Product and Pipeline Developments
In December 2007, the Company and Medarex, Inc. (Medarex) announced top-line data from the three registrational trials (008, 022, 007) that constitute the monotherapy program for ipilimumab in patients with metastatic melanoma. The results from study 008, conducted under Special Protocol Assessment, did not meet the primary endpoint, which was to rule out a best objective response rate of less than 10 percent. However, the totality of data from the registrational program included a clear dose response effect observed in study 022 and best objective response rates across the three studies ranging from mid-single digits to mid-teens as determined by independent radiology review. After the receipt of additional data from ongoing clinical trials, the companies plan to meet with the FDA to discuss the regulatory pathway, with the goal of submitting a regulatory filing by the middle of 2008, if supported by the data.
In November 2007, the Company and Pierre Fabre Medicament S.A. (Pierre Fabre) announced the termination of the license agreement for the development of vinflunine, a chemotherapy agent under investigation for the treatment of advanced or metastatic bladder cancer and other tumor types.
In November 2007, ABILIFY* was approved by the FDA as adjunctive, or add-on, treatment to antidepressant therapy in adults with major depressive disorder (MDD). ABILIFY* is the first medication approved by the FDA as add-on treatment for MDD. The FDA also approved ABILIFY* for the treatment of schizophrenia in adolescent patients (ages 13-17) and accepted for Priority Review the supplemental New Drug Application (sNDA) for the treatment of pediatric patients (ages 10-17) with Bipolar I Disorder.
An update to the SPRYCEL label to include a lower recommended starting dose of 100 mg once daily, from 70 mg twice daily, as a starting dose for patients with chronic-phase chronic myeloid leukemia resistant or intolerant to imatinib was approved by the FDA in November 2007 and by the European Commission in August 2007. During the first quarter of 2007, SPRYCEL received approval and/or reimbursement in additional European markets, including Ireland, Norway, Sweden and Greece, and was also approved in Canada and New Zealand.
In October 2007, ATRIPLA* (efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg) was approved in Canada as the first once-daily single-tablet regimen for the treatment of human immunodeficiency virus-1 infection in adults. In December 2007, the European Commission granted marketing authorization for ATRIPLA*, formally approving it for commercialization in the 27 countries of the European Union (EU), as well as in Norway and Iceland. ATRIPLA* has been launched in the UK, Germany and Austria.
In October 2007, the Company launched IXEMPRA, for the treatment of patients with metastatic or locally advanced breast cancer, in the U.S. In addition, the Japanese New Drug Application for ixabepilone was submitted in December 2007, and the Marketing Authorization Application for ixabepilone is under review by the European Medicines Evaluation Agency (EMEA), following submission in September 2007.
In October 2007, the Company acquired privately-held Adnexus, developer of a new therapeutic class of biologics called ADNECTINS. ADNECTINS are a proprietary class of targeted biologics based on a naturally occurring protein found in human serum.
In October 2007, the Company and ImClone Systems Incorporated (ImClone) announced that the FDA approved an update to the ERBITUX* product labeling to include overall survival data as a single agent in epidermal growth factor inhibitor (EGFR)-expressing metastatic colorectal cancer (mCRC) patients after the failure of both irinotecan- and oxaliplatin-based regiments. In September, the Company and ImClone announced that a Phase III study of ERBITUX* in combination with platinum-based chemotherapy, conducted by Merck KGaA, met its primary endpoint of increasing overall survival compared with chemotherapy alone in patients with advanced non-small cell lung cancer. As previously disclosed, an earlier study conducted by ImClone and the Company evaluating the use of ERBITUX* in combination with a different platinum-based therapy did not meet its primary endpoint of increasing progression-free survival in patients with advanced non-small cell lung cancer. Key secondary endpoints of this study, however, were statistically significant and favored the ERBITUX*-containing arm.
In September 2007, the FDA approved a sNDA for a single 300 mg tablet of PLAVIX*. The 300 mg loading dose has been proven effective in a broad acute coronary syndrome patient population. The 300 mg tablet of clopidogrel bisulfate was launched in the U.S. in December 2007 and is currently under EMEA review.

In August 2007, the Company and Pfizer finalized the collaborative agreement for the research, development and commercialization of a Pfizer discovery program which includes advanced pre-clinical compounds with potential applications for the treatment of metabolic disorders, including obesity and diabetes. The Company recorded an upfront charge of $60 million in accordance with the terms of the agreement. Pfizer will be responsible for all research and early-stage development activities for the metabolic disorders program, and the companies will jointly conduct Phase III development and commercialization activities. The companies will share all development and commercialization expenses along with profits/losses on a 60%-40% basis, with Pfizer assuming the larger share of both expenses and profits/losses.
 
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In August 2007, the FDA accepted, for filing and review, the supplemental Biologics License Application for ORENCIA for the treatment of pediatric patients with juvenile idiopathic arthritis. ORENCIA was approved by the European Commission in May 2007, and has received approval and/or reimbursement in several European markets, including the UK, Germany, Austria, Sweden, the Netherlands and Denmark. In April 2007, the FDA approved an update to the ORENCIA product labeling regarding the progression of structural joint damage – an important measure in the treatment of rheumatoid arthritis (RA). The indication was strengthened from “slowing” to “inhibiting” the progression of structural damage in adult patients with moderately to severely active RA who have had an inadequate response to one or more disease-modifying anti-rheumatic drugs, such as methotrexate or tumor necrosis factor antagonists.
In July 2007, the Company and ImClone amended the terms of their agreement for the codevelopment and copromotion of ERBITUX* in North America. Under this amendment, the companies have jointly agreed to expand the investment in the ongoing clinical development plan for ERBITUX*. Development costs, up to a threshold value, will be the sole responsibility of the Company; costs in excess of this threshold will be shared by both companies according to a pre-determined ratio. With this additional funding, the companies intend to further explore the use of ERBITUX* in additional tumor types including brain, breast, bladder, gastric, lung, pancreas and prostate.
In May 2007, the Company and Isis Pharmaceuticals, Inc. (Isis) entered into a collaborative agreement to discover, develop and commercialize novel antisense drugs targeting proprotein convertase subtilisin kexin 9 for the prevention and treatment of cardiovascular disease. The Company made an upfront payment of $15 million to Isis as part of this agreement and will provide Isis with at least $9 million in research funding over a period of three years.
In April 2007, the Company and Pfizer entered into a worldwide collaboration to develop and commercialize apixaban, an anticoagulant discovered by the Company being studied for the prevention and treatment of a broad range of venous and arterial thrombotic conditions. In accordance with the terms of the agreement, Pfizer made upfront payments of $250 million and $40 million to the Company in May 2007 and December 2007, respectively. Pfizer will fund 60% of all development costs effective January 1, 2007 going forward, and the Company will fund 40%. The Company may also receive additional payments of up to $780 million from Pfizer based on development and regulatory milestones. The companies will jointly develop the clinical and marketing strategy of apixaban, and will share commercialization expenses and profits/losses equally on a global basis.
In February 2007, BARACLUDE was added to the American Association for the Study of Liver Disease treatment guidelines for hepatitis B as a first-line treatment option. BARACLUDE also received approval and/or reimbursement in additional European markets, including Italy, throughout the first quarter of 2007.
In January 2007, the Company entered into two worldwide (except for Japan) codevelopment and cocommercialization agreements with AstraZeneca to develop and commercialize two investigational compounds being studied for the treatment of type 2 diabetes. The Company received upfront payments of $100 million from AstraZeneca. In addition, the Company will receive milestone payments from AstraZeneca upon successful achievement of various regulatory and sales related stages. The companies have agreed upon initial development plans for the two compounds. From 2007 through 2009, the majority of development costs will be paid by AstraZeneca and any subsequent development costs will generally be shared equally. In July 2007, the companies decided to move the investigational compound dapagliflozin, a selective inhibitor of the sodium-glucose transporter 2 being studied for the treatment of diabetes, into Phase III testing based on results of Phase II clinical trials.
In December 2006, the Company entered into a collaboration agreement with Exelixis Pharmaceuticals, Inc. (Exelixis) to discover, develop and commercialize novel targeted therapies for the treatment of cancer. The agreement became effective in January 2007 and in accordance with the terms of the agreement, the Company made an upfront payment of $60 million to Exelixis. In January 2008, the Company exercised an option to develop and commercialize compounds targeting one therapeutic target and paid Exelixis $20 million in February 2008. Exelixis is also eligible to receive $20 million for each of up to two additional investigational drug candidates selected by the Company. At the option of Exelixis, the companies will share equally all development costs along with commercial profits in the U.S.; otherwise, the Company will be responsible for development and will pay development milestones and royalties to Exelixis.
 
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RESULTS OF OPERATIONS
The following discussions of the Company’s results of continuing operations exclude the results related to the Medical Imaging business, which was previously presented as a component of the former Other Health Care operating segment prior to its divestiture in January 2008, and the Oncology Therapeutics Network (OTN) business, which was previously presented as a separate operating segment prior to its divestiture in 2005. These businesses have been segregated from continuing operations and reflected as discontinued operations for all periods presented. See “—Discontinued Operations” below. The Company’s results of operations were as follows:

 	  	2007	 	 	2006	 	 	2005	 	 	% Change	 	
Dollars in Millions	  			 			 			 	2007 vs. 2006	 	 	2006 vs. 2005	 	
Net Sales	  	$	19,348	 	 	$	17,256	 	 	$	18,605	 	 	12	%	 	(7	)%	
Earnings from Continuing Operations Before Minority Interest and Income Taxes	  	$	3,534	 	 	$	2,400	 	 	$	4,304	 	 	47	%	 	(44	)%	
% of net sales	  	 	18.3	%	 	 	13.9	%	 	 	23.1	%	 			 			
						
Provision for Income Taxes	  	$	803	 	 	$	538	 	 	$	870	 	 	49	%	 	(38	)%	
Effective tax rate	  	 	22.7	%	 	 	22.4	%	 	 	20.2	%	 			 			
						
Net Earnings from Continuing Operations	  	$	1,968	 	 	$	1,422	 	 	$	2,842	 	 	38	%	 	(50	)%	
% of net sales	  	 	10.2	%	 	 	8.2	%	 	 	15.3	%	 			 			
Net Sales
Net sales from continuing operations for 2007 increased 12% to $19.3 billion, including a 3% favorable foreign exchange impact, compared to 2006. U.S. net sales in 2007 increased 18% to $10.8 billion compared to 2006. International net sales in 2007 increased 5% to $8.5 billion compared to 2006, including a 7% favorable foreign exchange impact.
In 2006, net sales from continuing operations decreased 7% to $17.3 billion, compared to 2005. U.S. net sales in 2006 decreased 8% to $9.2 billion compared to 2005, while international net sales decreased 7% to $8.1 billion in 2006 as compared to 2005.
The composition of the change in net sales were as follows:

 	  	Total Change	 	 	Analysis of % Change	 	
 	  			 	Volume	 	 	Price	 	 	Foreign Exchange	 	
2007 vs. 2006	  	12	%	 	7	%	 	2	%	 	3	%	
2006 vs. 2005	  	(7	)%	 	(9	)%	 	2	%	 	—  	 	
In general, the Company’s business is not seasonal. For information on U.S. pharmaceutical prescriber demand, reference is made to the table within Business Segments under the Pharmaceuticals section below, which sets forth a comparison of changes in net sales to the estimated total prescription growth (for both retail and mail order customers) for certain of the Company’s key pharmaceutical products and new products sold by the U.S. Pharmaceuticals business.
The Company operates in three reportable segments—Pharmaceuticals, Nutritionals and ConvaTec (previously a component of the Other Health Care operating segment). In January 2008, the Company completed the sale to Avista of the Medical Imaging business, which was previously presented as a component of the Other Health Care operating segment. In May 2005, the Company completed the sale of OTN, which was previously presented as a separate operating segment. As such, the results of operations for Medical Imaging and OTN are presented as part of the Company’s results from discontinued operations in accordance with Statement of Financial Standards (SFAS) No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets. Accordingly, Medical Imaging and OTN results of operations in prior periods have been reclassified to discontinued operations to conform with current year presentations.
 
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The Company’s net sales by segment were as follows:

 	  	Net Sales	 	 	% Change	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	 	2007 vs. 2006	 	 	2006 vs. 2005	 	
Pharmaceuticals	  	$	15,622	 	 	$	13,861	 	 	$	15,408	 	 	13	%	 	(10	)%	
% of net sales	  	 	81	%	 	 	80	%	 	 	83	%	 			 			
						
Nutritionals	  	 	2,571	 	 	 	2,347	 	 	 	2,205	 	 	10	%	 	6	%	
% of net sales	  	 	13	%	 	 	14	%	 	 	12	%	 			 			
ConvaTec	  	 	1,155	 	 	 	1,048	 	 	 	992	 	 	10	%	 	6	%	
% of net sales	  	 	6	%	 	 	6	%	 	 	5	%	 			 			
	  	 	 	 	 	 	 	 	 	 	 	 	 			 			
Health Care Group	  	 	3,726	 	 	 	3,395	 	 	 	3,197	 	 	10	%	 	6	%	

Total	  	$	19,348	 	 	$	17,256	 	 	$	18,605	 	 	12	%	 	(7	)%	
	  	 	 	 	 	 	 	 	 	 	 	 	 			 			
The Company recognizes revenue net of various sales adjustments to arrive at net sales as reported on the Consolidated Statement of Earnings. These adjustments are referred to as gross-to-net sales adjustments and are further described in “—Critical Accounting Policies” below. The reconciliations of the Company’s gross sales to net sales by each significant category of gross-to-net sales adjustments were as follows:

 	  	For the Years Ended December 31,	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	
Gross Sales	  	$	22,175	 	 	$	20,120	 	 	$	22,389	 	
Gross-to-Net Sales Adjustments	  				 				 				
Prime Vendor Charge-Backs	  	 	(662	)	 	 	(703	)	 	 	(1,090	)	
Women, Infants and Children (WIC) Rebates	  	 	(848	)	 	 	(872	)	 	 	(843	)	
Managed Health Care Rebates and Other Contract Discounts	  	 	(387	)	 	 	(322	)	 	 	(502	)	
Medicaid Rebates	  	 	(169	)	 	 	(174	)	 	 	(595	)	
Cash Discounts	  	 	(251	)	 	 	(224	)	 	 	(271	)	
Sales Returns	  	 	(160	)	 	 	(230	)	 	 	(164	)	
Other Adjustments	  	 	(350	)	 	 	(339	)	 	 	(319	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Total Gross-to-Net Sales Adjustments	  	 	(2,827	)	 	 	(2,864	)	 	 	(3,784	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Sales	  	$	19,348	 	 	$	17,256	 	 	$	18,605	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
The slight decrease in gross-to-net sales adjustments in 2007 compared to 2006 was affected by a number of factors. Sales returns decreased primarily due to higher accruals in 2006 for Cardiovascular non-exclusive brands and from the discontinued commercialization of TEQUIN (gatifloxacin). The decrease in prime vendor charge-backs was primarily due to lower sales of TAXOL ® (paclitaxel) as a result of loss of exclusivity. This was partially offset by increases in managed health care rebates and other contract discounts, primarily as a result of higher PLAVIX* sales and the reversal of reserves in 2006 related to the TRICARE Retail Pharmacy Refund Program, partially offset by lower sales of PRAVACHOL due to loss of exclusivity. Additionally, the increase in cash discounts was primarily due to higher PLAVIX* sales volumes.
The decrease in gross-to-net sales adjustments in 2006 compared to 2005 was affected by a number of factors, including changes in customer mix and a portfolio shift, in each case towards products that required lower rebates, as well as changes in contract status. The decrease in prime vendor charge-backs was primarily the result of lower PLAVIX* net sales, volume erosion on highly-rebated PARAPLATIN (carboplatin) and TAXOL ® (paclitaxel) due to generic competition, as well as the impact from the discontinued commercialization of TEQUIN. Managed health care rebates and other contract discounts decreased primarily as a result of the reversal of reserves related to the TRICARE Retail Pharmacy Refund Program, as well as the exclusivity loss of PRAVACHOL, which also reduced Medicaid rebates. In addition, lower PLAVIX* net sales and the shift in patient enrollment from Medicaid to Medicare under Medicare Part D, resulted in a decrease in Medicaid rebates, partially offset by a corresponding increase in managed health care rebates. The decrease in cash discounts was primarily due to lower sales of PRAVACHOL due to loss of exclusivity and lower PLAVIX* sales volumes. The increase in sales returns was primarily due to higher returns trends for non-exclusive brands as well as from the discontinued commercialization of TEQUIN.
 
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The activities and ending balances of each significant category of gross-to-net sales adjustments were as follows:

Dollars in Millions	  	Prime Vendor
Charge-Backs	 	 	Women,
Infants and
Children
(WIC) Rebates	 	 	Managed
Health Care
Rebates and
Other
Contract
Discounts	 	 	Medicaid
Rebates	 	  	Cash
Discounts	 	  	Sales
Returns	 	  	Other
Adjustments	 	  	Total	 	
Balance at January 1, 2006	  	$	107	 	 	$	252	 	 	$	167	 	 	$	326	 	  	$	26	 	  	$	185	 	  	$	124	 	  	$	1,187	 	
Provision related to sales made in
current period	  	 	706	 	 	 	867	 	 	 	355	 	 	 	174	 	  	 	221	 	  	 	200	 	  	 	348	 	  	 	2,871	 	
Provision related to sales made in
prior periods	  	 	(3	)	 	 	5	 	 	 	(33	)	 	 	—  	 	  	 	3	 	  	 	30	 	  	 	(9	)	  	 	(7	)	
Returns and payments	  	 	(747	)	 	 	(894	)	 	 	(380	)	 	 	(363	)	  	 	(232	)	  	 	(196	)	  	 	(343	)	  	 	(3,155	)	
Impact of foreign currency
translation	  	 	—  	 	 	 	—  	 	 	 	1	 	 	 	—  	 	  	 	—  	 	  	 	2	 	  	 	4	 	  	 	7	 	
Discontinued operations	  	 	—  	 	 	 	—  	 	 	 	1	 	 	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	1	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
Balance at December 31, 2006	  	 	63	 	 	 	230	 	 	 	111	 	 	 	137	 	  	 	18	 	  	 	221	 	  	 	124	 	  	 	904	 	
Provision related to sales made in
current period	  	 	662	 	 	 	845	 	 	 	394	 	 	 	176	 	  	 	250	 	  	 	142	 	  	 	352	 	  	 	2,821	 	
Provision related to sales made in
prior periods	  	 	—  	 	 	 	3	 	 	 	(7	)	 	 	(7	)	  	 	1	 	  	 	18	 	  	 	(2	)	  	 	6	 	
Returns and payments	  	 	(655	)	 	 	(880	)	 	 	(360	)	 	 	(181	)	  	 	(245	)	  	 	(207	)	  	 	(356	)	  	 	(2,884	)	
Impact of foreign currency
translation	  	 	—  	 	 	 	—  	 	 	 	6	 	 	 	—  	 	  	 	—  	 	  	 	4	 	  	 	10	 	  	 	20	 	
Discontinued operations	  	 	—  	 	 	 	—  	 	 	 	(10	)	 	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	(10	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
Balance at December 31, 2007	  	$	70	 	 	$	198	 	 	$	134	 	 	$	125	 	  	$	24	 	  	$	178	 	  	$	128	 	  	$	857	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
In 2007, the Company recorded gross-to-net sales adjustments related to sales made in prior periods. The significant items included charges for sales returns of $18 million primarily related to higher than expected returns for certain non-exclusive products.
In 2006, the Company recorded gross-to-net sales adjustments related to sales made in prior periods. The significant items included charges for sales returns of $30 million primarily related to higher than expected return trends for certain non-exclusive products, as well as from the discontinued commercialization of TEQUIN; and credits in other contract discounts of $33 million, primarily due to the reversal of reserves related to the TRICARE Retail Pharmacy Refund Program.
No other significant revisions were made to the estimates for gross-to-net sales adjustments in 2007 and 2006.
Pharmaceuticals
The composition of the change in pharmaceutical sales were as follows:

 	  	Total Change	 	 	Analysis of % Change	 	
	  			 	Volume	 	 	Price	 	 	Foreign
Exchange	 	
2007 vs. 2006	  	13	%	 	8	%	 	2	%	 	3	%	
2006 vs. 2005	  	(10	)%	 	(12	)%	 	2	%	 	—  	 	

In 2007, Worldwide Pharmaceuticals sales increased 13% to $15,622 million, including a 3% favorable foreign exchange impact, compared to the same period in 2006. U.S. Pharmaceuticals sales increased 21% to $8,992 million from $7,417 million in 2006, primarily due to increased PLAVIX* sales reflecting the adverse impact of generic competition from August 2006 to mid-2007, as well as strong underlying sales growth. The sales growth was also attributed to increased sales of ABILIFY*, the SUSTIVA Franchise, REYATAZ, AVAPRO*/AVALIDE* and ERBITUX*, and sales of newer products SPRYCEL, ORENCIA, BARACLUDE and IXEMPRA. The increase was partially offset by increased generic competition for PRAVACHOL. International Pharmaceuticals sales increased 3%, including a 6% favorable foreign exchange impact, to $6,630 million in 2007 from $6,444 million in 2006. Excluding the impact of foreign exchange, the decrease in sales was primarily due to increased generic competition for PRAVACHOL and TAXOL ® (paclitaxel), partially offset by sales growth of ABILIFY*, REYATAZ, PLAVIX* and AVAPRO*/AVALIDE* and newer products BARACLUDE and SPRYCEL.
In 2006, Worldwide Pharmaceuticals sales decreased 10% to $13,861 million. U.S. Pharmaceuticals sales decreased 11% to $7,417 million from $8,338 million in 2005, primarily due to lower sales of PLAVIX* resulting from the launch of generic clopidogrel bisulfate in August 2006 and loss of exclusivity of PRAVACHOL, partially offset by continued growth of ABILIFY*, ERBITUX*, REYATAZ, the SUSTIVA Franchise and AVAPRO*/AVALIDE* and sales of newer products including ORENCIA,
 
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BARACLUDE and SPRYCEL. International Pharmaceuticals sales decreased 9% to $6,444 million in 2006 from $7,070 million in 2005, primarily due to a decline in PRAVACHOL and TAXOL ® (paclitaxel) sales resulting from increased generic competition in Europe, partially offset by increased sales of newer products including REYATAZ, ABILIFY* and BARACLUDE.
Key pharmaceutical products and their sales, representing 80%, 75% and 71% of total pharmaceutical sales in 2007, 2006 and 2005, respectively, were as follows:

 	  	2007	  	2006	  	2005	  	% Change	 	
Dollars in Millions	  		  		  		  	2007 vs. 2006	 	 	2006 vs. 2005	 	
Cardiovascular	  			  			  			  			 			
PLAVIX*	  	$	4,755	  	$	3,257	  	$	3,823	  	46	%	 	(15	)%	
AVAPRO*/AVALIDE*	  	 	1,204	  	 	1,097	  	 	982	  	10	%	 	12	%	
PRAVACHOL	  	 	443	  	 	1,197	  	 	2,256	  	(63	)%	 	(47	)%	
COUMADIN	  	 	201	  	 	220	  	 	212	  	(9	)%	 	4	%	
Virology	  			  			  			  			 			
REYATAZ	  	 	1,124	  	 	931	  	 	696	  	21	%	 	34	%	
SUSTIVA Franchise (total revenue)	  	 	956	  	 	791	  	 	680	  	21	%	 	16	%	
BARACLUDE	  	 	275	  	 	83	  	 	12	  	*	*	 	*	*	
Oncology	  			  			  			  			 			
ERBITUX*	  	 	692	  	 	652	  	 	413	  	6	%	 	58	%	
TAXOL ® (paclitaxel)	  	 	422	  	 	563	  	 	747	  	(25	)%	 	(25	)%	
SPRYCEL	  	 	158	  	 	25	  	 	—  	  	*	*	 	—  	 	
IXEMPRA	  	 	15	  	 	—  	  	 	—  	  	—  	 	 	—  	 	
Affective (Psychiatric) Disorders	  			  			  			  			 			
ABILIFY* (total revenue)	  	 	1,660	  	 	1,282	  	 	912	  	29	%	 	41	%	
Immunoscience	  			  			  			  			 			
ORENCIA	  	 	231	  	 	89	  	 	—  	  	160	%	 	—  	 	
Other Pharmaceuticals	  			  			  			  			 			
EFFERALGAN	  	 	308	  	 	266	  	 	283	  	16	%	 	(6	)%	

**	Change is in excess of 200%.	
 
•	 	Sales of PLAVIX*, a platelet aggregation inhibitor that is part of the Company’s alliance with Sanofi, increased 46%, including a 1% favorable foreign exchange impact, to $4,755 million in 2007 from $3,257 million in 2006. U.S. sales increased 53% to $4,060 million in 2007 from $2,655 million in 2006. The Company estimates the adverse effect of generic clopidogrel bisulfate, launched in August 2006, to be in the range of $1.2 billion to $1.4 billion for 2006. For 2007, the Company estimates the negative impact of generic clopidogrel bisulfate to be in the range of $250 million to $350 million, as inventory of generic clopidogrel bisulfate in the distribution channels was substantially depleted by June 30, 2007. Estimated total U.S. prescription demand for clopidogrel bisulfate (branded and generic) increased approximately 8% in 2007 compared to 2006, while estimated total U.S. prescription demand for branded PLAVIX* increased 34% in the same period. In 2006, sales decreased 15% to $3,257 million from $3,823 million in 2005. U.S. sales decreased 18% to $2,655 million in 2006 from $3,235 million in 2005. While market exclusivity for PLAVIX* is expected to expire in 2011 in the U.S. and 2013 in the major European markets, the composition of matter patent for PLAVIX* is the subject of litigation. Data exclusivity for PLAVIX* expires in July 2008 in the EU, and the key composition of matter patent expires in 2013 in the majority of the EU member countries. For additional information on the PLAVIX* litigations see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”	
 
•	 	Sales of AVAPRO*/AVALIDE*, an angiotensin II receptor blocker for the treatment of hypertension that is also part of the Sanofi alliance, increased 10%, including a 3% favorable foreign exchange impact, to $1,204 million in 2007 from $1,097 million in 2006. U.S. sales increased 7% to $692 million in 2007 from $647 million in 2006, primarily due to higher average net selling prices. Estimated total U.S. prescription demand decreased approximately 4% in 2007 compared to 2006. International sales increased 14%, including an 8% favorable foreign exchange impact, to $512 million from $450 million in 2006. In 2006, sales increased 12%, including a 1% favorable foreign exchange impact, to $1,097 million from $982 million in 2005. U.S. sales increased 13% to $647 million in 2006 from $574 million in 2005, while international sales increased 10%, including a 2% favorable foreign exchange impact, to $450 million from $408 million in 2005. Market exclusivity for AVAPRO*/AVALIDE* (known in the EU as APROVEL*/KARVEA*) is expected to expire in 2012 (including pediatric extension) in the U.S. and in 2012-2013 in most countries in the EU; the Company does not, but others do, market AVAPRO*/AVALIDE* in Japan.	
 
•	 	Sales of PRAVACHOL, an HMG Co-A reductase inhibitor, decreased 63%, including a 2% favorable foreign exchange impact, to $443 million in 2007 from $1,197 million in 2006, due to increased generic competition in the U.S. and key European markets. Estimated total U.S. prescription demand decreased approximately 82% in 2007 compared to 2006. In 2006, sales decreased 47%	
 
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 	to $1,197 million from $2,256 million in 2005, due to market exclusivity expiration in April 2006 resulting in generic competition for most strengths in the U.S. and generic competition in key European markets. Market exclusivity in the EU ended in 2004, with the exception of Sweden, where expiration occurred in March 2006; Italy, where expiration occurred in January 2008; and France, where generic competition that was not authorized by the Company commenced in July 2006. As previously disclosed, the Company authorized Watson Pharmaceutical to distribute pravastatin sodium tablets in the U.S.	
 
•	 	Sales of COUMADIN, an oral anticoagulant used predominantly in patients with atrial fibrillation or deep venous thrombosis/pulmonary embolism, decreased 9%, including a 1% favorable foreign exchange impact, to $201 million in 2007 from $220 million in 2006, primarily due to lower demand driven by continued competition, partially offset by higher average net selling prices. Estimated total U.S. prescription demand decreased approximately 16% in 2007 compared to 2006. In 2006, sales increased 4% to $220 million from $212 million in 2005, primarily due to higher average net selling prices, partially offset by lower demand driven by continued competition. Market exclusivity for COUMADIN expired in the U.S. in 1997.	
 
•	 	Sales of REYATAZ, a protease inhibitor for the treatment of HIV, increased 21%, including a 4% favorable foreign exchange impact, to $1,124 million in 2007 from $931 million in 2006, primarily due to increased demand in the majority of the markets. U.S. sales increased 14% to $587 million in 2007 from $514 million in 2006, primarily due to higher demand. Estimated total U.S. prescription demand increased approximately 13% in 2007 compared to 2006. International sales increased 29%, including an 8% favorable foreign exchange impact, to $537 million in 2007 from $417 million in 2006. In 2006, sales increased 34% to $931 million from $696 million in 2005, primarily due to increased demand in the U.S., Europe and Latin America. Market exclusivity for REYATAZ is expected to expire in 2017 in the U.S., in countries in the EU and Japan. Data exclusivity in the EU expires in 2014.	
 
•	 	Total revenue for the SUSTIVA Franchise, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV, increased 21%, including a 4% favorable foreign exchange impact, to $956 million in 2007 from $791 million in 2006. U.S. sales increased 22% to $604 million from $495 million in 2006 primarily due to higher demand, resulting from the successful launch of ATRIPLA* in July 2006. Estimated total U.S. prescription demand for the SUSTIVA Franchise increased approximately 20% in 2007 compared to 2006. International sales increased 19%, including a 10% favorable foreign exchange impact, to $352 million from $296 million in 2006, primarily due to higher demand across all markets. In July 2006, the Company and Gilead Sciences, Inc. (Gilead) launched ATRIPLA*, a once-daily single tablet three-drug regimen for HIV intended as a stand-alone therapy or in combination with other antiretrovirals. Total revenue for the SUSTIVA Franchise includes sales of SUSTIVA, as well as revenue from bulk efavirenz included in the combination therapy ATRIPLA*. The Company records revenue for the bulk efavirenz component of ATRIPLA* upon sales of ATRIPLA* by the joint venture with Gilead to third-party customers. In 2006, sales increased 16% to $791 million from $680 million in 2005 due to higher demand and the launch of ATRIPLA* in the third quarter of 2006. Market exclusivity for SUSTIVA is expected to expire in 2013 in the U.S. and in countries in the EU; the Company does not, but others do, market SUSTIVA in Japan. For additional information on revenue recognition of the SUSTIVA Franchise, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
 
•	 	Sales of BARACLUDE, an oral antiviral agent for the treatment of chronic hepatitis B, increased to $275 million in 2007 from $83 million in 2006 due to continued growth across all markets, including the U.S., China, Japan and Korea. In 2006, sales increased to $83 million from $12 million in 2005. BARACLUDE was launched in the U.S. in April 2005, China in February 2006, the UK and Germany in July 2006 and in France and Japan in September 2006. The Company has a composition of matter patent that expires in the U.S. in 2015, in the EU between 2011 and 2016 and in Japan in 2016. As previously disclosed, there is uncertainty about China’s exclusivity laws, and due to this uncertainty, it is possible that one or more companies in China could receive marketing authorization from China’s health authority by 2010.	
 
•	 	Sales of ERBITUX*, which is sold by the Company almost exclusively in the U.S., increased 6% to $692 million in 2007 from $652 million in 2006, primarily due to increased demand for usage in the treatment of head and neck cancer and a transition to a broader distribution model. In 2006, sales increased 58% to $652 million from $413 million in 2005. ERBITUX* is marketed by the Company under a distribution and copromotion agreement with ImClone. A use patent relating to combination therapy with cytotoxic treatments expires in 2017. There is no patent covering monotherapy. Currently, generic versions of biological products cannot be approved under U.S. law. However, the law could change in the future. Even in the absence of new legislation, the FDA is taking steps toward allowing generic versions of certain biologics. Competitors seeking approval of biological products must file their own safety and efficacy data, and address the challenges of biologics manufacturing, which involves more complex processes and are more costly than those of traditional pharmaceutical operations. The Company’s right to market ERBITUX* in North America and Japan under its agreement with ImClone expires in September 2018. The Company does not, but others do, market ERBITUX* in countries in the EU. As previously disclosed, ImClone and Yeda Research and Development Company Ltd. (Yeda) have been in litigation over the ownership of the use patent for combination therapy with cytotoxic treatments relating to ERBITUX*. In September 2006, the District court granted Yeda the complete ownership of that patent. Pursuant to a settlement agreement executed by ImClone, Sanofi and Yeda announced in December 2007 to end worldwide litigation related to the use patent. The settlement agreement does not change ImClone’s worldwide royalty rate for ERBITUX* sales. Under its commercial agreement with ImClone, the Company pays a royalty to ImClone on sales of ERBITUX* that is not impacted by the settlement agreement. For further information pertaining to legal proceedings involving ERBITUX*, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies,” and “—Note 2. Alliances and Investments.”	
 
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•	 	Sales of TAXOL ® (paclitaxel), an anti-cancer agent sold almost exclusively in the non-U.S. markets, decreased 25%, including a 1% favorable foreign exchange impact, to $422 million in 2007 from $563 million in 2006, primarily due to increased generic competition in Europe and Japan. In 2006, sales decreased 25%, including a 2% unfavorable foreign exchange impact, to $563 million from $747 million in 2005, primarily due to increased generic competition in Europe and generic entry in Japan during the third quarter of 2006. Market exclusivity protection for TAXOL ® (paclitaxel) expired in 2000 in the U.S. and in 2003 in countries in the EU. Two generic paclitaxel products have received regulatory approval in Japan, and both have entered the market.	
 
•	 	Sales of SPRYCEL, an oral inhibitor of multiple tyrosine kinases, for the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy, including GLEEVEC* (imatinib meslylate), increased to $158 million in 2007 from $25 million in 2006. SPRYCEL was launched in the U.S. in July 2006 and in certain European markets beginning in the fourth quarter of 2006. Market exclusivity for SPRYCEL is expected to expire in 2020 in the U.S. In several EU countries, the patent is pending and, if granted, would expire in 2020.	
 
•	 	Sales of IXEMPRA, a microtubule inhibitor for the treatment of patients with metastatic or locally advanced breast cancer, were $15 million in 2007. IXEMPRA was launched in the U.S. in October 2007. The Company has a composition of matter patent in the U.S and a corresponding patent in EU countries, both expiring in 2018. The Company has submitted its request for patent term extension for the composition of matter patent in the U.S., which could possibly extent the term of that patent. The corresponding patent in EU countries may be eligible for patent term restoration, which could possibly extend the term of the patent in EU countries.	
 
•	 	Total revenue for ABILIFY*, an antipsychotic agent for the treatment of schizophrenia, acute bipolar mania and bipolar disorder, increased 29%, including a 2% favorable foreign exchange impact, to $1,660 million in 2007 from $1,282 million in 2006. U.S. sales increased 24% to $1,305 million in 2007 from $1,052 million in 2006, primarily due to higher demand and higher average net selling prices. Estimated total U.S. prescription demand increased approximately 12% in 2007 compared to 2006. In 2006, sales increased 41% to $1,282 million from $912 million in 2005, primarily due to higher demand and higher average net selling prices. Total revenue for ABILIFY* primarily consists of alliance revenue representing the Company’s 65% share of net sales in countries where it copromotes with Otsuka Pharmaceutical Co., Ltd. (Otsuka) and the product is sold by an Otsuka affiliate as a distributor. Otsuka’s market exclusivity protection for ABILIFY* is expected to expire in 2014 in the U.S. (including the granted patent term extension). For information on patent litigations relating to ABILIFY*, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.” The Company also has the right to copromote ABILIFY* in several European countries (the UK, France, Germany and Spain) and to act as exclusive distributor for the product in the rest of the EU. A composition of matter patent is in force in Germany, the UK, France, Italy, the Netherlands, Romania, Sweden, Switzerland, Spain and Denmark. The original expiration date of 2009 has been extended to 2014 by grant of a supplemental protection certificate in all of the above countries except Romania and Denmark. Data exclusivity in the EU expires in 2014. The Company’s contractual right to market ABILIFY* expires in November 2012 in the U.S. and Puerto Rico and, for the countries in the EU where the Company has the exclusive right to market ABILIFY* until June 2014. For additional information on revenue recognition of ABILIFY*, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
 
•	 	Sales of ORENCIA, a fusion protein indicated for adult patients with moderate to severe RA who have had an inadequate response to one or more currently available treatments, such as methotrexate or anti-tumor necrosis factor therapy, increased 160%, including a 1% favorable foreign exchange impact, to $231 million in 2007 from $89 million in 2006, primarily due to demand. Substantially all sales of ORENCIA are currently in the U.S., where it was launched in February 2006. ORENCIA was launched in Europe in May 2007. The Company has submitted its request for patent term extension for one of the composition of matter patents that expires in 2015, which could possibly extend the term of the patent. As noted above, generic versions of biological products cannot be approved under U.S. law, but the law could change in the future.	
 
•	 	Sales of EFFERALGAN (paracetamol), a formulation of acetaminophen for pain relief sold principally in Europe, increased 16%, including a 9% favorable foreign exchange impact, to $308 million in 2007 from $266 million in 2006, primarily due to a severe 2007 flu season. In 2006, sales decreased 6% to $266 million from $283 million in 2005, primarily due to a change in government reimbursement.	
In most instances, the basic exclusivity loss date indicated above is the expiration date of the patent that claims the active ingredient of the drug or the method of using the drug for the approved indication. In some instances, the basic exclusivity loss date indicated is the expiration date of the data exclusivity period. In situations where there is only data exclusivity without patent protection, a competitor could seek regulatory approval prior to the expiration of the data exclusivity period by submitting its own clinical trial data to obtain marketing approval. The Company assesses the market exclusivity period for each of its products on a case-by-case basis. The length of market exclusivity for any of the Company’s products is difficult to predict with certainty because of the complex interaction between patent and regulatory forms of exclusivity and other factors. There can be no assurance that a
 
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particular product will enjoy market exclusivity for the full period of time that the Company currently anticipates. The estimates of market exclusivities reported above are for business planning purposes only and are not intended to reflect the Company’s legal opinion regarding the strength or weakness of any particular patent or other legal position.
The estimated U.S. prescription change data provided above includes information only from the retail and mail order channels and does not reflect information from other channels, such as hospitals, institutions and long-term care, among others. The estimated prescription data is based on the Next-Generation Prescription Service (NGPS) version 2.0 provided by IMS Health (IMS), a supplier of market research for the pharmaceutical industry, as described below.
The Company has calculated the estimated total U.S. prescription change based on NGPS version 2.0 data on a weighted-average basis to reflect the fact that mail order prescriptions include a greater volume of product supplied compared to retail prescriptions. Mail order prescriptions typically reflect a 90-day prescription whereas retail prescriptions typically reflect a 30-day prescription. The calculation is derived by multiplying NGPS mail order prescription data by a factor that approximates three and adding to this the NGPS retail prescriptions. The Company believes that this calculation of the estimated total U.S. prescription change based on the weighted-average approach with respect to the retail and mail order channels provides a superior estimate of total prescription demand. The Company uses this methodology for its internal demand forecasts.
 
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Estimated End-User Demand
The following tables set forth for each of the Company’s key pharmaceutical products sold by the U.S. Pharmaceuticals business, for the years ended December 31, 2007, 2006 and 2005: (i) total U.S. net sales for the period; (ii) change in reported U.S. net sales for the period; (iii) estimated total U.S. prescription change for the retail and mail order channels calculated by the Company based on NGPS version 2.0 on a weighted-average basis and (iv) months of inventory on hand in the distribution channel. Prior year prescription data were adjusted to conform to the NGPS 2.0 version data.

 	  	Year Ended December 31, 2007	 	 	As of December 31, 2007	
Dollars in Millions	  	Total U.S. Net Sales	  	% Change in U.S.
Net Sales (a)	 	 	% Change in U.S.
Total Prescriptions  (b)	 	 	Months on
Hand	
PLAVIX*	  	$	4,060	  	53	 	 	34	 	 	0.5	
AVAPRO*/AVALIDE*	  	 	692	  	7	 	 	(4	)	 	0.5	
PRAVACHOL	  	 	139	  	(75	)	 	(82	)	 	0.7	
COUMADIN	  	 	164	  	(12	)	 	(16	)	 	0.8	
REYATAZ	  	 	587	  	14	 	 	13	 	 	0.6	
SUSTIVA Franchise (c )  (total revenue)	  	 	604	  	22	 	 	20	 	 	0.6	
BARACLUDE (d)	  	 	88	  	76	 	 	77	 	 	0.6	
ERBITUX* (e)	  	 	683	  	6	 	 	N/A	 	 	0.5	
SPRYCEL (f)	  	 	58	  	164	 	 	**	 	 	0.9	
IXEMPRA (e, g)	  	 	15	  	—	 	 	N/A	 	 	0.9	
ABILIFY* (total revenue)	  	 	1,305	  	24	 	 	12	 	 	0.5	
ORENCIA (e , h)	  	 	216	  	145	 	 	N/A	 	 	0.5	
			
 	  	Year Ended December 31, 2006	 	 	As of December 31, 2006	
Dollars in Millions	  	Total U.S. Net Sales	  	% Change in U.S.
Net Sales (a)	 	 	% Change in U.S.
Total Prescriptions  (b)	 	 	Months on
Hand	
PLAVIX*	  	$	2,655	  	(18	)	 	(21	)	 	0.6	
AVAPRO*/AVALIDE*	  	 	647	  	13	 	 	2	 	 	0.5	
PRAVACHOL	  	 	553	  	(57	)	 	(59	)	 	0.6	
COUMADIN	  	 	186	  	2	 	 	(22	)	 	0.8	
REYATAZ	  	 	514	  	27	 	 	14	 	 	0.7	
SUSTIVA Franchise (c )  (total revenue)	  	 	495	  	23	 	 	9	 	 	0.7	
BARACLUDE (d)	  	 	50	  	**	 	 	**	 	 	0.7	
ERBITUX* (e)	  	 	646	  	57	 	 	N/A	 	 	0.4	
SPRYCEL (f)	  	 	22	  	—	 	 	—	 	 	1.4	
IXEMPRA (e, g)	  	 	—	  	—	 	 	N/A	 	 	—	
ABILIFY* (total revenue)	  	 	1,052	  	40	 	 	21	 	 	0.5	
ORENCIA (e , h)	  	 	88	  	—	 	 	N/A	 	 	0.4	
 
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 	  	Year Ended December 31, 2005	 	 	 
As of December 31, 2005	
Dollars in Millions	  	Total U.S.
Net Sales	  	% Change in U.S.
Net Sales (a)	 	 	% Change in U.S.
Total Prescriptions  (b)	 	 	Months on
Hand	
PLAVIX*	  	$	3,235	  	14	 	 	14	 	 	0.6	
AVAPRO*/AVALIDE*	  	 	574	  	2	 	 	10	 	 	0.6	
PRAVACHOL	  	 	1,274	  	(10	)	 	(17	)	 	0.6	
COUMADIN	  	 	183	  	(20	)	 	(20	)	 	0.8	
REYATAZ	  	 	405	  	33	 	 	42	 	 	0.5	
SUSTIVA Franchise (c )  (total revenue)	  	 	403	  	11	 	 	7	 	 	0.6	
BARACLUDE (d)	  	 	11	  	—	 	 	—	 	 	0.7	
ERBITUX* (e)	  	 	411	  	58	 	 	N/A	 	 	—	
SPRYCEL (f)	  	 	—	  	—	 	 	—	 	 	—	
IXEMPRA (e, g)	  	 	—	  	—	 	 	N/A	 	 	—	
ABILIFY* (total revenue)	  	 	750	  	35	 	 	42	 	 	0.6	
ORENCIA ( e, h)	  	 	—	  	—	 	 	N/A	 	 	—	

(a)	Reflects percentage change in net sales in dollar terms, including change in average selling prices and wholesaler buying patterns.	

(b)	Derived by multiplying NGPS mail order prescription data by a factor that approximates three and adding to this the NGPS retail prescriptions.	

(c)	Beginning in the third quarter of 2006, the SUSTIVA Franchise (total revenue) includes sales of SUSTIVA, as well as revenue of bulk efavirenz included in the combination therapy, ATRIPLA*. The change in U.S. total prescriptions growth for the SUSTIVA Franchise includes both branded SUSTIVA and ATRIPLA* prescription units.	

(d)	BARACLUDE was launched in the U.S. in April 2005.	

(e)	ERBITUX*, ORENCIA and IXEMPRA are parenterally administered products and do not have prescription-level data as physicians do not write prescriptions for these products.	

(f)	SPRYCEL was launched in the U.S. in July 2006.	

(g)	IXEMPRA was launched in the U.S. in October 2007.	

(h)	ORENCIA was launched in the U.S. in February 2006.	

**	Change is in excess of 200%.	
The estimated prescription change data reported throughout this Annual Report on Form 10-K only include information from the retail and mail order channels and do not reflect information from other channels, such as hospitals, institutions and long-term care, among others. The data provided by IMS are a product of IMS’ own recordkeeping processes and are themselves estimates based on IMS’ sampling procedures, subject to the inherent limitations of estimates based on sampling and a margin of error.
The Company continuously seeks to improve the quality of its estimates of prescription change amounts and ultimate patient/consumer demand through review of its methodologies and processes for calculation of these estimates and review and analysis of its own and third parties’ data used in such calculations. The Company expects that it will continue to review and refine its methodologies and processes for calculation of these estimates and will continue to review and analyze its own and third parties’ data used in such calculations.
Pursuant to the U.S. Securities and Exchange Commission (SEC) Consent Order described below under “—SEC Consent Order”, the Company monitors the level of inventory on hand in the U.S. wholesaler distribution channel and, outside of the U.S., in the direct customer distribution channel. The Company is obligated to disclose products with levels of inventory in excess of one month on hand or expected demand, subject to a de minimis exception. The following products had estimated levels of inventory in the distribution channel in excess of one month on hand as of (1) in the case of the Company’s U.S. Pharmaceuticals products, December 31, 2007 and (2) in the case of the Company’s International Pharmaceuticals, Nutritionals and ConvaTec products, December 31, 2007 and/or September 30, 2007.
At December 31, 2007, KENALOG had approximately 1.1 months of inventory on hand in the U.S. wholesaler distribution channel. The estimated value of KENALOG inventory in the U.S. wholesaler distribution channel over one month on hand was approximately $0.3 million at December 31, 2007. The increased level of inventory on hand at December 31, 2007 was due to the volatile demand for the product in the fourth quarter of 2007 as a result of a temporary product supply shortage. The Company expects to work down wholesaler inventory levels to one month on hand or less in the first quarter of 2008.
 
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As of December 31, 2007, DAFALGAN, an analgesic product sold principally in Europe, had approximately 1.2 months of inventory on hand at direct customers compared to approximately 1.1 months of inventory on hand at September 30, 2007. The increased level of inventory on hand was due primarily to private pharmacists purchasing DAFALGAN approximately once every eight weeks and the seasonality of the product.
As of December 31, 2007, MONOPRIL, a cardiovascular product, had approximately 1.1 months of inventory on hand at direct customers compared to 1.2 months of inventory on hand at September 30, 2007. The increased level of inventory on hand as of December 31, 2007 was due primarily to initial stocking of a new, exclusive distributor in Poland and stocking in support of the launch of MONOPRIL in Poland in 2007.
As of December 31, 2007, VIDEX/VIDEX EC, an antiviral product, had approximately 1.3 months of inventory on hand at direct customers compared to 1.4 months of inventory on hand at September 30, 2007. The increased level of inventory on hand was due primarily to government purchasing patterns in Brazil. The Company is contractually obligated to provide VIDEX/VIDEX EC to the Brazilian government upon placement of an order for product by the government. Under the terms of the contract, the Company has no control over the inventory levels relating to such orders.
As of December 31, 2007, the Ostomy business had approximately 1.1 months of inventory on hand at direct customers, compared to 0.9 months of inventory on hand at September 30, 2007. The increased level of inventory was due primarily to increased purchases by a significant wholesaler in anticipation of a price increase.
In the U.S., for all products sold exclusively through wholesalers or through distributors, the Company determines its months on hand estimates using information with respect to inventory levels of product on hand and the amount of out-movement of products provided by the Company’s three largest wholesalers, which accounted for approximately 90% of total gross sales of U.S. Pharmaceuticals products in 2007, and provided by the Company’s distributors. Factors that may influence the Company’s estimates include generic competition, seasonality of products, wholesaler purchases in light of increases in wholesaler list prices, new product launches, new warehouse openings by wholesalers and new customer stockings by wholesalers. In addition, such estimates are calculated using third-party data, which represent their own record-keeping processes and, as such, may also reflect estimates.
For pharmaceutical products in the U.S. that are not sold exclusively through wholesalers or distributors and for the Company’s Pharmaceuticals business outside of the U.S., Nutritionals and ConvaTec business units around the world, the Company has significantly more direct customers, limited information on direct customer product level inventory and corresponding out-movement information and the reliability of third-party demand information, where available, varies widely. In cases where direct customer product level inventory, ultimate patient/consumer demand or out-movement data do not exist or are otherwise not available, the Company has developed a variety of other methodologies to calculate estimates of such data, including using such factors as historical sales made to direct customers and third-party market research data related to prescription trends and end-user demand. Accordingly, the Company relies on a variety of methods to estimate direct customer product level inventory and to calculate months on hand for these business units. Factors that may affect the Company’s estimates include generic competition, seasonality of products, direct customer purchases in light of price increases, new product or product presentation launches, new warehouse openings by direct customers, new customer stockings by direct customers and expected direct customer purchases for governmental bidding situations.
HEALTH CARE GROUP
The Health Care Group consists of the Nutritionals and the ConvaTec operating segments. The Nutritionals operating segment consists of Mead Johnson Nutritionals, primarily an infant formula and children’s nutritionals business. The ConvaTec operating segment consists of the ostomy, wound and skin care business. The following discussions exclude sales related to the Medical Imaging business, a discontinued operation, which was previously included as a component of the former Other Health Care segment.
The combined 2007 revenues from the Health Care Group increased 10% to $3,726 million from 2006. The combined 2006 revenues from the Health Care Group increased 6% to $3,395 million from $3,197 million in 2005.
 
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Nutritionals
The composition of the change in Nutritionals sales were as follows:

 	  	 	 	Analysis of % Change	
	  	Total Change	 	Volume	 	Price	 	Foreign Exchange	
2007 vs. 2006	  	10%	 	3%	 	4%	 	3%	
2006 vs. 2005	  	6%	 	2%	 	3%	 	1%	
Key Nutritionals product lines and their sales, representing 96%, 96% and 95% of total Nutritional sales in 2007, 2006 and 2005, respectively, were as follows:

 	  	2007	  	2006	  	2005	  	% Change	
Dollars in Millions	  		  		  		  	2007 vs. 2006	 	2006 vs. 2005	
Infant Formulas	  	$	1,786	  	$	1,637	  	$	1,576	  	9%	 	4%	
ENFAMIL	  	 	1,082	  	 	1,007	  	 	992	  	7%	 	2%	
Toddler/Children’s Nutritionals	  	 	693	  	 	606	  	 	529	  	14%	 	15%	
ENFAGROW	  	 	295	  	 	262	  	 	206	  	13%	 	27%	
Worldwide Nutritionals sales increased 10%, including a 3% favorable foreign exchange impact, to $2,571 million in 2007 from 2006. In 2006, Worldwide Nutritionals sales were $2,347 million, an increase of 6%, including a 1% favorable foreign exchange impact, from $2,205 million in 2005.
International Nutritionals sales increased 15%, including a 6% favorable foreign exchange impact, to $1,443 million in 2007 from 2006, primarily due to increased sales of toddler and children’s nutritional products and ENFAMIL, the Company’s best selling infant formula. In 2006, international Nutritionals sales increased 11%, including a 3% favorable foreign exchange impact, to $1,256 million from $1,135 million in 2005, primarily due to increased sales of children’s nutritional products.
U.S. Nutritionals sales were $1,128 million, $1,091 million and $1,070 million in 2007, 2006 and 2005, respectively. The 3% increase in sales in 2007 and the 2% increase in sales in 2006 were primarily due to increased sales for ENFAMIL.
ConvaTec
The composition of the change in ConvaTec sales was as follows:

 	  	Total Change	 	Analysis of % Change	
	  		 	Volume	 	Price	 	Foreign Exchange	
2007 vs. 2006	  	10%	 	6%	 	(1)%	 	5%	
2006 vs. 2005	  	6%	 	5%	 	—  	 	1%	
ConvaTec sales by business and key products sales for the years ended December 31 were as follows:

Dollars in Millions	  	2007	  	2006	  	2005	  	% Change	
	  		  		  		  	2007 vs. 2006	 	2006 vs. 2005	
ConvaTec	  	$	1,155	  	$	1,048	  	$	992	  	10%	 	6%	
Ostomy	  	 	594	  	 	554	  	 	550	  	7%	 	1%	
Wound Therapeutics	  	 	488	  	 	441	  	 	416	  	11%	 	6%	
Worldwide ConvaTec sales increased 10%, including a 5% favorable foreign exchange impact, to $1,155 million in 2007 from 2006. Ostomy sales increased 7% to $594 million in 2007, including a 6% favorable foreign exchange impact. Sales of wound therapeutic products increased 11%, including a 6% favorable foreign exchange impact, to $488 million in 2007 from 2006, primarily due to continued growth of the AQUACEL Franchise. In 2006, Worldwide ConvaTec sales increased 6%, including a 1% favorable foreign exchange impact, to $1,048 million from $992 million in 2005, primarily due to sales of Flexi-Seal and AQUACEL.
International ConvaTec sales increased 11%, including a 8% favorable foreign exchange impact, to $784 million in 2007 from 2006, primarily due to continued growth of AQUACEL. In 2006, international ConvaTec sales increased 4%, including a 1% favorable foreign exchange impact, to $705 million from 2005, primarily due to growth of AQUACEL.
U.S. ConvaTec sales increased 8% to $371 million in 2007 from 2006, primarily due to Flexi-Seal and continued growth of the AQUACEL brand. In 2006, U.S. ConvaTec sales increased 10% to $343 million from 2005, primarily due to Flexi-Seal and continued growth of the AQUACEL brand.
 
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Geographic Areas
In general, the Company’s products are available in most countries in the world. The largest markets are in the U.S., France, Canada, Spain, Japan, Italy, Mexico and Germany. The Company’s sales by geographic areas were as follows:

Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	 	% Change	
	  			 			 			 	2007 vs. 2006	 	2006 vs. 2005	
United States	  	$	10,808	 	 	$	9,140	 	 	$	9,924	 	 	18%	 	(8)%	
% of Total	  	 	56	%	 	 	53	%	 	 	53	%	 		 		
Europe, Middle East and Africa	  	 	4,635	 	 	 	4,518	 	 	 	5,111	 	 	3%	 	(12)%	
% of Total	  	 	24	%	 	 	26	%	 	 	28	%	 		 		
Other Western Hemisphere	  	 	1,704	 	 	 	1,580	 	 	 	1,561	 	 	8%	 	1%	
% of Total	  	 	9	%	 	 	9	%	 	 	8	%	 		 		
Pacific	  	 	2,201	 	 	 	2,018	 	 	 	2,009	 	 	9%	 	—  	
% of Total	  	 	11	%	 	 	12	%	 	 	11	%	 		 		
	  	 	 	 	 	 	 	 	 	 	 	 	 		 		
Total	  	$	19,348	 	 	$	17,256	 	 	$	18,605	 	 	12%	 	(7)%	
	  	 	 	 	 	 	 	 	 	 	 	 	 		 		
Sales in the U.S. increased 18% in 2007, primarily due to increased PLAVIX* sales, the continued growth of ABILIFY*, the SUSTIVA Franchise, ERBITUX*, AVAPRO*/AVALIDE* and REYATAZ, as well as sales of newer products, BARACLUDE, ORENCIA and SPRYCEL, partially offset by increased generic competition for PRAVACHOL. In 2006, sales in the U.S. decreased 8%, primarily as a result of lower sales of PLAVIX* and the loss of exclusivity of PRAVACHOL in April 2006, partially offset by growth of the remaining pharmaceutical products, including recently launched products.
Sales in Europe, Middle East and Africa increased 3%, including an 8% favorable foreign exchange impact. Excluding the impact of foreign exchange, the decrease in sales was primarily due to increased generic competition for PRAVACHOL and TAXOL ® (paclitaxel), partially offset by sales growth in major European markets for SPRYCEL, REYATAZ, the SUSTIVA Franchise and ABILIFY*. In 2006, sales decreased 12% as a result of sales decline of PRAVACHOL and TAXOL ® (paclitaxel) due to increased generic competition. This decrease in sales was partially offset by increased sales in major European markets of REYATAZ and AVAPRO*/AVALIDE*.
Sales in the Other Western Hemisphere countries increased 8%, including a 4% favorable foreign exchange impact, primarily due to increased sales of PLAVIX* in Canada and Mexico, and key nutritional products and AVAPRO*/AVALIDE* in Canada, partially offset by the discontinued commercialization of TEQUIN. In 2006, sales increased 1%, including a 3% favorable foreign exchange impact. Excluding the impact of foreign exchange, the decrease in sales was primarily due to decreased sales of TEQUIN and other pharmaceutical products, partially offset by increased sales of AVAPRO*/AVALIDE* in Canada and key nutritional products.
Sales in the Pacific region increased 9%, including a 5% favorable foreign exchange impact, primarily due to increased sales of BARACLUDE in China, Japan and Korea and key nutritional products, partially offset by decreased sales of TAXOL ® (paclitaxel) and PRAVACHOL due to increased generic competition. In 2006, sales remained consistent compared to 2005.
 
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Expenses

Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	 	% Change	
	  			 			 			 	2007 vs. 2006	 	2006 vs. 2005	
Cost of products sold	  	$	6,218	 	 	$	5,739	 	 	$	5,737	 	 	8%	 	—  	
% of Net Sales	  	 	32.1	%	 	 	33.3	%	 	 	30.8	%	 		 		
Marketing, selling and administrative	  	$	4,855	 	 	$	4,800	 	 	$	4,989	 	 	1%	 	(4)%	
% of Net Sales	  	 	25.1	%	 	 	27.8	%	 	 	26.8	%	 		 		
Advertising and product promotion	  	$	1,465	 	 	$	1,340	 	 	$	1,464	 	 	9%	 	(8)%	
% of Net Sales	  	 	7.6	%	 	 	7.8	%	 	 	7.9	%	 		 		
Research and development	  	$	3,282	 	 	$	2,991	 	 	$	2,678	 	 	10%	 	12%	
% of Net Sales	  	 	17.0	%	 	 	17.3	%	 	 	14.4	%	 		 		
Acquired in-process research and development	  	$	230	 	 	$	—	 	 	$	—	 	 	—  	 	—  	
% of Net Sales	  	 	1.2	%	 	 	—	 	 	 	—	 	 		 		
Provision for restructuring, net	  	$	183	 	 	$	59	 	 	$	32	 	 	**	 	84%	
% of Net Sales	  	 	0.9	%	 	 	0.3	%	 	 	0.2	%	 		 		
Litigation expense, net	  	$	14	 	 	$	302	 	 	$	269	 	 	(95)%	 	12%	
% of Net Sales	  	 	0.1	%	 	 	1.8	%	 	 	1.5	%	 		 		
Gain on sale of product assets and businesses	  	$	(273	)	 	$	(200	)	 	$	(569	)	 	(37)%	 	65%	
% of Net Sales	  	 	(1.4	)%	 	 	(1.2	)%	 	 	(3.1	)%	 		 		
Equity in net income of affiliates	  	$	(524	)	 	$	(474	)	 	$	(334	)	 	(11)%	 	(42)%	
% of Net Sales	  	 	(2.7	)%	 	 	(2.7	)%	 	 	(1.8	)%	 		 		
Other expense, net	  	$	364	 	 	$	299	 	 	$	35	 	 	22%	 	**	
% of Net Sales	  	 	1.8	%	 	 	1.7	%	 	 	0.2	%	 		 		
Total Expenses, net	  	$	15,814	 	 	$	14,856	 	 	$	14,301	 	 	6%	 	4%	
% of Net Sales	  	 	81.7	%	 	 	86.1	%	 	 	76.9	%	 		 		

**	Change is in excess of 200%.	
 
•	 	Cost of products sold, as a percentage of sales, decreased to 32.1% in 2007 compared to 2006. The margin improvement was primarily due to sales growth of higher margin products, including increased sales of PLAVIX*. In 2006 and 2005, cost of products sold, as a percentage of sales, was 33.3% and 30.8%, respectively. In 2006, the Company included $91 million, or 0.5% as a percentage of sales, of certain costs in cost of products sold, which were reported in marketing, selling and administrative expenses in the prior year results. In addition to the reclassification, the increase was primarily due to the unfavorable impact of pharmaceutical net sales mix, including lower sales of PLAVIX* and impairment charges for TEQUIN and EMSAM* related assets, as well as for a manufacturing facility.	
 
•	 	Marketing, selling and administrative expenses increased 1% to $4,855 million as compared to 2006, primarily due to an unfavorable impact of foreign exchange and higher marketing expenses, partially offset by lower sales force expenses. In 2006, marketing, selling and administrative expenses decreased 4% to $4,800 million from $4,989 million in 2005, primarily due to above-mentioned reclassification, lower sales force expenses resulting from the previously announced restructuring of the U.S. primary care sales organization that became effective in March 2006 and lower expenses for PRAVACHOL, partially offset by the impact of the adoption of stock option expensing. Marketing, selling and administrative expenses as a percentage of sales were 25.1%, compared with 27.8%, which included a 0.5% decrease from the reclassification, and 26.8% in 2006 and 2005, respectively.	
 
•	 	Advertising and product promotion expenditures increased 9% to $1,465 million as compared to 2006, primarily driven by increased spending for direct-to-customer advertising for PLAVIX*, ABILIFY* and ORENCIA, investments to support the launch of IXEMPRA, higher spending on newer products in Europe and an unfavorable impact of foreign exchange in 2007. In 2006, advertising and product promotion expenditures decreased 8% to $1,340 million compared to $1,464 million in 2005, primarily driven by the divestiture of the Consumer Medicines business in 2005 and lower spending on mature brands, partially offset by increased investments in new products including ORENCIA and SPRYCEL.	
 
•	 	The Company’s investment in research and development was $3,282 million in 2007, an increase of 10% over 2006. In 2006, the investment in research and development was $2,991 million, which represented a 12% increase over $2,678 million in 2005. The increases in both 2007 and 2006 reflect the Company’s strategy with continued investments in late-stage compounds and developing a pipeline in disease areas that address significant unmet medical need. The 2007 increase was partially offset by sharing of codevelopment costs with alliance partners AstraZeneca and Pfizer. Research and development costs also included	
 
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 	charges of $162 million in 2007 for upfront and milestone payments to Exelixis, Pfizer, Adnexus and Isis. Research and development costs also included charges of $85 million and $72 million in 2006 and 2005, respectively, consisting primarily of upfront and milestone payments to Exelixis and Solvay Global in 2006 and Medarex and Pierre Fabre in 2005. Research and development spending dedicated to pharmaceutical products was 20.0% of pharmaceutical sales in 2007, compared to 20.2% and 16.5% in 2006 and 2005, respectively.	
 
•	 	Acquired in-process research and development charge of $230 million in 2007 was in connection with the purchase of Adnexus in the fourth quarter of 2007. For additional information on the acquisition, see “Item 8. Financial Statements—Note 4. Acquisitions and Divestitures.”	
 
•	 	Restructuring programs in 2007, including those under the PTI, which began in late 2007, as well as those in 2006 and 2005, have been implemented to realign and streamline operations in order to increase productivity, reduce operating expenses and to rationalize the Company’s manufacturing network, research facilities and the sales and marketing organizations. The PTI is expected to generate approximately $1.5 billion in cost reductions and cost avoidance by 2010. For additional information on restructuring, see “Item 8. Financial Statements—Note 3. Restructuring” and for additional information on the PTI, see “—Productivity Transformation Initiative” above.	
 
•	 	Litigation expense, net of settlement income and insurance recoveries, was $14 million in 2007, $302 million in 2006 and $269 million in 2005. The $14 million expense in 2007 was related to reserves recorded for the proposed settlement of certain pharmaceutical pricing and sales litigations. The $302 million net expense in 2006 consisted of an increase to the reserves of $353 million for the settlement in principle of certain pricing and sales investigations, partially offset by insurance recoveries of $37 million from an unrelated matter and $14 million in income from a settlement of a litigation matter. The $269 million net expense in 2005 consisted of increases to the reserves of $590 million for liabilities, primarily related to private litigations and governmental investigations, partially offset by insurance recoveries of $321 million. For additional information on litigation, see “Item 8. Financial Statements—Note 22. Legal Proceedings and Contingencies.”	
 
•	 	The gain on sale of product assets of $273 million ($161 million net of tax) in 2007 was for the sale of the BUFFERIN* and EXCEDRIN* brands in Japan, as well as certain assets related to dermatology products. The gain on sale of product assets of $200 million ($130 million net of tax) in 2006 was for the sale of inventory, patent and intellectual property rights related to DOVONEX*. The gain on sale of businesses of $569 million ($370 million net of tax) in 2005 was related to the sale of the Consumer Medicines business and related assets. For additional information on these transactions, see “Item 8. Financial Statements—Note 4. Acquisitions and Divestitures.”	
 
•	 	Equity in net income of affiliates for 2007 was $524 million, compared with $474 million and $334 million in 2006 and 2005, respectively. Equity in net income of affiliates is principally related to the Company’s joint venture with Sanofi and investment in ImClone. In 2007, the $50 million increase in equity in net income of affiliates was primarily due to increased net income in the Sanofi joint venture, partially offset by decreased net income from the equity investment in ImClone. In 2006, the $140 million increase in equity in net income of affiliates was primarily due to increased net income in the joint venture with Sanofi and income from the equity investment in ImClone in 2006 compared to a loss in 2005. For additional information on equity in net income of affiliates, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”	
 
•	 	Other expense, net, was $364 million, $299 million and $35 million in 2007, 2006 and 2005, respectively. Other expense, net includes net interest expense, foreign exchange gains and losses, income from third-party contract manufacturing, royalty income and expense, debt retirement costs, impairment of marketable securities, gains and losses on disposal of property, plant and equipment, gains and losses on sale of marketable securities, insurance recoveries, deferred income recognized and certain other litigation matters. The $65 million increase in other expense, net in 2007 from 2006 was primarily due to an impairment charge of $275 million on the Company’s investment in ARS and net unfavorability in foreign exchange in 2007, partially offset by lower net interest expense in 2007 and debt retirement costs incurred in 2006. The $264 million increase in other expense, net in 2006 from 2005 was primarily due to higher debt retirement costs in connection with the repurchase in 2006 of the $2.5 billion Notes due 2011 compared to the repurchase in 2005 of the $2.5 billion Notes due 2006, as well as $143 million of non-recurring income in 2005 resulting from the termination of the muraglitazar collaborative agreement, partially offset by lower net foreign exchange losses. For additional information, see “Item 8. Financial Statements—Note 7. Other Expense, Net”, “—Note 9. Cash, Cash Equivalents and Marketable Securities” and “—Note 15. Short-Term Borrowing and Long-Term Debt.”	
Stock-based compensation expense recognized under SFAS No. 123 (revised 2004), Share-Based Payment (SFAS No. 123(R)) for the years ended December 31, 2007 and 2006 was $133 million and $112 million, respectively. These expenses were recorded in cost of product sold; marketing, selling and administrative expenses and research and development expenses. Stock-based compensation expense recognized under Accounting Principles Board (APB) No. 25 for the year ended December 31, 2005 was $31 million. These expenses were recorded in marketing, selling and administrative expenses.
 
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During the years ended December 31, 2007, 2006 and 2005, the Company recorded several expense/(income) items that affected the comparability of results of the periods presented herein, which are set forth in the following table. For a discussion of these items, see “Item 8. Financial Statements—Note 2. Alliances and Investments;” “—Note 3. Restructuring and Other Items;” “—Note 4. Acquisitions and Divestitures;” “—Note 8. Income Taxes;” “—Note 9. Cash, Cash Equivalents and Marketable Securities;” “—Note 15. Short-Term Borrowings and Long-Term Debt;” and “—Note 22. Legal Proceedings and Contingencies.”

Year ended December 31, 2007	  	Cost of
products
sold	  	Marketing,
selling
and
administrative	  	Research
and
development	  	Acquired
in-process
research and
development	  	Provision
for
restructuring,
net	  	Litigation
expense,
net	  	Gain
on sale of
product
assets and
businesses	 	  	Other
expense,
net	 	  	Total	 	
										
Dollars in Millions	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	  	 	 	  	 	 	
Productivity Transformation
Initiative:	  			  			  			  			  			  			  				  				  				
Downsizing and streamlining
of worldwide operations	  	$	—  	  	$	—  	  	$	—  	  	$	—  	  	$	139	  	$	—  	  	$	—  	 	  	$	6	 	  	$	145	 	
Accelerated depreciation and
asset impairment	  	 	102	  	 	8	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	110	 	
Process standardization
implementation costs	  	 	—  	  	 	5	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	32	 	  	 	37	 	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
	  	 	102	  	 	13	  	 	—  	  	 	—  	  	 	139	  	 	—  	  	 	—  	 	  	 	38	 	  	 	292	 	
										
Other:	  			  			  			  			  			  			  				  				  				
Litigation settlement	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	14	  	 	—  	 	  	 	—  	 	  	 	14	 	
Insurance recovery	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	(11	)	  	 	(11	)	
Product liability	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	15	 	  	 	15	 	
Upfront and milestone
payments and acquired
in-process research and
development	  	 	—  	  	 	—  	  	 	162	  	 	230	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	392	 	
Auction rate securities
impairment	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	275	 	  	 	275	 	
Downsizing and streamlining
of worldwide operations	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	44	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	44	 	
Accelerated depreciation, asset
impairment and contract
termination	  	 	77	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	23	 	  	 	100	 	
Gain on sale of properties and
product assets	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	(273	)	  	 	(9	)	  	 	(282	)	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
	  	$	179	  	$	13	  	$	162	  	$	230	  	$	183	  	$	14	  	$	(273	)	  	$	331	 	  	 	839	 	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  				
Income taxes on items above	  			  			  			  				  				  	 	(33	)	
Change in estimate for taxes on a prior year item	  			  			  			  				  				  	 	(39	)	
	  			  			  			  			  			  			  				  				  	 	 	 	
(Increase)/Decrease to Net Earnings from Continuing Operations	  			  			  				  				  	$	767	 	

																												
Year ended December 31, 2006	  	Cost of
products
sold	  	Marketing,
selling and
administrative	  	Research
and
development	  	Provision for
restructuring,
net	  	Litigation
expense,
net	 	  	Gain on
sale of
product
assets and
businesses	 	  	Other
expense, 
net	  	Total	 	
									
Dollars in Millions	  	 	  	 	  	 	  	 	  	 	 	  	 	 	  	 	  	 	 	
Litigation Matters:	  			  			  			  			  				  				  			  				
Pharmaceutical pricing and sales
litigation	  	$	—  	  	$	—  	  	$	—  	  	$	—  	  	$	353	 	  	$	—  	 	  	$	—  	  	$	353	 	
Product liability	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	11	  	 	11	 	
Claim for damages	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	13	  	 	13	 	
Commercial litigations	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	(14	)	  	 	—  	 	  	 	—  	  	 	(14	)	
Insurance recovery	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	(37	)	  	 	—  	 	  	 	—  	  	 	(37	)	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	  	 	 	 	
	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	302	 	  	 	—  	 	  	 	24	  	 	326	 	
Other:	  			  			  			  			  				  				  			  				
Debt retirement costs	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	220	  	 	220	 	
Accelerated depreciation, asset
impairment and contract
termination	  	 	167	  	 	4	  	 	15	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	—  	  	 	186	 	
Upfront and milestone payments	  	 	—  	  	 	—  	  	 	70	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	—  	  	 	70	 	
Downsizing and streamlining of
worldwide operations	  	 	—  	  	 	—  	  	 	—  	  	 	59	  	 	—  	 	  	 	—  	 	  	 	—  	  	 	59	 	
Gain on sale of product asset	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	(200	)	  	 	—  	  	 	(200	)	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	  	 	 	 	
	  	$	167	  	$	4	  	$	85	  	$	59	  	$	302	 	  	$	(200	)	  	$	244	  	 	661	 	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	  				
Income taxes on items above	  			  				  				  			  	 	(149	)	
Change in estimate for taxes on prior year items	  				  				  			  	 	39	 	
	  			  			  			  			  				  				  			  	 	 	 	
(Increase)/Decrease to Net Earnings from Continuing Operations	 	  				  			  	$	551	 	

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Year ended December 31, 2005	  	Cost of
products
sold	  	Research
and
development	  	Provision
for
restructuring,
net	  	Litigation
expense,
net	 	  	Gain on
sale of
product
assets and
businesses	 	  	Other
expense,
net	 	  	Total	 	
								
Dollars in Millions	  	 	  	 	  	 	  	 	 	  	 	 	  	 	 	  	 	 	
Litigation Matters:	  			  			  			  				  				  				  				
Private litigation and governmental investigations	  	$	—  	  	$	—  	  	$	—  	  	$	558	 	  	$	—  	 	  	$	—  	 	  	$	558	 	
ERISA liability and other matters	  	 	—  	  	 	—  	  	 	—  	  	 	20	 	  	 	—  	 	  	 	—  	 	  	 	20	 	
Pharmaceutical pricing and sales litigation	  	 	—  	  	 	—  	  	 	—  	  	 	12	 	  	 	—  	 	  	 	—  	 	  	 	12	 	
Insurance recoveries	  	 	—  	  	 	—  	  	 	—  	  	 	(321	)	  	 	—  	 	  	 	—  	 	  	 	(321	)	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
	  	 	—  	  	 	—  	  	 	—  	  	 	269	 	  	 	—  	 	  	 	—  	 	  	 	269	 	
								
Other:	  			  			  			  				  				  				  				
Accelerated depreciation and asset impairment	  	 	96	  	 	14	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	110	 	
Debt retirement costs	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	69	 	  	 	69	 	
Downsizing and streamlining of worldwide operations	  	 	1	  	 	14	  	 	32	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	47	 	
Upfront and milestone payments	  	 	—  	  	 	44	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	—  	 	  	 	44	 	
Loss on sale of fixed assets	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	18	 	  	 	18	 	
Gain on sale of equity investment	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	(27	)	  	 	(27	)	
Termination of muraglitazar agreement	  	 	5	  	 	—  	  	 	—  	  	 	—  	 	  	 	—  	 	  	 	(143	)	  	 	(138	)	
Gain on sale of Consumer Medicines businesses	  	 	—  	  	 	—  	  	 	—  	  	 	—  	 	  	 	(569	)	  	 	—  	 	  	 	(569	)	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	 	
	  	$	102	  	$	72	  	$	32	  	$	269	 	  	$	(569	)	  	$	(83	)	  	 	(177	)	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  				
Income taxes on items above	  			  			  			  				  				  				  	 	126	 	
Adjustment on taxes on repatriation of foreign earnings	  			  				  				  				  	 	(135	)	
	  			  			  			  				  				  				  	 	 	 	
(Increase)/Decrease to Net Earnings from Continuing Operations	  			  				  				  				  	$	(186	)	
	  			  			  			  				  				  				  	 	 	 	
Earnings From Continuing Operations Before Minority Interest and Income Taxes

 	  	Earnings From Continuing Operations
Before Minority Interest and Income Taxes	 	 	% Change	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	 	2007 vs. 2006	 	2006 vs. 2005	
Pharmaceuticals	  	$	3,471	 	 	$	2,569	 	 	$	3,739	 	 	35%	 	(31)%	
						
Nutritionals	  	 	708	 	 	 	696	 	 	 	677	 	 	  2%	 	    3%	
ConvaTec	  	 	348	 	 	 	315	 	 	 	288	 	 	10%	 	    9%	
	  	 	 	 	 	 	 	 	 	 	 	 	 		 		
Health Care Group	  	 	1,056	 	 	 	1,011	 	 	 	965	 	 	4%	 	    5%	

Total segments	  	 	4,527	 	 	 	3,580	 	 	 	4,704	 	 	26%	 	(24)%	
Corporate/Other	  	 	(993	)	 	 	(1,180	)	 	 	(400	)	 	16%	 	(195)%	
	  	 	 	 	 	 	 	 	 	 	 	 	 		 		
Total	  	$	3,534	 	 	$	2,400	 	 	$	4,304	 	 	47%	 	(44)%	
	  	 	 	 	 	 	 	 	 	 	 	 	 		 		
In 2007, earnings from continuing operations before minority interest and income taxes increased 47% to $3,534 million from $2,400 million in 2006. The increase was primarily driven by increased PLAVIX* sales, strong sales growth of other key products, improved gross margins and an increase in equity in net income of affiliates, partially offset by the net impact of items that affect the comparability of results as discussed above, investment in advertising, product promotion, and research and development.
In 2006, earnings from continuing operations before minority interest and income taxes decreased 44% to $2,400 million from $4,304 million in 2005. The decrease was primarily driven by the net impact of items that affected the comparability of results as discussed above, lower net sales for pharmaceutical products resulting from lower PLAVIX* net sales and loss of exclusivity of PRAVACHOL, and increased spending on research and development, partially offset by an increase in equity in net income of affiliates and lower advertising and promotion expenses.

Pharmaceuticals
Earnings from continuing operations before minority interest and income taxes increased 35% to $3,471 million in 2007 from 2006. The increase in 2007 from 2006 was primarily due to increased PLAVIX* sales, strong sales growth of other key products, improved gross margins and an increase in equity in net income of affiliates, partially offset by acquired in-process research and development charge, continued investment in research and development, including upfront and milestone payments, and investment in advertising and product promotion. Earnings from continuing operations before minority interest and income taxes decreased 31% to $2,569 million in 2006 from $3,739 million in 2005, primarily due to lower net sales as a result of lower PLAVIX* sales and loss of exclusivity of PRAVACHOL, investment in research and development and continued investment in key products and new products.
 
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Nutritionals
Earnings from continuing operations before minority interest and income taxes increased 2% to $708 million in 2007 from 2006, primarily due to growth of key products, partially offset by lower gross margins, primarily due to higher dairy costs, increased investment in advertising and product promotion and the establishment of an allowance for a doubtful account in 2007. Earnings from continuing operations before minority interest and income taxes increased 3% to $696 million in 2006 from $677 million in 2005, primarily due to sales growth of children’s nutritional products, partially offset by increased investments in advertising expense and research and development programs.
ConvaTec
Earnings from continuing operations before minority interest and income taxes increased 10% to $348 million in 2007 from 2006, primarily due to increased growth of key products and improved gross margins, partially offset by increased investment in research and development programs and in product promotion. Earnings from continuing operations before minority interest and income taxes increased 9% to $315 million in 2006 from $288 million in 2005, primarily driven by increased sales.
Corporate/Other
Loss from continuing operations before minority interest and income taxes decreased to $993 million in 2007 from 2006. The 2007 and 2006 results included gains on sale of product assets of $273 million and $200 million, respectively. The additional difference was primarily due to debt retirement costs and increases in reserves for a pricing and sales litigation settlement, both in 2006, and lower net interest expense in 2007, partially offset by impairments of certain ARS and other properties, and higher restructuring charges. Loss from continuing operations before minority interest and income taxes increased to $1,180 million in 2006 from $400 million in 2005, primarily due to lower gain on sale of a product asset in 2006 compared to the gain on sale for Consumer Medicines business in 2005, higher debt retirement costs in 2006 compared to 2005, and a $143 million income item in 2005 resulting from the termination of the muraglitazar collaborative agreement, as well as lower insurance recoveries in 2006 as compared to 2005, partially offset by lower litigation charges in 2006 compared to 2005.
Income Taxes
The effective income tax rate on earnings from continuing operations before minority interest and income taxes was 22.7% in 2007 compared with 22.4% in 2006 and 20.2% in 2005. The 2007 tax rate was unfavorably impacted by the impairment on the Company’s investment in certain ARS with no tax benefit and the non-deductible write-off of acquired in-process research and development expenses related to the acquisition of Adnexus, partially offset by a tax benefit of $105 million in the first quarter of 2007 due to the favorable resolution of certain tax matters with the U.S. Internal Revenues Service (IRS) related to the deductibility of litigation settlement expenses and the impact of foreign tax credits. The effective tax rate for 2006 was unfavorably impacted by the elimination of tax benefits under Section 936 of the Internal Revenue Code, the treatment of provisions for a portion of certain litigation reserves as non-deductible, partially offset by favorable U.S. tax legislation enacted in 2006 related to the tax treatment of certain intercompany transactions amongst the Company’s foreign subsidiaries, and the implementation of tax planning strategies related to the utilization of certain charitable contributions. The increase in the 2006 effective tax rate from 2005 was primarily due to the aforementioned Section 936 benefit elimination, the treatment of provisions for a portion of certain litigation reserves as non-deductible, tax benefits in 2005 associated with the settlement of an IRS examination and a favorable adjustment in 2005 to taxes on special dividends under the American Jobs Creation Act of 2004, partially offset by favorable U.S. tax legislation enacted in 2006 related to the tax treatment of certain intercompany transactions amongst the Company’s foreign subsidiaries, and the implementation of tax planning strategies in 2006 related to the utilization of certain charitable contributions.
The Company has recorded significant deferred tax assets at December 31, 2007 related to U.S. foreign tax credit carryforwards of approximately $1,140 million, U.S. research tax credit carryforwards of approximately $275 million and charitable contribution carryforwards of $80 million. The charitable contribution carryforwards expire in varying amounts beginning in 2009, while the foreign tax credit and research tax credit carryforwards expire in varying amounts beginning in 2012. The foreign tax credit and research tax credit have been reduced due to derecognition under FIN No. 48. Realization of these credits and the charitable contribution carryforwards is dependent on generating sufficient domestic taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized. The Company anticipates increasing its level of domestic profitability over time by undertaking actions such as its PTI, increasing its biologics manufacturing capacity in the U.S. and implementing tax planning strategies. While increasing domestic profitability will likely cause the Company’s effective tax rate to increase, it will also further enhance the Company’s ability to utilize its foreign tax credit, research tax credit and charitable contribution carryforwards.
 
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Minority Interest
Minority interest, net of taxes increased to $763 million in 2007 from 2006, primarily due to higher earnings in the Company’s partnership with Sanofi for the territory covering the Americas. In 2006, minority interest, net of taxes decreased to $440 million from $592 million in 2005, primarily due to lower earnings in the Company’s partnership with Sanofi for the territory covering the Americas. The changes in the three years reflect the negative impact of generic clopidogrel bisulfate from August 2006 to mid-2007.
Discontinued Operations
In December 2007, the Company entered into a definitive agreement with Avista for the sale of its Medical Imaging business for a purchase price of approximately $525 million in cash, subject to customary post-closing adjustments. The closing of the transaction was completed on January 7, 2008. As a result of this transaction, the Company expects to recognize a pre-tax gain of approximately $20 million to $40 million ($30 million to $50 million loss net of tax) in the first quarter of 2008, subject to the post-closing adjustments. Medical Imaging was previously included in the former Other Health Care operating segment.
In May 2005, the Company completed the sale of OTN to One Equity Partners LLC for cash proceeds of $197 million, including the impact of a preliminary working capital adjustment. The Company recorded a pre-tax gain of $63 million ($13 million net of tax), that was presented as a gain on sale of discontinued operations in the consolidated statement of earnings. OTN was previously presented as a separate segment.
The following summarized financial information related to the Medical Imaging and OTN businesses have been segregated from continuing operations and reported as discontinued operations through the date of disposition and do not reflect the costs of certain services provided to Medical Imaging and OTN. Such costs, which were not allocated by the Company to Medical Imaging and OTN, were for services, which included legal counsel, insurance, external audit fees, payroll processing, certain human resource services and information technology systems support.

 	  	Year ended December 31,	
Dollars in Millions	  	2007	  	2006	  	2005	
Net sales	  	$	629	  	$	658	  	$	1,617	
				
Earnings/(loss) before incomes taxes	  	$	273	  	$	235	  	$	204	
Provision for income taxes	  	 	76	  	 	72	  	 	59	
	  	 	 	  	 	 	  	 	 	
Net earnings/(loss) from discontinued operations	  	$	197	  	$	163	  	$	145	
	  	 	 	  	 	 	  	 	 	
Financial Position, Liquidity and Capital Resources
Cash, cash equivalents and marketable securities were approximately $2.2 billion at December 31, 2007, compared to $4.0 billion at December 31, 2006. The Company continues to maintain a sufficient level of working capital, which was approximately $1.7 billion at December 31, 2007, decreasing from $3.8 billion at December 31, 2006. In 2008 and future periods, the Company expects cash generated by its U.S. operations, together with existing cash, cash equivalents, marketable securities and borrowings from the capital markets, to be sufficient to cover cash needs for working capital, capital expenditures (which the Company expects to include substantial investments in facilities to increase and maintain the Company’s capacity to provide biologics on a commercial scale), milestone payments and dividends paid in the U.S. Cash and cash equivalents, marketable securities, the conversion of other working-capital items and borrowings are expected to fund near-term operations outside the U.S.
As of December 31, 2007, the Company had approximately $14.1 billion of undistributed earnings of foreign subsidiaries for which taxes have not been provided as the Company has invested or expects to invest these undistributed earnings permanently offshore. If, in the future, these earnings are repatriated to the U.S., or if the Company determines such earnings will be remitted in the foreseeable future, additional tax provisions would be required. Due to complexities in the tax laws and the assumptions that would have to be made, it is not practicable to estimate the amounts of income taxes that would have to be provided.
Cash and cash equivalents at December 31, 2007 and 2006 primarily consisted of bank deposits, time deposits and money market funds. Cash equivalents are primarily highly liquid investments with original maturities of three months or less at the time of purchase and are recorded at cost, which approximates fair value. The Company maintains cash and cash equivalent balances in U.S. dollars and foreign currencies which are subject to currency rate risk. In January 2008, the Company converted a substantial portion of its cash equivalents from money market funds to U.S. Treasury bills and similar investments.

Marketable securities at December 31, 2007 consisted of U.S. dollar-denominated floating rate securities (FRS), which are primarily ‘AAA/Aaa’ rated. FRS are long-term debt securities with coupons that are reset periodically against a benchmark interest rate. The underlying assets of the Company’s FRS consist of primarily investment grade corporate bonds and loans. The carrying value of FRS was reduced by $25 million, from $362 million to $337 million at December 31, 2007, reflecting the change in fair market value. The Company assessed this decline in fair market value to be temporary, and recorded a pre-tax $25 million reduction ($16 million net of tax) in shareholders’ equity in accumulated other comprehensive income (OCI).
 
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As previously disclosed, in September 2006, the Company and Sanofi each posted $200 million towards a $400 million bond with the U.S. District Court for the Southern District of New York (District court) as collateral in support of the preliminary injunction issued on August 31, 2006. This collateral was reported as marketable securities on the Company’s consolidated balance sheet at December 31, 2006. As a result of the outcome of the PLAVIX* patent litigation noted above, on June 21, 2007, the District court ordered release of the $400 million bond and release of the issuer of the bond from any liability in connection with the bond. As such, the Company’s obligations under the collateral arrangements with respect to the bond were effectively terminated.
In addition, at December 31, 2007, the Company had $811 million of principal invested in ARS. The ARS held by the Company are private placement securities with long-term nominal maturities for which the interest rates are reset through a dutch auction each month. The monthly auctions historically have provided a liquid market for these securities. The Company’s investments in ARS represent interests in collateralized debt obligations supported by pools of residential and commercial mortgages or credit cards, insurance securitizations and other structured credits, including corporate bonds. Some of the underlying collateral for the ARS held by the Company consists of sub-prime mortgages.
Consistent with the Company’s investment policy guidelines, the ARS investments held by the Company all had AAA/Aaa credit ratings at the time of purchase. With the liquidity issues experienced in global credit and capital markets, the ARS held by the Company at December 31, 2007 have experienced multiple failed auctions as the amount of securities submitted for sale has exceeded the amount of purchase orders. In addition, in the fourth quarter of 2007, $79 million of principal invested in ARS held by the Company were downgraded and others were placed on credit watch. All of these securities retained at least one AAA rating as of December 31, 2007.
The estimated market value of the Company’s ARS holdings at December 31, 2007 was $419 million, which reflects a $392 million adjustment to the principal value of $811 million. Although the ARS continue to pay interest according to their stated terms, based on valuation models and an analysis of other-than-temporary impairment factors, the Company has recorded a pre-tax impairment charge of $275 million in the fourth quarter of 2007, reflecting the portion of ARS holdings that the Company has concluded have an other-than-temporary decline in value. In addition, the Company recorded an unrealized loss of $117 million (pre-tax and net of tax) in accumulated OCI as a reduction in shareholders’ equity, reflecting adjustments to ARS holdings that the Company has concluded have a temporary decline in value. The $275 million impairment charge does not have a material impact on the Company’s liquidity or financial flexibility.
Historically, given the liquidity created by the auctions, ARS were presented as current assets under marketable securities. Given the failed auctions, the Company’s ARS are illiquid until there is a successful auction for them. Accordingly, the entire amount of such remaining ARS has been reclassified from marketable securities to non-current other assets.
The credit and capital markets have continued to deteriorate in 2008. If uncertainties in these credit and capital markets continue, these markets deteriorate further or the Company experiences any additional ratings downgrades on any investments in its portfolio (including on ARS), the Company may incur additional impairments to its investment portfolio, which could negatively affect the Company’s financial condition, cash flow and reported earnings. The Company believes that based on the Company’s current cash, cash equivalents and marketable securities balances of $2.2 billion at December 31, 2007 and expected operating cash flows, the current lack of liquidity in the credit and capital markets will not have a material impact on the Company’s liquidity, cash flow, financial flexibility or its ability to fund its operations, including the dividend.
On February 21, 2008, the Company completed the sale and leaseback of an administrative facility in Paris, France, for approximately €155 million. The Company expects to record a gain, of which the majority will be deferred and will reduce future lease rental costs over the lease period. In December 2006, the Company completed the sale and leaseback of several administrative facilities in New Jersey for $283 million, which resulted in a pre-tax gain from the transaction of $154 million, of which $145 million was deferred and will reduce future lease rental costs over the lease periods ranging from 8 to 12 years.
Short-term borrowings at the end of 2007 and 2006 were $1.9 billion and $187 million, respectively. The Company maintains cash balances and short-term investments in excess of short-term borrowings. The $108 million of 1.10% Yen Notes, due 2008; the $31 million of 1.43% Yen Notes, due 2008; the $400 million of 4.00% Notes, due 2008, and associated unamortized discount and interest rate swap valuation; and the $1.2 billion of Floating Rate Convertible Debentures, due 2023 (with a 2008 put/call), were reclassified from long-term debt to short-term borrowings in 2007.
Long-term debt was $4.4 billion at December 31, 2007 compared to $7.2 billion at December 31, 2006. The $2.8 billion reduction was primarily due to the reclassification to short-term borrowings noted above and the September 2007 repayment of the remaining $1.3 billion balance of the Floating Rate Bank Term Facility, due 2010.

During the fourth quarter of 2006, the Company restructured its long-term debt by retiring all of its outstanding $2.5 billion principal amount of 5.75% Notes due 2011 through a cash tender offer and subsequent redemption and issuing €500 million aggregate principal of 4.375% Notes due 2016, €500 million aggregate principal of 4.625% Notes due 2021, as well as $1.25 billion aggregate principal of 5.875% Notes due 2036. The Company incurred an aggregate pre-tax expense of approximately $220 million in
 
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connection with the early redemption of the 2011 Notes and termination of related interest rate swaps, which included the write-off of the related unamortized discount, issuance costs and deferred loss on an interest rate lock. In addition, the Company repaid $1.2 billion of its $2.5 billion Floating Rate Bank Term Facility, due 2010.
In December 2006, the Company replaced its prior $2 billion revolving credit facility with a new $2 billion five-year revolving credit facility from a syndicate of lenders, which is extendable on the anniversary date with the consent of the lenders. This facility contains customary terms and conditions substantially similar to the prior facility, including a financial covenant whereby the ratio of consolidated debt to consolidated capital cannot exceed 50% at the end of each quarter. The Company has been in compliance with this covenant since the inception of this facility. There were no borrowings outstanding under the revolving credit facility at December 31, 2007.
During the second quarter of 2005, the Company repurchased all of its outstanding $2.5 billion aggregate principal amount 4.75% Notes due 2006, and incurred an aggregate pre-tax loss of approximately $69 million in connection with the early redemption of the Notes and termination of related interest rate swaps.
A majority of the Company’s debt is fixed rate. The Company, however, has entered into fixed to floating interest rate swaps for $2.6 billion and €1 billion ($1.5 billion at December 31, 2007) of its long-term debt. Pre-tax interest expense, net of interest swap gains, was $422 million, $498 million and $349 million, in 2007, 2006 and 2005, respectively. The decrease in interest expense in 2007 from 2006 was primarily due to the effects of the 2006 debt restructuring, and the increase in interest expense in 2006 from 2005 was primarily due to higher interest rates.
The Moody’s Investors Service (Moody’s) long-term and short-term credit ratings for the Company are currently A2 and Prime-1, respectively. Moody’s long-term credit rating remains on stable outlook. Standard & Poor’s (S&P) long-term and short-term credit ratings for the Company are currently A+ and A-1, respectively. In the second quarter of 2007, S&P revised its long-term credit rating outlook to stable from negative. Fitch Ratings (Fitch) long-term and short-term credit ratings for the Company are currently A+ and F1, respectively. In the third quarter of 2007, Fitch revised its long-term credit rating outlook to stable from negative.
Working capital for the years ended December 31, 2007 and 2006 were as follows:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Working capital	  	$	1,704	  	$	3,806	
The decrease in working capital of $2.1 billion from December 31, 2006 to December 31, 2007 was impacted by:
 
 	•	 	Decrease in marketable securities due to a reduction to the carrying value of floating rate securities and certain other ARS to fair market value and the subsequent reclassifications of the remaining value of ARS to other non-current assets.	
 
 	•	 	Increase in short-term borrowings from long-term debt due to the reclassifications as noted above.	
 
 	•	 	Increase in accrued royalties resulting from increased PLAVIX* sales.	
 
 	•	 	Increase in receivables primarily due to increased PLAVIX* sales in the U.S.	
 
 	•	 	Reclassification of Medical Imaging and other assets and liabilities to held for sale in 2007.	
 
 	•	 	Reclassification of certain tax contingencies from current U.S. and foreign income taxes payable to non-current upon the adoption of FIN No. 48 on January 1, 2007.	
The following discussions of the Company’s cash flow activities include discontinued operations. The Company’s cash flow activities for the years ended December 31, 2007, 2006 and 2005 were as follows:

 	  	Year Ended December 31,	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	
Cash flow provided by/(used in):	  				 				 				
Operating activities	  	$	3,153	 	 	$	2,083	 	 	$	1,836	 	
Investing activities	  	 	(202	)	 	 	206	 	 	 	1,191	 	
Financing activities	  	 	(3,213	)	 	 	(3,351	)	 	 	(3,637	)	
Net cash provided by operating activities was $3.2 billion in 2007 and $2.1 billion in 2006. The $1,070 million increase in 2007 compared to 2006 is attributable to higher net earnings of $580 million, higher net changes in adjustments to net earnings of $8 million and higher net changes in operating assets and liabilities of $482 million.
 
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Net positive changes in adjustments to net earnings in 2007 compared to 2006, of $8 million, mainly included:
 
 	•	 	A $288 million negative cash flow variance due to lower litigation settlement expenses in 2007.	
 
 	•	 	A $259 million positive cash flow variance resulting from impairment charges and asset write-offs mainly from the reduction of the carrying value of ARS to fair value and from the impending closure of manufacturing facilities.	
 
 	•	 	A $230 positive cash flow variance for acquired in-process research and development related to the acquisition of Adnexus in 2007.	
 
 	•	 	A $180 million negative cash flow variance in deferred income tax benefit. The 2007 adjustments included the deferred tax benefits from the restructuring of the Company’s international operations, upfront cash receipts from alliance partners and the resolution of an audit issue with the IRS, partially offset by litigation payments. The 2006 adjustments included a net deferred tax charge for the payment of litigation settlements offset by the deferred tax benefit on additional litigation accruals, the accrual of additional foreign tax credits and the deferred tax benefit on equity-based compensation.	
 
 	•	 	A $124 million positive cash flow variance due to higher provision for restructuring in 2007 in connection with the PTI.	
Net positive changes in operating assets and liabilities in 2007 compared to 2006, of $482 million, mainly included:
 
 	•	 	A $966 million positive cash flow variance from accounts payable and accrued expenses is primarily due to an increase in accrued royalties in 2007 resulting from increased PLAVIX* sales, higher purchases of raw materials, a significant paydown of payables in early 2006 resulting from lower payment of invoices in December 2005 and a reduction of accrued rebates and returns in the first quarter of 2006, primarily resulting from lower sales volume.	
 
 	•	 	A $671 million negative cash flow variance from receivables, primarily due to increased PLAVIX* sales in 2007 and lower collection in 2007 resulting from lower PRAVACHOL sales.	
 
 	•	 	A $368 million positive cash flow variance in deferred income and other liabilities, mainly due to upfront cash receipts from alliance partners in 2007.	
 
 	•	 	A $132 million negative cash flow variance from inventories, primarily due to an increase in inventories in 2007 in anticipation of new product launches and strategic builds for existing products, and the reduction in inventories in 2006 resulting from PRAVACHOL exclusivity loss.	
 
 	•	 	A $108 million negative cash flow variance from income taxes payable, primarily related to payments to settle various tax issues for the 2002-2003 IRS audit.	
Net cash used in investing activities was $202 million in 2007 and net cash provided by investing activities was $206 million in 2006. The $408 million negative cash flow variance is primarily attributable to:
 
 	•	 	A $432 million negative cash flow variance from the acquisition of Adnexus.	
 
 	•	 	A $281 million negative cash flow variance for proceeds from the disposal of properties in connection with a sales and leaseback transaction in 2006.	
 
 	•	 	A $280 million positive cash flow variance from licensing milestone payments in 2006 to ImClone and Somerset Pharmaceuticals, Inc.	
Net cash used in financing activities was $3,213 million in 2007 and $3,351 million in 2006. The $138 million positive cash flow variance is mainly attributable to:
 
 	•	 	A $163 million positive cash flow variance mainly from higher cash proceeds from the exercise of stock options in 2007 compared to 2006.	
Net cash provided by operating activities was $2.1 billion in 2006 and $1.8 billion in 2005. The $247 million increase in 2006 compared to 2005 is mainly attributable to significant changes in adjustments to net earnings of $1,398 million and net changes in operating assets and liabilities of $264 million, offset by lower net earnings of $1,415 million.
Significant positive changes in adjustments to net earnings in 2006 compared to 2005, of $1,398 million, mainly included:
 
 	•	 	A $576 million positive cash flow variance in deferred income tax benefit, due to a lower level of increase in deferred tax benefit in 2006 compared to 2005. In 2006, there was an increase in deferred tax benefits associated with U.S. research and development, foreign tax credits and an increase in litigation reserves. In 2005, there was an increase in deferred tax benefits associated with the reversal of the tax liability related to the repatriation of special dividends under the AJCA.	
 
 	•	 	A $425 million positive cash flow variance, due to lower gain on sale of a product asset in 2006 as compared to sale of a business in 2005.	
 
 	•	 	A $143 million positive cash flow variance for deferred income recognized related to the termination of the muraglitazar collaborative agreement in 2005.	
 
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Net positive changes in operating assets and liabilities in 2006 compared to 2005, of $264 million, mainly included:
 
 	•	 	A $329 million negative cash flow variance from receivables. In 2006, the increase in cash flow was driven by increases in receivables, due from alliance partners, which were partially offset by lower trade receivable volume. In 2005, the increase in cash flow is driven by the collection of foreign withholding taxes and from alliance partners.	
 
 	•	 	A $448 million positive cash flow variance from inventories, primarily due to an increase in inventories in 2005 resulting from the growth of newer products and in anticipation of new product launches, and the reduction in inventories in 2006 resulting from PRAVACHOL exclusivity loss.	
 
 	•	 	A $283 million negative cash flow variance in litigation, primarily due to settlement payments of $339 million in 2006 for the DPA and the Vanlev litigation, which were partially offset by unrelated insurance recoveries of $67 million.	
 
 	•	 	A $443 million positive cash flow variance from income taxes payable, primarily related to payments in 2005 for the settlement of examinations by the IRS for years 1998 through 2001 and the repatriation of special dividends under AJCA.	
Net cash provided by investing activities was $206 million in 2006 compared to net cash provided of $1,191 million in 2005. The $985 million negative cash flow variance is primarily attributable to:
 
 	•	 	A $281 million negative cash flow variance mainly from the sale of marketable securities in 2005.	
 
 	•	 	A $617 million negative cash flow variance from lower proceeds for the sale of a product asset in 2006 compared to the sale of the Consumer Medicines and OTN businesses in 2005.	
 
 	•	 	A $280 million negative cash flow variance from milestone payments in 2006, primarily related to ImClone.	
 
 	•	 	A $281 million positive cash flow variance for proceeds from the disposal of properties in connection with a sale and leaseback transaction in 2006.	
Net cash used in financing activities was $3,351 million in 2006 compared to $3,637 million in 2005. The $286 million positive cash flow variance was mainly attributable to:
 
 	•	 	A $1,655 million positive cash flow variance from the repayment of short-term borrowings in 2005.	
 
 	•	 	A $1,198 negative cash flow variance from the retirement of long-term debt. In 2006, the Company repaid debt of $1,200 million and retired the 5.75% Notes due 2011 for $2,425 million. In 2005, the Company retired the 4.75% Notes due 2006 for $2,507 million.	
Cash provided from operations and borrowings was primarily used over the past three years to pay dividends of approximately $6.6 billion. The Company has also invested approximately $2.4 billion over the past three years in capital expansion to improve plant efficiency and maintain superior research facilities.
Over the past three years, the Company did not repurchase any of its common stock. The share repurchase program authorizes the Company to purchase common stock from time to time in the open market or through private transactions as market conditions permit. This program is intended to reduce the increase in shares outstanding from option exercises and to obtain shares for general corporate purposes.
Dividends declared per common share were $1.15 for 2007 and $1.12 for each of 2006 and 2005. In December 2007, the Company declared a quarterly dividend of $.31 per common share and indicated a dividend for the full year 2008 of $1.24 per share. Dividend decisions are made on a quarterly basis by the Company’s Board of Directors.
The Company’s financial condition and liquidity could be affected by obligations to make milestone or other one-time payments, by the outcome of pending litigations and investigations, including the challenge to the PLAVIX* patent and/or the potential for renewed or additional generic competition for PLAVIX*, and by additional impairments to its investment portfolio. For more information, see “Item 8. Financial Statements—Note 2. Alliances and Investments,” “—Note 9. Cash, Cash Equivalents and Marketable Securities,” “—Note 15. Short-Term Borrowings and Long-Term Debt” and “—Note 22. Legal Proceedings and Contingencies.”
 
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Contractual Obligations
Payments due by period for the Company’s contractual obligations at December 31, 2007 were as follows:

 	  	Obligations Expiring by Period	
Dollars in Millions	  	Total	  	2008	  	2009	  	2010	  	2011	  	2012	  	Later Years	
Short-term borrowings	  	$	1,891	  	$	1,891	  	$	—  	  	$	—  	  	$	—  	  	$	—  	  	$	—  	
Long-term debt (1)	  	 	4,381	  	 	—  	  	 	9	  	 	31	  	 	—  	  	 	—  	  	 	4,341	
Operating leases	  	 	704	  	 	143	  	 	116	  	 	90	  	 	72	  	 	71	  	 	212	
Purchase obligations	  	 	3,415	  	 	830	  	 	514	  	 	488	  	 	471	  	 	434	  	 	678	
Stand-by letters of credit/performance guarantees	  	 	236	  	 	175	  	 	45	  	 	10	  	 	3	  	 	1	  	 	2	
Uncertain tax positions (2)	  	 	195	  	 	195	  	 	—  	  	 	—  	  	 	—  	  	 	—  	  	 	—  	
Pension and other liabilities	  	 	1,253	  	 	126	  	 	173	  	 	117	  	 	113	  	 	111	  	 	613	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
Total	  	$	12,075	  	$	3,360	  	$	857	  	$	736	  	$	659	  	$	617	  	$	5,846	

(1)	The current portion of long-term debt obligations is included in short-term borrowings on the Company’s consolidated balance sheet at December 31, 2007 and all balances approximate the outstanding nominal long-term debt values. The contractual obligations table above excludes interest payment obligations. The Company’s convertible debenture is included as due for payment in 2008, as it contains a 2008 put and call feature.	
 
(2)	Due to the uncertainty related to the timing of the reversal of uncertain tax positions, only the short-term uncertain tax benefits have been provided in the table above. The long-term amounts excluded from the table above total $537 million.	
In addition to the above, the Company has committed to make potential future “milestone” payments to third parties as part of in-licensing and development programs. Payments under these agreements generally become due and payable only upon achievement of certain developmental, regulatory and/or commercial milestones, for which the specific timing cannot be predicted. Because the achievement of these milestones is neither probable nor reasonably estimable, such contingencies have not been recorded on the Company’s consolidated balance sheet.
For a discussion of contractual obligations, see “Item 8. Financial Statements—Note 15. Short-Term Borrowings and Long-Term Debt;” “—Note 18. Financial Instruments;” “—Note 20. Leases;” and “—Note 21. Pension and Other Postretirement Benefit Plans.”
SEC Consent Order
As previously disclosed, on August 4, 2004, the Company entered into a final settlement with the SEC, concluding an investigation concerning certain wholesaler inventory and accounting matters. The settlement was reached through a Consent, a copy of which was attached as Exhibit 10 to the Company’s quarterly report on Form 10-Q for the period ended September 30, 2004.
Under the terms of the Consent, the Company agreed, subject to certain defined exceptions, to limit sales of all products sold to its direct customers (including wholesalers, distributors, hospitals, retail outlets, pharmacies and government purchasers) based on expected demand or on amounts that do not exceed approximately one month of inventory on hand, without making a timely public disclosure of any change in practice. The Company also agreed in the Consent to certain measures that it has implemented including: (a) establishing a formal review and certification process of its annual and quarterly reports filed with the SEC; (b) establishing a business risk and disclosure group; (c) retaining an outside consultant to comprehensively study and help re-engineer the Company’s accounting and financial reporting processes; (d) publicly disclosing any sales incentives offered to direct customers for the purpose of inducing them to purchase products in excess of expected demand; and (e) ensuring that the Company’s budget process gives appropriate weight to inputs that come from the bottom to the top, and not just those that come from the top to the bottom, and adequately documenting that process.
The Company has established a company-wide policy to limit its sales to direct customers for the purpose of complying with the Consent. This policy includes the adoption of various procedures to monitor and limit sales to direct customers in accordance with the terms of the Consent. These procedures include a governance process to escalate to appropriate management levels potential questions or concerns regarding compliance with the policy and timely resolution of such questions or concerns. In addition, compliance with the policy is monitored on a regular basis.

The Company maintains IMAs with most of its U.S. pharmaceutical wholesalers that account for nearly 100% of total gross sales of U.S. pharmaceutical products. Under the current terms of the IMAs, the Company’s three largest wholesaler customers provide the Company with weekly information with respect to months on hand product-level inventories and the amount of out-movement of products. These three wholesalers currently account for approximately 90% of total gross sales of U.S. Pharmaceuticals products in 2007, 2006 and 2005. The inventory information received from these wholesalers, together with the Company’s internal information, is used to estimate months on hand product level inventories at these wholesalers. The Company estimates months on hand product inventory levels for its U.S. Pharmaceutical business’s wholesaler customers other than the three largest wholesalers by extrapolating from the months on hand calculated for the three largest wholesalers. In contrast, for the Company’s Pharmaceutical business outside of the U.S., Nutritionals and ConvaTec business units around the world, the Company has significantly more direct customers, limited information on direct customer product level inventory and corresponding out-movement information and the reliability of third-party demand information, where available, varies widely. Accordingly, the Company relies on a variety of methods to estimate months on hand product level inventories for these business units.
 
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The Company believes the above-described procedures provide a reasonable basis to ensure compliance with the Consent.
As previously disclosed, on June 15, 2005, the Company entered into a DPA with the U.S. Attorney’s Office for the District of New Jersey resolving the investigation by the USAO of the Company relating to wholesaler inventory and various accounting matters covered by the Company’s settlement with the SEC. Pursuant to the DPA, the USAO filed a criminal complaint against the Company alleging conspiracy to commit securities fraud, but agreed to defer prosecution of the Company and dismiss the complaint after two years if the Company satisfied all of the requirements of the DPA. A copy of the DPA was filed as Exhibit 99.2 to a Form 8-K filed by the Company on June 16, 2005 and is incorporated by reference hereto as Exhibit 10w to the Form 10-K for the fiscal year ended December 31, 2006. Under the terms of the DPA, the Company agreed to retain a Monitor. The Monitor had defined powers and responsibilities under the DPA, including to oversee the Company’s compliance with all of the terms of the DPA, the Consent and the settlements of the derivative action and the Federal securities class action. These powers and responsibilities of the Monitor ended on April 12, 2007. The Monitor filed a final report with the USAO on June 8, 2007. On June 15, 2007 the DPA expired and the complaint has been dismissed. The Company has no on-going obligations under the DPA.
Recently Issued Accounting Standards
At its December 2007 meeting, the Financial Accounting Standards Board (FASB) ratified the consensus reached by the Emerging Issues Task Force (EITF) in Issue No. 07-1, Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property . The EITF concluded that a collaborative arrangement is one in which the participants are actively involved and are exposed to significant risks and rewards that depend on the ultimate commercial success of the endeavor. Revenues and costs incurred with third parties in connection with collaborative arrangements would be presented gross or net based on the criteria in EITF 99-19, Reporting Revenue Gross as a Principal versus Net as an Agent , and other accounting literature. Payments to or from collaborators would be evaluated and presented based on the nature of the arrangement and its terms, the nature of the entity’s business and whether those payments are within the scope of other accounting literature. The nature and purpose of collaborative arrangements are to be disclosed along with the accounting policies and the classification and amounts of significant financial statement amounts related to the arrangements. Activities in the arrangement conducted in a separate legal entity should be accounted for under other accounting literature; however, required disclosure under EITF 07-1 applies to the entire collaborative agreement. This Issue is effective for fiscal years beginning after December 15, 2008, and is to be applied retrospectively to all periods presented for all collaborative arrangements existing as of the effective date. The Company is currently in the process of evaluating the impact of adopting this pronouncement.
In December 2007, the FASB issued SFAS No. 141(R), Business Combinations , which replaces SFAS No. 141, Business Combinations , and requires an acquirer to recognize the assets acquired, the liabilities assumed, and any non-controlling interest in the acquiree at the acquisition date, measured at their fair values as of that date, with limited exceptions. This Statement also requires the acquirer in a business combination achieved in stages to recognize the identifiable assets and liabilities, as well as the non-controlling interest in the acquiree, at the full amounts of their fair values. SFAS No. 141(R) makes various other amendments to authoritative literature intended to provide additional guidance or to confirm the guidance in that literature to that provided in this Statement. This Statement applies to business combinations for which the acquisition date is in fiscal years beginning after December 15, 2008. The Company is currently in the process of evaluating the impact of adopting this pronouncement.
In December 2007, FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements—an amendment of ARB No.51 . SFAS No. 160 establishes accounting and reporting standards that require the ownership interests in subsidiaries held by parties other than the parent to be clearly identified, labeled and presented in the consolidated statement of financial position within equity, but separate from the parent’s equity. This Statement also requires the amount of consolidated net income attributable to the parent and to the noncontrolling interest to be clearly identified and presented on the face of the consolidated statement of income. Changes in a parent’s ownership interest while the parent retains its controlling financial interest in its subsidiary must be accounted for consistently, and when a subsidiary is deconsolidated, any retained noncontrolling equity investment in the former subsidiary must be initially measured at fair value. The gain or loss on the deconsolidation of the subsidiary is measured using the fair value of any noncontrolling equity investment. The Statement also requires entities to provide sufficient disclosures that clearly identify and distinguish between the interests of the parent and the interests of the noncontrolling owners. This Statement is effective for fiscal years beginning after December 15, 2008. The Company is currently in the process of evaluating the impact of adopting this pronouncement.
In June 2007, the EITF reached a consensus on Issue No. 07-3, Accounting for Nonrefundable Advance Payments for Goods or Services Received to Be Used in Future Research and Development Activities . Nonrefundable advance payments for goods or services that will be used or rendered for future research and development activities should be deferred and capitalized. Such amounts should be recognized as an expense as the related goods are delivered or the services are performed, or when the goods or services are no longer expected to be provided. This Issue is effective for fiscal years beginning after December 15, 2007, and earlier application is not permitted. The pronouncement is not expected to have a material effect on the Company’s consolidated financial statements.
 
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In February 2007, the FASB issued SFAS No. 159, The Fair Value Option for Financial Assets and Financial Liabilities—Including an amendment of FASB Statement No. 115 , which permits an entity to measure certain financial assets and financial liabilities at fair value. The objective of SFAS No. 159 is to improve financial reporting by allowing entities to mitigate volatility in reported earnings caused by the measurement of related assets and liabilities using different attributes, without having to apply complex hedge accounting provisions. Under SFAS No. 159, entities that elect the fair value option (by instrument) will report unrealized gains and losses in earnings at each subsequent reporting date. The fair value option election is irrevocable, unless a new election date occurs. SFAS No. 159 establishes presentation and disclosure requirements to help financial statement users understand the effect of the entity’s election on its earnings, but does not eliminate disclosure requirements of other accounting standards. Assets and liabilities that are measured at fair value must be displayed on the face of the balance sheet. This Statement is effective for fiscal years beginning after November 15, 2007. The Company did not elect early adoption of this pronouncement as permitted. The adoption of this accounting pronouncement is not expected to have a material effect on the Company’s consolidated financial statements.
In September 2006, the FASB issued Statement SFAS No. 158 , Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans—an amendment of FASB Statements No. 87, 88, 106, and 132(R) . This pronouncement requires an employer to recognize the overfunded or underfunded status of a defined benefit postretirement plan (other than a multiemployer plan) as an asset or liability in its statement of financial position and to recognize changes in that funded status in the year in which the changes occur through comprehensive income of a business entity. This pronouncement also requires an employer to measure the funded status of a plan as of the date of its year-end statement of financial position, with limited exceptions. The pronouncement does not require prior periods to be restated to reflect the impact of SFAS No. 158. The Company adopted SFAS No. 158 in the fiscal year ended December 31, 2006 and the adoption of this accounting pronouncement resulted in a $1,064 million reduction of accumulated OCI in stockholders’ equity, a $767 million reduction in total assets and a $297 million increase in total liabilities. The adoption of SFAS No. 158 did not impact the Company’s results of operations or cash flows.
In September 2006, the FASB issued SFAS No. 157, Fair Value Measurements. This pronouncement defines fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This Statement is effective for fiscal years beginning after November 15, 2007. On November 14, 2007, the FASB agreed to a one-year deferral for the implementation of SFAS No. 157 for other non-financial assets and liabilities. The adoption of this accounting pronouncement is not expected to have a material effect on the Company’s consolidated financial statements for financial assets and liabilities and any other assets and liabilities carried at fair value. The Company is currently in the process of evaluating the impact of adopting this pronouncement for other non-financial assets or liabilities.
In September 2006, the SEC issued Staff Accounting Bulletin (SAB) No. 108, Considering the Effects of Prior Year Misstatements when Quantifying the Misstatements in Current Year Financial Statements , that expresses the staff’s views regarding the process of quantifying financial statement misstatements. This bulletin is effective for any interim period of the first fiscal year ending after November 15, 2006. SAB No. 108 requires that companies utilize a “dual approach” to assess the quantitative effects of financial statement misstatements. The dual approach includes both an income statement focus and balance sheet focus assessment. The adoption of this bulletin did not have any effect on the Company’s consolidated financial statements.
In July 2006, the FASB issued FASB Interpretation (FIN) No. 48, Accounting for Uncertainty in Income Taxes – an interpretation of FASB Statement No. 109, which, in the case of the Company, is effective as of January 1, 2007. FIN No. 48 clarifies the accounting for uncertainty in income taxes recognized in an enterprise’s financial statements in accordance with SFAS No. 109, Accounting for Income Taxes . FIN No. 48 requires that all tax positions be evaluated using a recognition threshold and measurement attribute for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. Differences between tax positions taken in a tax return and amounts recognized in the financial statements are recorded as adjustments to income taxes payable or receivable, or adjustments to deferred taxes, or both. FIN No. 48 also requires expanded disclosure at the end of each reporting period including a tabular reconciliation of unrecognized tax benefits. The Company adopted FIN No. 48 on January 1, 2007. As a result of the adoption of this accounting pronouncement, the Company recognized $27 million of previously unrecognized tax benefits, which was accounted for as an increase to the opening balance of retained earnings. In May 2007, the FASB issued FASB Staff Position (FSP) FIN No. 48-1, Definition of Settlement in FASB Interpretation No. 48 , which is effective retroactively to January 1, 2007. FSP FIN No. 48-1 provides guidance on how to determine whether a tax position is effectively settled for the purpose of recognizing previously unrecognized tax benefits. The adoption of FSP FIN No. 48-1 did not have any effect on the Company’s consolidated financial statements.
In March 2006, the FASB issued SFAS No. 156, Accounting for Servicing of Financial Assets – an amendment of FASB Statement No. 140. This pronouncement relates to the accounting for separately recognized servicing assets and servicing liabilities. This Statement is effective for fiscal years beginning after September 15, 2006. The adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
 
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In February 2006, the FASB issued SFAS No. 155, Accounting for Certain Hybrid Financial Instruments, an amendment of FASB Statements No. 133 and 140 . This pronouncement primarily resolves certain issues addressed in the implementation of SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities , concerning beneficial interests in securitized financial assets. The Statement is effective for all financial instruments acquired, issued or subject to a remeasurement event occurring after the beginning of the 2007 fiscal year. The adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
In May 2005, the FASB issued SFAS No. 154, Accounting Changes and Error Corrections—a replacement of APB Opinion No. 20 and FASB Statement No. 3 . This pronouncement applies to all voluntary changes in accounting principle, and revises the requirements for accounting for and reporting a change in accounting principle. SFAS No. 154 requires retrospective application to prior periods’ financial statements of a voluntary change in accounting principle, unless it is impracticable to do so. This pronouncement also requires that a change in the method of depreciation, amortization or depletion for long-lived, non-financial assets be accounted for as a change in accounting estimate that is affected by a change in accounting principle. SFAS No. 154 is effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. The Statement does not change the transition provisions of any existing accounting pronouncements, including those that are in a transition phase as of the effective date of SFAS No. 154. The adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
In March 2005, the FASB issued FIN No. 47, Accounting for Conditional Asset Retirement Obligations—an interpretation of FASB Statement No. 143 . FIN No. 47 clarifies that an entity must record a liability for a conditional asset retirement obligation if the fair value of the obligation can be reasonably estimated. Asset retirement obligations covered by FIN No. 47 are those for which an entity has a legal obligation to perform an asset retirement activity, even if the timing and method of settling the obligation are conditional on a future event that may or may not be within the control of the entity. FIN No. 47 also clarifies when an entity would have sufficient information to reasonably estimate the fair value of an asset retirement obligation. This Interpretation was effective no later than the end of fiscal years ending after December 15, 2005. The Company adopted the provisions of FIN No. 47 in the fiscal year ended December 31, 2005, and adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
In December 2004, the FASB issued SFAS No. 123 (revised 2004), Share-Based Payment (SFAS No. 123(R)), which requires the measurement and recognition of compensation expense for all stock-based payment awards made to employees and directors based on estimated fair values. SFAS No. 123(R) supersedes the Company’s previous accounting under APB No. 25, Accounting for Stock Issued to Employees , for periods beginning January 1, 2006. In March 2005, the SEC issued SAB No. 107, Share-Based Payment , relating to SFAS No. 123(R). The Company has applied the provisions of SAB No. 107 in its adoption of SFAS No. 123(R). The Company adopted SFAS No. 123(R) using the modified prospective transition method, which requires the application of the accounting standard as of January 1, 2006, and has elected the alternative method as provided in FSP 123(R)-3, Transition Election Related to Accounting for the Tax Effects of Share-Based Payment Awards , in determining the Company’s pool of excess tax benefits. The Company’s consolidated financial statements for the year ended December 31, 2006 reflect the impact of SFAS No. 123(R). In accordance with the modified prospective transition method, the Company’s consolidated financial statements for prior periods have not been restated to reflect, and do not include, the impact of SFAS No. 123(R). Stock-based compensation expense recognized under SFAS No. 123(R) for the year ended December 31, 2006 was $112 million ($73 million, net of tax) or $0.04 per share, with a corresponding amount recorded in additional paid-in capital within stockholders’ equity. Additionally, $10 million related to performance awards was reclassified from liabilities to stockholders’ equity in connection with the adoption of SFAS No. 123(R).
Critical Accounting Policies
The Company prepares its financial statements in conformity with accounting principles generally accepted in the U.S. The preparation of financial statements in conformity with U.S. GAAP requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and contingent liabilities, at the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. The Company’s critical accounting policies are those that are both most important to the Company’s financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results may vary from these estimates.
The Company believes that the following discussion represents its critical accounting policies. Management has discussed the Company’s critical accounting policies with the Audit Committee of the Board of Directors.
 
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Revenue Recognition
The Company recognizes revenue in accordance with SAB No. 101, Revenue Recognition in Financial Statements , as amended by SAB No. 104, Revenue Recognition . The Company’s accounting policy for revenue recognition has a substantial impact on its reported results and relies on certain estimates that require difficult, subjective and complex judgments on the part of management. The Company recognizes revenue (net of the gross-to-net sales adjustments discussed below, all of which involve significant estimates and judgments) when title and substantially all the risks and rewards of ownership have transferred to the customer, which generally occurs on the date of shipment.
In the case of new products for which the product introduction is not an extension of an existing line of product, where the Company determines that there are not products in a similar therapeutic category, or where the Company determines the new product has dissimilar characteristics with existing products, such that the Company cannot reliably estimate expected returns of the new product, the Company defers recognition of revenue until the right of return no longer exists or until the Company has developed sufficient historical experience to estimate sales returns.
For discussions on revenue recognition, see “Item 8. Financial Statements—Note 1. Accounting Policies—Revenue Recognition and Sales Rebate and Return Accruals.”
Gross-to-Net Sales Adjustments
The Company has the following significant categories of gross-to-net sales adjustments: prime vendor charge-backs, WIC rebates, managed health care rebates and other contract discounts, Medicaid rebates, cash discounts, sales returns, and other adjustments, all of which involve significant estimates and judgments and require the Company to use information from external sources. The Company accounts for these gross-to-net sales adjustments in accordance with EITF Issue No. 01-9, Accounting for Consideration Given by a Vendor to a Customer (Including a Reseller of the Vendor’s Products) , and SFAS No. 48, Revenue Recognition When Right of Return Exists, as applicable. See “—Net Sales” section above for a reconciliation of the Company’s gross sales to net sales by each significant category of gross-to-net sales adjustment.
Prime vendor charge-backs
The Company’s U.S. businesses participate in prime vendor programs with government entities, the most significant of which are the U.S. Department of Defense and the U.S. Department of Veterans Affairs, and other parties whereby pricing on products is extended below wholesaler list price to participating entities. These entities purchase products through wholesalers at the lower prime vendor price and the wholesalers charge the difference between their acquisition cost and the lower prime vendor price back to the Company. The Company accounts for prime vendor charge-backs by reducing accounts receivable in an amount equal to the Company’s estimate of charge-back claims attributable to a sale. The Company determines its estimate of the prime vendor charge-backs primarily based on historical experience regarding prime vendor charge-backs and current contract prices under the prime vendor programs. The Company considers prime vendor payments, levels of inventory in the distribution channel, and the Company’s claim processing time lag and adjusts the reduction to accounts receivable periodically throughout each quarter to reflect actual experience.
WIC rebates
The Company’s U.S. Nutritionals business participates on a competitive bidding basis in nutrition programs sponsored by states, tribal governments, the Commonwealth of Puerto Rico and the U.S. territories for WIC. Under these programs, the Company reimburses these entities for the difference between wholesaler list price and the contract price on eligible products. The Company accounts for WIC rebates by establishing an accrual in an amount equal to the Company’s estimate of WIC rebate claims attributable to a sale. The Company determines its estimate of the WIC rebate accrual primarily based on historical experience regarding WIC rebates and current contract prices under the WIC programs. The Company considers levels of inventory in the distribution channel, new WIC contracts, terminated WIC contracts, changes in existing WIC contracts, and WIC participation and adjusts the accrual periodically throughout each quarter to reflect actual experience.
Managed health care rebates and other contract discounts
The Company offers rebates and discounts to managed health care organizations in the U.S. which manage prescription drug programs and Medicare Advantage prescription drug plans covering the Medicare Part D drug benefit in addition to their commercial plans, as well as globally to other contract counterparties such as hospitals and group purchasing organizations. The Company accounts for managed health care rebates and other contract discounts by establishing an accrual in an amount equal to the Company’s estimate of managed health care rebates and other contract discounts attributable to a sale. The Company determines its
 
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estimate of the managed health care rebates and other contract discounts accrual primarily based on historical experience regarding these rebates and discounts and current contract prices. The Company considers the sales performance of products subject to managed health care rebates and other contract discounts and levels of inventory in the distribution channel and adjusts the accrual periodically throughout each quarter to reflect actual experience.
Medicaid rebates
The Company’s U.S. businesses participate in state government-managed Medicaid programs as well as certain other qualifying Federal and state government programs whereby discounts and rebates are provided to participating state and local government entities. Discounts and rebates provided through these latter programs are included in the Company’s Medicaid rebate accrual and are considered Medicaid rebates for the purposes of this discussion. The Company accounts for Medicaid rebates by establishing an accrual in an amount equal to the Company’s estimate of Medicaid rebate claims attributable to a sale. The Company determines its estimate of the Medicaid rebates accrual primarily based on historical experience regarding Medicaid rebates, as well as any expansion on a prospective basis of its participation in the non-mandatory aspects of the qualifying Federal and state government programs, legal interpretations of applicable laws related to Medicaid and qualifying Federal and state government programs, and any new information regarding changes in the Medicaid programs’ regulations and guidelines that would impact the amount of the rebates. The Company considers outstanding Medicaid claims, Medicaid payments, and levels of inventory in the distribution channel and adjusts the accrual periodically throughout each quarter to reflect actual experience.
Cash discounts
In the U.S. and certain other countries, the Company offers cash discounts, approximating 2% of the sales price, as an incentive for prompt payment. The Company accounts for cash discounts by reducing accounts receivable by the full amount of the discounts. The Company considers payment performance and adjusts the accrual to reflect actual experience.
Sales returns
The Company accounts for sales returns in accordance with SFAS No. 48, Revenue Recognition When Right of Return Exists , by establishing an accrual in an amount equal to the Company’s estimate of sales recorded for which the related products are expected to be returned. In 2007, 2006 and 2005, the provision for sales returns was $160 million, $230 million and $164 million, respectively, or 1% of gross sales for each of the three years.
For returns of established products, the Company determines its estimate of the sales return accrual primarily based on historical experience regarding sales returns, but also considers other factors that could impact sales returns. These factors include levels of inventory in the distribution channel, estimated shelf life, product recalls, product discontinuances, price changes of competitive products, introductions of generic products and introductions of competitive new products. The Company considers all of these factors and adjusts the accrual periodically throughout each quarter to reflect actual experience.
The Company considers the level of inventory in the distribution channel and determines whether it believes an adjustment to the sales return accrual is appropriate. The Company adjusts the sales return accrual based on historical experience, the Company’s returned goods policy, the shelf life of the Company’s products, and life cycle of the product levels of inventory in the distribution channel. The Company considers introductions of generic products and factors the impact into the sales returns calculation based on historical experience and the Company’s returned goods policy.
In the event of a product recall or product discontinuance, the Company considers the reasons for and impact of such actions and adjusts the sales return accrual as appropriate, taking into account historical experience, estimated levels of inventory in the distribution channel and, for product discontinuances, estimates of continuing demand.
Sales returns accruals from new products are estimated and primarily based on the historical sales returns experience of similar products, such as those within the same line of product or those within the same or similar therapeutic category. In limited circumstances, where the new product is not an extension of an existing line of product or where the Company has no historical experience with products in a similar therapeutic category, such that the Company cannot reliably estimate expected returns of the new product, the Company defers recognition of revenue until the right of return no longer exists or until the Company has developed sufficient historical experience to estimate sales returns. The Company also considers the shelf life of new products and determines whether it believes an adjustment to the sales return accrual is appropriate. The shelf life in connection with new products tends to be shorter than the shelf life for more established products because the Company may still be developing an optimal manufacturing process for the new product that would lengthen its shelf life. In addition, higher launch quantities may have been manufactured in advance of the launch date to ensure sufficient supply exists to satisfy market demand. In those cases, the Company assesses the reduced shelf life, together with estimated levels of inventory in the distribution channel and projected demand, and determines whether it believes an adjustment to the sales return accrual is appropriate.
 
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Other adjustments
In addition to the gross-to-net sales adjustments described above, the Company makes other gross-to-net sales adjustments. For example, the Company offers sales discounts, most significantly in its non-U.S. businesses, and also offers consumer coupons and rebates, most significantly in its U.S. Nutritionals and Pharmaceuticals businesses. In addition, in a number of countries outside the U.S., including major European countries, the Company provides rebates to government entities. The Company generally accounts for these other gross-to-net adjustments by establishing an accrual in an amount equal to the Company’s estimate of the adjustments attributable to a sale. The Company generally determines its estimates of the accruals for these other gross-to-net sales adjustments primarily based on historical experience, performance on commitments to government entities and other relevant factors, including estimated levels of inventory in the distribution channel, and adjusts the accruals periodically throughout each quarter to reflect actual experience.
Use of information from external sources
The Company uses information from external sources to estimate its gross-to-net sales adjustments. The Company’s estimates of inventory at the wholesalers and deferred revenue on consigned inventory are based on the projected prescription demand-based sales for its products and historical inventory experience, as well as the Company’s analysis of third-party information, including written and oral information obtained from certain wholesalers with respect to their inventory levels and sell-through to customers and third-party market research data, and the Company’s internal information. The inventory information received from wholesalers is a product of their recordkeeping process and excludes inventory held by intermediaries to whom they sell, such as retailers and hospitals. The Company receives information from IMS, a supplier of market research to the pharmaceutical industry, which it uses to project the prescription demand-based sales for many of its U.S. Pharmaceutical products. Prior to the third quarter of 2005, the Company had historically reported estimated total U.S. prescription growth and estimated therapeutic category shares based on data from the IMS National Prescription Audit (NPA) under IMS’ legacy national projection methodology, which IMS made available on a subscription basis, and reported these data based on a simple unweighted sum of projected U.S. prescriptions in the retail and mail order channels. In the third quarter of 2005, the Company began disclosing these NPA prescription growth and therapeutic category share data based on Version 1.0 of IMS’ new and revised NGPS projection methodology. For consistency, NGPS Version 1.0 data were used for both current and comparative time periods to properly account for trend breaks under the new projection methodology. Coincident with the change to reporting IMS data on an NGPS Version 1.0 basis, the Company also began reporting retail and mail prescription growth and category shares on a weighted, retail-equivalent basis, which accounts for the significantly larger size of the average mail order prescription, as compared to the size of the average retail prescription. Retail equivalization calculations were applied to mail order volumes and shares for each reported product and time period. In 2007, IMS further refined and improved its NGPS projection methodology and fully rolled out NGPS Version 2.0 to all NPA subscribers, which resulted in newly revised volume estimates for historic time periods. Therefore, since the first quarter of 2007, the Company has used the new IMS standard NGPS Version 2.0 projection methodology and has applied NGPS Version 2.0 data for reporting prescription growth and market shares to all periods presented in the Annual Report on Form 10-K. The Company has also continued the practice of combining retail and mail prescription volume on a retail-equivalent basis. The Company uses this methodology for its internal demand forecasts. The Company also uses information from external sources to identify prescription trends, patient demand and average selling prices. The Company’s estimates are subject to inherent limitations of estimates that rely on third-party information, as certain third-party information was itself in the form of estimates, and reflect other limitations including lags between the date as of which third-party information is generated and the date on which the Company receives third-party information.
Retirement Benefits
The Company’s pension plans and postretirement benefit plans are accounted for using actuarial valuations required by SFAS No. 87, Employers’ Accounting for Pensions , and SFAS No. 106 , Employers’ Accounting for Postretirement Benefits Other Than Pensions . The Company considers accounting for retirement plans critical because management is required to make significant subjective judgments about a number of actuarial assumptions, including discount rates, salary growth, long-term return on plan assets, retirement, turnover, health care cost trend rates, and mortality rates. Depending on the assumptions and estimates used, the pension and postretirement benefit expense could vary within a range of outcomes and have a material effect on reported earnings. In addition, the assumptions can materially affect projected benefit obligations and future cash funding.
The Company adopted SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans—an amendment of FASB Statements No. 87, 88, 106, and 132(R), in the fiscal year ended December 31, 2006 and the adoption of this accounting pronouncement resulted in a $1,064 million reduction of accumulated other comprehensive income in stockholders’ equity, a $767 million reduction in total assets and a $297 million increase in total liabilities. The adoption of SFAS No. 158 did not impact the Company’s results of operations or cash flows.
 
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Plan Description
The Company and certain of its subsidiaries have defined benefit pension plans, defined contribution plans, and termination indemnity plans for regular full-time employees. The principal defined benefit pension plan is the Bristol-Myers Squibb Retirement Income Plan and the principal defined contribution plan is the Bristol-Myers Squibb Savings and Investment Program.
Approximately 75% of total Company defined benefit pension plan assets and liabilities are held in U.S. plans. The assets for the U.S. plans are held in a single trust with a common asset allocation. Unless specified otherwise, the references in this section are to total Company plans (i.e., U.S. plans together with international plans).
Benefits under the Company’s defined benefit pension plans are based primarily on years of credited service and on participants’ compensation. Assets under the Company’s defined benefit plans consist primarily of equity and fixed-income securities. At December 31, 2007, the fair market value of plan assets for the Company’s defined benefit plans increased to $6,019 million from $5,658 million at December 31, 2006. For the U.S. plans, assets were allocated 67% to equity securities (compared to 69% at the end of 2006), 24% to fixed income securities (compared to 23% at the end of 2006) and 9% to private equity and other investments (compared to 8% at the end of 2006). Bristol-Myers Squibb common stock represented less than 1% of assets for the U.S. plans at the end of 2007 and 2006.
The Company provides comprehensive medical and group life benefits for substantially all U.S. retirees who elect to participate in the Company’s comprehensive medical and group life plans. The asset allocation for these postretirement plans is identical to the asset allocation described above for the U.S. defined benefit pension plans.
Accrual Accounting and Significant Assumptions
Consistent with the requirements of SFAS No. 87, the Company accounts for pension benefits using the accrual method, recognizing pension expense before the payment of benefits to retirees. The accrual method of accounting for pension benefits necessarily requires actuarial assumptions concerning future events that will determine the amount and timing of the benefit payments.
The Company’s key assumptions used in calculating its cost of pension benefits are the discount rate, the rate of compensation increase, and the expected long-term rate of return on plan assets. The Company, in consultation with its actuaries, evaluates the key actuarial assumptions and other assumptions used in calculating its cost of pension benefits, such as retirement, turnover and mortality rates, based on expectations or actual experience, as appropriate, and determines such assumptions on December 31 of each year to calculate liability information as of that date and pension expense for the following year. Depending on the assumptions used, the pension expense could vary within a range of outcomes and have a material effect on reported earnings. In addition, the assumptions can materially affect projected benefit obligations and future cash funding. Actual results in any given year may differ from those estimated because of economic and other factors.
In determining the discount rate, the Company uses the yield on high quality corporate bonds that coincides with the cash flows of its plans’ estimated payouts. The Citigroup Above Median yield curve is used in determining the discount rate for the U.S. plans. The assumed rate of compensation increase used by the Company for determining future pension obligations reflects an estimate of the change in actual future compensation levels due to general price levels, productivity, seniority and other factors.
In 2007, net pension expense for the Company’s defined benefit pension plans included in earnings before minority interest and income taxes was $313 million compared to $332 million in 2006.
The U.S. plans’ pension expense for 2007 was determined using a 6.0% assumed discount rate and a 3.56% assumed rate of compensation increase. The present value of benefit obligations at December 31, 2007 for the U.S. plans was determined using a 6.75% assumed discount rate and a 3.56% assumed rate of compensation increase. If the assumed discount rate used in determining the U.S. plans’ pension expense for 2007 had been reduced by 0.25%, such expense would have increased by approximately $17 million. If the assumed rate of compensation increase used in determining the U.S. plans’ pension expense for 2007 had been reduced by 0.25%, such expense would have decreased by approximately $9 million. If the assumed discount rate used in determining the accumulated benefit obligation at December 31, 2007 had been reduced by 0.25%, the accumulated benefit obligation would have increased by $115 million.
The U.S. plans’ pension expense for 2007 was determined using an 8.75% expected long-term rate of return on plan assets. If the expected long-term rate of return on plan assets used in determining the U.S. plans’ pension expense for 2007 had been reduced by 1%, such expense would have increased by $41 million.
 
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Actual rates of return earned on U.S. plan assets for each of the last 10 years were as follows:

Year	  	Return	 	 	Year	  	Return	 	
2007	  	10.3	%	 	2002	  	(13.4	)%	
2006	  	14.9	%	 	2001	  	(6.1	)%	
2005	  	9.8	%	 	2000	  	3.5	%	
2004	  	12.6	%	 	1999	  	18.2	%	
2003	  	25.0	%	 	1998	  	13.3	%	
At December 31, 2007, the Company increased its assumed discount rate for U.S. plans from 6.00% to 6.75% and maintained its assumed rate of compensation increase at 3.56%. Compensation is assumed to increase on a scale with different rates for different ages. The 3.56% rate disclosed at December 31, 2007 is the single rate, which, if used at each age, would produce the same present value of benefit obligations.
The Company maintained the expected rate of return on U.S. plan assets at 8.75% for 2008.
The Company expects that the net pension expense for its defined benefit pension plans included in earnings before minority interest and income taxes will be approximately $20 million lower in 2008 than the $313 million in 2007, reflecting primarily the increase in the discount rate.
The Company has used the same assumed discount rates and expected long-term rates of return on plan assets in calculating its cost of pension benefits and its cost of other postretirement benefits for U.S. plans except in the case of the discount rates at December 31, 2007 and 2006. Rates of 6.75% and 6.00%, respectively, were used for pension benefits versus 6.50% and 5.75%, respectively, for other postretirement benefits to reflect the shorter duration of the other postretirement liabilities at December 31, 2007 and 2006, respectively.
U.S. health care costs for the retiree population are assumed to increase 9.5% in 2008 and then trend down to an expected increase of 4.5% per year by 2018. If actual costs are higher than those assumed, this will likely put significant upward pressure on the Company’s expense for retiree health care.
The effects of the Medicare Prescription Drug, Improvement and Modernization Act of 2003 are reflected in 2007 net periodic postretirement benefit cost (a reduction of $11 million) and accumulated postretirement benefit obligation at January 1, 2007 (a reduction of $98 million).
Recognition of Actuarial Gains and Losses
In 2006, SFAS No. 158 required the recognition of actuarial gains and losses as a component of stockholders’ equity in accumulated other comprehensive income while SFAS No. 87 provides for delayed recognition in years prior to 2006. These amounts arise from changes in the estimated plan benefit obligations due to changes in the assumed discount rate, differences between the actual and expected returns on plan assets, and other assumption changes. The net actuarial gain or loss, determined based on the market-related value of plan assets (which differs from fair market value and is a calculated value that recognizes changes in fair value in a systematic and rational manner over not more than five years), is amortized in pension income or expense for the year to the extent that such unrecognized net actuarial loss or gain exceeds 10% of the greater of the projected benefit obligation or the market-related value of plan assets at the beginning of the year. These net gains and losses are recognized as pension income or expense prospectively over a period that approximates the average remaining service period of active employees expected to receive benefits under the plans (approximately 10 years) to the extent that they are not offset by losses and gains in subsequent years.
The unrecognized net actuarial loss reflects in large part the steady reduction of the weighted-average discount rate over the years. Unless offset by future unrecognized gains from higher discount rates or higher than expected returns on plan assets, amortization of the unrecognized loss is expected to increase pension expense by $98 million in 2008 and by progressively lower amounts for each of the following nine years.
Plan Funding
The Company’s funding policy for defined benefit plans is to contribute amounts to provide for current service and to fund past service liability. The Company contributed $323 million and $325 million to the defined benefit plans in 2007 and 2006, respectively.
For discussions on retirement benefits, see “Item 8. Financial Statements—Note 21. Pension and Other Postretirement Benefit Plans.”
 
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Acquired In-Process Research and Development
The fair value of in-process research and development acquired in a business combination is determined based on the present value of each research project’s projected cash flows. An income approach is utilized that is consistent with guidance in the practice aid issued by the American Institute of Certified Public Accountants, Assets Acquired in a Business Combination to Be Used in Research and Development Activities: A Focus on Software, Electronic Devices and Pharmaceutical Industries . Future cash flows are predominately based on the net income forecast of each project, consistent with historical pricing, margins, and expense levels of similar products. Revenues are estimated based on relevant market size and growth factors, expected industry trends, individual project life cycles, and the life of each research project’s underlying patent. In determining the fair value of each research project, expected revenues are first adjusted for technical risk of completion. The resulting cash flows are then discounted at a rate approximating the Company’s weighted-average cost of capital. Other acquired in-process research and development is expensed as incurred when the underlying product has not received regulatory approval and does not have any future alternative use. In addition, costs that are nonrefundable, related to the acquisition or licensing of products that have not yet received regulatory approval to be marketed and that have no alternative future use, are charged to earnings as incurred.
For discussions on acquired in-process research and development, see “Item 8. Financial Statements—Note 1. Accounting Policies—Acquired In-Process Research and Development.”
Impairment of Long-Lived Assets
In accordance with SFAS No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets , the Company periodically evaluates whether current facts or circumstances indicate that the carrying value of its depreciable assets to be held and used may not be recoverable. If such circumstances are determined to exist, an estimate of undiscounted future cash flows produced by the long-lived asset, or the appropriate grouping of assets, is compared to the carrying value to determine whether impairment exists. If an asset is determined to be impaired, the loss is measured based on the difference between the asset’s fair value and its carrying value. An estimate of the asset’s fair value is based on quoted market prices in active markets, if available. If quoted market prices are not available, the estimate of fair value is based on various valuation techniques, including a discounted value of estimated future cash flows. The Company reports an asset to be disposed of at the lower of its carrying value or its estimated net realizable value.
In accordance with SFAS No. 142, Goodwill and Other Intangible Assets , goodwill is tested at least annually for impairment using a two-step process. The first step is to identify a potential impairment, and the second step measures the amount of the impairment loss, if any. Goodwill is deemed to be impaired if the carrying amount of a reporting unit’s goodwill exceeds its estimated fair value. SFAS No. 142 requires that indefinite-lived intangible assets be tested for impairment using a one-step process, which consists of a comparison of the fair value to the carrying value of the intangible asset. Such intangible assets are deemed to be impaired if their net book value exceeds their estimated fair value. All other intangible assets are evaluated for impairment in accordance with SFAS No. 144 as described above.
The estimates of future cash flows, based on reasonable and supportable assumptions and projections, require management’s judgment. Any changes in key assumptions about the Company’s businesses and their prospects, or changes in market conditions, could result in an impairment charge.
For discussions on impairment of long-lived assets, see “Item 8. Financial Statements—Note 1. Accounting Policies—Impairment of Long-Lived Assets” and “—Goodwill and Other Intangible Assets.”
Equity Investments
The Company reviews its equity investments for impairment based on its determination of whether the decline in market value of the investment below the Company’s carrying value is other than temporary. In making this determination, the Company considers APB Opinion No. 18, The Equity Method of Accounting for Investments in Common Stock and related interpretations , which set forth factors to be evaluated in determining whether a loss in value should be recognized, including the Company’s ability to hold its investment, the market price and market price fluctuations of the investment’s publicly traded shares and inability of the investee to sustain an earnings capacity, which would justify the carrying amount of the investment. The Company’s investment in ImClone is subject to this accounting. For a discussion of the Company’s investment in ImClone, see “Item 8. Financial Statements—Note 2. Alliances and Investments.”
For discussions on equity investments, see “Item 8. Financial Statements—Note 1. Accounting Policies—Investments” and “—Note 2. Alliances and Investments.”
 
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Marketable Securities
The Company’s marketable securities at December 31, 2007 consisted of U.S. dollar denominated FRS, which are primarily ‘AAA/Aaa’ rated. FRS are long long-term debt securities with coupons that are reset periodically against a benchmark interest rate. The underlying assets of the Company’s FRS consist of primarily investment grade corporate bonds and loans. The Company accounts for its marketable securities in accordance with SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities , and classifies them as “available for sale.”
In addition, at December 31, 2007, the Company had principal invested in ARS. The ARS held by the Company are private placement securities with long-term nominal maturities for which the interest rates are reset through a dutch auction each month. The monthly auctions historically have provided a liquid market for these securities. The Company’s investments in ARS represent interests in collateralized debt obligations supported by pools of residential and commercial mortgages or credit cards, insurance securitizations and other structured credits, including corporate bonds. Some of the underlying collateral for the ARS held by the Company consists of sub-prime mortgages.
Due to the lack of availability of observable market quotes on the Company’s investment portfolio of marketable securities and ARS, the Company utilizes valuation models including those that are based on expected cash flow streams and collateral values, including assessments of counterparty credit quality, default risk underlying the security, discount rates and overall capital market liquidity. The valuation of the Company’s investment portfolio is subject to uncertainties that are difficult to predict. Factors that may impact the Company’s valuation include changes to credit ratings of the securities as well as to the underlying assets supporting those securities, rates of default of the underlying assets, underlying collateral value, discount rates, counterparty risk and ongoing strength and quality of market credit and liquidity.
The credit and capital markets have continued to deteriorate in 2008. If uncertainties in these markets continue, these markets deteriorate further or the Company experiences any additional ratings downgrades on any investments in its portfolio (including on ARS), the Company may incur additional impairments to its investment portfolio, which could negatively affect the Company’s financial condition, cash flow and reported earnings.
For discussions on marketable securities, see “Item 8. Financial Statements—Note 9. Cash, Cash Equivalents and Marketable Securities.”
Restructuring
To streamline operations and rationalize manufacturing facilities, the Company has periodically recorded restructuring charges. As a result, the Company has made estimates and judgments regarding its future plans, including future termination benefits and other exit costs to be incurred when the restructuring actions take place. Actual results could vary from these estimates. Adjustments of $6 million, $14 million and $1 million were recorded in 2007, 2006 and 2005, respectively, and reflect changes in estimates for restructuring actions taken in prior periods.
For discussions on restructuring, see “Item 8. Financial Statements—Note 1. Accounting Policies—Restructuring” and “—Note 3. Restructuring and Other Items.”
Contingencies
In the normal course of business, the Company is subject to contingencies, such as legal proceedings and claims arising out of its business, that cover a wide range of matters, including, among others, government investigations, shareholder lawsuits, and product and environmental liability. In accordance with SFAS No. 5, Accounting for Contingencies , the Company records accruals for such contingencies when it is probable that a liability will be incurred and the amount of the loss can be reasonably estimated. These estimates are subject to uncertainties that are difficult to predict and, as such, actual results could vary from these estimates.
For discussions on contingencies, see “Item 8. Financial Statements—Note 1. Accounting Policies—Contingencies;” and “—Note 22. Legal Proceedings and Contingencies.”
Income Taxes
The provision for income taxes has been determined using the asset and liability approach of accounting for income taxes. Under this approach, deferred taxes represent the future tax consequences expected to occur when the reported amounts of assets and liabilities are recovered or paid. The provision for income taxes represents income taxes paid or payable for the current year plus the change in deferred taxes during the year. Deferred taxes result from differences between the financial and tax bases of the Company’s assets and liabilities and are adjusted for changes in tax rates and tax laws when changes are enacted. Valuation allowances are recorded to reduce deferred tax assets when it is more likely than not that a tax benefit will not be realized. The assessment of whether or not a valuation allowance is required often requires significant judgment including the long-range forecast of future taxable income and the evaluation of tax planning initiatives. Adjustments to the deferred tax valuation allowances are made to earnings in the period when such assessments are made. As of December 31, 2007 and 2006, the Company had net deferred tax assets of $3,483 million and $3,154 million, respectively, net of valuation allowances of $1,950 million and $625 million, respectively.
 
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The Company has recorded significant deferred tax assets at December 31, 2007 related to U.S. foreign tax credit carryforwards of approximately $1,140 million, U.S. research tax credit carryforwards of approximately $275 million and charitable contribution carryfowards of $80 million. The charitable contribution carryforwards expire in varying amounts beginning in 2009, while the foreign tax credit and research tax credit carryforwards expire in varying amounts beginning in 2012. The foreign tax credit and research credit have been reduced due to derecognition under FIN No. 48. Realization of these credits and charitable contribution carryforwards is dependent on generating sufficient domestic taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized. The Company anticipates increasing its level of domestic profitability over time by undertaking actions such as its PTI, increasing its biologics manufacturing capacity in the U.S. and implementing tax planning strategies. While increasing domestic profitability will likely cause the Company’s effective tax rate to increase, it will also further enhance the Company’s ability to utilize its foreign tax credit, research tax credit and charitable contribution carryforwards.
The Company conducts business in various countries throughout the world and is subject to tax in numerous jurisdictions. As a result of its business activities, the Company files a significant number of tax returns that are subject to examination by various Federal, state, and local tax authorities. Tax examinations are often complex as tax authorities may disagree with the treatment of items reported by the Company and may require several years to resolve. The Company establishes liabilities for possible assessments by tax authorities resulting from known tax exposures including, but not limited to, transfer pricing matters, tax credits and deductibility of certain expenses. Such liabilities represent a reasonable provision for taxes ultimately expected to be paid, and may need to be adjusted over time as more information becomes known.
The Company adopted FIN No. 48 on January 1, 2007. As a result of the adoption of this accounting pronouncement, the Company recognized $27 million of previously unrecognized tax benefits, which was accounted for as an increase to the opening balance of retained earnings.
As previously reported, upon the adoption of FIN No. 48, the Company’s total amount of uncertain tax benefits as of January 1, 2007, net of deferred income tax benefits, and excluding interest and penalties, was $960 million. In addition, the Company derecognized on adoption $180 million of unrecognized tax benefits for which there is no tax rate impact when settled. As such, the gross unrecognized tax benefits at January 1, 2007 were $1,140 million. The total amount of unrecognized tax benefits on December 31, 2007, excluding amounts recorded as reductions in deferred tax assets, and excluding interest and penalties decreased to $798 million. This reduction is primarily due to tax benefits recognized from the favorable resolution of uncertain tax positions, partially offset by additional uncertain tax benefits accrued during 2007. For additional information on unrecognized tax benefits, see “Item 8. Financial Statements—Note 8. Income Taxes”
As of December 31, 2007, the Company had approximately $14.1 billion of undistributed earnings of foreign subsidiaries for which taxes have not been provided, as the Company has invested or expects to invest these undistributed earnings permanently offshore. If, in the future, these earnings are repatriated to the U.S., or if the Company determines such earnings will be remitted in the foreseeable future, additional tax provisions would be required. Due to complexities in the tax laws and the assumptions that would have to be made, it is not practicable to estimate the amounts of income taxes that would have to be provided.
For discussions on income taxes, see “Item 8. Financial Statements—Note 1. Accounting Policies—Income Taxes” and “—Note 8. Income Taxes.”
Stock-Based Compensation Expense
The Company adopted SFAS No. 123(R), Share-Based Payment , which requires the measurement and recognition of compensation expense for all stock-based payment awards made to employees and directors based on estimated fair values. The Company uses the modified prospective transition method, which requires the application of the accounting standard as of January 1, 2006, and has elected the alternative method as provided in FSP No. 123(R)-3 in determining the Company’s pool of excess tax benefits. The Company’s consolidated financial statements for the years ended December 31, 2007 and 2006 reflect the impact of SFAS No. 123(R). In accordance with the modified prospective transition method, the Company’s consolidated financial statements for prior periods have not been restated to reflect, and do not include, the impact of SFAS No. 123(R). Stock-based compensation expense recognized under SFAS No. 123(R) for the years ended December 31, 2007 and 2006 was $133 million and $112 million, respectively ($88 million and $73 million, net of tax, respectively) or $0.04 and $0.04 per share, respectively, with a corresponding amount recorded in additional paid-in capital within stockholders’ equity. Comparatively, on a pro forma basis, stock-based compensation expense of $31 million ($20 million, net of tax), was recognized for the year ended December 31, 2005 under APB No. 25. Additionally, $10 million related to performance awards was reclassified from liabilities to stockholders’ equity in connection with the adoption of SFAS No. 123(R).

The Company estimates the fair value of stock-based payment awards on the date of grant using an option-pricing model. The value of the portion of the award that is ultimately expected to vest is recognized as expense over the requisite service periods in the Company’s consolidated statement of earnings. Prior to the adoption of SFAS No. 123(R), the Company accounted for stock-based awards to employees and directors using the intrinsic value method related to stock options in accordance with APB No. 25, as
 
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allowed under SFAS No. 123, Accounting for Stock-Based Compensation . Under the intrinsic value method, no stock-based compensation expense had been recognized in the Company’s consolidated statement of earnings because the exercise price of the Company’s stock options granted to employees and directors equaled the fair market value of the underlying stock at the date of grant.
Stock-based compensation expense recognized during the period is based on the value of the portion of stock-based payment awards that is ultimately expected to vest during the period. Stock-based compensation expense recognized in the Company’s consolidated statement of earnings for the years ended December 31, 2007 and 2006 included compensation expense for stock-based payment awards granted prior to, but not yet vested as of, January 1, 2006 based on the grant date fair value estimated in accordance with the pro forma provisions of SFAS No. 123(R) and compensation expense for the stock-based payment awards granted subsequent to January 1, 2006 based on the grant date fair value estimated in accordance with the provisions of SFAS No. 123(R).
In conjunction with the adoption of SFAS No. 123(R), the Company changed its method of attributing the value of stock-based compensation expense from the accelerated multiple-option approach to the straight-line single option method. Compensation expense for all stock-based payment awards granted prior to 2006 will continue to be recognized using the accelerated multiple-option approach while compensation expense for all stock-based payment awards, with a service condition only, granted on or subsequent to January 1, 2006 is recognized using the straight-line single-option method. Stock-based payment awards granted on or subsequent to January 1, 2006, with both a service and market condition, will be recognized using the accelerated multiple-option approach as required under SFAS No. 123(R).
Prior to 2006, the Company applied APB Opinion No. 25, and did not recognize compensation expense for stock options granted under the plans as the exercise price of the option on the date of grant is equal to the fair market value as of that date. However, for grants of restricted stock, the Company recognized compensation expense on a straight-line basis over the period that the restrictions expire.
The fair value of the options granted during 2007, 2006 and 2005 was estimated as $ 6.56 per common share, $4.74 per common share and $5.49 per common share, respectively, on the date of grant using the Black-Scholes option–pricing model. The assumptions used in the Black-Scholes option-pricing model were as follows:

 	  	2007	 	 	2006	 	 	2005	 	
Expected volatility	  	28.9	%	 	26.7	%	 	29.4	%	
Risk-free interest rate	  	4.7	%	 	4.6	%	 	4.4	%	
Dividend yield	  	4.5	%	 	4.8	%	 	4.6	%	
Expected life	  	6.2 yrs	 	 	6.3 yrs	 	 	7.0 yrs	 	
The Company determines fair value of certain stock-based payment awards on the date of grant using an option-pricing model. This model is affected by the Company’s stock price as well as assumptions regarding a number of highly complex and subjective variables. These variables include, but are not limited to: the Company’s expected stock price volatility over the term of the awards, and actual and projected employee stock option exercise behaviors.
With respect to the accounting treatment of retirement eligibility provisions of employee stock-based compensation awards, the Company has historically followed the nominal vesting period approach. Upon the adoption of SFAS No. 123(R), the Company follows the non-substantive vesting period approach and recognizes compensation cost over a one-year period for awards granted to retirement-eligible employees, or over the period from the grant date to the date retirement eligibility is achieved if more than one year, but less than the vesting period. The impact of applying the non-substantive vesting period approach is not material to the Company’s consolidated financial statements.
As stock-based compensation expense recognized in the consolidated statements of earnings for the year ended December 31, 2007 and 2006 is based on awards ultimately expected to vest, it has been reduced for estimated forfeitures. The Company estimates forfeitures at the time of grant and revises, if necessary, in subsequent periods if actual forfeitures differ from those estimates. In the Company’s pro forma information required under SFAS No. 123 for the periods prior to 2006, the Company accounted for forfeitures as they occurred.

Special Note Regarding Forward-Looking Statements
This annual report and other written and oral statements the Company makes from time to time contain certain “forward-looking” statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You can identify these forward-looking statements by the fact they use words such as “should”, “expect”, “anticipate”, “estimate”, “target”, “may”, “project”, “guidance”, “intend”, “plan”, “believe” and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance. One can also identify forward-looking statements by the fact that they do not relate strictly to historical or current facts. Such forward-looking statements are based on
 
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current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes to differ materially from current expectations. These statements are likely to relate to, among other things, the Company’s goals, plans and projections regarding its financial position, results of operations, cash flows, market position, product development, product approvals, sales efforts, expenses, performance or results of current and anticipated products and the outcome of contingencies such as legal proceedings, and financial results, which are based on current expectations that involve inherent risks and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years. The Company has included important factors in the cautionary statements included in this annual report, particularly under “Item 1A. Risk Factors,” that the Company believes could cause actual results to differ materially from any forward-looking statement.
Although the Company believes it has been prudent in its plans and assumptions, no assurance can be given that any goal or plan set forth in forward-looking statements can be achieved and readers are cautioned not to place undue reliance on such statements, which speak only as of the date made. The Company undertakes no obligation to release publicly any revisions to forward-looking statements as a result of new information, future events or otherwise.
 
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Item 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.
The Company is exposed to market risk due to changes in currency exchange rates, interest rates and the deterioration of the credit and capital markets. To reduce that risk, the Company enters into certain derivative financial instruments, when available on a cost-effective basis, to hedge its underlying economic exposure. These instruments are managed on a consolidated basis to efficiently net exposures and thus take advantage of any natural offsets. Derivative financial instruments are not used for speculative purposes. Gains and losses on hedging transactions are offset by gains and losses on the underlying exposures being hedged. Any ineffective portion of hedges is reported in earnings as it occurs.
The Company’s primary net foreign currency translation exposures are the Euro, Canadian dollar, Japanese yen, Mexican peso and Chinese renminbi. The Company utilizes foreign currency contracts to hedge anticipated transactions, primarily intercompany transactions, on certain foreign currencies and designates these derivative instruments as foreign currency cash flow hedges when appropriate.
The table below summarizes the Company’s outstanding foreign exchange forward contracts as of December 31, 2007. The fair value of all foreign exchange forward contracts is based on year-end currency rates. The fair value of foreign exchange forward contracts should be viewed in relation to the fair value of the underlying hedged transactions and the overall reduction in exposure to adverse fluctuations in foreign currency exchange rates.

Dollars in Millions, except currency rates	  	Weighted-Average
Strike Price	  	Notional Amount	  	Fair Value
Asset/(Liability)	 	 	Maturity	
Foreign Exchange Forwards:	  		  			  				 		
Cash Flow Hedges	  		  			  				 		
Australian Dollar	  	0.80	  	$	72	  	$	(6	)	 	2008	
British Pound	  	2.01	  	 	79	  	 	1	 	 	2008	
Canadian Dollar	  	1.08	  	 	130	  	 	(12	)	 	2008	
Euro	  	1.36	  	 	636	  	 	(43	)	 	2008	
Japanese Yen	  	107.62	  	 	159	  	 	3	 	 	2008	
Mexican Peso	  	10.95	  	 	54	  	 	1	 	 	2008	
Polish Zloty	  	2.53	  	 	18	  	 	—  	 	 	2008	
Swedish Krona	  	6.48	  	 	47	  	 	—  	 	 	2008	
Swiss Franc	  	1.16	  	 	30	  	 	—  	 	 	2008	
	  		  	 	 	  	 	 	 	 		
Total Cash Flow Hedges	  		  	 	1,225	  	 	(56	)	 		
	  		  	 	 	  	 	 	 	 		
Non-Qualifying Hedges (1)	  		  			  				 		
Australian Dollar	  	0.90	  	 	71	  	 	3	 	 	2008	
British Pound	  	2.06	  	 	41	  	 	2	 	 	2008	
Canadian Dollar	  	0.95	  	 	131	  	 	6	 	 	2008	
Euro	  	1.45	  	 	13	  	 	(1	)	 	2008	
Japanese Yen	  	106.78	  	 	71	  	 	2	 	 	2008	
Polish Zloty	  	2.53	  	 	61	  	 	(1	)	 	2008	
Turkish Lira	  	1.27	  	 	43	  	 	(2	)	 	2008	
	  		  	 	 	  	 	 	 	 		
Total Non-Qualifying Hedges	  		  	 	431	  	 	9	 	 		

Total Contracts	  		  	$	1,656	  	$	(47	)	 		

(1)	Non-qualifying hedges are hedges that do not qualify for hedge accounting treatment as prescribed by SFAS 133, Accounting for Derivative Instruments and Hedging Activities.	
At December 31, 2007, the Company held foreign exchange option contracts to buy and sell Japanese Yen. The total notional and fair market value for buy contracts is $145 million and $1 million, respectively, which are fully offset by the total notional and fair market value for sell contracts of $145 million and $1 million, respectively. At December 31, 2007, the Company held foreign exchange forward contracts with maturity dates in 2008; their notional amounts and fair values are expressed in the table below, dollars in millions:

Year of Maturity	  	Notional Amount	  	Fair Value	 	
2008	  	$	1,656	  	$	(47	)	

At December 31, 2007, the fair value of the Company’s foreign exchange forward contracts was a net liability of $47 million, of which $16 million was recorded as a non-current asset and $63 million was recorded as a current liability. The Company estimates that a 10% appreciation or depreciation in the underlying currencies being hedged from their levels against the dollar as of December 31, 2007, with all other variables held constant, would decrease by $170 million or increase by $155 million, respectively, the fair value of foreign exchange forward contracts held at December 31, 2007.
 
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The Company is obligated to settle foreign exchange forward contracts based on the specified contract rates. As of December 31, 2007, the balance of deferred losses on foreign exchange forward contracts included in accumulated other comprehensive income (OCI) on a pre-tax basis was $54 million ($37 million net of tax), all of which is expected to be reclassified into earnings within the next 12 months.
At December 31, 2006, the fair value of the Company’s foreign exchange forward contracts was a net liability of $33 million, of which $18 million was recorded as a non-current asset and $51 million was recorded as a current liability.
For the years ended December 31, 2007, 2006 and 2005, the impact of hedge ineffectiveness on earnings was not significant. Additionally, for the years ended December 31, 2007, 2006 and 2005, the impact of discontinued hedges was a pre-tax loss of $12 million, a pre-tax loss of $10 million and a pre-tax gain of $2 million, respectively. Furthermore, the Company uses foreign exchange forward contracts to offset its exposure to certain assets and liabilities and earnings denominated in foreign currencies. These foreign exchange forward contracts are not designated as hedges and, therefore, changes in the fair value of these derivatives are recognized in earnings as they occur. The notional and fair value amounts of foreign exchange forward contracts at December 31, 2007 are described in the table above. There were no foreign exchange forward contracts of this type outstanding at December 31, 2006. In 2007, the impact of foreign exchange forward contracts that are not designated as hedges was a pre-tax gain of $4 million. In 2006 and 2005, the amounts recognized in earnings related to foreign exchange forward contracts that did not qualify for hedge accounting treatment were not significant.
In addition to the foreign exchange hedge contracts noted above, the Company utilizes forward contracts to hedge foreign currency-denominated monetary assets and liabilities. The primary objective of these forward contracts is to protect the U.S. dollar value of foreign currency-denominated monetary assets and liabilities from the effects of volatility in foreign exchange rates that might occur prior to their receipt or settlement in U.S. dollars. These foreign currency-denominated monetary assets and liabilities are primarily denominated in Euro. The forward contracts are not designated as hedges and are marked to market through other expense, net. The notional and fair value amounts of purchased foreign exchange forward contracts were not material at December 31, 2007, and were $24 million and a $1 million asset, respectively, at December 31, 2006. There were no notional and fair value amounts of sold foreign exchange forward contracts at December 31, 2007, and $22 million and a $1 million liability, respectively, at December 31, 2006.
The Company uses non-U.S. dollar borrowings, primarily the €500 Million Notes due 2016 and the €500 Million Notes due 2021 to hedge the foreign currency exposures of the Company’s net investment in certain foreign affiliates. These non-U.S. dollar borrowings are designated as hedges of net investments. The effective portion of foreign exchange gains or losses on these hedges is recorded as part of the foreign currency translation component of accumulated OCI. At December 31, 2007 and 2006, $168 million and $27 million in losses, respectively, were recorded in the foreign currency translation component of accumulated OCI.
The Company uses derivative instruments as part of its interest rate risk management strategy. The derivative instruments used are comprised principally of fixed to floating rate interest rate swaps, which are subject to fair-value hedge accounting treatment. In November 2006, in connection with the funding of the retirement of the 2011 fixed rate debt, the Company executed several fixed to floating interest rate swaps to convert $1.3 billion and €1 billion ($1.3 billion at inception) of the Company’s newly issued fixed rate debt to be paid in 2016, 2021 and 2036 to variable rate debt. The total notional amount of outstanding interest rate swaps were $2.6 billion and €1 billion ($1.5 billion) as of December 31, 2007 and $2.6 billion and €1 billion ($1.3 billion) as of December 31, 2006. In accordance with SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities , the Company recognized a net increase in interest expense of $13 million and $18 million in 2007 and 2006, respectively, and a net reduction in interest expense of $54 million in 2005 from the impact of interest rate swaps.
 
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SFAS No. 133 requires the revaluation, at fair value, of the swap contracts as well as the underlying debt being hedged. As such, the swap contracts and the underlying debt have been revalued resulting in an increase in non-current assets of $72 million and current liabilities of $96 million, and a reduction in long-term debt of $24 million at December 31, 2007, and an increase in non-current assets of $7 million and current liabilities of $57 million, and a reduction in long-term debt of $50 million at December 31, 2006. Swap contracts are generally held to maturity and are intended to create an appropriate balance of fixed and floating rate debt for the Company. Swap contracts that qualify as fair value hedges that are terminated prior to their maturity dates are reported as part of the carrying value of the underlying debt and are amortized to earnings over the remaining life of the debt. Swap contracts that qualify as cash flow hedges that are terminated are reported in accumulated OCI and amortized to earnings over the remaining life of the debt. The following tables summarize the interest rate swaps outstanding as of December 31, 2007 and the earnings impact from terminated interest rate swap contracts for 2007, 2006 and 2005:
Interest Rate Swaps Outstanding

Interest Rate Contracts	  	Notional
Amount of
Underlying
Debt	  	Variable Rate
Received	  	Year of
Transaction	  	Maturity	  	Fair
Value	 	
Dollars in Millions	  	 	  	 	  	 	  	 	  	 	 	
Swaps associated with:	  			  		  		  		  				
4.00% Notes due 2008	  	$	400	  	1 month U.S. $ LIBOR +0.35%	  	2003	  	2008	  	$	(2	)	
5.25% Notes due 2013	  	 	600	  	1 month U.S. $ LIBOR +0.42%	  	2003	  	2013	  	 	16	 	
4.375% €500 Million Notes due 2016	  	 	725	  	3 month EUR € EURIBOR +0.40%	  	2006	  	2016	  	 	(37	)	
4.625% €500 Million Notes due 2021	  	 	725	  	3 month EUR € EURIBOR +0.56%	  	2006	  	2021	  	 	(57	)	
7.15% Notes due 2023	  	 	350	  	1 month U.S. $ LIBOR +1.66%	  	2004	  	2023	  	 	20	 	
5.875% Notes due 2036	  	 	1,250	  	1 month U.S. $ LIBOR +0.62%	  	2006	  	2036	  	 	36	 	
	  	 	 	  		  		  		  	 	 	 	
	  	$	4,050	  		  		  		  	$	(24	)	
	  	 	 	  		  		  		  	 	 	 	
Earnings Impact from Terminated Interest Rate Swap Contracts

 	  	Year of
Termination	  	Notional
Amount of
Underlying
Debt	  	Total Pre-Tax
Deferred
Gain/(Loss)	 	 	 
 
Pre-Tax Income/(Expense) Recognized	 	
   	  		  		  			 	2007	  	2006	 	 	2005	 	
Interest Rate Contracts	  	 	  	 	  	 	 	 	 	  	 	 	 	 	 	
Dollars in Millions	  	 	  	 	  	 	 	 	 	  	 	 	 	 	 	
Interest rate swap lock associated with:	  		  			  				 			  				 				
5.75% Notes due 2011 (1)	  	2001	  	$	2,500	  	$	(58	)	 	$	—  	  	$	(37	)	 	$	(5	)	
4.75% Note due 2006 (2)	  	2001	  	 	2,000	  	 	(48	)	 	 	—  	  	 	—  	 	 	 	(15	)	
Swaps associated with:	  		  			  				 			  				 				
4.75% Notes due 2006 (2)	  	2005	  	 	2,000	  	 	(13	)	 	 	—  	  	 	—  	 	 	 	(13	)	
5.75% Notes due 2011 (1)	  	2005	  	 	500	  	 	(23	)	 	 	—  	  	 	(21	)	 	 	(2	)	
6.8% Notes due 2026 (3)	  	2005	  	 	350	  	 	39	 	 	 	1	  	 	1	 	 	 	—  	 	
5.75% Notes due 2011 (1)	  	2006	  	 	2,000	  	 	(62	)	 	 	—  	  	 	(62	)	 	 	—  	 	
	  		  			  	 	 	 	 	 	 	  	 	 	 	 	 	 	 	
	  		  			  	$	(165	)	 	$	1	  	$	(119	)	 	$	(35	)	

(1)	The underlying 2011 Notes were extinguished in 2006.	

(2)	The underlying 2006 Notes were extinguished in 2005.	

(3)	The underlying 2026 Notes have not been extinguished.	
At December 31, 2007, the Company held interest rate swap contracts with a notional value of $2.6 billion and €1.0 billion ($1.5 billion) and a fair value of a net liability of $24 million. It is estimated that an increase or decrease of 100 and 200 basis points in short-term or long-term interest rates would not have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
The Company had $4,381 million and $7,248 million of long-term debt outstanding at December 31, 2007 and 2006, respectively. For additional information, see “Item 8. Financial Statements—Note 15. Short-Term Borrowings and Long-Term Debt” and “—Note 18. Financial Instruments.”

The Company’s marketable securities at December 31, 2007 consisted of U.S. dollar denominated floating rate securities (FRS), which are primarily ‘AAA/Aaa’ rated. FRS are long long-term debt securities with coupons that are reset periodically against a benchmark interest rate. The underlying assets of the Company’s FRS consist of primarily investment grade corporate bonds and loans. The Company accounts for its marketable securities in accordance with SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities , and classifies them as “available for sale.” The carrying value of FRS was reduced by $25 million, from
 
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$362 million to $337 million at December 31, 2007, reflecting the change in fair market value. The Company assessed this decline in fair market value to be temporary, and recorded a pre-tax $25 million reduction ($16 million net of tax) in shareholders’ equity in accumulated OCI.
In addition, at December 31, 2007, the Company had $811 million of principal invested in auction rate securities (ARS). The ARS held by the Company are private placement securities with long-term nominal maturities for which the interest rates are reset through a dutch auction each month. The monthly auctions historically have provided a liquid market for these securities. The Company’s investments in ARS represent interests in collateralized debt obligations supported by pools of residential and commercial mortgages or credit cards, insurance securitizations and other structured credits, including corporate bonds. Some of the underlying collateral for the ARS held by the Company consists of sub-prime mortgages.
Consistent with the Company’s investment policy guidelines, the ARS investments held by the Company all had AAA/Aaa credit ratings at the time of purchase. With the liquidity issues experienced in global credit and capital markets, the ARS held by the Company at December 31, 2007 have experienced multiple failed auctions as the amount of securities submitted for sale has exceeded the amount of purchase orders. In addition, in the fourth quarter of 2007, $79 million of principal invested in ARS held by the Company were downgraded and others were placed on credit watch. All of these securities retain at least one AAA rating as of December 31, 2007.
The estimated market value of the Company’s ARS holdings at December 31, 2007 was $419 million, which reflects a $392 million adjustment to the principal value of $811 million. Although the ARS continue to pay interest according to their stated terms, based on third-party valuation models and an analysis of other-than-temporary impairment factors, the Company has recorded a pre-tax impairment charge of $275 million in the fourth quarter of 2007, reflecting the portion of ARS holdings that the Company has concluded have an other-than-temporary decline in value. In addition, the Company recorded an unrealized loss of $117 million (pre-tax and net of tax) in accumulated OCI as a reduction in shareholders’ equity, reflecting adjustments to ARS holdings that the Company has concluded have a temporary decline in value. The $275 million impairment charge does not have a material impact on the Company’s liquidity or financial flexibility.
Due to the lack of availability of observable market quotes on the Company’s investment portfolio of marketable securities and ARS, the Company utilizes valuation models including those that are based on expected cash flow streams and collateral values, including assessments of counterparty credit quality, default risk underlying the security, discount rates and overall capital market liquidity. The valuation of the Company’s investment portfolio is subject to uncertainties that are difficult to predict. Factors that may impact the Company’s valuation include changes to credit ratings of the securities as well as to the underlying assets supporting those securities, rates of default of the underlying assets, underlying collateral value, discount rates, counterparty risk and ongoing strength and quality of market credit and liquidity.
The credit and capital markets have continued to deteriorate in 2008. If uncertainties in these markets continue, these markets deteriorate further or the Company experiences any additional ratings downgrades on any investments in its portfolio (including on ARS), the Company may incur additional impairments to its investment portfolio, which could negatively affect the Company’s financial condition, cash flow and reported earnings.
Marketable securities at December 31, 2006 consisted of U.S. dollar-denominated ARS and FRS. The principal values of ARS and FRS were $1,462 million and $466 million, respectively. The Company’s carrying value of ARS and FRS at December 31, 2006 was at principal value, which approximated fair value.
 
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 BRISTOL-MYERS SQUIBB COMPANY
CONSOLIDATED STATEMENTS OF EARNINGS
Dollars and Shares in Millions, Except Per Share Data
 
Item 8.	FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.	

 	  	Year Ended December 31,	 	
 	  	2007	 	 	2006	 	 	2005	 	
EARNINGS	  				 				 				
Net Sales	  	$	19,348	 	 	$	17,256	 	 	$	18,605	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Costs of products sold	  	 	6,218	 	 	 	5,739	 	 	 	5,737	 	
Marketing, selling and administrative	  	 	4,855	 	 	 	4,800	 	 	 	4,989	 	
Advertising and product promotion	  	 	1,465	 	 	 	1,340	 	 	 	1,464	 	
Research and development	  	 	3,282	 	 	 	2,991	 	 	 	2,678	 	
Acquired in-process research and development	  	 	230	 	 	 	—  	 	 	 	—  	 	
Provision for restructuring, net	  	 	183	 	 	 	59	 	 	 	32	 	
Litigation expense, net	  	 	14	 	 	 	302	 	 	 	269	 	
Gain on sale of product assets and businesses	  	 	(273	)	 	 	(200	)	 	 	(569	)	
Equity in net income of affiliates	  	 	(524	)	 	 	(474	)	 	 	(334	)	
Other expense, net	  	 	364	 	 	 	299	 	 	 	35	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Total expenses, net	  	 	15,814	 	 	 	14,856	 	 	 	14,301	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Earnings from Continuing Operations Before Minority Interest and Income Taxes	  	 	3,534	 	 	 	2,400	 	 	 	4,304	 	
Provision for income taxes	  	 	803	 	 	 	538	 	 	 	870	 	
Minority interest, net of taxes	  	 	763	 	 	 	440	 	 	 	592	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Earnings from Continuing Operations	  	 	1,968	 	 	 	1,422	 	 	 	2,842	 	

Discontinued Operations:	  				 				 				
Earnings, net of taxes	  	 	197	 	 	 	163	 	 	 	145	 	
Gain on disposal, net of taxes	  	 	—  	 	 	 	—  	 	 	 	13	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
	  	 	197	 	 	 	163	 	 	 	158	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Earnings	  	$	2,165	 	 	$	1,585	 	 	$	3,000	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Earnings per Common Share	  				 				 				
Basic:	  				 				 				
Net Earnings from Continuing Operations	  	$	1.00	 	 	$	0.73	 	 	$	1.45	 	
Discontinued Operations:	  				 				 				
Earnings, net of taxes	  	 	0.10	 	 	 	0.08	 	 	 	0.07	 	
Gain on disposal, net of taxes	  	 	—  	 	 	 	—  	 	 	 	0.01	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Earnings per Common Share	  	$	1.10	 	 	$	0.81	 	 	$	1.53	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Diluted:	  				 				 				
Net Earnings from Continuing Operations	  	$	0.99	 	 	$	0.73	 	 	$	1.44	 	
Discontinued Operations:	  				 				 				
Earnings, net of taxes	  	 	0.10	 	 	 	0.08	 	 	 	0.07	 	
Gain on disposal, net of taxes	  	 	—  	 	 	 	—  	 	 	 	0.01	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Earnings per Common Share	  	$	1.09	 	 	$	0.81	 	 	$	1.52	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Average Common Shares Outstanding	  				 				 				
Basic	  	 	1,970	 	 	 	1,960	 	 	 	1,952	 	
Diluted	  	 	1,980	 	 	 	1,963	 	 	 	1,983	 	
Dividends declared per common share	  	$	1.15	 	 	$	1.12	 	 	$	1.12	 	
The accompanying notes are an integral part of these financial statements.
 
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 BRISTOL-MYERS SQUIBB COMPANY
CONSOLIDATED STATEMENTS OF COMPREHENSIVE
INCOME AND RETAINED EARNINGS
Dollars in Millions

 	  	Year Ended December 31,	 	
 	  	2007	 	 	2006	 	 	2005	 	
COMPREHENSIVE INCOME	  				 				 				
				
Net Earnings	  	$	2,165	 	 	$	1,585	 	 	$	3,000	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Other Comprehensive Income/(Loss):	  				 				 				
Foreign currency translation, no tax effect in 2007 and 2006 and net of tax liability of $3 in 2005	  	 	99	 	 	 	129	 	 	 	(270	)	
Deferred gains/(losses) on derivatives qualifying as hedges, net of tax benefit of $9 in 2007 and $10 in 2006 and net of tax liability of $122 in 2005	  	 	(14	)	 	 	(39	)	 	 	325	 	
Minimum pension liability adjustment, net of tax liability of $44 in 2006 and net of tax benefit of $4 in 2005	  	 	—  	 	 	 	82	 	 	 	(6	)	
Deferred gains on pension and other postretirement benefits, net of tax liability of $102 in 2007	  	 	238	 	 	 	—  	 	 	 	—  	 	
Deferred gains/(losses) on available for sale securities, net of tax benefit of $19 in 2007, net of tax liability of $6 in 2006 and net of tax benefit of $12 in 2005	  	 	(139	)	 	 	12	 	 	 	(22	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Total Other Comprehensive Income	  	 	184	 	 	 	184	 	 	 	27	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Comprehensive Income	  	$	2,349	 	 	$	1,769	 	 	$	3,027	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
RETAINED EARNINGS	  				 				 				
				
Retained Earnings, January 1	  	$	19,845	 	 	$	20,464	 	 	$	19,651	 	
Cumulative effect of adoption of FIN No. 48	  	 	27	 	 	 	—  	 	 	 	—  	 	
Net earnings	  	 	2,165	 	 	 	1,585	 	 	 	3,000	 	
Cash dividends declared	  	 	(2,275	)	 	 	(2,204	)	 	 	(2,187	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Retained Earnings, December 31	  	$	19,762	 	 	$	19,845	 	 	$	20,464	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
The accompanying notes are an integral part of these financial statements.
 
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 BRISTOL-MYERS SQUIBB COMPANY
CONSOLIDATED BALANCE SHEETS
Dollars in Millions, Except Per Share Data

 	  	December 31,	 	
 	  	2007	 	 	2006	 	
ASSETS	  				 				
Current Assets:	  				 				
Cash and cash equivalents	  	$	1,801	 	 	$	2,018	 	
Marketable securities	  	 	424	 	 	 	1,995	 	
Receivables, net of allowances of $180 and $150	  	 	4,240	 	 	 	3,247	 	
Inventories, net	  	 	2,162	 	 	 	2,079	 	
Deferred income taxes, net of valuation allowances	  	 	851	 	 	 	649	 	
Prepaid expenses	  	 	310	 	 	 	314	 	
Assets held for sale	  	 	560	 	 	 	—  	 	
	  	 	 	 	 	 	 	 	
Total Current Assets	  	 	10,348	 	 	 	10,302	 	
	  	 	 	 	 	 	 	 	
Property, plant and equipment, net	  	 	5,650	 	 	 	5,673	 	
Goodwill	  	 	4,998	 	 	 	4,829	 	
Other intangible assets, net	  	 	1,330	 	 	 	1,852	 	
Deferred income taxes, net of valuation allowances	  	 	2,716	 	 	 	2,577	 	
Other assets	  	 	1,130	 	 	 	342	 	
	  	 	 	 	 	 	 	 	
Total Assets	  	$	26,172	 	 	$	25,575	 	
	  	 	 	 	 	 	 	 	
LIABILITIES	  				 				
			
Current Liabilities:	  				 				
Short-term borrowings	  	$	1,891	 	 	$	187	 	
Accounts payable	  	 	1,442	 	 	 	1,239	 	
Accrued expenses	  	 	2,951	 	 	 	2,332	 	
Deferred income	  	 	447	 	 	 	411	 	
Accrued rebates and returns	  	 	763	 	 	 	823	 	
U.S. and foreign income taxes payable	  	 	296	 	 	 	444	 	
Dividends payable	  	 	614	 	 	 	552	 	
Accrued litigation liabilities	  	 	205	 	 	 	508	 	
Liabilities related to assets held for sale	  	 	35	 	 	 	—  	 	
	  	 	 	 	 	 	 	 	
Total Current Liabilities	  	 	8,644	 	 	 	6,496	 	
	  	 	 	 	 	 	 	 	
Pension liabilities and other postretirement liabilities	  	 	782	 	 	 	942	 	
Deferred income	  	 	714	 	 	 	354	 	
U.S. and foreign income taxes payable	  	 	537	 	 	 	—  	 	
Other liabilities	  	 	552	 	 	 	544	 	
Long-term debt	  	 	4,381	 	 	 	7,248	 	
	  	 	 	 	 	 	 	 	
Total Liabilities	  	 	15,610	 	 	 	15,584	 	
	  	 	 	 	 	 	 	 	
Commitments and contingencies (Note 22)	  				 				
			
STOCKHOLDERS’ EQUITY	  				 				
			
Preferred stock, $2 convertible series: Authorized 10 million shares; issued and outstanding 5,815 in 2007 and 6,001 in 2006, liquidation value of $50 per share	  	 	—  	 	 	 	—  	 	
Common stock, par value of $.10 per share: Authorized 4.5 billion shares; 2.2 billion issued in both 2007 and 2006	  	 	220	 	 	 	220	 	
Capital in excess of par value of stock	  	 	2,722	 	 	 	2,626	 	
Restricted stock	  	 	(97	)	 	 	(128	)	
Accumulated other comprehensive loss	  	 	(1,461	)	 	 	(1,645	)	
Retained earnings	  	 	19,762	 	 	 	19,845	 	
	  	 	 	 	 	 	 	 	
	  	 	21,146	 	 	 	20,918	 	
Less cost of treasury stock — 226 million common shares in 2007 and 238 million in 2006	  	 	(10,584	)	 	 	(10,927	)	
	  	 	 	 	 	 	 	 	
Total Stockholders’ Equity	  	 	10,562	 	 	 	9,991	 	
	  	 	 	 	 	 	 	 	
Total Liabilities and Stockholders’ Equity	  	$	26,172	 	 	$	25,575	 	
	  	 	 	 	 	 	 	 	
The accompanying notes are an integral part of these financial statements.
 
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 BRISTOL-MYERS SQUIBB COMPANY
CONSOLIDATED STATEMENTS OF CASH FLOWS
Dollars in Millions

 	  	Year Ended December 31,	 	
 	  	2007	 	 	2006	 	 	2005	 	
Cash Flows From Operating Activities:	  				 				 				
Net earnings	  	$	2,165	 	 	$	1,585	 	 	$	3,000	 	
Adjustments to reconcile net earnings to net cash provided by operating activities:	  				 				 				
Depreciation	  	 	542	 	 	 	564	 	 	 	577	 	
Amortization	  	 	350	 	 	 	363	 	 	 	352	 	
Deferred income tax benefits	  	 	(416	)	 	 	(236	)	 	 	(812	)	
Litigation settlement expense, net of recoveries	  	 	14	 	 	 	302	 	 	 	269	 	
Stock-based compensation expense	  	 	133	 	 	 	112	 	 	 	—  	 	
Provision for restructuring	  	 	183	 	 	 	59	 	 	 	32	 	
Gain on sale of product asset and businesses	  	 	(273	)	 	 	(207	)	 	 	(632	)	
Deferred income recognized	  	 	—  	 	 	 	—  	 	 	 	(143	)	
Acquired in-process research and development	  	 	230	 	 	 	—  	 	 	 	—  	 	
Impairment charges and asset write-offs	  	 	379	 	 	 	120	 	 	 	42	 	
Loss on disposal of property, plant and equipment and investment in other companies	  	 	50	 	 	 	26	 	 	 	36	 	
Deferred expenses on extinguishment of long-term debt	  	 	—  	 	 	 	62	 	 	 	—  	 	
(Under)/over distribution of earnings from affiliates	  	 	(36	)	 	 	(35	)	 	 	50	 	
Unfunded pension expense	  	 	(10	)	 	 	8	 	 	 	(31	)	
Changes in operating assets and liabilities:	  				 				 				
Receivables	  	 	(461	)	 	 	210	 	 	 	539	 	
Inventories	  	 	(54	)	 	 	78	 	 	 	(370	)	
Prepaid expenses and other assets	  	 	33	 	 	 	(43	)	 	 	38	 	
Litigation settlement payments, net of insurance recoveries	  	 	(318	)	 	 	(272	)	 	 	11	 	
Accounts payable and accrued expenses	  	 	506	 	 	 	(460	)	 	 	(378	)	
Product liability	  	 	(21	)	 	 	(50	)	 	 	(48	)	
U.S. and foreign income taxes payable	  	 	(199	)	 	 	(91	)	 	 	(534	)	
Deferred income and other liabilities	  	 	356	 	 	 	(12	)	 	 	(162	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Cash Provided by Operating Activities	  	 	3,153	 	 	 	2,083	 	 	 	1,836	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Cash Flows From Investing Activities:	  				 				 				
Proceeds from marketable securities	  	 	20,634	 	 	 	31,479	 	 	 	29,532	 	
Purchases of marketable securities	  	 	(19,878	)	 	 	(30,717	)	 	 	(28,489	)	
Additions to property, plant and equipment and capitalized software	  	 	(843	)	 	 	(785	)	 	 	(738	)	
Proceeds from disposal of property, plant and equipment and investment in other companies	  	 	44	 	 	 	10	 	 	 	73	 	
Proceeds from sale of product assets and businesses	  	 	273	 	 	 	226	 	 	 	843	 	
Proceeds from sale and leaseback of properties	  	 	—  	 	 	 	281	 	 	 	—  	 	
Milestone payments	  	 	—  	 	 	 	(280	)	 	 	—  	 	
Purchase of Adnexus Therapeutics, net of cash acquired	  	 	(432	)	 	 	—  	 	 	 	—  	 	
Purchases of other investments	  	 	—  	 	 	 	(8	)	 	 	(30	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Cash (Used in)/Provided by Investing Activities	  	 	(202	)	 	 	206	 	 	 	1,191	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Cash Flows From Financing Activities:	  				 				 				
Short-term (repayments)/borrowings	  	 	(33	)	 	 	30	 	 	 	(1,625	)	
Long-term borrowings	  	 	—  	 	 	 	2,506	 	 	 	2,510	 	
Long-term debt repayments	  	 	(1,300	)	 	 	(3,700	)	 	 	(2,502	)	
Charges on extinguishment of long-term debt	  	 	—  	 	 	 	(158	)	 	 	—  	 	
Issuances of common stock under stock plans and excess tax benefits from share-based payment arrangements	  	 	333	 	 	 	170	 	 	 	166	 	
Dividends paid	  	 	(2,213	)	 	 	(2,199	)	 	 	(2,186	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Net Cash Used in Financing Activities	  	 	(3,213	)	 	 	(3,351	)	 	 	(3,637	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Effect of Exchange Rates on Cash and Cash Equivalents	  	 	45	 	 	 	30	 	 	 	(20	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Decrease in Cash and Cash Equivalents	  	 	(217	)	 	 	(1,032	)	 	 	(630	)	
Cash and Cash Equivalents at Beginning of Period	  	 	2,018	 	 	 	3,050	 	 	 	3,680	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Cash and Cash Equivalents at End of Period	  	$	1,801	 	 	$	2,018	 	 	$	3,050	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
The consolidated statements of cash flows include the activities of the Medical Imaging business.
The accompanying notes are an integral part of these financial statements.
 
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Basis of Consolidation
The consolidated financial statements, prepared in conformity with United States (U.S.) generally accepted accounting principles (GAAP), include the accounts of Bristol-Myers Squibb Company (BMS, the Company or Bristol-Myers Squibb) and all of its controlled majority-owned subsidiaries. All intercompany balances and transactions have been eliminated. Certain prior year amounts have been reclassified to conform to the current year presentation.
Use of Estimates
The preparation of financial statements requires the use of estimates and assumptions, based on complex judgments that are considered reasonable, that affect the reported amounts of assets and liabilities and disclosure of contingent assets and contingent liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The most significant assumptions are employed in estimates used in determining values of intangible assets, restructuring charges and accruals, sales rebate and return accruals, legal contingencies, tax assets and tax liabilities, stock-based compensation costs, retirement and postretirement benefits (including the actuarial assumptions), financial instruments with no observable market quotes, as well as in estimates used in applying the revenue recognition policy. Actual results may or may not differ from estimated results.
Revenue Recognition
The Company recognizes revenue in accordance with Staff Accounting Bulletin (SAB) No. 101, Revenue Recognition in Financial Statements , as amended by SAB No. 104, Revenue Recognition , when title and substantially all the risks and rewards of ownership have transferred to the customer. Generally, revenue is recognized at time of shipment. However, in the case of certain sales made by the Nutritionals and ConvaTec segments and certain non-U.S. businesses within the Pharmaceuticals segment, revenue is recognized on the date of receipt by the purchaser. In accordance with Statements of Financial Accounting Standards (SFAS) No. 48, Revenue Recognition When Right of Return Exists , revenues are reduced at the time of recognition to reflect expected returns that are estimated based on historical experience and business trends. Additionally, in accordance with Emerging Issues Task Force (EITF) Issue No. 01-9, Accounting for Consideration Given by a Vendor to a Customer (Including a Reseller of the Vendor’s Products) , provisions are made at the time of revenue recognition for discounts, rebates and estimated sales allowances based on historical experience updated for changes in facts and circumstances, as appropriate. Such provisions are recorded as a reduction of revenue.
In the case of new products for which the product introduction is not an extension of an existing line of product, where the Company determines that there are not products in a similar therapeutic category, or where the Company determines the new product has dissimilar characteristics with existing products such that the Company cannot reliably estimate expected returns of the new product, the Company defers recognition of revenue until the right of return no longer exists or until the Company has developed sufficient historical experience to estimate sales returns.
Sales Rebate and Return Accruals
Medicaid rebate accruals were $125 million and $137 million at December 31, 2007 and 2006, respectively; Women, Infants and Children (WIC) rebate accruals were $198 million and $230 million at December 31, 2007 and 2006, respectively; sales return accruals were $178 million and $221 million at December 31, 2007 and 2006, respectively; and managed health care rebate and other contractual discount accruals were $134 million and $111 million at December 31, 2007 and 2006, respectively. These and other rebate accruals were established in the same period the related revenue was recognized, resulting in a reduction to sales and the establishment of a liability, which is included in accrued liabilities. An accrual is recorded based on an estimate of the proportion of recorded revenue that will result in a rebate or return. Prime vendor charge-back accruals, established in a similar manner, are recorded as a reduction to accounts receivable and were $70 million and $63 million at December 31, 2007 and 2006, respectively.

Income Taxes
The provision for income taxes has been determined using the asset and liability approach of accounting for income taxes. Under this approach, deferred taxes represent the future tax consequences expected to occur when the reported amounts of assets and liabilities are recovered or paid. The provision for income taxes represents income taxes paid or payable for the current year plus the change in deferred taxes during the year. Deferred taxes result from differences between the financial and tax bases of the Company’s assets and liabilities and are adjusted for changes in tax rates and tax laws when changes are enacted. Valuation allowances are recorded to reduce deferred tax assets when it is more likely than not that a tax benefit will not be realized. The assessment of whether or not a valuation allowance is required often requires significant judgment including the long-range forecast of future taxable income and the evaluation of tax planning initiatives. Adjustments to the deferred tax valuation allowances are made to earnings in the period when such assessments are made. As of December 31, 2007 and 2006, the Company had net deferred tax assets of $3,483 million and $3,154 million, respectively, net of valuation allowances of $1,950 million and $625 million, respectively.
 
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The Company has recorded significant deferred tax assets at December 31, 2007 related to U.S. foreign tax credit carryforwards of approximately $1,140 million, U.S. research tax credit carryforwards of approximately $275 million and charitable contribution carryforwards of $80 million. The charitable contribution carryforwards expire in varying amounts beginning in 2009, while the foreign tax credit and research tax credit carryforwards expire in varying amounts beginning in 2012. The foreign tax credit and research credit have been reduced due to derecognition under Financial Accounting Standards Board (FASB) Interpretation (FIN) No. 48 , Accounting for Uncertainty in Income Taxes – an Interpretation of FASB Statement No. 109 . Realization of these credits and charitable contribution carryforwards is dependent on generating sufficient domestic taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized. The Company anticipates increasing its level of domestic profitability over time by undertaking actions such as its Productivity Transformation Initiative (PTI), increasing its biologics manufacturing capacity in the U.S. and implementing tax planning strategies. While increasing domestic profitability will likely cause the Company’s effective tax rate to increase, it will also further enhance the Company’s ability to utilize its foreign tax credit, research tax credit and charitable contribution carryforwards.
The Company conducts business in various countries throughout the world and is subject to tax in numerous jurisdictions. As a result of its business activities, the Company files a significant number of tax returns that are subject to examination by various Federal, state and local tax authorities. Tax examinations are often complex, as tax authorities may disagree with the treatment of items reported by the Company and may require several years to resolve. The Company establishes liabilities for possible assessments by tax authorities resulting from known tax exposures including, but not limited to, transfer pricing matters, tax credits and deductibility of certain expenses. Such liabilities represent a reasonable provision for taxes ultimately expected to be paid, and may need to be adjusted over time as more information becomes known. The effect of changes in estimates related to contingent tax liabilities is included in the effective tax rate reconciliation in “—Note 8. Income Taxes.”
In July 2006, the FASB issued FIN No. 48, which, in the case of the Company, was effective as of January 1, 2007. FIN No. 48 clarifies the accounting for uncertainty in income taxes recognized in an enterprise’s financial statements in accordance with SFAS No. 109, Accounting for Income Taxes . FIN No. 48 requires that all tax positions be evaluated using a recognition threshold and measurement attribute for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. Differences between tax positions taken in a tax return and amounts recognized in the financial statements are recorded as adjustments to income taxes payable or receivable, or adjustments to deferred taxes, or both. FIN No. 48 also requires expanded disclosure at the end of each reporting period including a tabular reconciliation of unrecognized tax benefits. The Company adopted FIN No. 48 on January 1, 2007. As a result of the adoption of this accounting pronouncement, the Company recognized $27 million of previously unrecognized tax benefits, which was accounted for as an increase to the opening balance of retained earnings. In May 2007, the FASB issued FASB Staff Position (FSP) FIN No. 48-1, Definition of Settlement in FASB Interpretation No. 48 , which is effective retroactively to January 1, 2007. FSP FIN No. 48-1 provides guidance on how to determine whether a tax position is effectively settled for the purpose of recognizing previously unrecognized tax benefits. The adoption of FSP FIN No. 48-1 did not have any effect on the Company’s consolidated financial statements.
As previously reported, upon the adoption of FIN No. 48, the Company’s total amount of uncertain tax benefits as of January 1, 2007, net of deferred income tax benefits, and excluding interest and penalties, was $960 million. In addition, the Company derecognized on adoption $180 million of unrecognized tax benefits, for which there is no tax rate impact when settled. As such, the gross unrecognized tax benefits at January 1, 2007 were $1,140 million.
As of December 31, 2007, the Company had approximately $14.1 billion of undistributed earnings of foreign subsidiaries for which taxes have not been provided as the Company has invested or expects to invest these undistributed earnings permanently offshore. If, in the future, these earnings are repatriated to the U.S., or if the Company determines such earnings will be remitted in the foreseeable future, additional tax provisions would be required. Due to complexities in the tax laws and the assumptions that would have to be made, it is not practicable to estimate the amounts of income taxes that would have to be provided.
Cash and Cash Equivalents
Cash and cash equivalents primarily consist of bank deposits, time deposits and money market funds. Cash equivalents are primarily highly liquid investments with original maturities of three months or less at the time of purchase and are recorded at cost, which approximates fair value. The Company maintains cash and cash equivalent balances in U.S. dollars and foreign currencies which are subject to currency rate risk.
Marketable Securities
The Company accounts for marketable securities in accordance with SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities . The Company determined the appropriate classification of all marketable securities was “available-for-sale” at the time of purchase. As such, at December 31, 2007 and 2006, all of the Company’s investments in marketable securities were reported at fair value. Fair value is determined based on observable market quotes or valuation models using assessments of
 
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counterparty credit worthiness, credit default risk or underlying security and overall capital market liquidity. Declines in fair value that are considered other than temporary are charged to earnings and those that are considered temporary are reported as a component of accumulated other comprehensive income (OCI) in stockholders’ equity. The Company uses the average cost method of determining the cost basis in computing realized gains and losses on the sale of its available-for-sale securities. Realized gains and losses are included in other income (expense).
Inventory Valuation
Inventories are generally stated at average cost, not in excess of market.
Capital Assets and Depreciation
Expenditures for additions, renewals and improvements are capitalized at cost. Depreciation is generally computed on a straight-line method based on the estimated useful lives of the related assets. The estimated useful lives of the major classes of depreciable assets are 50 years for buildings and 3 to 40 years for machinery, equipment and fixtures. The Company periodically evaluates whether current events or circumstances indicate that the carrying value of its depreciable assets may not be recoverable.
Impairment of Long-Lived Assets
The Company periodically evaluates whether current facts or circumstances indicate that the carrying value of its depreciable assets to be held and used may not be recoverable. If such circumstances are determined to exist, an estimate of undiscounted future cash flows produced by the long-lived asset, or the appropriate grouping of assets, is compared to the carrying value to determine whether impairment exists. If an asset is determined to be impaired, the loss is measured based on the difference between the asset’s fair value and its carrying value. An estimate of the asset’s fair value is based on quoted market prices in active markets, if available. If quoted market prices are not available, the estimate of fair value is based on various valuation techniques, including a discounted value of estimated future cash flows. The Company reports an asset to be disposed of at the lower of its carrying value or its estimated net realizable value.
Capitalized Software
Certain costs to obtain internal use software for significant systems projects are capitalized and amortized over the estimated useful life of the software, which ranges from 3 to 10 years. Costs to obtain software for projects that are not significant are expensed as incurred. Capitalized software, net of accumulated amortization, included in other intangible assets, was $248 million and $291 million at December 31, 2007 and 2006, respectively. Amortization expense was $116 million, $124 million and $116 million for the years ended December 31, 2007, 2006 and 2005, respectively.
Investments
The Company accounts for 50% or less-owned companies over which it has the ability to exercise significant influence using the equity method of accounting, otherwise the cost method is used. The Company’s share of net income or losses of equity investments is included in equity in net income of affiliates in the consolidated statement of earnings. Losses are recognized in other income (expense) when a decline in market value is deemed to be other than temporary. The Company reviews its equity investments for impairment based on its determination of whether the decline in market value of the investment below the Company’s carrying value is other than temporary. In making this determination, the Company considers Accounting Principles Board (APB) Opinion No. 18, The Equity Method of Accounting for Investments in Common Stock and related interpretations, which set forth factors to be evaluated in determining whether a loss in value should be recognized, including the Company’s ability to hold its investment, the market price and market price fluctuations of the investment’s publicly traded shares and inability of the investee to sustain an earnings capacity, which would justify the carrying amount of the investment.
Goodwill and Other Intangible Assets
In accordance with SFAS No. 142, Goodwill and Other Intangible Assets , goodwill is tested for impairment annually using a two-step process. The first step is to identify a potential impairment, and the second step measures the amount of the impairment loss, if any. Goodwill is deemed to be impaired if the carrying amount of a reporting unit’s goodwill exceeds its estimated fair value. The Company completed its annual goodwill impairment assessment in the first quarter of 2007 and monitored for any potential impairment in the remaining quarters of 2007, neither of which indicated an impairment of goodwill.

Other intangible assets, consisting of patents, trademarks, technology, licenses, and capitalized software, are amortized on a straight-line basis over their useful lives, ranging from 3 to 17 years. Such intangible assets, other than capitalized software, are deemed to be impaired if their net carrying value exceeds their estimated fair value. Capitalized software is evaluated for impairment as described under “—Impairment of Long-Lived Assets” above.
 
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Restructuring
To streamline operations and rationalize manufacturing facilities, the Company has periodically recorded restructuring charges. As a result, the Company has made estimates and judgments regarding its future plans, including future termination benefits and other exit costs to be incurred when the restructuring actions take place. Actual results may vary from these estimates.
Product Liability
Accruals for product liability (including associated legal costs) are recorded on an undiscounted basis when it is probable that a liability has been incurred and the amount of the liability can be reasonably estimated based on existing information. These accruals are adjusted periodically as assessment efforts progress or as additional information becomes available. Receivables for related insurance or other third-party recoveries for product liabilities are recorded, on an undiscounted basis, when it is probable that a recovery will be realized and are classified as a reduction of litigation charges in the consolidated statement of earnings.
Contingencies
In the normal course of business, the Company is subject to loss contingencies, such as legal proceedings and claims arising out of its business, that cover a wide range of matters, including, among others, government investigations, shareholder lawsuits, product and environmental liability, and tax matters. In accordance with SFAS No. 5, Accounting for Contingencies , the Company records accruals for such loss contingencies when it is probable that a liability will be incurred and the amount of loss can be reasonably estimated. The Company, in accordance with SFAS No. 5, does not recognize gain contingencies until realized. For a discussion of contingencies, see “—Note 8. Income Taxes” and “—Note 22. Legal Proceedings and Contingencies.”
Derivative Financial Instruments
Derivative financial instruments are used by the Company principally in the management of its interest rate and foreign currency exposures. The Company does not hold or issue derivative financial instruments for speculative purposes.
The Company records all derivative instruments on the balance sheet at fair value. Changes in a derivative’s fair value are recognized in earnings unless specific hedge criteria are met. If the derivative is designated as a fair value hedge, the changes in the fair value of the derivative and of the hedged item attributable to the hedged risk are recognized in the consolidated statement of earnings. If the derivative is designated as a cash flow hedge, the effective portions of changes in the fair value of the derivative are recorded in OCI and are subsequently recognized in the consolidated statement of earnings when the hedged item affects earnings; cash flows are classified consistent with the underlying hedged item. For purchased foreign currency options, the entire change in fair value is included in the measurement of hedge effectiveness for cash flow hedges. Ineffective portions of changes in the fair value of cash flow hedges, if any, are recognized as a charge or credit to earnings.
The Company designates and assigns derivatives as hedges of forecasted transactions, specific assets or specific liabilities. When hedged assets or liabilities are sold or extinguished or the forecasted transactions being hedged are no longer expected to occur, the Company immediately recognizes the gain or loss on the designated hedging financial instruments in the consolidated statement of earnings.
Shipping and Handling Costs
The Company typically does not charge customers for shipping and handling costs. Therefore, shipping and handling costs are included in marketing, selling and administrative expenses and were $262 million in 2007, $251 million in 2006 and $230 million in 2005.
Advertising Costs
Advertising costs are expensed as incurred. Advertising expense was $505 million, $474 million and $500 million in 2007, 2006 and 2005, respectively.
 
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Research and Development
Research and development costs are expensed as incurred. The Company from time to time will enter into strategic alliances with third parties, which give the Company rights to develop, manufacture, market and/or sell pharmaceutical products, the rights to which are owned by such third parties. As a result of these alliances, the Company may be obligated to make payments to alliance partners in connection with research and development contingent upon the achievement of certain pre-determined criteria. For milestones achieved prior to regulatory approval of the product, such payments are expensed as research and development. Milestone payments made in connection with regulatory approvals, including non-U.S. regulatory approvals and additional indications, are capitalized and amortized to cost of products sold over the remaining useful life of the asset. All capitalized milestone payments are tested for recoverability periodically or whenever events or changes in circumstances indicate that the carrying amounts may not be recoverable. The Company records research and development, net of reimbursements, in connection with collaboration agreements.
Acquired In-Process Research and Development
The fair value of in-process research and development acquired in a business combination is determined based on the present value of each research project’s projected cash flows. An income approach is utilized that is consistent with guidance in the practice aid issued by the American Institute of Certified Public Accountants, Assets Acquired in Business Combinations to Be Used in Research and Development Activities: A Focus on Software, Electronic Devices and Pharmaceutical Industries . Future cash flows are predominately based on the net income forecast of each project, consistent with historical pricing, margins and expense levels of similar products. Revenues are estimated based on relevant market size and growth factors, expected industry trends, individual project life cycles and the life of each research project’s underlying patent. In determining the fair value of each research project, expected revenues are first adjusted for technical risk of completion. The resulting cash flows are then discounted at a rate approximating the Company’s weighted-average cost of capital. Other acquired in-process research and development is expensed as incurred when the underlying product has not received regulatory approval and does not have any future alternative use. In addition, costs that are nonrefundable, related to the acquisition or licensing of products that have not yet received regulatory approval to be marketed and that have no alternative future use, are charged to earnings as incurred.
Earnings Per Share
Basic earnings per common share are computed using the weighted-average number of shares outstanding during the year. Diluted earnings per common share are computed using the weighted-average number of shares outstanding during the year plus the incremental shares outstanding assuming the exercise of dilutive stock options, restricted stock and convertible instruments.
Foreign Currency Translation
The statements of earnings of the Company’s foreign subsidiaries are translated into U.S. dollars using average exchange rates. The net assets of the Company’s foreign subsidiaries are translated into U.S. dollars using current exchange rates. The U.S. dollar effects that arise from translating the net assets of these subsidiaries at changing rates are recorded in the foreign currency translation adjustment account, which is included in accumulated OCI.
Recently Issued Accounting Standards
At its December 2007 meeting, the FASB ratified the consensus reached by the EITF in issue No. 07-1, Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property . The EITF concluded that a collaborative arrangement is one in which the participants are actively involved and are exposed to significant risks and rewards that depend on the ultimate commercial success of the endeavor. Revenues and costs incurred with third parties in connection with collaborative arrangements would be presented gross or net based on the criteria in EITF 99-19, Reporting Revenue Gross as a Principal versus Net as an Agent , and other accounting literature. Payments to or from collaborators would be evaluated and presented based on the nature of the arrangement and its terms, the nature of the entity’s business, and whether those payments are within the scope of other accounting literature. The nature and purpose of collaborative arrangements are to be disclosed along with the accounting policies and the classification and amounts of significant financial statement amounts related to the arrangements. Activities in the arrangement conducted in a separate legal entity should be accounted for under other accounting literature; however required disclosure under EITF 07-1 applies to the entire collaborative agreement. This Issue is effective for fiscal years beginning after December 15, 2008, and is to be applied retrospectively to all periods presented for all collaborative arrangements existing as of the effective date. The Company is currently in the process of evaluating the impact of adopting this pronouncement.

In December 2007, the FASB issued SFAS No. 141(R), Business Combinations , which replaces SFAS No. 141, Business Combinations , and requires an acquirer to recognize the assets acquired, the liabilities assumed, and any non-controlling interest in the acquiree at the acquisition date, measured at their fair values as of that date, with limited exceptions. This Statement also requires the
 
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acquirer in a business combination achieved in stages to recognize the identifiable assets and liabilities, as well as the non-controlling interest in the acquiree, at the full amounts of their fair values. SFAS No. 141(R) makes various other amendments to authoritative literature intended to provide additional guidance or to confirm the guidance in that literature to that provided in this Statement. This Statement applies to business combinations for which the acquisition date is on or after December 15, 2008. The Company is currently in the process of evaluating the impact of adopting this pronouncement.
In December 2007, FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements—an amendment of ARB No. 51 . SFAS No. 160 establishes accounting and reporting standards that require the ownership interests in subsidiaries held by parties other than the parent to be clearly identified, labeled and presented in the consolidated statement of financial position within equity, but separate from the parent’s equity. This statement also requires the amount of consolidated net income attributable to the parent and to the noncontrolling interest to be clearly identified and presented on the face of the consolidated statement of income. Changes in a parent’s ownership interest while the parent retains its controlling financial interest in its subsidiary must be accounted for consistently, and when a subsidiary is deconsolidated, any retained noncontrolling equity investment in the former subsidiary must be initially measured at fair value. The gain or loss on the deconsolidation of the subsidiary is measured using the fair value of any noncontrolling equity investment. The Statement also requires entities to provide sufficient disclosures that clearly identify and distinguish between the interests of the parent and the interests of the noncontrolling owners. This Statement is effective for fiscal years beginning after December 15, 2008. The Company is currently in the process of evaluating the impact of adopting this pronouncement.
In June 2007, the EITF reached a consensus on Issue No. 07-3, Accounting for Nonrefundable Advance Payments for Goods or Services Received to Be Used in Future Research and Development Activities . Nonrefundable advance payments for goods or services that will be used or rendered for future research and development activities should be deferred and capitalized. Such amounts should be recognized as an expense as the related goods are delivered or the services are performed, or when the goods or services are no longer expected to be provided. This Issue is effective for fiscal years beginning after December 15, 2007, and earlier application is not permitted. The pronouncement is not expected to have a material effect on the Company’s consolidated financial statements.
In February 2007, the FASB issued SFAS No. 159, The Fair Value Option for Financial Assets and Financial Liabilities—Including an amendment of FASB Statement No. 115 , which permits an entity to measure certain financial assets and financial liabilities at fair value. The objective of SFAS No. 159 is to improve financial reporting by allowing entities to mitigate volatility in reported earnings caused by the measurement of related assets and liabilities using different attributes, without having to apply complex hedge accounting provisions. Under SFAS No. 159, entities that elect the fair value option (by instrument) will report unrealized gains and losses in earnings at each subsequent reporting date. The fair value option election is irrevocable, unless a new election date occurs. SFAS No. 159 establishes presentation and disclosure requirements to help financial statement users understand the effect of the entity’s election on its earnings, but does not eliminate disclosure requirements of other accounting standards. Assets and liabilities that are measured at fair value must be displayed on the face of the balance sheet. This Statement is effective for fiscal years beginning after November 15, 2007. The Company did not elect early adoption of this pronouncement as permitted. The adoption of this accounting pronouncement is not expected to have a material effect on the Company’s consolidated financial statements.
In September 2006, the FASB issued Statement SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans—an amendment of FASB Statements No. 87, 88, 106, and 132(R). This pronouncement requires an employer to recognize the overfunded or underfunded status of a defined benefit postretirement plan (other than a multiemployer plan) as an asset or liability in its statement of financial position and to recognize changes in that funded status in the year in which the changes occur through comprehensive income of a business entity. This pronouncement also requires an employer to measure the funded status of a plan as of the date of its year-end statement of financial position, with limited exceptions. The pronouncement does not require prior periods to be restated to reflect the impact of SFAS No. 158. The Company adopted SFAS No. 158 in the fiscal year ended December 31, 2006 and the adoption of this accounting pronouncement resulted in a $1,064 million reduction of accumulated OCI in stockholders’ equity, a $767 million reduction in total assets and a $297 million increase in total liabilities. The adoption of SFAS No. 158 did not impact the Company’s results of operations or cash flows.
In September 2006, the FASB issued SFAS No. 157, Fair Value Measurements. This pronouncement defines fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This Statement is effective for fiscal years beginning after November 15, 2007. On November 14, 2007, the FASB agreed to a one-year deferral for the implementation of SFAS No. 157 for other non-financial assets and liabilities. The adoption of this accounting pronouncement is not expected to have a material effect on the Company’s consolidated financial statements for financial assets and liabilities and any other assets and liabilities carried at fair value. The Company is currently in the process of evaluating the impact of adopting this pronouncement for other non-financial assets or liabilities.
 
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Note 1 ACCOUNTING POLICIES (Continued)
 
In September 2006, the U.S. Securities and Exchange Commission (SEC) issued SAB No. 108, Considering the Effects of Prior Year Misstatements when Quantifying the Misstatements in Current Year Financial Statements, that expresses the staff’s views regarding the process of quantifying financial statement misstatements. This bulletin is effective for any interim period of the first fiscal year ending after November 15, 2006. SAB No. 108 requires that companies utilize a “dual approach” to assess the quantitative effects of financial statement misstatements. The dual approach includes both an income statement focus and balance sheet focus assessment. The adoption of this bulletin did not have any effect on the Company’s consolidated financial statements.
In July 2006, the FASB issued FASB Interpretation (FIN) No. 48, Accounting for Uncertainty in Income Taxes – an interpretation of FASB Statement No. 109, which, in the case of the Company, is effective as of January 1, 2007. FIN No. 48 clarifies the accounting for uncertainty in income taxes recognized in an enterprise’s financial statements in accordance with SFAS No. 109, Accounting for Income Taxes . FIN No. 48 requires that all tax positions be evaluated using a recognition threshold and measurement attribute for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. Differences between tax positions taken in a tax return and amounts recognized in the financial statements are recorded as adjustments to income taxes payable or receivable, or adjustments to deferred taxes, or both. FIN No. 48 also requires expanded disclosure at the end of each reporting period including a tabular reconciliation of unrecognized tax benefits. The Company adopted FIN No. 48 on January 1, 2007. As a result of the adoption of this accounting pronouncement, the Company recognized $27 million of previously unrecognized tax benefits, which was accounted for as an increase to the opening balance of retained earnings. In May 2007, the FASB issued FSP FIN No. 48-1, Definition of Settlement in FASB Interpretation No. 48 , which is effective retroactively to January 1, 2007. FSP FIN No. 48-1 provides guidance on how to determine whether a tax position is effectively settled for the purpose of recognizing previously unrecognized tax benefits. The adoption of FSP FIN No. 48-1 did not have any effect on the Company’s consolidated financial statements.
In March 2006, the FASB issued SFAS No. 156, Accounting for Servicing of Financial Assets – an amendment of FASB Statement No. 140. This pronouncement relates to the accounting for separately recognized servicing assets and servicing liabilities. This Statement is effective for fiscal years beginning after September 15, 2006. The adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
In February 2006, the FASB issued SFAS No. 155, Accounting for Certain Hybrid Financial Instruments, an amendment of FASB Statements No. 133 and 140 . This pronouncement primarily resolves certain issues addressed in the implementation of SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities , concerning beneficial interests in securitized financial assets. The Statement is effective for all financial instruments acquired, issued or subject to a remeasurement event occurring after the beginning of the 2007 fiscal year. The adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
In May 2005, the FASB issued SFAS No. 154, Accounting Changes and Error Corrections—a replacement of APB Opinion No. 20 and FASB Statement No. 3 . This pronouncement applies to all voluntary changes in accounting principle, and revises the requirements for accounting for and reporting a change in accounting principle. SFAS No. 154 requires retrospective application to prior periods’ financial statements of a voluntary change in accounting principle, unless it is impracticable to do so. This pronouncement also requires that a change in the method of depreciation, amortization, or depletion for long-lived, non-financial assets be accounted for as a change in accounting estimate that is effected by a change in accounting principle. SFAS No. 154 is effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. The Statement does not change the transition provisions of any existing accounting pronouncements, including those that are in a transition phase as of the effective date of SFAS No. 154. The adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.
In March 2005, the FASB issued FIN No. 47, Accounting for Conditional Asset Retirement Obligations—an interpretation of FASB Statement No. 143 . FIN No. 47 clarifies that an entity must record a liability for a conditional asset retirement obligation if the fair value of the obligation can be reasonably estimated. Asset retirement obligations covered by FIN No. 47 are those for which an entity has a legal obligation to perform an asset retirement activity, even if the timing and method of settling the obligation are conditional on a future event that may or may not be within the control of the entity. FIN No. 47 also clarifies when an entity would have sufficient information to reasonably estimate the fair value of an asset retirement obligation. This Interpretation was effective no later than the end of fiscal years ending after December 15, 2005. The Company adopted the provisions of FIN No. 47 in the fiscal year ended December 31, 2005, and adoption of this accounting pronouncement did not have a material effect on the Company’s consolidated financial statements.

In December 2004, the FASB issued SFAS No. 123 (revised 2004), Share-Based Payment (SFAS No. 123(R)), which requires the measurement and recognition of compensation expense for all stock-based payment awards made to employees and directors based on estimated fair values. SFAS No. 123(R) supersedes the Company’s previous accounting under APB No. 25, Accounting for Stock Issued to Employees , for periods beginning January 1, 2006. In March 2005, the SEC issued SAB No. 107, Share-Based
 
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Payment , relating to SFAS No. 123(R). The Company has applied the provisions of SAB No. 107 in its adoption of SFAS No. 123(R). The Company adopted SFAS No. 123(R) using the modified prospective transition method, which requires the application of the accounting standard as of January 1, 2006, and has elected the alternative method as provided in FSP No. 123(R)-3, Transition Election Related to Accounting for the Tax Effects of Share-Based Payment Awards , in determining the Company’s pool of excess tax benefits. The Company’s consolidated financial statements for the year ended December 31, 2006 reflect the impact of SFAS No. 123(R). In accordance with the modified prospective transition method, the Company’s consolidated financial statements for prior periods have not been restated to reflect, and do not include, the impact of SFAS No. 123(R). Stock-based compensation expense recognized under SFAS No. 123(R) for the year ended December 31, 2006 was $112 million ($73 million, net of tax) or $0.04 per share, with a corresponding amount recorded in additional paid-in capital within stockholders’ equity. Additionally, $10 million related to performance awards was reclassified from liabilities to stockholders’ equity in connection with the adoption of SFAS No. 123(R).
Note 2 ALLIANCES AND INVESTMENTS
Sanofi-Aventis
The Company has agreements with Sanofi-Aventis (Sanofi) for the codevelopment and cocommercialization of AVAPRO*/AVALIDE* (irbesartan), an angiotensin II receptor antagonist indicated for the treatment of hypertension and diabetic nephropathy, and PLAVIX* (clopidogrel), a platelet aggregation inhibitor. The worldwide alliance operates under the framework of two geographic territories; one in the Americas (principally the U.S., Canada, Puerto Rico and Latin American countries) and Australia and the other in Europe and Asia. Accordingly, two territory partnerships were formed to manage central expenses, such as marketing, research and development and royalties, and to supply finished product to the individual countries. In general, at the country level, agreements either to copromote (whereby a partnership was formed between the parties to sell each brand) or to comarket (whereby the parties operate and sell their brands independently of each other) are in place. The agreements expire on the later of (i) with respect to PLAVIX*, 2013 and, with respect to AVAPRO*/AVALIDE*, 2012 in the Americas and Australia and 2013 in Europe and Asia and (ii) the expiration of all patents and other exclusivity rights in the applicable territory. The Company acts as the operating partner for the territory covering the Americas and Australia and owns a 50.1% majority controlling interest in this territory. Sanofi’s ownership interest in this territory is 49.9%. As such, the Company consolidates all country partnership results for this territory and records Sanofi’s share of the results as a minority interest, net of taxes, which was $746 million in 2007, $428 million in 2006 and $578 million in 2005. The Company recorded sales in this territory and in comarketing countries in the territory covering Europe and Asia of $5,958 million in 2007, $4,355 million in 2006 and $4,805 million in 2005.
Cash flows from operating activities of the partnerships in the territory covering the Americas and Australia are recorded as operating activities within the Company’s consolidated statement of cash flows. Distributions of partnership profits to Sanofi and Sanofi’s funding of ongoing partnership operations occur on a routine basis and are also recorded within operating activities on the Company’s consolidated statement of cash flows.
Sanofi acts as the operating partner of the territory covering Europe and Asia and owns a 50.1% majority financial controlling interest within this territory. The Company’s ownership interest in the partnerships within this territory is 49.9%. The Company accounts for the investment in partnership entities in this territory under the equity method and records its share of the results in equity in net income of affiliates in the consolidated statement of earnings. The Company’s share of net income from these partnership entities before taxes was $526 million in 2007, $439 million in 2006 and $345 million in 2005.
The Company routinely receives distributions of profits and provides funding for the ongoing operations of the partnerships in the territory covering Europe and Asia. These transactions are recorded as operating activities within the Company’s consolidated statement of cash flows.
In 2001, the Company and Sanofi (the Companies) formed an alliance for the copromotion of irbesartan, as part of which the Company contributed the irbesartan distribution rights in the U.S. and Sanofi paid the Company a total of $350 million in the two years ended December 31, 2002. The Company accounted for this transaction as a sale of an interest in a license. The $350 million was deferred and is being amortized to other income over the expected useful life of the license, which is approximately 11 years from the formation of the irbesartan copromotion alliance. The Company recognized other income of $32 million, $31 million and $31 million in 2007, 2006 and 2005, respectively. The unamortized portion of the deferred income is recorded in the liabilities section of the consolidated balance sheet and was $154 million and $186 million as of December 31, 2007 and 2006, respectively.
 
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Note 2 ALLIANCES AND INVESTMENTS (Continued)
 
The following is the summarized financial information for the Company’s equity investments in the partnership with Sanofi for the territory covering Europe and Asia:

Dollars in Millions	  	2007	  	2006	  	2005	
Revenues	  	$	3,090	  	$	2,785	  	$	2,436	
Gross profit	  	 	2,379	  	 	2,156	  	 	1,875	
Net income	  	 	1,070	  	 	942	  	 	709	
Current assets	  	 	1,727	  	 	1,595	  	 	1,398	
Current liabilities	  	 	1,727	  	 	1,595	  	 	1,398	
Otsuka
The Company has a worldwide commercialization agreement with Otsuka Pharmaceutical Co., Ltd. (Otsuka), to codevelop and copromote with Otsuka ABILIFY* (aripiprazole) for the treatment of schizophrenia and related psychiatric disorders, except in Japan, China, Taiwan, North Korea, South Korea, the Philippines, Thailand, Indonesia, Pakistan and Egypt. The product is currently copromoted with Otsuka in the United Kingdom (UK), Germany, France and Spain. In the U.S., Germany and Spain, where the product is invoiced to third-party customers by the Company on behalf of Otsuka, the Company records alliance revenue for its 65% contractual share of third-party net sales and records all expenses related to the product. The Company recognizes this alliance revenue when ABILIFY* is shipped and all risks and rewards of ownership have transferred to third-party customers. In the UK, France and Italy, where the Company is presently the exclusive distributor for the product, the Company records 100% of the net sales and related cost of products sold and expenses. The Company also has an exclusive right to sell ABILIFY* in other countries in Europe, the Americas and a number of countries in Asia. In these countries, the Company records 100% of the net sales and related cost of products sold.
Under the terms of the agreement, the Company purchases the product from Otsuka and performs finish manufacturing for sale by the Company or Otsuka to third-party customers. The agreement expires in November 2012 in the U.S. For the entire European Union, the agreement expires in June 2014. In each other country where the Company has the exclusive right to sell ABILIFY*, the agreement expires on the later of the 10th anniversary of the first commercial sale in such country or expiration of the applicable patent in such country.
The Company recorded total revenue for ABILIFY* of $1,660 million in 2007, $1,282 million in 2006 and $912 million in 2005. Total milestone payments made to Otsuka under the agreement through December 2007 were $217 million, of which $157 million was expensed as acquired in-process research and development in 1999. The remaining $60 million was capitalized in other intangible assets and is amortized in cost of products sold over the remaining life of the agreement in the U.S., ranging from 8 to 11 years. The Company amortized in cost of products sold $6 million in each of 2007, 2006 and 2005. The unamortized capitalized payment balance was $29 million and $35 million as of December 31, 2007 and 2006, respectively.
ImClone
The Company has a commercialization agreement expiring in September 2018 with ImClone Systems Incorporated (ImClone), a biopharmaceutical company focused on developing targeted cancer treatments, for the codevelopment and copromotion of ERBITUX* in the U.S. In 2004, the U.S. Food and Drug Administration (FDA) approved the Biologics License Application for ERBITUX* for use in combination with irinotecan in the treatment of patients with Epidermal Growth Factor Receptor (EGFR)-expressing, metastatic colorectal cancer (mCRC) who are refractory to irinotecan-based chemotherapy and for use as a single agent in the treatment of patients with EGFR-expressing mCRC who are intolerant to irinotecan-based chemotherapy. In March 2006, the FDA approved ERBITUX* for use in the treatment of squamous cell carcinoma of the head and neck in combination with radiation or as monotherapy. The Company paid $250 million as a milestone payment to ImClone for each of the FDA approvals in 2004 and 2006. Under the agreement, ImClone receives a distribution fee based on a flat rate of 39% of net sales in North America. In October 2007, the Company and ImClone amended their codevelopment agreement with Merck KGaA to provide for cocommercialization of ERBITUX* in Japan, which expires in 2032. ImClone has the ability to terminate the agreement after 2018 if they determine that it is commercially unreasonable for them to continue. ERBITUX* is not yet marketed in Japan, although an application has been submitted with the Japanese Pharmaceuticals and Medical Devices Agency for the use of ERBITUX* in treating patients with advanced colorectal cancer.
The Company accounts for the $500 million total approval milestones paid in 2004 and 2006 as license acquisitions, and amortizes the payments into the cost of products sold over the remaining term of the agreement, which ends in 2018. In 2007, 2006 and 2005, the Company amortized into cost of products sold $38 million, $34 million and $17 million, respectively. The unamortized portion of the approval payments is recorded in other intangible assets, and was $397 million and $435 million at December 31, 2007 and 2006, respectively.
 
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Note 2 ALLIANCES AND INVESTMENTS (Continued)
 
The Company accounts for its investment in ImClone under the equity method and records its share of the results in equity in net income of affiliates in the consolidated statement of earnings. The Company’s recorded investment and the market value of its holdings in ImClone common stock was $114 million and approximately $619 million as of December 31, 2007, respectively, and $109 million and approximately $385 million as of December 31, 2006, respectively. The Company holds 14.4 million shares of ImClone stock, representing approximately 17% of ImClone’s shares outstanding at December 31, 2007 and 2006. On a per share basis, the carrying value of the ImClone investment and the closing market price of the ImClone shares as of December 31, 2007 were $7.92 and $43.00, respectively, compared to $7.59 and $26.76, respectively, as of December 31, 2006.
The Company determines its equity share in ImClone’s net income or loss by eliminating from ImClone’s results the milestone revenue ImClone recognizes for the $400 million in pre-approval milestone payments made by the Company from 2001 through 2003. The Company recorded $80 million of the pre-approval milestone payments as an equity investment and expensed the remaining $320 million as acquired in-process research and development during that period. Milestone revenue recognized by ImClone in excess of $400 million is not eliminated by the Company in determining its equity share in ImClone’s results. For its share of ImClone’s results of operations, the Company recorded net income of $7 million in 2007, net income of $43 million in 2006 and a net loss of $5 million in 2005. The Company recorded net sales for ERBITUX* of $692 million in 2007, $652 million in 2006 and $413 million in 2005.
Gilead
In 2004, the Company and Gilead Sciences, Inc. (Gilead) entered into a joint venture to develop and commercialize a fixed-dose combination of the Company’s SUSTIVA (efavirenz) and Gilead’s TRUVADA* (emtricitabine and tenofovir disoproxil fumarate) in the U.S. In July 2006, the FDA granted approval of ATRIPLA* (efavirenz 600 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg) for the treatment of human immunodeficiency virus infection in adults. In September 2006, the companies amended their agreements to commercialize ATRIPLA* in Canada. ATRIPLA* was approved by Health Canada in October 2007 and by the European Commission in December 2007 for commercialization in the 27 countries of the EU, as well as Norway and Iceland.
Gilead records 100% of ATRIPLA* revenues and consolidates the results of the joint venture in its operating results. The Company records revenue for the bulk efavirenz component of ATRIPLA* upon sales of that product by the joint venture with Gilead to third-party customers. The Company’s revenue for the efavirenz component is determined by applying a percentage to ATRIPLA* revenue, which approximates revenue for the SUSTIVA brand. The Company recorded efavirenz revenues of $335 million in 2007 and $76 million in 2006, respectively, related to ATRIPLA* sales. The Company accounts for its participation in the joint venture under the equity method of accounting and records its share of the joint venture results in equity in net income of affiliates in the consolidated statement of earnings. The Company recorded an equity loss on the joint venture with Gilead of $9 million in 2007, $6 million in 2006 and $4 million in 2005.
AstraZeneca
In January 2007, the Company entered into two worldwide (except for Japan) codevelopment and cocommercialization agreements with AstraZeneca PLC (AstraZeneca), one for the codevelopment and cocommercialization of saxagliptin, a DPP-IV inhibitor (Saxagliptin Agreement), and one for the codevelopment and cocommercialization of dapagliflozin, a sodium-glucose contransporter-2 (SGLT2) inhibitor (SGLT2 Agreement). Both compounds are being studied for the treatment of diabetes and were discovered by the Company. Under the terms of the agreements, the Company received from AstraZeneca an upfront payment of $100 million in January 2007, which was deferred and is being recognized over the useful life of the products into other income. The Company amortized into other income $7 million of upfront payments in 2007. The unamortized portion of the upfront payment was $93 million as of December 31, 2007. Milestone payments are expected to be received by the Company upon the successful achievement of various development and regulatory events as well as sales-related milestones. Under the Saxagliptin Agreement, the Company could receive up to $300 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met. Under the SGLT2 Agreement, the Company could receive up to $350 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met. Under each agreement, the Company and AstraZeneca also share in development and commercialization costs. The majority of development costs under the initial development plans through 2009 will be paid by AstraZeneca and any additional development costs will generally be shared equally. The Company records development costs related to saxagliptin and dapagliflozin net of AstraZeneca’s share in research and development expenses. Under each agreement, the two companies will jointly develop the clinical and marketing strategy and share commercialization expenses and profits/losses equally on a global basis, excluding Japan, and the Company will manufacture both products.

Pfizer
        In April 2007, the Company and Pfizer Inc. (Pfizer) entered into a worldwide codevelopment and cocommercialization agreement for apixaban, an anticoagulant discovered by the Company being studied for the prevention and treatment of a broad range of venous and arterial thrombotic conditions. In accordance with the terms of the agreement, Pfizer made an upfront payment of $250
 
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Note 2 ALLIANCES AND INVESTMENTS (Continued)
 
million to the Company in May 2007, which was deferred and is being recognized over the life of the agreement into other income. In December 2007, the Company and Pfizer agreed to include Japan in the worldwide agreement. In connection with the Japan agreement, Pfizer made an additional upfront payment of $40 million in December 2007 which was deferred and is being recognized over the useful life of the product into other income. The Company amortized into other income $11 million of the two upfront payments in 2007. The unamortized portion of the upfront payment is $279 million as of December 31, 2007. Pfizer will fund 60% of all development costs effective January 1, 2007 going forward, and the Company will fund 40%. The Company records apixaban development costs net of Pfizer’s share in research and development expenses. The Company may also receive additional payments of up to $780 million from Pfizer based on development and regulatory milestones. The companies will jointly develop the clinical and marketing strategy, will share commercialization expenses and profits/losses equally on a global basis and will manufacture product under this arrangement.
Note 3 RESTRUCTURING
2007 Activities
In December 2007, the Company announced a three-year plan to fundamentally change the way it runs its business to meet the challenges of a changing business environment and to take advantage of the diverse opportunities in the marketplace as the Company is transformed into a next-generation biopharmaceutical company. With its previously announced PTI, the Company aims to achieve a culture of continuous improvement that will enhance its efficiency, effectiveness and competitiveness and substantially improve its cost base.
During 2007, the Company recorded pre-tax charges of $189 million, relating to the termination benefits and other related costs for workforce reductions of approximately 2,800 manufacturing, selling and administrative personnel across all geographic regions. These charges were offset by $6 million of adjustments reflecting changes in estimates for restructuring actions taken in prior periods.
The following table presents detail of the charges by segment and type. The Company expects to substantially complete these activities by the end of 2008.

Dollars in Millions	  	Termination
Benefits	 	 	Other
Exit Costs	  	Total	 	
Pharmaceuticals	  	$	156	 	 	$	—  	  	$	156	 	
Nutritionals	  	 	3	 	 	 	—  	  	 	3	 	
ConvaTec	  	 	6	 	 	 	—  	  	 	6	 	
Corporate/Other	  	 	23	 	 	 	1	  	 	24	 	
	  	 	 	 	 	 	 	  	 	 	 	
Subtotal	  	 	188	 	 	 	1	  	 	189	 	
Changes in estimates	  	 	(6	)	 	 	—  	  	 	(6	)	
	  	 	 	 	 	 	 	  	 	 	 	
Provision for restructuring, net	  	$	182	 	 	$	1	  	$	183	 	
	  	 	 	 	 	 	 	  	 	 	 	
2006 Activities
During 2006, the Company recorded pre-tax charges of $73 million, relating to the termination benefits and other related costs for workforce reductions of approximately 1,080 selling, operating and administrative personnel primarily in North America, Europe, Asia and Latin America. These charges were decreased by $14 million of adjustments reflecting changes in estimates for restructuring actions taken in prior periods.
The following table presents detail of the charges by segment and type. The Company expects to substantially complete these activities during 2008.

 	  	Termination
Benefits	 	 	Other
Exit Costs	 	 	Total	 	
Dollars in Millions	  	 	 	 	 	 	 	 	 	
Pharmaceuticals	  	$	62	 	 	$	1	 	 	$	63	 	
Nutritionals	  	 	3	 	 	 	1	 	 	 	4	 	
ConvaTec	  	 	6	 	 	 	—  	 	 	 	6	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Subtotal	  	 	71	 	 	 	2	 	 	 	73	 	
Changes in estimates	  	 	(13	)	 	 	(1	)	 	 	(14	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Provision for restructuring, net	  	$	58	 	 	$	1	 	 	$	59	 	

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Note 3 RESTRUCTURING (Continued)
 
2005 Activities
During 2005, the Company recorded pre-tax charges of $33 million, relating to the termination benefits and other related costs for workforce reductions of approximately 640 selling and administrative personnel primarily in North America, Latin America, Europe, Africa and Asia. This charge includes the restructuring of the U.S. cardiovascular/metabolics primary care sales organization. These charges were offset by $1 million of adjustments reflecting changes in estimates for restructuring actions taken in prior periods.
The following table presents detail of the charges by segment and type. The Company substantially completed these restructuring activities in 2006.

Dollars in Millions	  	Termination
Benefits	 	 	Other
Exit Costs	  	Total	 	
Pharmaceuticals	  	$	27	 	 	$	3	  	$	30	 	
Nutritionals	  	 	1	 	 	 	—  	  	 	1	 	
ConvaTec	  	 	2	 	 	 	—  	  	 	2	 	
	  	 	 	 	 	 	 	  	 	 	 	
Subtotal	  	 	30	 	 	 	3	  	 	33	 	
Changes in estimates	  	 	(3	)	 	 	2	  	 	(1	)	
	  	 	 	 	 	 	 	  	 	 	 	
Provision for restructuring, net	  	$	27	 	 	$	5	  	$	32	 	
	  	 	 	 	 	 	 	  	 	 	 	
Restructuring charges and spending against liabilities associated with prior and current actions are as follows:

Dollars in Millions	  	Employee
Termination
Liability	 	 	Other
Exit Cost
Liability	 	 	Total	 	
Balance at January 1, 2005	  	$	78	 	 	$	2	 	 	$	80	 	
Charges	  	 	30	 	 	 	2	 	 	 	32	 	
Spending	  	 	(45	)	 	 	(6	)	 	 	(51	)	
Changes in estimates	  	 	(3	)	 	 	2	 	 	 	(1	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Balance at December 31, 2005	  	 	60	 	 	 	—  	 	 	 	60	 	
Charges	  	 	71	 	 	 	2	 	 	 	73	 	
Spending	  	 	(44	)	 	 	—  	 	 	 	(44	)	
Changes in estimates	  	 	(13	)	 	 	(1	)	 	 	(14	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Balance at December 31, 2006	  	 	74	 	 	 	1	 	 	 	75	 	
Charges	  	 	188	 	 	 	1	 	 	 	189	 	
Spending	  	 	(88	)	 	 	(3	)	 	 	(91	)	
Changes in estimates	  	 	(6	)	 	 	—  	 	 	 	(6	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Balance at December 31, 2007	  	$	168	 	 	$	(1	)	 	$	167	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
In addition to these charges, the Company recorded $110 million, $186 million and $110 million of accelerated depreciation and fixed asset impairment charges primarily related to the rationalization of its manufacturing network in 2007, 2006 and 2005, respectively. These charges were primarily recorded in cost of products sold on the consolidated statement of operations and primarily related to the Pharmaceuticals segment.
Note 4 ACQUISITIONS AND DIVESTITURES
In October 2007, the Company completed the acquisition of Adnexus Therapeutics, Inc. (Adnexus), developer of a new therapeutic class of biologics called ADNECTINS, for a net purchase price of $415 million. In addition, in the event that certain future development and regulatory milestones are achieved, the Company is obligated under the terms of the agreement to pay the former stockholders of Adnexus up to an additional $74 million. The net purchase price for the acquisition was preliminarily allocated to tangible and identifiable intangible assets acquired and liabilities assumed based on their estimated fair values at the acquisition date. Of the $415 million, $230 million was allocated to acquired in-process research and development, which was immediately expensed, and $27 million was assigned to identifiable intangible assets, predominantly related to existing process technology to be used in future discovery. The excess of the purchase price and associated transaction costs over the estimated fair values of net assets acquired was recorded as goodwill. This acquisition was accounted for by the purchase method, and, accordingly, results of operations have been included in the accompanying consolidated financial statements from the date of acquisition. Pro forma supplemental financial information for 2007 is not included as the impact of the business combination is not material.
In July 2007, the Company completed the sale of the BUFFERIN* and EXCEDRIN* brands in Japan, Asia (excluding China and Taiwan) and certain Oceanic countries to Lion Corporation (Japan) for $247 million in cash. As a result of this transaction, the Company recognized a pre-tax gain of $247 million ($144 million net of tax) in the third quarter of 2007.

In January 2006, the Company completed the sale of its inventory, trademark, patent and intellectual property rights in the U.S. related to DOVONEX*, a treatment for psoriasis, to Warner Chilcott Company, Inc. for $200 million in cash. In addition, the Company received a royalty based on 5% of net sales of DOVONEX* through the end of 2007. As a result of this transaction, the Company recognized a pre-tax gain of $200 million ($130 million net of tax) in the first quarter of 2006.
 
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Note 4 ACQUISITIONS AND DIVESTITURES (Continued)
 
In the third quarter of 2005, the Company completed the sale of its U.S. and Canadian Consumer Medicines (Consumer Medicines) business and related assets to Novartis AG (Novartis). Under the terms of the agreement, Novartis acquired the trademarks, patents and intellectual property rights of Consumer Medicines for $661 million in cash, including the impact of a working capital adjustment, of which $15 million is attributable to a post-closing supply arrangement between the Company and Novartis. The related assets include the rights to the U.S. Consumer Medicines brands in Latin America, Europe, the Middle East and Africa. The results of operations of Consumer Medicines are included in the Company’s consolidated statement of earnings up to the date of disposal. As a result of this transaction, the Company recorded a pre-tax gain of $569 million ($370 million net of tax) in the third quarter of 2005.
Note 5 DISCONTINUED OPERATIONS AND ASSETS HELD FOR SALE
In December 2007, the Company entered into a definitive agreement with Avista Capital Partners L.P. (Avista) for the sale of its Medical Imaging business, for a purchase price of approximately $525 million in cash, subject to customary post-closing adjustments. The closing of the transaction was completed on January 7, 2008. The Company expects to recognize a pre-tax gain of approximately $20 million to $40 million ($30 million to $50 million loss net of tax) in the first quarter of 2008, subject to the post-closing adjustments. The results of the Medical Imaging business, which previously were included in the former Other Health Care operating segment, are included in income/(loss) from discontinued operations, net of tax, for all periods presented. The net assets associated with the Medical Imaging business, totaling approximately $483 million, as well as other assets totaling $42 million, have been reclassified to assets held for sale as of December 31, 2007.
For a period of time, the Company will continue to generate cash flows and to report income statement activity in income/(loss) from discontinued operations, net of tax, associated with the Medical Imaging business. The activities that give rise to these cash flows and income statement activities are transitional in nature and generally result from agreements that ensure and facilitate the orderly transfer of business operations. The agreements include services for accounting, customer service, distribution and manufacturing. These activities are not expected to be material to the Company’s results of operations or cash flows. These agreements extend for periods generally less than 24 months, with the majority ranging between 3 to 6 months.
The following assets and liabilities have been segregated and classified as assets held for sale and liabilities related to assets held for sale, as appropriate, in the consolidated balance sheet as of December 31, 2007. These assets and liabilities relate to the Medical Imaging business described above, totaling $483 million, as well as other assets totaling $42 million. The balances as of December 31, 2006 were not reclassified. The amounts presented below were adjusted to exclude cash and intercompany receivables and payables between the business held for sale and the Company, which were excluded from the divestiture. In addition, goodwill at December 31, 2007 of $2 million has been excluded from the following summary of net assets held for sale, which will be considered in determining the gain on sale in 2008.

Dollars in millions	  	December 31, 2007	
Assets	  			
Receivables, net of allowances of $2	  	$	62	
Inventories, net	  	 	20	
Other assets	  	 	31	
Property, plant and equipment, net	  	 	174	
Other intangible assets, net	  	 	273	
	  	 	 	
Total assets held for sale	  	 	560	

Liabilities	  			
Accounts payable	  	 	12	
Accrued liabilities	  	 	23	
	  	 	 	
Total liabilities related to assets held for sale	  	 	35	

Net assets held for sale	  	$	525	
	  	 	 	
In May 2005, the Company completed the sale of Oncology Therapeutics Network (OTN) to One Equity Partners LLC for cash proceeds of $197 million, including the impact of a preliminary working capital adjustment. The Company recorded a pre-tax gain of $63 million ($13 million net of tax), that was presented as a gain on sale of discontinued operations in the consolidated statement of earnings. OTN was previously presented as a separate segment.
 
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Note 5 DISCONTINUED OPERATIONS AND ASSETS HELD FOR SALE (Continued)
 
The following summarized financial information related to the Medical Imaging and OTN businesses have been segregated from continuing operations and reported as discontinued operations through the date of disposition and do not reflect the costs of certain services provided to Medical Imaging and OTN by the Company. Such costs, which were not allocated by the Company to Medical Imaging and OTN, were for services, which included legal counsel, insurance, external audit fees, payroll processing, certain human resource services and information technology systems support.

 	  	Year ended December 31,	
Dollars in Millions	  	2007	  	2006	  	2005	
Net sales	  	$	629	  	$	658	  	$	1,617	
				
Earnings before incomes taxes	  	$	273	  	$	235	  	$	204	
Provision for income taxes	  	 	76	  	 	72	  	 	59	
	  	 	 	  	 	 	  	 	 	
Net earnings from discontinued operations	  	$	197	  	$	163	  	$	145	
	  	 	 	  	 	 	  	 	 	
The consolidated statement of cash flows includes the Medical Imaging and OTN businesses through the date of disposition. The Company uses a centralized approach to the cash management and financing of its operations and accordingly, debt was not allocated to this business.
 
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Note 6 EARNINGS PER SHARE
The numerator for basic earnings per share is net earnings available to common stockholders. The numerator for diluted earnings per share is net earnings available to common stockholders with interest expense added back for the assumed conversion of the convertible debt into common stock. The denominator for basic earnings per share is the weighted-average number of common stock outstanding during the period. The denominator for diluted earnings per share is weighted-average shares outstanding adjusted for the effect of dilutive stock options and assumed conversion of the convertible debt into common stock. The computations for basic and diluted earnings per common share were as follows:

 	  	Year Ended December 31,	
Amounts in Millions, except per share data	  	2007	  	2006	  	2005	
Basic :	  			  			  			
Net Earnings from Continuing Operations	  	$	1,968	  	$	1,422	  	$	2,842	
	  	 	 	  	 	 	  	 	 	
Discontinued Operations	  			  			  			
Earnings, net of taxes	  	 	197	  	 	163	  	 	145	
Gain on disposal, net of taxes	  	 	—  	  	 	—  	  	 	13	
	  	 	 	  	 	 	  	 	 	
Net Earnings	  	$	2,165	  	$	1,585	  	$	3,000	
	  	 	 	  	 	 	  	 	 	
Basic Earnings Per Share :	  			  			  			
Average Common Shares Outstanding – Basic	  	 	1,970	  	 	1,960	  	 	1,952	
				
Net Earnings from Continuing Operations	  	$	1.00	  	$	0.73	  	$	1.45	
	  	 	 	  	 	 	  	 	 	
Discontinued Operations	  			  			  			
Earnings, net of taxes	  	 	0.10	  	 	0.08	  	 	0.07	
Gain on disposal, net of taxes	  	 	—  	  	 	—  	  	 	0.01	
	  	 	 	  	 	 	  	 	 	
Net Earnings per Common Share	  	$	1.10	  	$	0.81	  	$	1.53	
	  	 	 	  	 	 	  	 	 	
Diluted :	  			  			  			
Net Earnings from Continuing Operations	  	$	1,968	  	$	1,422	  	$	2,842	
Interest expense on conversion of convertible debt, net of taxes (a)	  	 	—  	  	 	—  	  	 	22	
	  	 	 	  	 	 	  	 	 	
Net Earnings from Continued Operations used for Diluted Earnings per Common Share Calculation	  	 	1,968	  	 	1,422	  	 	2,864	
Discontinued Operations	  			  			  			
Earnings, net of taxes	  	 	197	  	 	163	  	 	145	
Gain on disposal, net of taxes	  	 	—  	  	 	—  	  	 	13	
	  	 	 	  	 	 	  	 	 	
Net Earnings	  	$	2,165	  	$	1,585	  	$	3,022	
	  	 	 	  	 	 	  	 	 	
Diluted Earnings Per Share :	  			  			  			
Average Common Shares Outstanding	  	 	1,970	  	 	1,960	  	 	1,952	
Conversion of convertible debt (a)	  	 	—  	  	 	—  	  	 	29	
Incremental shares outstanding assuming the exercise/vesting of dilutive stock options/restricted stock	  	 	10	  	 	3	  	 	2	
	  	 	 	  	 	 	  	 	 	
Average Common Shares Outstanding - Diluted	  	 	1,980	  	 	1,963	  	 	1,983	
	  	 	 	  	 	 	  	 	 	
Net Earnings from Continuing Operations	  	$	0.99	  	$	0.73	  	$	1.44	
	  	 	 	  	 	 	  	 	 	
Discontinued Operations	  			  			  			
Earnings, net of taxes	  	 	0.10	  	 	0.08	  	 	0.07	
Gain on disposal, net of taxes	  	 	—  	  	 	—  	  	 	0.01	
	  	 	 	  	 	 	  	 	 	
Net Earnings per Common Share	  	$	1.09	  	$	0.81	  	$	1.52	
	  	 	 	  	 	 	  	 	 	
Weighted-average shares issuable upon the exercise of stock options, which were not included in the diluted earnings per share calculation because they were anti-dilutive, were 107 million in 2007, 164 million in 2006 and 156 million in 2005, respectively.

(a)	In 2007 and 2006, the 29 million weighted-average shares issuable, as well as $38 million and $35 million, respectively, of interest expense, net of tax, on the assumed conversion of convertible debt, were not included in the diluted earnings per share calculation because they were anti-dilutive.	
 
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Note 7 OTHER EXPENSE, NET
The components of other expense, net were as follows:

 	  	Year Ended December 31,	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	
Interest expense	  	$	422	 	 	$	498	 	 	$	349	 	
Interest income	  	 	(241	)	 	 	(274	)	 	 	(148	)	
Foreign exchange transaction losses	  	 	28	 	 	 	6	 	 	 	56	 	
Other, net	  	 	155	 	 	 	69	 	 	 	(222	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
Other expense, net	  	$	364	 	 	$	299	 	 	$	35	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
In 2007, interest expense was increased by net interest swap losses of $13 million. In 2006, interest expense was increased by net interest swap losses of $18 million, and in 2005, interest expense was reduced by net interest swap gains of $54 million. Other, net includes income from third-party contract manufacturing, royalty income and expense, debt retirement costs, impairment of marketable securities, gains and losses on disposal of property, plant and equipment, gains and losses on sale of marketable securities, insurance recoveries, deferred income recognized and certain other litigation matters. See “Item 8. Financial Statements—Note 18. Financial Instruments.” for additional discussion on terminated swap contracts.
Note 8 INCOME TAXES
The components of earnings (loss) from continuing operations before minority interest and income taxes were as follows:

 	  	Year Ended December 31,	
Dollars in Millions	  	2007	  	2006	 	 	2005	
U.S.	  	$	1,047	  	$	(903	)	 	$	632	
Non-U.S.	  	 	2,487	  	 	3,303	 	 	 	3,672	
	  	 	 	  	 	 	 	 	 	 	
	  	$	3,534	  	$	2,400	 	 	$	4,304	
	  	 	 	  	 	 	 	 	 	 	
The above amounts are categorized based on the location of the taxing authorities.
The provision/(benefit) for income taxes attributable to continuing operations consisted of:

 	  	Year Ended December 31,	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	
Current:	  				 				 				
U.S.	  	$	274	 	 	$	82	 	 	$	995	 	
Non-U.S.	  	 	751	 	 	 	693	 	 	 	687	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
	  	 	1,025	 	 	 	775	 	 	 	1,682	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Deferred:	  				 				 				
U.S.	  	 	(162	)	 	 	(204	)	 	 	(852	)	
Non-U.S.	  	 	(60	)	 	 	(33	)	 	 	40	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
	  	 	(222	)	 	 	(237	)	 	 	(812	)	
	  	 	 	 	 	 	 	 	 	 	 	 	
	  	$	803	 	 	$	538	 	 	$	870	 	

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Note 8 INCOME TAXES (Continued)
 
Effective Tax Rate
The Company’s provision for income taxes in 2007, 2006 and 2005 was different from the amount computed by applying the statutory U.S. Federal income tax rate to earnings from continuing operations before minority interest and income taxes, as a result of the following:

 	  	% of Earnings Before Minority Interest and Income Taxes	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	
Earnings from Continuing Operations Before Minority Interest and Income Taxes	  	$	3,534	 	 			 	$	2,400	 	 			 	$	4,304	 	  			
	  	 	 	 	 			 	 	 	 	 			 	 	 	 	  			
U.S. statutory rate	  	 	1,237	 	 	35.0	%	 	 	840	 	 	35.0	%	 	 	1,506	 	  	35.0	%	
Foreign tax effect of operations in Ireland, Puerto Rico and Switzerland	  	 	(492	)	 	(13.9	)%	 	 	(616	)	 	(25.7	)%	 	 	(708	)	  	(16.4	)%	
State and local taxes (net of valuation allowance)	  	 	10	 	 	0.3	%	 	 	42	 	 	1.8	%	 	 	2	 	  	0.1	%	
U.S. Federal & foreign contingent tax matters	  	 	(60	)	 	(1.7	)%	 	 	87	 	 	3.6	%	 	 	114	 	  	2.6	%	
Dividend repatriation under AJCA	  	 	—  	 	 	—  	 	 	 	—  	 	 	—  	 	 	 	(135	)	  	(3.1	)%	
U.S. Federal research tax credit	  	 	(98	)	 	(2.8	)%	 	 	(85	)	 	(3.5	)%	 	 	(63	)	  	(1.5	)%	
Acquired in-process research and development expense	  	 	81	 	 	2.3	%	 	 	—  	 	 	—  	 	 	 	—  	 	  	—  	 	
Impairment of auction rate securities	  	 	96	 	 	2.7	%	 	 	—  	 	 	—  	 	 	 	—  	 	  	—  	 	
U.S. Federal and foreign valuation allowance	  	 	—  	 	 	—  	 	 	 	(24	)	 	(1.0	)%	 	 	32	 	  	0.7	%	
Foreign and other	  	 	29	 	 	0.8	%	 	 	294	 	 	12.2	%	 	 	122	 	  	2.8	%	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	
	  	$	803	 	 	22.7	%	 	$	538	 	 	22.4	%	 	$	870	 	  	20.2	%	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	
The effective income tax rate on earnings from continuing operations before minority interest and income taxes was 22.7% in 2007 compared with 22.4% in 2006 and 20.2% in 2005. The 2007 tax rate was unfavorably impacted by the impairment on the Company’s investment in certain auction rate securities (ARS) with no tax benefit and the non-deductible write-off of acquired in-process research and development expenses related to the acquisition of Adnexus, partially offset by a tax benefit of $105 million in the first quarter of 2007 due to the favorable resolution of certain tax matters with the U.S. Internal Revenues Service (IRS) related to the deductibility of litigation settlement expenses and the impact of foreign tax credits. The effective tax rate for 2006 was unfavorably impacted by the elimination of tax benefits under Section 936 of the Internal Revenue Code, the treatment of provisions for a portion of certain litigation reserves as non-deductible, partially offset by favorable U.S. tax legislation enacted in 2006 related to the tax treatment of certain intercompany transactions amongst the Company’s foreign subsidiaries, and the implementation of tax planning strategies related to the utilization of certain charitable contributions. The increase in the 2006 effective tax rate from 2005 was primarily due to the aforementioned Section 936 benefit elimination, the treatment of provisions for a portion of certain litigation reserves as non-deductible, tax benefits in 2005 associated with the settlement of an IRS examination and a favorable adjustment in 2005 to taxes on special dividends under the American Jobs Creation Act of 2004, partially offset by favorable U.S. tax legislation enacted in 2006 related to the tax treatment of certain intercompany transactions amongst the Company’s foreign subsidiaries, and the implementation of tax planning strategies in 2006 related to the utilization of certain charitable contributions.
 
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Note 8 INCOME TAXES (Continued)
 
Deferred Taxes and Valuation Allowance
The components of current and non-current deferred income tax assets (liabilities) were as follows:

 	  	December 31,	 	
Dollars in Millions	  	2007	 	 	2006	 	
Acquired in-process research and development	  	$	839	 	 	$	891	 	
Intercompany profit and other inventory items	  	 	263	 	 	 	248	 	
U.S. Federal foreign tax credit carryforward	  	 	1,140	 	 	 	1,071	 	
Deferred income	  	 	276	 	 	 	99	 	
U.S. Federal research and development tax credit carryforward	  	 	275	 	 	 	258	 	
U.S. Federal charitable contribution carryforward	  	 	80	 	 	 	40	 	
State net operating loss carryforwards	  	 	451	 	 	 	394	 	
Foreign net operating loss carryforwards	  	 	1,461	 	 	 	196	 	
Other foreign deferred tax assets	  	 	146	 	 	 	120	 	
Pension and postretirement benefits  	  	 	248	 	 	 	403	 	
Depreciation	  	 	(131	)	 	 	(155	)	
Share based compensation	  	 	78	 	 	 	47	 	
Repatriation of foreign earnings	  	 	150	 	 	 	—  	 	
Legal settlements	  	 	47	 	 	 	101	 	
Other, net	  	 	110	 	 	 	66	 	
	  	 	 	 	 	 	 	 	
	  	 	5,433	 	 	 	3,779	 	
Valuation allowance	  	 	(1,950	)	 	 	(625	)	
	  	 	 	 	 	 	 	 	
Deferred tax assets, net	  	$	3,483	 	 	$	3,154	 	
	  	 	 	 	 	 	 	 	
Recognized as:	  				 				
Deferred Income Taxes – Current	  	$	851	 	 	$	649	 	
Deferred Income Taxes – Non-Current	  	 	2,716	 	 	 	2,577	 	
U.S. and Foreign Income Taxes Payable	  	 	(4	)	 	 	(4	)	
Other Liabilities – Non-Current	  	 	(80	)	 	 	(68	)	
	  	 	 	 	 	 	 	 	
Total	  	$	3,483	 	 	$	3,154	 	

The Company has recorded significant deferred tax assets at December 31, 2007 related to U.S. foreign tax credit carryforwards of approximately $1,140 million, U.S. research tax credit carryforwards of approximately $275 million and charitable contribution carryforwards of $80 million. The charitable contribution carryforwards expire in varying amounts beginning in 2009, while the foreign tax credit and research tax credit carryforwards expire in varying amounts beginning in 2012. The foreign tax credit and research tax credit have been reduced due to derecognition under FIN No. 48. Realization of these credits and the charitable contribution carryforwards is dependent on generating sufficient domestic taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized. The Company anticipates increasing its level of domestic profitability over time by undertaking actions such as its PTI, increasing its biologics manufacturing capacity in the U.S. and implementing tax planning strategies. While increasing domestic profitability will likely cause the Company’s effective tax rate to increase, it will also further enhance the Company’s ability to utilize its foreign tax credit, research tax credit and charitable contribution carryforwards.
The Company also recorded deferred tax assets related to foreign net operating loss carryforwards of $1,461 million at December 31, 2007, an increase of $1,265 million compared to $196 million at December 31, 2006, primarily due to an international reorganization of two of the Company’s foreign affiliates. These operating loss carryforwards related to the international reorganization were fully offset by the establishment of a valuation allowance of $1,261 million, reflecting the Company’s view that the loss carryfowards are not expected to be realized.
The valuation allowance of $1,950 million at December 31, 2007 relates to $72 million of state deferred tax assets, $1,448 million of foreign net operating loss and tax credit carryforwards, $426 million of state net operating loss and tax credit carryforwards that the Company believes, more likely than not, will not be realized, and $4 million of state deferred tax assets related to the Adnexus acquisition that was offset against goodwill.
Income taxes paid during the year were $994 million, $741 million and $1,556 million in 2007, 2006 and 2005, respectively.

In October 2007, the Company filed a refund claim with the IRS for the years 2000 and 2001 to carry back foreign tax credits to recover taxes paid in 2000 and 2001. The principal amount of the refund claim is approximately $334 million. In the fourth quarter of 2007, the Company accrued interest income on this refund claim for approximately $45 million, net of federal benefit, which has been reflected in provision for income taxes.
 
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Note 8 INCOME TAXES (Continued)
 
The current tax benefit realized upon the exercise of stock options is credited to capital in excess of par value of stock and amounted to $5 million, $10 million and $19 million in 2007, 2006 and 2005, respectively.
As of December 31, 2007, the Company had approximately $14.1 billion of undistributed earnings of foreign subsidiaries for which taxes have not been provided as the Company has invested or expects to invest these undistributed earnings permanently offshore. If, in the future, these earnings are repatriated to the U.S., or if the Company determines such earnings will be remitted in the foreseeable future, additional tax provisions would be required. Due to complexities in the tax laws and the assumptions that would have to be made, it is not practicable to estimate the amounts of income taxes that would have to be provided.
The Company conducts business in various countries throughout the world and is subject to tax in numerous jurisdictions. As a result of its business activities, the Company files a significant number of tax returns that are subject to examination by various Federal, state and local tax authorities. Tax examinations are often complex, as tax authorities may disagree with the treatment of items reported by the Company and may require several years to resolve. The Company establishes liabilities for possible assessments by tax authorities resulting from known tax exposures including, but not limited to, transfer pricing matters, tax credits and deductibility of certain expenses. Such liabilities represent a reasonable provision for taxes ultimately expected to be paid and may need to be adjusted over time as more information becomes known. The effect of changes in estimates related to contingent tax liabilities is included in the effective tax rate reconciliation above.
The Company adopted the provisions of FIN No. 48 on January 1, 2007, resulting in the recognition of $27 million of previously unrecognized tax benefits which was accounted for as an increase to the opening balance of retained earnings. A reconciliation of the Company’s changes in uncertain tax positions from January 1, 2007 to December 31, 2007 is as follows:

Dollars in Millions	  	Unrecognized
Federal, State
and Foreign
Tax Benefits	 	 	Interest	 	 	Penalties	 	 	Unrecognized
Income Tax Benefits,
Including
Interest and Penalties	 	  	Deferred
Income Tax
Benefits	 	  	Unrecognized
Income Tax Benefits,
Including Interest and Penalties,
Net of Deferred Income
Tax Benefits	 	
Total uncertain tax positions that, if
recognized, would impact the effective
tax rate as of January 1, 2007	  	$	898	 	 	$	72	 	 	$	22	 	 	$	992	 	  	$	(56	)	  	$	936	 	
Add: Tax attributable to deferred tax
items at January 1, 2007	  	 	242	 	 	 	—  	 	 	 	—  	 	 	 	242	 	  	 	—  	 	  	 	242	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Balance, gross uncertain tax positions,
January 1, 2007	  	 	1,140	 	 	 	72	 	 	 	22	 	 	 	1,234	 	  	 	(56	)	  	 	1,178	 	
Gross additions to tax positions related to
current year	  	 	208	 	 	 	—  	 	 	 	1	 	 	 	209	 	  	 	(3	)	  	 	206	 	
Gross reductions to tax positions related to
current year	  	 	(4	)	 	 	—  	 	 	 	—  	 	 	 	(4	)	  	 	—  	 	  	 	(4	)	
Gross additions to tax positions related to
prior years	  	 	193	 	 	 	79	 	 	 	6	 	 	 	278	 	  	 	(27	)	  	 	251	 	
Gross reductions to tax positions related
to prior years	  	 	(253	)	 	 	(20	)	 	 	(1	)	 	 	(274	)	  	 	17	 	  	 	(257	)	
Settlements	  	 	(240	)	 	 	(54	)	 	 	(3	)	 	 	(297	)	  	 	10	 	  	 	(287	)	
Reductions to tax positions related to
lapse of statute	  	 	(1	)	 	 	—  	 	 	 	(1	)	 	 	(2	)	  	 	—  	 	  	 	(2	)	
Cumulative translation adjustment	  	 	15	 	 	 	4	 	 	 	3	 	 	 	22	 	  	 	—  	 	  	 	22	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Balance, gross uncertain tax positions,
December 31, 2007	  	 	1,058	 	 	 	81	 	 	 	27	 	 	 	1,166	 	  	 	(59	)	  	 	1,107	 	
Less: Tax attributable to deferred tax
items at December 31, 2007	  	 	(264	)	 	 	—  	 	 	 	—  	 	 	 	(264	)	  	 	—  	 	  	 	(264	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Total uncertain tax positions that, if
recognized, would impact the effective
tax rate as of December 31, 2007	  	$	794	 	 	$	81	 	 	$	27	 	 	$	902	 	  	$	(59	)	  	$	843	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
The uncertain tax benefits as of December 31, 2007 are recorded against the Company’s deferred tax assets to the extent the uncertainty directly related to that asset; otherwise, they are recorded as either current or non-current income tax payable.

As previously reported, upon the adoption of FIN No. 48, the Company’s total amount of uncertain tax benefits as of January 1, 2007, net of deferred income tax benefits and excluding interest and penalties, was $960 million. In addition, the Company derecognized upon adoption $180 million of unrecognized tax benefits, for which there is no tax rate impact when settled. As such, the gross unrecognized tax benefits at January 1, 2007 were $1,140 million.
 
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Note 8 INCOME TAXES (Continued)
 
Included in the balance of unrecognized tax benefits was $242 million of uncertain tax positions as of January 1, 2007 and $264 million as of December 31, 2007, for which the ultimate deductibility is highly certain but for which there is uncertainty as to the timing of such deductibility. Because of the impact of deferred tax accounting, other than interest and penalties, if applicable, the disallowance of the shorter deductibility period would not affect the annual effective tax rate but would accelerate the payment of cash to the taxing authority or utilization of tax attributes to an earlier period.
The amounts of unrecognized tax benefits that, if recognized, would impact the effective tax rate were $898 million as of January 1, 2007, and $794 million as of December 31, 2007.
The Company classifies interest and penalties related to unrecognized tax benefits as income tax expense. These amounts are reflected separately on the reconciliation above. The total amount of interest and penalties related to uncertain tax positions and recognized in the statement of earnings for 2007 was $59 million for interest and $5 million for penalties. The total amount of interest and penalties related to uncertain tax positions and recognized in the balance sheet as of December 31, 2007 was $81 million for interest and $27 million for penalties.
The Company is currently under examination by a number of tax authorities, including all of the major tax jurisdictions listed in the table below, which have proposed adjustments to tax for issues such as transfer pricing, certain tax credits and the deductibility of certain expenses. The Company estimates that it is reasonably possible that the balance of unrecognized tax benefits as of December 31, 2007 will decrease in the range of approximately $175 million to $215 million in the next twelve months as a result of the anticipated effective settlement of certain tax audits for the jurisdictions listed below. Such settlements will involve the payment of additional taxes, the adjustment of certain deferred taxes and/or the recognition of tax benefits. The Company also anticipates that it is reasonably possible that new issues will be raised by tax authorities who may require increases to the balance of unrecognized tax benefits; however, an estimate of such increases cannot be made. The Company believes that it has adequately provided for all open tax years by tax jurisdiction under FIN No. 48.
The Company files income tax returns in the U.S. Federal jurisdiction and various state and foreign jurisdictions. With few exceptions, the Company is subject to U.S. Federal, state and local, and non-U.S. income tax examinations by tax authorities. The following is a summary of major tax jurisdictions for which tax authorities may assert additional taxes against the Company based upon tax years currently under audit and subsequent years that will likely be audited:

	 	U.S.	 	2002 to 2007	 		
	 	Canada	 	2001 to 2007	 		
	 	France	 	2004 to 2007	 		
	 	Germany	 	1999 to 2007	 		
	 	Italy	 	2002 to 2007	 		
	 	Mexico	 	2002 to 2007	 		
 
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Note 9 CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES
Cash and cash equivalents at December 31, 2007 and 2006 primarily consisted of bank deposits, time deposits and money market funds. Cash equivalents are primarily highly liquid investments with original maturities of three months or less at the time of purchase and are recorded at cost, which approximates fair value. The Company maintains cash and cash equivalent balances in U.S. dollars and foreign currencies which are subject to currency rate risk.
Marketable securities at December 31, 2007 consisted of U.S. dollar-denominated floating rate securities (FRS), which are primarily ‘AAA/Aaa’ rated. FRS are long-term debt securities with coupons that are reset periodically against a benchmark interest rate. The underlying assets of the Company’s FRS consist of primarily investment grade corporate bonds and loans. The Company accounts for its marketable securities in accordance with SFAS 115, Accounting for Certain Investments in Debt and Equity Securities , and classifies them as “available for sale.” The carrying value of FRS was reduced by $25 million, from $362 million to $337 million at December 31, 2007, reflecting the change in fair market value. The Company assessed this decline in fair market value to be temporary, and recorded a pre-tax $25 million reduction ($16 million net of tax) in shareholders’ equity in accumulated OCI.
In addition, at December 31, 2007, the Company had $811 million of principal invested in ARS. The ARS held by the Company are private placement securities with long-term nominal maturities for which the interest rates are reset through a dutch auction each month. The monthly auctions historically have provided a liquid market for these securities. The Company’s investments in ARS represent interests in collateralized debt obligations supported by pools of residential and commercial mortgages or credit cards, insurance securitizations and other structured credits, including corporate bonds. Some of the underlying collateral for the ARS held by the Company consists of sub-prime mortgages.
Consistent with the Company’s investment policy guidelines, the ARS investments held by the Company all had AAA/Aaa credit ratings at the time of purchase. With the liquidity issues experienced in global credit and capital markets, the ARS held by the Company at December 31, 2007 have experienced multiple failed auctions as the amount of securities submitted for sale has exceeded the amount of purchase orders. In addition, in the fourth quarter of 2007, $79 million of principal invested in ARS held by the Company were downgraded and others were placed on credit watch. All of these securities retained at least one AAA rating as of December 31, 2007.
The estimated market value of the Company’s ARS holdings at December 31, 2007 was $419 million, which reflects a $392 million adjustment to the principal value of $811 million. Although the ARS continue to pay interest according to their stated terms, based on valuation models and an analysis of other-than-temporary impairment factors, the Company has recorded a pre-tax impairment charge of $275 million in the fourth quarter of 2007, reflecting the portion of ARS holdings that the Company has concluded have an other-than-temporary decline in value. In addition, the Company recorded an unrealized loss of $117 million (pre-tax and net of tax) in accumulated OCI as a reduction in shareholders’ equity, reflecting adjustments to ARS holdings that the Company has concluded have a temporary decline in value. The $275 million impairment charge does not have a material impact on the Company’s liquidity or financial flexibility.
ARS were classified in prior periods as current assets under marketable securities. Given the failed auctions, the Company’s ARS are illiquid until there is a successful auction for them. Accordingly, the entire amount of such remaining ARS has been reclassified from marketable securities to non-current other assets.
Marketable securities at December 31, 2006 consisted of U.S. dollar-denominated ARS and FRS. The principal values of ARS and FRS were $1,462 million and $466 million, respectively. The Company’s carrying value of ARS and FRS at December 31, 2006 was at principal value, which approximates fair value.
The following tables summarize the Company’s available for sale debt securities at December 31, 2007 and December 31, 2006:

December 31, 2007	  	Cost	  	Fair Value	  	Carrying Value	  	Unrealized Loss
in Accumulated
OCI	 	
Dollars in Millions	  	 	  	 	  	 	  	 	 	
Short-term	  			  			  			  				
Floating rate securities	  	$	362	  	$	337	  	$	337	  	$	(25	)	
Other	  	 	87	  	 	87	  	 	87	  	 	—  	 	
	  	 	 	  	 	 	  	 	 	  	 	 	 	
Total short-term	  	$	449	  	$	424	  	$	424	  	$	(25	)	
	  	 	 	  	 	 	  	 	 	  	 	 	 	
Long-term	  			  			  			  				
Available for sale	  			  			  			  				
Auction rate securities (a)	  	$	811	  	$	419	  	$	419	  	$	(117	)	
	  	 	 	  	 	 	  	 	 	  	 	 	 	
Total long-term	  	$	811	  	$	419	  	$	419	  	$	(117	)	

(a)	The Company recorded a pre-tax other-than-temporary impairment charge of $275 million in earnings at December 31, 2007 related to these securities.	
 
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Note 9 CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES (Continued)

December 31, 2006	  	Cost	  	Fair Value	  	Carrying Value	  	Unrealized Loss in
Accumulated OCI	
Dollars in Millions	  	 	  	 	  	 	  	 	
Short-term	  			  			  			  			
Auction rate securities	  	$	1,462	  	$	1,462	  	$	1,462	  	$	—  	
Floating rate securities	  	 	466	  	 	466	  	 	466	  	 	—  	
Other	  	 	67	  	 	67	  	 	67	  	 	—  	
	  	 	 	  	 	 	  	 	 	  	 	 	
Total short-term	  	$	1,995	  	$	1,995	  	$	1,995	  	$	—  	
	  	 	 	  	 	 	  	 	 	  	 	 	
The contractual maturities of the carrying value of the available-for-sale debt securities as of December 31, 2007, follow:

Dollars in Millions	  	Within 1 Year	  	Over 1 to 5 Years	  	Over 5 to 10
Years	  	Over 10 Years	  	Total	
Available for Sale Debt Securities	  			  			  			  			  			
Floating Rate Securities	  	$	100	  	$	204	  	$	33	  	$	—  	  	$	337	
Auction Rate Securities	  	 	—  	  	 	—  	  	 	201	  	 	218	  	 	419	
Other	  	 	87	  	 	—  	  	 	—  	  	 	—  	  	 	87	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
Total Debt Securities	  	$	187	  	$	204	  	$	234	  	$	218	  	$	843	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
In 2007, 2006 and 2005, the Company purchased $19.9 billion, $30.7 billion and $28.5 billion of debt securities respectively; and sold $20.6 billion, $31.5 billion and $29.5 billion of debt securities, respectively. The purchase and sale value of the debt securities approximated the principal value of the security.
Note 10 RECEIVABLES
The major categories of receivables were as follows:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Trade receivables	  	$	2,805	  	$	2,400	
Miscellaneous receivables	  	 	1,615	  	 	997	
	  	 	 	  	 	 	
	  	 	4,420	  	 	3,397	
Less allowances	  	 	180	  	 	150	
	  	 	 	  	 	 	
Receivables, net	  	$	4,240	  	$	3,247	
	  	 	 	  	 	 	
Miscellaneous receivables for 2007 and 2006 include $824 million and $647 million, respectively, of receivables from alliance partners. Miscellaneous receivables for 2007 also included $472 million of income tax refund claims. For additional information on the Company’s alliance partners, see “—Note 2. Alliances and  Investments.”
Note 11 INVENTORIES
The major categories of inventories were as follows:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Finished goods	  	$	904	  	$	1,003	
Work in process	  	 	834	  	 	682	
Raw and packaging materials	  	 	424	  	 	394	
	  	 	 	  	 	 	
Inventories, net	  	$	2,162	  	$	2,079	

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Note 12 PROPERTY, PLANT AND EQUIPMENT
The major categories of property, plant and equipment were as follows:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Land	  	$	185	  	$	254	
Buildings	  	 	4,696	  	 	4,630	
Machinery, equipment and fixtures	  	 	4,418	  	 	4,540	
Construction in progress	  	 	915	  	 	720	
	  	 	 	  	 	 	
	  	 	10,214	  	 	10,144	
Less accumulated depreciation	  	 	4,564	  	 	4,471	
	  	 	 	  	 	 	
Property, plant and equipment, net	  	$	5,650	  	$	5,673	
	  	 	 	  	 	 	
Capitalized interest is $35 million, $18 million and $9 million in the years ended  December 31, 2007, 2006 and 2005, respectively, and is included in the categories of property, plant and equipment shown above.
Note 13 GOODWILL
The changes in the carrying amount of goodwill for the years ended December 31, 2007 and 2006 were as follows:

Dollars in Millions	  	Pharmaceuticals
Segment	 	 	Nutritionals
Segment	  	ConvaTec
Segment	  	Discontinued
Operations	  	Total	 	
Balance as of January 1, 2006	  	$	4,448	 	 	$	113	  	$	260	  	$	2	  	$	4,823	 	
Adjustments:	  				 			  			  			  				
Reduction due to sale of business	  	 	(1	)	 	 	—  	  	 	—  	  	 	—  	  	 	(1	)	
Purchase price and allocation adjustments	  	 	(2	)	 	 	—  	  	 	9	  	 	—  	  	 	7	 	
	  	 	 	 	 	 	 	  	 	 	  	 	 	  	 	 	 	
Balance as of December 31, 2006	  	 	4,445	 	 	 	113	  	 	269	  	 	2	  	 	4,829	 	
Adjustments:	  				 			  			  			  				
Purchase price and other adjustments	  	 	158	 	 	 	—  	  	 	11	  	 	—  	  	 	169	 	
	  	 	 	 	 	 	 	  	 	 	  	 	 	  	 	 	 	
Balance as of December 31, 2007	  	$	4,603	 	 	$	113	  	$	280	  	$	2	  	$	4,998	 	
	  	 	 	 	 	 	 	  	 	 	  	 	 	  	 	 	 	
Goodwill of $156 million was recorded in 2007 by the Pharmaceuticals segment as a result of the acquisition of Adnexus. The Medical Imaging goodwill of $2 million is reported as discontinued operations and will be written off as part of the pre-tax gain on disposal in 2008. For a discussion of acquisitions, see “—Note 4. Acquisitions  and Divestitures.”
Note 14 OTHER INTANGIBLE ASSETS
As of December 31, 2007 and 2006, other intangible assets consisted of the following:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Patents/Trademarks	  	$	179	  	$	258	
Less accumulated amortization	  	 	99	  	 	145	
	  	 	 	  	 	 	
Patents/Trademarks, net	  	 	80	  	 	113	

Licenses	  	 	663	  	 	659	
Less accumulated amortization	  	 	215	  	 	162	
	  	 	 	  	 	 	
Licenses, net	  	 	448	  	 	497	

Technology	  	 	1,214	  	 	1,787	
Less accumulated amortization	  	 	660	  	 	836	
	  	 	 	  	 	 	
Technology, net	  	 	554	  	 	951	

Capitalized Software	  	 	917	  	 	844	
Less accumulated amortization	  	 	669	  	 	553	
	  	 	 	  	 	 	
Capitalized Software, net	  	 	248	  	 	291	

Total other intangible assets, net	  	$	1,330	  	$	1,852	

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Note 14 OTHER INTANGIBLE ASSETS (Continued)
 
Included in the decrease in patents/trademarks and technology is the $273 million reclassification of Medical Imaging assets to held for sale.
Amortization expense for other intangible assets for the years ended December 31, 2007, 2006 and 2005 was $350 million, $363 million and $352 million, respectively, and includes $65 million, $67 million and $68 million of amortization expense related to Medical Imaging discontinued operations for the years ended December 31, 2007, 2006 and 2005, respectively.
Expected amortization expense related to the current net carrying amount of other intangible assets follows:

Years Ending December 31,	  	Dollars in Millions	
2008	  	$	244	
2009	  	 	226	
2010	  	 	211	
2011	  	 	199	
2012	  	 	156	
Later Years	  	 	294	
Note 15 SHORT-TERM BORROWINGS AND LONG-TERM DEBT
Short-term borrowings at the end of 2007 and 2006 were $1.9 billion and $187 million, respectively. Long-term debt was $4.4 billion at December 31, 2007 compared to $7.2 billion at December 31, 2006.
In 2007, the Company reclassified from long-term debt to short-term borrowings the $108 million of 1.10% Yen Notes, due 2008; the $31 million of 1.43% Yen Notes, due 2008; the $400 million of 4.00% Notes, due 2008, and associated unamortized discount and interest rate swap valuation; and the $1.2 billion of Floating Rate Convertible Debentures, due 2023 (with a 2008 put/call).
In September 2007, the Company repaid the $1.3 billion remaining balance of the five-year tranche of its Floating Rate Bank Term Facility, due 2010.
During the fourth quarter of 2006, the Company restructured its long-term debt by retiring all of its outstanding $2.5 billion, 5.75% Notes due 2011, through a cash tender offer and subsequent redemption and issuing €500 million ($641 million at inception) aggregate principal amount of 4.375% Notes due 2016 and €500 million ($641 million at inception) aggregate principal amount of 4.625% Notes due 2021, as well as $1.25 billion aggregate principal amount of 5.875% Notes due 2036, which resulted in a $220 million pre-tax expense, which are comprised of the items discussed below. The premium paid on the debt tender and make whole was $72 million and $24 million, respectively. In addition, the Company recognized in earnings $12 million of unamortized discount and debt issuance costs associated with the 2011 debt, incurred a pre-tax loss of $62 million related to the termination of the remaining $2.0 billion notional amount of its 2011 fixed-to-floating interest rate swap agreements and recognized in earnings the pre-tax unamortized portion of $18 million from the aforementioned loss incurred on the termination of $500 million notional amount on the 2011 fixed-to-floating interest rate swaps that occurred in June 2005. Furthermore, in November 2006 the Company recognized in earnings from accumulated OCI the pre-tax unamortized portion of $32 million ($21 million net of tax) from the loss incurred on the 2011 settlement of its interest rate lock contracts, which were used to manage its exposure to changes in interest rates for the anticipated issuance of the 2011 long-term fixed rate debt.
In December 2006, the Company replaced its prior $2 billion revolving credit facility with a new $2 billion five-year revolving credit facility from a syndicate of lenders, which is extendable on the anniversary date with the consent of the lenders. This facility contains customary terms and conditions substantially similar to the prior facility, including a financial covenant whereby the ratio of consolidated debt to consolidated capital cannot exceed 50% at the end of each quarter. The Company has been in compliance with this covenant since the inception of this new facility. There were no borrowings outstanding under the revolving credit facility at December 31, 2007. The Company has unused short-term lines of credit and available trade finance facilities with foreign banks of $109 million and $402 million at December 31, 2007 and 2006, respectively.
 
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Note 15 SHORT-TERM BORROWINGS AND LONG-TERM DEBT (Continued)
 
The components of long-term debt were as follows:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Floating Rate Bank Term Facility, due 2010	  	$	—  	  	$	1,300	
5.875% Notes, due 2036	  	 	1,284	  	 	1,238	
Floating Rate Convertible Debentures, due 2023 (1)	  	 	—  	  	 	1,200	
4.375% Euro Notes, due 2016	  	 	688	  	 	645	
4.625% Euro Notes, due 2021	  	 	662	  	 	634	
5.25% Notes, due 2013	  	 	614	  	 	588	
4.00% Notes, due 2008	  	 	—  	  	 	391	
6.80% Debentures, due 2026	  	 	383	  	 	383	
7.15% Debentures, due 2023	  	 	365	  	 	352	
6.88% Debentures, due 2097	  	 	296	  	 	296	
1.10% Yen Notes, due 2008	  	 	—  	  	 	104	
5.75% Industrial Revenue Bonds, due 2024	  	 	34	  	 	34	
1.43% Yen Notes, due 2008	  	 	—  	  	 	30	
1.81% Yen Notes, due 2010	  	 	31	  	 	29	
Variable Rate Industrial Revenue Bonds, due 2030	  	 	15	  	 	15	
Other	  	 	9	  	 	9	
	  	 	 	  	 	 	
	  	$	4,381	  	$	7,248	

(1)	The Company’s outstanding $1.2 billion of convertible debentures pay interest quarterly at an annual rate equal to three-month LIBOR, reset quarterly, minus 0.50% (the yield never to be less than zero) and have a final maturity of September 15, 2023. The debentures are callable at par at any time on or after September 21, 2008 by the issuer. Holders can also redeem some or all of their debentures at par on September 15, 2008, 2013 and 2018, or if a fundamental change in ownership of the Company occurs. The bond has an initial conversion price of $41.28, or a conversion rate of 24.2248 shares, which will be adjustable depending on the average closing prices for the applicable period. The maximum conversion rate is 38.7597 shares.	
The Company has entered into fixed to floating interest rate swaps for $4.1 billion (U.S. dollar value at December 31, 2007) of its long-term debt. In 2006, in conjunction with the new issuance of $1.25 billion 5.875% Notes due 2036 and €1.0 billion Notes ($1.3 billion at inception), the Company executed several fixed to floating interest rate swaps to convert the new fixed rate debt to be paid in 2016, 2021 and 2036 to variable rate debt. For the years ended December 31, 2007 and 2006, the Company realized net increases in interest expense of $13 million and $18 million, respectively, as a result of the higher floating rates obtained in the swap agreements.
In November 2006, in connection with the early retirement of its outstanding $2.5 billion 5.75% Notes due 2011, the Company terminated the remaining $2.0 billion notional amount of its 2011 fixed to floating interest rate swap agreements and incurred a pre-tax loss of $62 million. In April 2005, in connection with the early redemption of its $2.5 billion Notes due 2006, the Company terminated $2 billion notional amount of its 2006 fixed-to-floating interest rate swap agreements and incurred a pre-tax loss of $28 million. In June 2005, the Company terminated $500 million notional amount of its 2011 fixed-to-floating interest rate swap agreements related to its $2.5 billion Notes due 2011 and incurred a pre-tax loss of $23 million. This loss was amortized to interest expense, with $3 million and $2 million recognized in 2006 and 2005, respectively. The remaining loss of $18 million, together with the $62 million loss incurred from the unwind of $2.0 billion swap was fully recognized in 2006. In September 2005, the Company terminated $350 million notional amount of its 2026 fixed-to-floating interest rate swap agreements related to its $350 million Debentures due 2026 at a pre-tax gain of $39 million. This gain will be recognized against interest expense over the remaining life of the Debentures due 2026, of which approximately $1 million, pre-tax, was recognized in 2007 and 2006.
Cash payments for interest, including payments due to interest rate swaps, were $610 million, $682 million and $598 million in 2007, 2006 and 2005, respectively. The Company’s cash receipts from interest rate swaps were $210 million, $205 million and $275 million in 2007, 2006 and 2005, respectively, and were excluded from cash payments for interest.

 	  	Payments due by period	
Dollars in Millions	  	Total	  	2008	  	2009	  	2010	  	2011	  	2012	  	Later
years	
Long-Term Debt (2)	  	$	4,381	  	$	—  	  	$	9	  	$	31	  	$	—  	  	$	—  	  	$	4,341	

(2)	2008 obligations are included in short-term borrowings on the Company’s consolidated balance sheet at December 31, 2007 and all balances approximate the outstanding nominal long-term debt values. The Company’s convertible debenture is included as due for payment in 2008, as it contains a 2008 put and call feature as described above.	
 
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Note 15 SHORT-TERM BORROWINGS AND LONG-TERM DEBT (Continued)
 
At December 31, 2007, the Company had provided a total of $236 million financial guarantees in the form of stand-by letters of credit and performance bonds. The stand-by letters of credit are with insurance companies in support of third-party liability programs. The performance bonds have been issued to support a range of ongoing operating activities, including sale of Company products to hospitals and foreign ministries of health, bonds for customs, duties and value added tax and guarantees related to miscellaneous legal actions. A significant majority of the Company’s  outstanding financial guarantees will expire within the year and are not expected to be funded.
Note 16 STOCKHOLDERS’ EQUITY
Changes in common shares, treasury stock, capital in excess of par value of stock and restricted stock were as follows:

Dollars and Shares in Millions	  	Common Shares
Issued	  	Treasury
Shares	 	 	Cost
of Treasury
Stock	 	 	Capital in Excess
of Par Value
of Stock	 	  	Restricted
Stock	 	
Balance at January 1, 2005	  	2,202	  	255	 	 	$	(11,311	)	 	$	2,491	 	  	$	(57	)	
Issued pursuant to stock plans and options	  	3	  	(7	)	 	 	148	 	 	 	36	 	  	 	(40	)	
Amortization of restricted stock	  	—  	  	—  	 	 	 	—  	 	 	 	—  	 	  	 	22	 	
Lapses and forfeitures of restricted stock	  	—  	  	—  	 	 	 	(5	)	 	 	1	 	  	 	4	 	
	  	 	  	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Balance at December 31, 2005	  	2,205	  	248	 	 	 	(11,168	)	 	 	2,528	 	  	 	(71	)	
	  	 	  	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Issued pursuant to stock plans and options	  	—  	  	(11	)	 	 	262	 	 	 	67	 	  	 	(81	)	
Amortization of restricted stock	  	—  	  	—  	 	 	 	—  	 	 	 	33	 	  	 	1	 	
Lapses and forfeitures of restricted stock	  	—  	  	1	 	 	 	(21	)	 	 	(2	)	  	 	23	 	
	  	 	  	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Balance at December 31, 2006	  	2,205	  	238	 	 	 	(10,927	)	 	 	2,626	 	  	 	(128	)	
	  	 	  	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Issued pursuant to stock plans and options	  	—  	  	(12	)	 	 	359	 	 	 	64	 	  	 	(4	)	
Amortization of restricted stock	  	—  	  	—  	 	 	 	—  	 	 	 	30	 	  	 	22	 	
Lapses and forfeitures of restricted stock	  	—  	  	—  	 	 	 	(16	)	 	 	2	 	  	 	13	 	
	  	 	  	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Balance at December 31, 2007	  	2,205	  	226	 	 	$	(10,584	)	 	$	2,722	 	  	$	(97	)	
	  	 	  	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Each share of the Company’s preferred stock is convertible into 16.96 shares of common stock and is callable at the Company’s option. The reductions in the number of issued shares of preferred stock in 2007, 2006 and 2005 were due to conversions into shares of common stock.
Dividends declared per common share were $1.15 in 2007, $1.12 in 2006 and $1.12 in 2005.
The accumulated balances related to each component of OCI, net of taxes, were as follows:

Dollars in Millions	  	Foreign
Currency
Translation	 	 	Deferred
(Income)/Loss on
Effective Hedges	 	 	Minimum
Pension
Liability
Adjustment	 	 	Deferred Charges
on Pension and
Other
Postretirement
Benefits	 	  	Available for
Sale Securities	 	  	Accumulated
Other
Comprehensive
Income/(Loss)	 	
Balance at January 1, 2005	  	$	(283	)	 	$	(309	)	 	$	(223	)	 	$	—  	 	  	$	23	 	  	$	(792	)	
Other comprehensive income/(loss)	  	 	(270	)	 	 	325	 	 	 	(6	)	 	 	—  	 	  	 	(22	)	  	 	27	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Balance at December 31, 2005	  	 	(553	)	 	 	16	 	 	 	(229	)	 	 	—  	 	  	 	1	 	  	 	(765	)	
Other comprehensive income/(loss)	  	 	129	 	 	 	(39	)	 	 	82	 	 	 	—  	 	  	 	12	 	  	 	184	 	
Adjustments on adoption of SFAS No. 158	  	 	—  	 	 	 	—  	 	 	 	147	 	 	 	(1,211	)	  	 	—  	 	  	 	(1,064	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Balance at December 31, 2006	  	 	(424	)	 	 	(23	)	 	 	—  	 	 	 	(1,211	)	  	 	13	 	  	 	(1,645	)	
Other comprehensive income/(loss)	  	 	99	 	 	 	(14	)	 	 	—  	 	 	 	238	 	  	 	(139	)	  	 	184	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Balance at December 31, 2007	  	$	(325	)	 	$	(37	)	 	$	—  	 	 	$	(973	)	  	$	(126	)	  	$	(1,461	)	

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Note 17 EMPLOYEE STOCK BENEFIT PLANS
Employee Stock Plans
On May 1, 2007, the stockholders approved the Company’s 2007 Stock Award and Incentive Plan (the 2007 Plan). The 2007 Plan replaced the 2002 Stock Incentive Plan (the 2002 Plan) that expired on May 31, 2007. The 2007 Plan provides for 42 million new shares of common stock reserved for delivery to participants, plus shares remaining available for new grants under the 2002 Plan and shares recaptured from outstanding awards under the 2002 Plan. Only the number of shares actually delivered to participants in connection with an award after all restrictions have lapsed will be counted against the number of shares reserved. Shares tendered in a prior year to pay the purchase price of options and the number of shares previously utilized to satisfy withholding tax obligations upon exercise continue to be available and reserved. At December 31, 2007, 352 million shares of common stock were reserved for issuance pursuant to stock plans, options and conversions of preferred stock. There were 98 million and 39 million shares available to be granted for the active plans as of December 31, 2007 and 2006, respectively, adjusted for the combination of plans.
Under the Company’s 2007 Plan and the 2002 Plan, executive officers and key employees may be granted options to purchase the Company’s common stock at no less than 100% of the market price on the date the option is granted. Options generally become exercisable in installments of 25% per year on each of the first through the fourth anniversaries of the grant date and have a maximum term of 10 years. Generally, the Company issues shares for the stock option exercise from treasury stock. Additionally, the plan provides for the granting of stock appreciation rights whereby the grantee may surrender exercisable rights and receive common stock and/or cash measured by the excess of the market price of the common stock over the option exercise price.
The 2007 Plan and the 2002 Plan provide for the granting of common stock to key employees, subject to restrictions as to continuous employment. Restrictions generally expire over a four-year period from date of grant. Compensation expense is recognized over the restricted period. During the first quarter of 2007, the Company began granting restricted stock units instead of restricted stock.
The 2007 Plan and the 2002 Plan also incorporate the Company’s long-term performance awards. These awards, which are delivered in the form of a target number of performance shares, have a three-year cycle. For 2007 to 2009, the awards have annual goals set at the beginning of each performance period and are based 50% on earnings per share and 50% on sales. Maximum performance will result in a maximum payout of 220%. The goals for the 2005 through 2007 and the 2006 through 2008 awards are set for the three-year period and are based 50% on cumulative earnings per share and 50% on cumulative sales, with the ultimate payout modified by the Company’s total stockholder return versus the 11 companies in its proxy peer group. Maximum performance for all three measures will result in a maximum payout of 253% of target. If threshold targets are not met for the performance period, no payment will be made under the plan.
Under the TeamShare Stock Option Plan, which terminated on January 3, 2005, full-time employees, excluding key executives, were granted options to purchase the Company’s common stock at the market price on the date the options were granted. The Company authorized 66 million shares for issuance under the plan. Individual grants generally became exercisable evenly on the third, fourth and fifth anniversary of the grant date and have a maximum term of 10 years. Options on 35.6 million shares have been exercised under the plan as of December 31, 2007.
The Company’s results of operations for the years ended December 31, 2007 and 2006 reflect the impact of SFAS No. 123(R), which includes the impact of the expensing of stock options. The Company has elected the alternative method as provided in FSP No. 123(R)-3 in determining the Company’s pool of excess tax benefits. The results of operations for the year ended December 31, 2005 were not restated to reflect the impact of expensing of stock options and are prepared in accordance with APB No. 25. The following table summarizes stock-based compensation expense, net of tax, related to employee stock options, restricted stock and long-term performance awards for the years ended December 31, 2007, 2006 and 2005:

 	  	Years Ended December 31,	
Dollars in Millions	  	2007	  	2006	  	2005	
Cost of products sold	  	$	13	  	$	11	  	$	—  	
Marketing, selling and administrative	  	 	80	  	 	67	  	 	31	
Research and development	  	 	40	  	 	34	  	 	—  	
	  	 	 	  	 	 	  	 	 	
Total stock-based compensation expense	  	 	133	  	 	112	  	 	31	
Deferred tax benefit	  	 	45	  	 	39	  	 	11	
	  	 	 	  	 	 	  	 	 	
Stock-based compensation, net of tax	  	$	88	  	$	73	  	$	20	

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Note 17 EMPLOYEE STOCK BENEFIT PLANS (Continued)
 
The table below reflects pro forma net income and diluted net income per share for the year ended December 31, 2005:

Dollars in Millions, except per share data	  	Year Ended
December 31,
2005	 	
	  			
Net Earnings:	  				
As reported	  	$	3,000	 	
Total stock-based employee compensation expense, included in reported net earnings, net of related tax effects	  	 	20	 	
Total stock-based employee compensation expense determined under fair value-based method for all awards, net of related tax effects	  	 	(112	)	
	  	 	 	 	
Pro forma	  	$	2,908	 	
	  	 	 	 	
Basic Earnings per Share:	  				
As reported	  	$	1.53	 	
Pro forma	  	 	1.49	 	
Diluted Earnings per Share:	  				
As reported	  	$	1.52	 	
Pro forma	  	 	1.48	 	
Stock Options
A summary of option activities were as follows:

Shares in Millions	  	Shares of Common
Stock Issued
Under Plan	 	 	Weighted-Average
Exercise Price of
Shares	
Balance at January 1, 2005	  	163	 	 	$	38.87	
Granted	  	20	 	 	 	25.37	
Exercised	  	(9	)	 	 	16.26	
Expired or forfeited	  	(10	)	 	 	37.67	
	  	 	 	 			
Balance at December 31, 2005	  	164	 	 	 	38.45	
Granted	  	16	 	 	 	23.18	
Exercised	  	(8	)	 	 	21.00	
Expired or forfeited	  	(9	)	 	 	33.53	
	  	 	 	 			
Balance at December 31, 2006	  	163	 	 	 	38.16	
Granted	  	15	 	 	 	26.31	
Exercised	  	(13	)	 	 	27.02	
Expired or forfeited	  	(17	)	 	 	32.84	
	  	 	 	 			
Balance at December 31, 2007	  	148	 	 	 	38.53	

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Note 17 EMPLOYEE STOCK BENEFIT PLANS (Continued)
 
Information related to stock option grants and exercises under both the 2007 Plan and the 2002 Plan are summarized as follows:

 	  	For the Years Ending December 31,	
Amounts in Millions, except per share data	  	2007	  	2006	  	2005	
Available for stock option awards	  	 	97.7	  	 	39.4	  	 	33.5	
Stock options granted	  	 	15.3	  	 	15.3	  	 	20.2	
Weighted-average grant-date fair value (per share)	  	$	6.56	  	$	4.74	  	$	5.49	
Total intrinsic value of stock options exercised	  	$	37	  	$	17	  	$	69	
Cash proceeds from exercise of stock options	  	$	345	  	$	167	  	$	137	
As of December 31, 2007, there was $104 million of total unrecognized compensation cost related to stock options and is expected to be recognized over a weighted-average period of 2.5 years.
The following tables summarize information concerning the Company’s stock compensation plans and currently outstanding and exercisable options:

Shares in Millions	 	Number of securities to be issued
upon exercise of outstanding
options and rights	 	Weighted-average exercise
price of outstanding
options and rights	 	Number of securities
remaining available for future
issuance under equity
compensation plans excluding
securities reflected in column (a)	
 	 	(a)	 	(b)	 	(c)	
Plan Category	 		 			 		
Equity compensation plans approved by security
holders	 	130	 	$	37.88	 	98	
Equity compensation plans not approved by
security holders  (1)	 	18	 	 	43.22	 	—  	
	 	 	 			 	 	
	 	148	 	 	38.53	 	98	

(1)	Shares under this plan are no longer being issued.	
The following table summarizes significant ranges of outstanding and exercisable options as of December 31, 2007 (amounts in millions, except per share data):

Range of Exercise Prices	  	Number
Outstanding	  	Options Outstanding	  	Aggregate
Intrinsic
Value (in
millions)	  	Number
Exercisable	  	Options Exercisable	
	  		  	Weighted-
Average
Remaining
Contractual
Life (in
Years)	  	Weighted-
Average
Exercise
Price Per
Share	  		  		  	Weighted-
Average
Remaining
Contractual
Life (in
Years)	  	Weighted-
Average
Exercise
Price Per
Share	  	Aggregate
Intrinsic
Value (in
millions)	
$1   - $20	  	1	  	9.16	  	$	4.33	  	$	12	  	—  	  	8.60	  	$	1.36	  	$	—  	
$20 - $30	  	78	  	6.94	  	 	25.67	  	 	109	  	45	  	5.97	  	 	25.63	  	 	71	
$30 - $40	  	—  	  	8.38	  	 	30.90	  	 	—  	  	—  	  	4.42	  	 	30.15	  	 	—  	
$40 - $50	  	40	  	1.78	  	 	47.04	  	 	—  	  	40	  	1.78	  	 	47.04	  	 	—  	
$50 - $60	  	12	  	2.99	  	 	58.19	  	 	—  	  	11	  	2.96	  	 	58.06	  	 	—  	
$60 and up	  	17	  	1.48	  	 	63.30	  	 	—  	  	17	  	1.48	  	 	63.30	  	 	—  	
	  	 	  		  			  	 	 	  	 	  		  			  	 	 	
	  	148	  	4.58	  	 	38.53	  	$	121	  	113	  	3.50	  	 	42.21	  	$	71	

Vested or expected to vest	  	146	  	4.53	  	 	38.69	  	$	118	  		  		  			  			
The aggregate intrinsic value in the preceding table represents the total pre-tax intrinsic value, based on the Company’s closing stock price of $26.52 on December 31, 2007, which would have been received by the option holders had all option holders exercised their options as of that date. The total number of in-the-money options exercisable as of December 31, 2007 was 28 million. As of December 31, 2006, 123 million outstanding options were exercisable and the weighted-average exercise price was $42.03.
 
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Note 17 EMPLOYEE STOCK BENEFIT PLANS (Continued)
 
The fair value of employee stock options granted in 2007 were estimated on the date of the grant and, prior to January 1, 2006, were estimated using a weighted-average estimated per option value granted, using the Black-Scholes option pricing model with the following assumptions:

 	  	2007	 	 	2006	 	 	2005	 	
Expected volatility	  	28.9	%	 	26.7	%	 	29.4	%	
Risk-free interest rate	  	4.7	%	 	4.6	%	 	4.4	%	
Dividend yield	  	4.5	%	 	4.8	%	 	4.6	%	
Expected life	  	6.2 yrs	 	 	6.3 yrs	 	 	7.0 yrs	 	
The Company derived the expected volatility assumption required in the Black-Scholes model by calculating a 10-year historical volatility and weighting that equally against the derived implied volatility, consistent with SFAS No. 123(R) and SAB No. 107. Prior to 2006, the Company had used its historical stock price volatility in accordance with SFAS No. 123 for purposes of its pro forma information. The selection of the blended historical and implied volatility approach was based on the Company’s assessment that this calculation of expected volatility is more representative of future stock price trends than using only historical volatility.
The risk-free interest rate assumption is based upon the U.S. Treasury yield curve in effect at the time of grant. The dividend yield assumption is based on the Company’s history and expectation of dividend payouts.
The expected life of employee stock options represents the weighted-average period the stock options are expected to remain outstanding and is a derived output of the lattice-binomial model. The expected life of employee stock options is impacted by all of the underlying assumptions and calibration of the Company’s model. The lattice-binomial model assumes that employees’ exercise behavior is a function of the option’s remaining vested life and the extent to which the option is in-the-money. The lattice-binomial model estimates the probability of exercise as a function of these two variables based on the entire history of exercises and cancellations on all past option grants made by the Company.
Prior to 2006, the Company used an option-pricing model to indirectly estimate the expected life of the stock options. The expected life and expected volatility of the stock options were based upon historical and other economic data trended into the future. Forfeitures of employee stock options were accounted for on an as-incurred basis.
As stock-based compensation expense recognized in the consolidated statement of earnings for the 12 months ended December 31, 2007 and 2006 is based on awards ultimately expected to vest, it has been reduced for estimated forfeitures. SFAS No. 123(R) requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. Forfeitures were estimated based on historical experience. In the Company’s pro forma information required under SFAS No. 123 for the periods prior to 2006, the Company accounted for forfeitures as they occurred.
The Company acquired Adnexus on October 19, 2007. As part of the acquisition agreement, the Company assumed 24 million shares of Adnexus incentive stock options (ISOs) and replaced them with 0.6 million shares of Company ISOs. The converted options retain their original vesting schedules, including the vesting commencement date, as well as the expiration date. A Black-Scholes model was used to determine the expected term and the individual ISOs valuations. The result was a weighted-average expected term of 5.2 years and a weighted-average fair value on October 19, 2007 of $20.34.
 
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Note 17 EMPLOYEE STOCK BENEFIT PLANS (Continued)
 
Restricted Stock Awards and Restricted Stock Units
The fair value of nonvested shares of the Company’s common stock is determined based on the average trading price of the Company’s common stock on the grant date.
Restricted share activities were as follows:

Shares in Thousands	  	Number of Shares	 	 	Weighted-Average
Grant-Date Fair Value	
Nonvested shares at January 1, 2005	  	2,945	 	 	$	31.12	
Granted	  	1,786	 	 	 	24.61	
Vested	  	(375	)	 	 	38.56	
Forfeited	  	(194	)	 	 	31.37	
	  	 	 	 			
Nonvested shares at December 31, 2005	  	4,162	 	 	 	27.36	
Granted	  	4,295	 	 	 	23.45	
Vested	  	(645	)	 	 	32.48	
Forfeited	  	(921	)	 	 	26.64	
	  	 	 	 			
Nonvested shares at December 31, 2006	  	6,891	 	 	 	24.58	
Granted	  	3,584	 	 	 	27.14	
Vested	  	(1,360	)	 	 	25.51	
Forfeited	  	(892	)	 	 	25.13	
	  	 	 	 			
Nonvested shares at December 31, 2007	  	8,223	 	 	 	25.48	

Expected to vest	  	7,772	 	 	 	25.48	
As of December 31, 2007 and 2006, there was $145 million and $126 million, respectively, of total unrecognized compensation cost related to nonvested restricted stock and restricted stock units. That cost is expected to be recognized over a weighted-average period of 2.6 years for the balance at December 31, 2007 and 2.75 years for the balance at December 31, 2006. The total cost of non-vested shares and share units granted that was recognized as compensation expense during the twelve months ended December 31, 2007, 2006 and 2005 was $53 million, $34 million and $27 million, respectively. The total fair value of shares and share units that vested during the 12 months ended December 31, 2007, 2006 and 2005 was $35 million, $21 million and $14 million, respectively.
Performance Awards
Prior to the adoption of SFAS No. 123(R), compensation expense related to performance awards was determined based on the market price of the Company’s stock at the time of the award applied to the expected number of shares contingently issuable (up to 100%) and was amortized over the three-year performance cycle.
Since the adoption of SFAS No. 123(R), the fair value of the 2006 through 2008 performance award was estimated on the date of grant using a Monte Carlo simulation model due to a market condition. The Monte Carlo simulation model utilizes multiple input variables that determine the probability of satisfying each market condition stipulated in the award grant and calculates the fair market value for the long-term performance awards. For the 2007 through 2009 performance award, because the award does not contain a market condition, the fair value was based on the closing trading price of the Company’s common stock on the grant date.
The valuation model for the 2006 through 2008 award used the following assumptions:

Grant Year	  	Grant Date	  	Weighted-Average
Expected Volatility	 	 	Expected
Dividend Yield	 	 	Risk-Free
Interest Rate	 	
2006	  	3/7/2006	  	20.4	%	 	4.9	%	 	4.4	%	
Weighted-average expected volatility is based on the three-year historical volatility levels on the Company’s common stock. Expected dividend yield is based on historical dividend payments. Risk-free interest rate reflects the yield on five-year zero coupon U.S. Treasury bonds, based on the performance shares’ contractual term. The fair value of the performance awards is amortized over the performance period of the award.
 
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Note 17 EMPLOYEE STOCK BENEFIT PLANS (Continued)
 
Information related to performance awards under both the 2007 Plan and the 2002 Plan is summarized as follows:

Shares in Thousands	  	Performance Cycle
Measurement Date	  	Shares Granted	  	Weighted-Average
Grant Date Fair Value	  	Performance Shares Outstanding	
Grant Date	  		  		  		  	December 31, 2007	  	December 31, 2006	
3/2/04	  	12/31/06	  	456	  	$	28.11	  	—  	  	417	
3/1/05	  	12/31/07	  	1,087	  	 	25.45	  	830	  	894	
3/7/06	  	12/31/08	  	640	  	 	20.00	  	415	  	461	
3/6/07	  	Annually on 12/31	  	219	  	 	27.01	  	209	  	—  	
5/1/07	  	Annually on 12/31	  	57	  	 	28.68	  	57	  	—  	
	  		  		  			  	 	  	 	
Total outstanding	  		  		  			  	1,511	  	1,772	
	  		  		  			  	 	  	 	
At December 31, 2007 and 2006, there was $11 million and $2 million, respectively, of total unrecognized compensation cost related to the performance share plan, which is expected to be recognized over a weighted-average period of 1.8 years and 2.0 years, respectively.
Accuracy of Fair Value Estimates
The Company’s determination of fair value of stock-based payment awards on the date of grant using an option-pricing model is affected by the Company’s stock price, as well as assumptions regarding a number of highly complex and subjective variables. These variables include, but are not limited to the Company’s expected stock price volatility over the term of the awards and actual and projected employee stock option exercise behaviors. Option-pricing models were developed for use in estimating the value of traded options that have no vesting or hedging restrictions and are fully transferable. Because the Company’s employee stock options have certain characteristics that are significantly different from traded options, and because changes in the subjective assumptions can materially affect the estimated value, in management’s opinion, the existing valuation models may not provide an accurate measure of the fair value of the Company’s employee stock options. Although the fair value of employee stock options is determined in accordance with SFAS No. 123(R) and SAB 107 using an option-pricing model, that value may not be indicative of the fair value observed in a willing buyer/willing seller market transaction.
The Company adopted SFAS No. 123(R), which requires the measurement and recognition of compensation expense for all stock-based payment awards made to employees and directors based on estimated fair values. SFAS No. 123(R) supersedes the Company’s previous accounting under APB No. 25 for periods beginning January 1, 2006. In March 2005, the SEC issued SAB No. 107 relating to SFAS No. 123(R). The Company has applied the provisions of SAB No. 107 in its adoption of SFAS No. 123(R).
The Company adopted SFAS No. 123(R) using the modified prospective transition method, which requires the application of the accounting standard as of January 1, 2006, and has elected the alternative method as provided in FSP No. 123(R)-3 in determining the Company’s pool of excess tax benefits. The Company’s consolidated financial statements for the year ended December 31, 2006 reflect the impact of SFAS No. 123(R). In accordance with the modified prospective transition method, the Company’s consolidated financial statements for prior periods have not been restated to reflect, and do not include, the impact of SFAS No. 123(R). Stock-based compensation expense recognized under SFAS No. 123(R) for the years ended December 31, 2007 and 2006 was $133 million and $112 million, respectively, ($88 million and $73 million, net of tax, respectively) or $0.04 per share and $0.04 per share, respectively, with a corresponding amount recorded in additional paid-in capital within stockholders’ equity. Additionally, in 2006, $10 million related to performance awards was reclassified from liabilities to stockholders’ equity in connection with the adoption of SFAS No. 123(R).
 
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Note 18 FINANCIAL INSTRUMENTS
The Company is exposed to market risk due to changes in currency exchange rates and interest rates. To reduce that risk, the Company enters into certain derivative financial instruments, when available on a cost-effective basis, to hedge its underlying economic exposure. These instruments are managed on a consolidated basis to efficiently net exposures and thus take advantage of any natural offsets. Derivative financial instruments are not used for speculative purposes.
The Company’s primary net foreign currency translation exposures are the Euro, Canadian dollar, Japanese yen, Mexican peso and Chinese renminbi.
The Company utilizes foreign currency contracts to hedge anticipated transactions, primarily intercompany transactions, on certain foreign currencies and designates these derivative instruments as foreign currency cash flow hedges when appropriate. The notional amounts of the Company’s foreign exchange derivative contracts at December 31, 2007 and 2006 were $1,656 million and $1,585 million, respectively. For these derivatives, in which the majority qualify as hedges of future anticipated cash flows, the effective portion of changes in fair value is temporarily deferred in accumulated OCI and then recognized in earnings when the hedged item affects earnings.
The table below summarizes the Company’s outstanding foreign exchange forward contracts as of December 31, 2007. The fair value of all foreign exchange forward contracts is based on year-end currency rates. The fair value of foreign exchange forward contracts should be viewed in relation to the fair value of the underlying hedged transactions and the overall reduction in exposure to adverse fluctuations in foreign currency exchange rates.

Dollars in Millions, except currency rates	  	Weighted-Average
Strike Price	  	Notional Amount	  	Fair Value
Asset/(Liability)	 	 	Maturity	
Foreign Exchange Forwards:	  		  			  				 		
Cash Flow Hedges	  		  			  				 		
Australian Dollar	  	0.80	  	$	72	  	$	(6	)	 	2008	
British Pound	  	2.01	  	 	79	  	 	1	 	 	2008	
Canadian Dollar	  	1.08	  	 	130	  	 	(12	)	 	2008	
Euro	  	1.36	  	 	636	  	 	(43	)	 	2008	
Japanese Yen	  	107.62	  	 	159	  	 	3	 	 	2008	
Mexican Peso	  	10.95	  	 	54	  	 	1	 	 	2008	
Polish Zloty	  	2.53	  	 	18	  	 	—  	 	 	2008	
Swedish Krona	  	6.48	  	 	47	  	 	—  	 	 	2008	
Swiss Franc	  	1.16	  	 	30	  	 	—  	 	 	2008	
	  		  	 	 	  	 	 	 	 		
Total Cash Flow Hedges	  		  	 	1,225	  	 	(56	)	 		

Non-Qualifying Hedges (1)	  		  			  				 		
Australian Dollar	  	0.90	  	 	71	  	 	3	 	 	2008	
British Pound	  	2.06	  	 	41	  	 	2	 	 	2008	
Canadian Dollar	  	0.95	  	 	131	  	 	6	 	 	2008	
Euro	  	1.45	  	 	13	  	 	(1	)	 	2008	
Japanese Yen	  	106.78	  	 	71	  	 	2	 	 	2008	
Polish Zloty	  	2.53	  	 	61	  	 	(1	)	 	2008	
Turkish Lira	  	1.27	  	 	43	  	 	(2	)	 	2008	
	  		  	 	 	  	 	 	 	 		
Total Non-Qualifying Hedges	  		  	 	431	  	 	9	 	 		

Total Contracts	  		  	$	1,656	  	$	(47	)	 		

(1)	Non-qualifying hedges are hedges that do not qualify for hedge accounting treatment as prescribed by SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities.	
At December 31, 2007, the Company held foreign exchange option contracts to buy and sell Japanese Yen. The total notional and fair market value for buy contracts is $145 million and $1 million, respectively, which are fully offset by the total notional and fair market value for sell contracts of $145 million and $1 million, respectively.
During 2007, 2006 and 2005, the Company reclassified pre-tax deferred losses of $56 million, $18 million and $130 million, respectively, from accumulated OCI to earnings, the majority of which was classified as cost of products sold. As of December 31, 2007, the balance of deferred losses on foreign exchange forward contracts included in accumulated OCI on a pre-tax basis was $54 million ($37 million net of tax), all of which is expected to be reclassified into earnings within the next 12 months.
 
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Note 18 FINANCIAL INSTRUMENTS (Continued)
 
SFAS No.133 requires that the Company perform periodic assessments of hedge effectiveness. These assessments determine whether derivatives designated as qualifying hedges continue to be highly effective in offsetting changes in the cash flows of hedged items. Any ineffective portion of fair value can no longer be deferred in accumulated OCI and is included in current period earnings. For the years ended December 31, 2007 and 2006, the impact of hedge ineffectiveness on earnings was not significant. Additionally, for the years ended December 31, 2007 and 2006, the impact of discontinued hedges was a pre-tax loss of $12 million and a pre-tax loss of $10 million, respectively. Furthermore, the Company uses foreign exchange forward contracts to offset its exposure to certain currency assets and liabilities and earnings denominated in certain foreign currencies. These foreign exchange forward contracts are not designated as hedges and, therefore, changes in the fair value of these derivatives are recognized in earnings as other income, net, as they occur. The notional and fair value amounts of foreign exchange forward contracts at December 31, 2007 are described in the table above. There were no foreign exchange forward contracts of this type outstanding at December 31, 2006. In 2007, the impact of foreign exchange forward contracts that are not designated as hedges was a pre-tax gain of $4 million. In 2006 and 2005, the amounts recognized in earnings related to these types of foreign exchange forward contracts that did not qualify for hedge accounting treatment were not significant.
The fair value of forward contracts was a net liability of $47 million at December 31, 2007, of which $16 million was recorded as a non-current asset and $63 million was recorded as a current liability. The fair value of forward contracts was a net liability of $33 million at December 31, 2006, of which $18 million was recorded as a non-current asset and $51 million was recorded as a current liability. The fair value of all foreign exchange contracts is based on year-end currency rates (and the Black-Scholes model in the case of option contracts).
In addition to the foreign exchange hedge contracts noted above, the Company utilizes forward contracts to hedge foreign currency-denominated monetary assets and liabilities. The primary objective of these forward contracts is to protect the U.S. dollar value of foreign currency-denominated monetary assets and liabilities from the effects of volatility in foreign exchange rates that might occur prior to their receipt or settlement in U.S. dollars. These foreign currency-denominated monetary assets and liabilities are primarily denominated in Euro. The forward contracts are not designated as hedges and are marked to market through other expense, net. The notional and fair value amount of purchased foreign exchange forward contracts was not material at December 31, 2007, and $24 million and a $1 million asset, respectively, at December 31, 2006. There were no notional and fair value amounts of sold foreign exchange forward contracts at December 31, 2007, and $22 million and a $1 million liability, respectively, at December 31, 2006.
The Company also uses non-U.S. dollar borrowings, primarily the €500 Million Notes due 2016 and the €500 Million Notes due 2021, to hedge the foreign currency exposures of the Company’s net investment in certain foreign affiliates. These non-U.S. dollar borrowings are designated as hedges of net investments. The effective portion of foreign exchange gains or losses on these hedges is recorded as part of the foreign currency translation component of accumulated OCI. At December 31, 2007 and 2006, $168 million and $27 million in losses, respectively, were recorded in the foreign currency translation component of accumulated OCI.
The Company had unhedged exposures to net foreign currency-denominated assets and liabilities of approximately $1.9 billion and $1.6 billion at December 31, 2007 and 2006, respectively, primarily in Mexico, Japan, the UK, China, Australia and Canada.
The Company uses derivative instruments as part of its interest rate risk management strategy. The derivative instruments used are comprised principally of fixed to floating rate interest rate swaps, which are subject to fair-value hedge accounting treatment. In November 2006, in connection with the funding of the retirement of the 2011 fixed rate debt, the Company executed several fixed to floating interest rate swaps to convert $1.3 billion and €1 billion ($1.3 billion at inception) of the Company’s newly-issued fixed rate debt to be paid in 2016, 2021 and 2036 to variable rate debt. The total notional amounts of outstanding interest rate swaps were $2.6 billion and €1 billion ($1.5 billion) as of December 31, 2007 and $2.6 billion and €1 billion ($1.3 billion) as of December 31, 2006. In accordance with SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities , the Company recognized a net increase in interest expense of $13 million and $18 million in 2007 and 2006, respectively, and a net reduction in interest expense of $54 million in 2005 from the impact of interest rate swaps.
The swap contracts, as well as the underlying debt being hedged, are recorded at fair value, which resulted in an increase in non-current assets of $72 million, current liabilities of $96 million and a reduction in long-term debt of $24 million at December 31, 2007; and an increase in non-current assets of $7 million, current liabilities of $57 million and a reduction in long-term debt of $50 million at December 31, 2006. Swap contracts are generally held to maturity and are intended to create an appropriate balance of fixed and floating rate debt for the Company. Swap contracts that qualify as fair value hedges that are terminated prior to their maturity dates are reported as part of the carrying value of the underlying debt and are amortized to earnings over the remaining life of the debt. Swap contracts that qualify as cash flow hedges that are terminated are reported in accumulated OCI and amortized to earnings over the remaining life of the debt. The following tables summarize the interest rate swaps outstanding as of December 31, 2007 and 2006 the earnings impact from terminated interest rate swap contracts for 2007, 2006 and 2005:
 
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Note 18 FINANCIAL INSTRUMENTS (Continued)
 
Interest Rate Swaps Outstanding

Interest Rate Contracts	  	Notional
Amount of
Underlying
Debt	  	Variable Rate
Received	  	Year of
Transaction	  	Maturity	  	Fair
Value	 	
Dollars in Millions	  	 	  	 	  	 	  	 	  	 	 	
Swaps associated with:	  			  		  		  		  				
4.00% Notes due 2008	  	$	400	  	1 month U.S. $  LIBOR +0.35%	  	2003	  	2008	  	$	(2	)	
5.25% Notes due 2013	  	 	600	  	1 month U.S. $  LIBOR +0.42%	  	2003	  	2013	  	 	16	 	
4.375% €500 Million Notes due 2016	  	 	725	  	3 month EUR € EURIBOR +0.40%	  	2006	  	2016	  	 	(37	)	
4.625% €500 Million Notes due 2021	  	 	725	  	3 month EUR € EURIBOR +0.56%	  	2006	  	2021	  	 	(57	)	
7.15% Notes due 2023	  	 	350	  	1 month U.S. $  LIBOR +1.66%	  	2004	  	2023	  	 	20	 	
5.875% Notes due 2036	  	 	1,250	  	1 month U.S. $  LIBOR +0.62%	  	2006	  	2036	  	 	36	 	
	  	 	 	  		  		  		  	 	 	 	
	  	$	4,050	  		  		  		  	$	(24	)	
	  	 	 	  		  		  		  	 	 	 	
Earnings Impact from Terminated Interest Rate Swap Contracts

   	  	Year of
Termination	  	Notional
Amount of
Underlying
Debt	  	Total Pre-Tax
Deferred
Gain/(Loss)	 	 	Pre-Tax Income/(Expense)
Recognized	 	
   	  		  		  			 	2007	  	2006	 	 	2005	 	
Interest Rate Contracts	  	 	  	 	  	 	 	 	 	  	 	 	 	 	 	
Dollars in Millions	  	 	  	 	  	 	 	 	 	  	 	 	 	 	 	
Interest rate swap lock associated with:	  		  			  				 			  				 				
5.75% Notes due 2011 (1)	  	2001	  	$	2,500	  	$	(58	)	 	$	—  	  	$	(37	)	 	$	(5	)	
4.75% Note due 2006 (2)	  	2001	  	 	2,000	  	 	(48	)	 	 	—  	  	 	—  	 	 	 	(15	)	
Swaps associated with:	  		  			  				 			  				 				
4.75% Notes due 2006 (2)	  	2005	  	 	2,000	  	 	(13	)	 	 	—  	  	 	—  	 	 	 	(13	)	
5.75% Notes due 2011 (1)	  	2005	  	 	500	  	 	(23	)	 	 	—  	  	 	(21	)	 	 	(2	)	
6.8% Notes due 2026 (3)	  	2005	  	 	350	  	 	39	 	 	 	1	  	 	1	 	 	 	—  	 	
5.75% Notes due 2011 (1)	  	2006	  	 	2,000	  	 	(62	)	 	 	—  	  	 	(62	)	 	 	—  	 	
	  		  			  	 	 	 	 	 	 	  	 	 	 	 	 	 	 	
	  		  			  	$	(165	)	 	$	1	  	$	(119	)	 	$	(35	)	

(1)	The underlying 2011 Notes were extinguished in 2006.	

(2)	The underlying 2006 Notes were extinguished in 2005.	

(3)	The underlying 2026 Notes have not been extinguished.	
The carrying amount of the Company’s other financial instruments, which includes cash, cash equivalents, accounts receivable and accounts payable, approximates their fair value at December 31, 2007 and 2006. For a discussion on cash, cash equivalents and marketable securities, see “—Note 9. Cash, Cash Equivalents and Marketable Securities” above. For long-term debt, the difference between the fair value and carrying value is not material.
Note 19 SEGMENT INFORMATION
The Company is organized in three reportable segments—Pharmaceuticals, Nutritionals and ConvaTec. The Pharmaceuticals segment is comprised of the global pharmaceutical and international consumer medicines businesses. The Nutritionals segment consists of Mead Johnson, primarily an infant formula business and children’s nutritional business. The ConvaTec segment consists of the ostomy, wound and skin care business.
        In December 2007, the Company entered into a definitive agreement with Avista for the sale of its Medical Imaging business. The closing of the transaction was completed in January 2008. The results of the Medical Imaging business, which previously was included in the former Other Health Care operating segment, are included in income from discontinued operations, net of tax, for all periods. The net assets associated with the Medical Imaging business, totaling approximately $483 million, as well as other assets totaling $42 million, have been reclassified to assets held for sale as of December 31, 2007 and are included in Corporate/Other below. In May 2005, the Company completed the sale of OTN to One Equity Partners LLC. The results of OTN, which previously was presented as a separate operating segment, are included in income from discontinued operations, net of tax, for the year ended December 31, 2005. The results of both the Medical Imaging business and OTN are not included in the tables below.
In the third quarter of 2005, the Company completed the sale of its Consumer Medicines business, which is included in the Pharmaceuticals operating segment. For additional information on the sale of Consumer Medicines, see “—Note 4. Acquisitions and Divestitures.”
 
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Note 19 SEGMENT INFORMATION (Continued)
 
The Company’s products are sold principally to the wholesale and retail trade, both nationally and internationally. Certain products are also sold to other drug manufacturers, hospitals, clinics, government agencies and the medical profession. Three wholesalers accounted for approximately 19%, 16% and 12%, respectively, of the Company’s total net sales in 2007. In 2006, sales to these wholesalers accounted for approximately 19%, 16% and 11%, respectively, of the Company’s total net sales. In 2005, the same three wholesalers accounted for 21%, 18% and 12%, respectively, of the Company’s total net sales. These sales were concentrated in the Pharmaceuticals segment.

 	  	Net Sales	  	Earnings From Continuing Operations
Before Minority Interest and Income Taxes	 	  	Year-end Assets	
Dollars in Millions	  	2007	  	2006	  	2005	  	2007	 	  	2006	 	  	2005	 	  	2007	  	2006	
Pharmaceuticals	  	$	15,622	  	$	13,861	  	$	15,408	  	$	3,471	 	  	$	2,569	 	  	$	3,739	 	  	$	12,549	  	$	11,644	
									
Nutritionals	  	 	2,571	  	 	2,347	  	 	2,205	  	 	708	 	  	 	696	 	  	 	677	 	  	 	1,274	  	 	1,167	
ConvaTec	  	 	1,155	  	 	1,048	  	 	992	  	 	348	 	  	 	315	 	  	 	288	 	  	 	715	  	 	666	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	  	 	 	
Health Care Group	  	 	3,726	  	 	3,395	  	 	3,197	  	 	1,056	 	  	 	1,011	 	  	 	965	 	  	 	1,989	  	 	1,833	

Total segments	  	 	19,348	  	 	17,256	  	 	18,605	  	 	4,527	 	  	 	3,580	 	  	 	4,704	 	  	 	14,538	  	 	13,477	
Corporate/Other	  	 	—  	  	 	—  	  	 	—  	  	 	(993	)	  	 	(1,180	)	  	 	(400	)	  	 	11,634	  	 	12,098	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	  	 	 	
Total	  	$	19,348	  	$	17,256	  	$	18,605	  	$	3,534	 	  	$	2,400	 	  	$	4,304	 	  	$	26,172	  	$	25,575	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	 	  	 	 	 	  	 	 	  	 	 	
Net sales of the Company’s key products were as follows:

Dollars in Millions	  	Sales by Products	
	  	2007	  	2006	  	2005	
Pharmaceuticals	  			  			  			
PLAVIX*	  	$	4,755	  	$	3,257	  	$	3,823	
AVAPRO*/AVALIDE*	  	 	1,204	  	 	1,097	  	 	982	
PRAVACHOL	  	 	443	  	 	1,197	  	 	2,256	
COUMADIN	  	 	201	  	 	220	  	 	212	
REYATAZ	  	 	1,124	  	 	931	  	 	696	
SUSTIVA Franchise (total revenue)	  	 	956	  	 	791	  	 	680	
BARACLUDE	  	 	275	  	 	83	  	 	12	
ERBITUX*	  	 	692	  	 	652	  	 	413	
TAXOL ® (paclitaxel)	  	 	422	  	 	563	  	 	747	
SPRYCEL	  	 	158	  	 	25	  	 	—  	
IXEMPRA	  	 	15	  	 	—  	  	 	—  	
ABILIFY* (total revenue)	  	 	1,660	  	 	1,282	  	 	912	
Other Pharmaceuticals	  	 	3,717	  	 	3,763	  	 	4,675	
	  	 	 	  	 	 	  	 	 	
Total Pharmaceuticals	  	 	15,622	  	 	13,861	  	 	15,408	
	  	 	 	  	 	 	  	 	 	
Nutritionals	  			  			  			
ENFAMIL	  	 	1,082	  	 	1,007	  	 	992	
ENFAGROW	  	 	295	  	 	262	  	 	206	
Other Nutritionals	  	 	1,194	  	 	1,078	  	 	1,007	
	  	 	 	  	 	 	  	 	 	
Total Nutritionals	  	 	2,571	  	 	2,347	  	 	2,205	
ConvaTec	  			  			  			
Ostomy	  	 	594	  	 	554	  	 	550	
Wound Therapeutics	  	 	488	  	 	441	  	 	416	
Other ConvaTec	  	 	73	  	 	53	  	 	26	
	  	 	 	  	 	 	  	 	 	
Total ConvaTec	  	 	1,155	  	 	1,048	  	 	992	

Total	  	$	19,348	  	$	17,256	  	$	18,605	
	  	 	 	  	 	 	  	 	 	
Corporate/Other consists principally of interest income, interest expense, certain administrative expenses and allocations to the business segments of certain corporate programs, litigation expense, impairment of auction rate securities, debt retirement costs, gain on sale of businesses and product assets, deferred income recognized from collaboration agreement and restructuring charges. Corporate/Other assets include cash and cash equivalents, marketable securities, assets of discontinued operations and certain other assets.
 
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Note 19 SEGMENT INFORMATION (Continued)

 	  	Capital Expenditures	  	Depreciation	
Dollars in Millions	  	2007	  	2006	  	2005	  	2007	  	2006	  	2005	
Pharmaceuticals	  	$	639	  	$	538	  	$	545	  	$	430	  	$	453	  	$	475	
							
Nutritionals	  	 	63	  	 	65	  	 	65	  	 	44	  	 	41	  	 	38	
ConvaTec	  	 	25	  	 	19	  	 	25	  	 	19	  	 	18	  	 	20	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
Health Care Group	  	 	88	  	 	84	  	 	90	  	 	63	  	 	59	  	 	58	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
Total segments	  	 	727	  	 	622	  	 	635	  	 	493	  	 	512	  	 	533	
Corporate/Other (a)	  	 	74	  	 	58	  	 	58	  	 	49	  	 	52	  	 	44	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
Total	  	$	801	  	$	680	  	$	693	  	$	542	  	$	564	  	$	577	

(a)	The Corporate/Other amounts include the activities of the Medical Imaging business, including capital expenditures of $5 million, $14 million and $13 million for 2007, 2006 and  2005, respectively, and depreciation expense of $9 million, $10 million and $7 million for 2007, 2006 and 2005, respectively.	
Geographic Areas

 	  	Net Sales	  	Year-end Assets	
Dollars in Millions	  	2007	  	2006	  	2005	  	2007	  	2006	
United States	  	$	10,808	  	$	9,140	  	$	9,924	  	$	17,283	  	$	16,942	
Europe, Middle East and Africa	  	 	4,635	  	 	4,518	  	 	5,111	  	 	5,198	  	 	5,032	
Other Western Hemisphere	  	 	1,704	  	 	1,580	  	 	1,561	  	 	2,271	  	 	2,237	
Pacific	  	 	2,201	  	 	2,018	  	 	2,009	  	 	1,420	  	 	1,364	
	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	
Total	  	$	19,348	  	$	17,256	  	$	18,605	  	$	26,172	  	$	25,575	

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Note 20 LEASES
Minimum rental commitments under all non-cancelable operating leases, primarily real estate and motor vehicles, in effect at December 31, 2007, were as follows:

Years Ending December 31,	  	Dollars in Millions	
2008	  	$	143	
2009	  	 	116	
2010	  	 	90	
2011	  	 	72	
2012	  	 	71	
Later years	  	 	212	
	  	 	 	
Total minimum payments	  	 	704	
Less total minimum sublease rentals	  	 	39	
	  	 	 	
Net minimum rental commitments	  	$	665	
	  	 	 	
Operating lease rental expense (net of sublease rental income of $17 million in 2007, $21 million in 2006 and $15 million in 2005) was $166 million in 2007, $149 million in 2006 and $150 million in 2005.
In December 2006, the Company completed the sale and leaseback of several administrative facilities in New Jersey for $283 million, which resulted in a pre-tax gain from the transaction of $154 million, of which $145 million was deferred and will reduce future lease rental costs over the lease periods ranging from 8 to 12 years.
Note 21 PENSION AND OTHER POSTRETIREMENT BENEFIT PLANS
The Company and certain of its subsidiaries have defined benefit pension plans, defined contribution plans and termination indemnity plans for regular full-time employees. The principal pension plan is the Bristol-Myers Squibb Retirement Income Plan in the U.S. The funding policy is to contribute amounts to provide for current service and to fund past service liability. Plan benefits are based primarily on the participant’s years of credited service and compensation. Plan assets consist principally of equity and fixed-income securities.
The Company also provides comprehensive medical and group life benefits for substantially all U.S. retirees who elect to participate in its comprehensive medical and group life plans. The medical plan is contributory. Contributions are adjusted periodically and vary by date of retirement and the original retiring Company. The life insurance plan is noncontributory. Plan assets consist principally of equity and fixed-income securities. Similar plans exist for employees in certain countries outside of the U.S.
The net periodic benefit cost of the Company’s defined benefit pension and postretirement benefit plans included the following components:

 	  	Pension Benefits	 	 	Other Benefits (a)	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	 	2007	 	  	2006	 	  	2005	 	
Service cost — benefits earned during the year	  	$	249	 	 	$	238	 	 	$	223	 	 	$	8	 	  	$	9	 	  	$	9	 	
Interest cost on projected benefit obligation	  	 	352	 	 	 	326	 	 	 	314	 	 	 	36	 	  	 	34	 	  	 	36	 	
Expected return on plan assets	  	 	(442	)	 	 	(410	)	 	 	(361	)	 	 	(25	)	  	 	(22	)	  	 	(20	)	
Amortization of prior service cost/(benefit)	  	 	11	 	 	 	12	 	 	 	13	 	 	 	(3	)	  	 	(3	)	  	 	(4	)	
Amortization of loss	  	 	140	 	 	 	166	 	 	 	203	 	 	 	6	 	  	 	4	 	  	 	7	 	
Amortization of transitional obligation	  	 	—  	 	 	 	1	 	 	 	—  	 	 	 	—  	 	  	 	—  	 	  	 	—  	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Net periodic benefit cost	  	 	310	 	 	 	333	 	 	 	392	 	 	 	22	 	  	 	22	 	  	 	28	 	
Curtailments and settlements	  	 	3	 	 	 	(1	)	 	 	—  	 	 	 	1	 	  	 	—  	 	  	 	—  	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	  	 	 	 	
Total net periodic benefit cost	  	$	313	 	 	$	332	 	 	$	392	 	 	$	23	 	  	$	22	 	  	$	28	 	

(a)	The Company has recognized the impact of the Medicare Prescription Drug Improvement and Modernization Act of 2003 in 2007, 2006 and 2005, and in accordance with FSP No. 106-2, Accounting and Disclosure Requirements Related to the Medicare Prescription Drug, Improvement and Modernization Act of 2003 , recorded $11 million for each of 2007, 2006 and 2005, respectively, as a reduction in net periodic benefit costs.	
 
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Note 21 PENSION AND OTHER POSTRETIREMENT BENEFIT PLANS (Continued)
 
Net actuarial loss and prior service cost/(benefit) amortized from accumulated OCI into net periodic benefit costs for 2007 were $140 million and $11 million, respectively, for pension benefits; and were $6 million and a benefit of $3 million, respectively, for other benefits. The estimated net actuarial loss and prior service cost that will be amortized from accumulated OCI into net periodic benefit cost in 2008 are:

Dollars in Millions	  	Pension Benefits	  	Other Benefits	 	
Amortization of net actuarial loss	  	$	98	  	$	6	 	
Amortization of prior service cost/(benefit)	  	 	11	  	 	(3	)	
	  	 	 	  	 	 	 	
	  	$	109	  	$	3	 	
	  	 	 	  	 	 	 	
Changes in benefit obligations, plan assets, funded status and amounts recognized on the balance sheet as of and for the years ended December 31, 2007 and 2006, for the Company’s defined benefit and postretirement benefit plans, were as follows:

 	  	Pension Benefits	 	 	Other Benefits (b)	 	
Dollars in Millions	  	2007	 	 	2006	 	 	2007	 	 	2006	 	
Benefit obligation at beginning of year	  	$	6,186	 	 	$	5,918	 	 	$	651	 	 	$	643	 	
Service cost—benefits earned during the year	  	 	249	 	 	 	238	 	 	 	9	 	 	 	9	 	
Interest cost on projected benefit obligation	  	 	352	 	 	 	326	 	 	 	36	 	 	 	34	 	
Plan participants’ contributions	  	 	4	 	 	 	3	 	 	 	16	 	 	 	12	 	
Curtailments and settlements	  	 	(28	)	 	 	(2	)	 	 	(2	)	 	 	—  	 	
Actuarial losses/(gains)	  	 	(179	)	 	 	10	 	 	 	11	 	 	 	27	 	
Plan amendments	  	 	2	 	 	 	7	 	 	 	—  	 	 	 	—  	 	
Retiree Drug Subsidy Received	  	 	—  	 	 	 	—  	 	 	 	5	 	 	 	6	 	
Benefits paid	  	 	(496	)	 	 	(432	)	 	 	(87	)	 	 	(81	)	
Special termination benefit	  	 	4	 	 	 	—  	 	 	 	2	 	 	 	—  	 	
Exchange rate (gains)/losses	  	 	90	 	 	 	118	 	 	 	5	 	 	 	1	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Benefit obligation at end of year	  	$	6,184	 	 	$	6,186	 	 	$	646	 	 	$	651	 	

Fair value of plan assets at beginning of year	  	$	5,658	 	 	$	5,017	 	 	$	291	 	 	$	253	 	
Actual return on plan assets	  	 	458	 	 	 	649	 	 	 	29	 	 	 	38	 	
Employer contribution	  	 	323	 	 	 	325	 	 	 	66	 	 	 	63	 	
Plan participants’ contributions	  	 	4	 	 	 	3	 	 	 	16	 	 	 	12	 	
Settlements	  	 	(9	)	 	 	—  	 	 	 	—  	 	 	 	—  	 	
Retiree Drug Subsidy Received	  	 	—  	 	 	 	—  	 	 	 	5	 	 	 	6	 	
Benefits paid	  	 	(496	)	 	 	(432	)	 	 	(87	)	 	 	(81	)	
Exchange rate (losses)/gains	  	 	81	 	 	 	96	 	 	 	—  	 	 	 	—  	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Fair value of plan assets at end of year	  	$	6,019	 	 	$	5,658	 	 	$	320	 	 	$	291	 	

Funded status	  	$	(165	)	 	$	(528	)	 	$	(326	)	 	$	(360	)	

Amounts recognized in the balance sheet consist of:	  				 				 				 				
Other assets	  	$	291	 	 	$	45	 	 	$	—  	 	 	$	—  	 	
Accrued expenses	  	 	(27	)	 	 	(25	)	 	 	(58	)	 	 	(56	)	
Pension and other postretirement liabilities (accrued benefit cost)	  	 	(429	)	 	 	(548	)	 	 	(268	)	 	 	(304	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
Net amount recognized	  	$	(165	)	 	$	(528	)	 	$	(326	)	 	$	(360	)	

Amounts recognized in accumulated other comprehensive loss	  				 				 				 				
Net actuarial loss	  	$	1,358	 	 	$	1,711	 	 	$	117	 	 	$	117	 	
Net obligation at adoption	  	 	2	 	 	 	2	 	 	 	—  	 	 	 	—  	 	
Prior service cost	  	 	46	 	 	 	55	 	 	 	(20	)	 	 	(24	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	
	  	$	1,406	 	 	$	1,768	 	 	$	97	 	 	$	93	 	

(b)	The Company has recognized the impact of the Medicare Prescription Drug Improvement and Modernization Act of 2003 in 2007, 2006 and 2005, and in accordance with FSP No. 106-2, recorded $98 million and $94 million in 2007 and 2006, respectively, as a reduction in accumulated postretirement benefit obligation.	
Several plans had underfunded accrued benefit obligations that exceeded their accrued benefit liabilities at December 31, 2006. Additional minimum liabilities were established to increase the accrued benefit liabilities to the values of the underfunded accrued benefit obligations. The additional minimum liabilities totaled $232 million at December 31, 2006 prior to the adoption of SFAS No. 158, which were for a U.S. unfunded benefit equalization plan and several international plans. These liabilities were reversed against accumulated OCI upon the adoption of SFAS No. 158.
 
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Note 21 PENSION AND OTHER POSTRETIREMENT BENEFIT PLANS (Continued)
 
The accumulated benefit obligation for all defined benefit pension plans was $5,417 million and $5,422 million at December 31, 2007 and 2006, respectively.
Information related to the Company’s pension plans at December 31 was as follows:

 	  	December 31,	
Dollars in Millions	  	2007	  	2006	
Pension plans with projected benefit obligations in excess of plan assets:	  			  			
Projected benefit obligation	  	$	1,376	  	$	1,646	
Fair value of plan assets	  	 	921	  	 	1,073	
			
Pension Plans with accumulated benefit obligation in excess of plan assets:	  			  			
Accumulated benefit obligation	  	$	352	  	$	1,137	
Fair value of plan assets	  	 	62	  	 	795	
This is attributable primarily to an unfunded U.S. benefit equalization plan and several plans in the international markets. The unfunded U.S. benefit equalization plan provides pension benefits for employees with compensation above IRS limits and cannot be funded in a tax-advantaged manner.
Additional information pertaining to the Company’s pension and postretirement plans were as follows:

 	  	Pension Benefits	 	 	Other Benefits	
Dollars in Millions	  	2007	  	2006	 	 	2005	 	 	2007	  	2006	  	2005	
(Decrease)/Increase in minimum liability, including the impact of foreign currency fluctuations, included in other comprehensive income	  	$	—  	  	$	(96	)	 	$	(20	)	 	$	—  	  	$	—  	  	$	—  	
Weighted-average assumptions used to determine benefit obligations at December 31 were as follows:

 	  	Pension Benefits	 	 	Other Benefits	 	
 	  	2007	 	 	2006	 	 	2007	 	 	2006	 	
Discount rate	  	6.46	%	 	5.74	%	 	6.46	%	 	5.73	%	
Rate of compensation increase	  	3.67	%	 	3.63	%	 	3.60	%	 	3.60	%	
Weighted-average actuarial assumptions used to determine net periodic benefit cost for the years ended December 31 were as follows:

 	  	Pension Benefits	 	 	Other Benefits	 	
 	  	2007	 	 	2006	 	 	2005	 	 	2007	 	 	2006	 	 	2005	 	
Discount rate	  	5.74	%	 	5.49	%	 	5.57	%	 	5.73	%	 	5.49	%	 	5.52	%	
Expected long-term return on plan assets	  	8.30	%	 	8.39	%	 	8.41	%	 	8.75	%	 	8.75	%	 	8.75	%	
Rate of compensation increase	  	3.63	%	 	3.60	%	 	3.59	%	 	3.60	%	 	3.61	%	 	3.59	%	
At December 31, 2007, the Company’s expected long-term rate of return on U.S. pension plan assets was 8.75%. The target asset allocation is 70% public equity (58% U.S., 12% international), 8% private equity and 22% fixed income. The 8.75% was approximated by applying expected returns of 9% on public equity, 15% on private equity and 6% on fixed income to the target allocation. The actual historical returns are also relevant. Annualized returns for periods ended December 31, 2007 were 8.2% for 10 years, 10.4% for 15 years and 10.6% for 20 years.
U.S. pension plan assets represented approximately 75% of total Company pension plan assets at December 31, 2007. The 8.30% disclosed above for total Company expected return on assets for 2007 is below the 8.75% for U.S. pension plans, due to the impact of international pension plans, which typically employ a less aggressive asset allocation.
An 8.75% expected return is disclosed for Other Benefits in 2007, as the relevant assets are invested in the same manner as U.S. pension plan assets and there are no international plan assets.
 
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Note 21 PENSION AND OTHER POSTRETIREMENT BENEFIT PLANS (Continued)
 
Assumed health care cost trend rates at December 31 were as follows:

 	  	2007	 	 	2006	 	 	2005	 	
Health care cost trend rate assumed for next year	  	9.37	%	 	9.87	%	 	7.93	%	
Rate to which the cost trend rate is assumed to decline (the ultimate trend rate)	  	4.49	%	 	4.49	%	 	4.42	%	
Year that the rate reaches the ultimate trend rate	  	2018	 	 	2018	 	 	2012	 	
Assumed health care cost trend rates do have an effect on the amounts reported for the health care plans. A one-percentage-point change in assumed health care cost trend rates would have the following effects:

Dollars in Millions	  	1-Percentage-
Point Increase	  	1-Percentage-
Point Decrease	 	
Effect on total of service and interest cost	  	$	1	  	$	(1	)	
Effect on postretirement benefit obligation	  	 	36	  	 	(27	)	
The Company’s asset allocation for pension and postretirement benefits at December 31, 2007 and 2006, were as follows:

 	  	Pension Benefits	 	 	Other Benefits	 	
 	  	2007	 	 	2006	 	 	2007	 	 	2006	 	
Public equity securities	  	65.1	%	 	67.2	%	 	67.3	%	 	69.2	%	
Debt securities (including cash)	  	27.3	 	 	26.9	 	 	23.7	 	 	23.3	 	
Private equity	  	6.7	 	 	5.6	 	 	8.7	 	 	7.2	 	
Other	  	0.9	 	 	0.3	 	 	0.3	 	 	0.3	 	
	  	 	 	 	 	 	 	 	 	 	 	 	
Total	  	100.0	%	 	100.0	%	 	100.0	%	 	100.0	%	
	  	 	 	 	 	 	 	 	 	 	 	 	
The Company’s investment strategy emphasizes equities in order to achieve high expected returns and, in the long run, low expense and low required cash contributions. For the U.S. pension plans, a target asset allocation of 70% public equity (58% U.S., 12% international), 8% private equity and 22% fixed income is maintained and cash flow (i.e., cash contributions, benefit payments) is used to rebalance back to the targets as necessary. Investments are well diversified within each of the three major asset categories. About 30% of the U.S. equity is passively managed. Otherwise, all investments are actively managed.
Investment strategies for international pension plans are typically similar, although the asset allocations are usually more conservative.
Bristol–Myers Squibb Company common stock represents less than 1% of the plan assets at December 31, 2007 and 2006.
Assets for postretirement benefits are commingled with U.S. pension plan assets and, therefore, the investment strategy is identical to that described above for U.S. pension plans.
Contributions
Although no minimum contributions were required, the Company made cash contributions to the U.S. pension plans of $238 million, $235 million and $318 million in 2007, 2006 and 2005, respectively. The Company also plans to make a cash contribution to the U.S. pension plans in 2008.
When contributions are made to the U.S. pension plans, the Company may make tax-deductible contributions to the 401(h) account for retiree medical benefits equal to a portion of the pension normal cost.
Contributions to the international pension plans were $85 million, $90 million and $105 million in 2007, 2006 and 2005, respectively. Contributions to the international plans are now expected to be in the range of $70 million to $90 million in 2008.
 
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Note 21 PENSION AND OTHER POSTRETIREMENT BENEFIT PLANS (Continued)
 
Estimated Future Benefit Payments
The following benefit payments for mainly the U.S pension plans, which reflect expected future service, as appropriate, are expected to be paid:

Dollars in Millions	  	Pension Benefits	  	Other Benefits	
	  		  	Gross	  	Medicare Subsidy	  	Net	
2008	  	$	376	  	$	69	  	$	9	  	$	60	
2009	  	 	371	  	 	69	  	 	9	  	 	60	
2010	  	 	390	  	 	70	  	 	10	  	 	60	
2011	  	 	418	  	 	70	  	 	11	  	 	59	
2012	  	 	442	  	 	69	  	 	12	  	 	57	
Years 2013 – 2017	  	 	2,553	  	 	328	  	 	57	  	 	271	
Adoption of SFAS No. 158
The Company adopted SFAS No. 158 in the fiscal year ended December 31, 2006, resulting in a $1,064 million reduction of accumulated OCI in stockholders’ equity, a $767 million reduction in total assets and a $297 million increase in total liabilities. The impact of the adoption is summarized as follows:

 	  	SFAS No. 158 Adjustments	 	
Dollars in Millions	  	Pre-SFAS No. 158	 	 	Pre-tax	 	 	Tax	 	 	Net	 	 	Post-SFAS No. 158	 	
Current Assets:	  				 				 				 				 				
Deferred income taxes	  	$	573	 	 	$	—  	 	 	$	76	 	 	$	76	 	 	$	649	 	
Non-Current Assets:	  				 				 				 				 				
Deferred income taxes	  	 	2,139	 	 	 	—  	 	 	 	438	 	 	 	438	 	 	 	2,577	 	
Prepaid pension	  	 	1,324	 	 	 	(1,324	)	 	 	—  	 	 	 	(1,324	)	 	 	—  	 	
Other assets	  	 	299	 	 	 	43	 	 	 	—  	 	 	 	43	 	 	 	342	 	
Current Liabilities:	  				 				 				 				 				
Accrued expenses	  	 	2,251	 	 	 	81	 	 	 	—  	 	 	 	81	 	 	 	2,332	 	
U.S. and foreign income taxes payable	  	 	445	 	 	 	—  	 	 	 	(1	)	 	 	(1	)	 	 	444	 	
Non-Current Liabilities:	  				 				 				 				 				
Other Liabilities	  	 	327	 	 	 	269	 	 	 	(52	)	 	 	217	 	 	 	544	 	
Stockholders’ Equity:	  				 				 				 				 				
Accumulated other comprehensive loss	  	 	(581	)	 	 	(1,631	)	 	 	567	 	 	 	(1,064	)	 	 	(1,645	)	
Savings Plan
The principal defined contribution plan is the Bristol-Myers Squibb Savings and Investment Program. The Company’s contribution is based on employee contributions and the level of Company match. The Company’s contributions to the plan were $60 million in 2007, $56 million in 2006 and $51 million in 2005.
Termination Indemnity Plans
The Company operates in certain jurisdictions, primarily in Europe, which require the recording of statutory termination obligations. These obligations were assessed in accordance with EITF Issue No. 88-1, Determination of Vested Benefit Obligation for a Defined Benefit Pension Plan . The total pension liability recorded for these obligations was $70 million at December 31, 2007 and $75 million at December 31, 2006.
 
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Note 22 LEGAL PROCEEDINGS AND CONTINGENCIES
Various lawsuits, claims, proceedings and investigations are pending involving the Company and certain of its subsidiaries. In accordance with SFAS No. 5, Accounting for Contingencies , the Company records accruals for such contingencies when it is probable that a liability will be incurred and the amount of loss can be reasonably estimated. These matters involve antitrust, securities, patent infringement, pricing, sales and marketing practices, environmental, health and safety matters, consumer fraud, employment matters, product liability and insurance coverage. The most significant of these matters are described below.
There can be no assurance that there will not be an increase in the scope of pending matters or that any future lawsuits, claims, proceedings or investigations will not be material.
INTELLECTUAL PROPERTY
PLAVIX* Litigation
PLAVIX* is currently the Company’s largest product ranked by net sales. Net sales of PLAVIX* were approximately $4.8 billion for the year ended December 31, 2007, $3.3 billion for the year ended December 31, 2006 and $3.8 billion for the year ended December 31, 2005, and U.S. net sales of PLAVIX* were $4.1 billion in 2007, $2.7 billion in 2006 and $3.2 billion in 2005. The PLAVIX* patents are subject to a number of challenges in the U.S., including the litigation with Apotex Inc. and Apotex Corp. (Apotex) described below, and in other less significant markets for the product. It is not possible reasonably to estimate the impact of these lawsuits on the Company. However, loss of market exclusivity of PLAVIX* and sustained generic competition would be material to the Company’s sales of PLAVIX*, results of operations and cash flows, and could be material to the Company’s financial condition and liquidity. The Company and its product partner, Sanofi, (the Companies) intend to vigorously pursue enforcement of their patent rights in PLAVIX*.
PLAVIX* Litigation – United States
Patent Infringement Litigation against Apotex and Related Matters
As previously disclosed, the Company’s U.S. territory partnership under its alliance with Sanofi is a plaintiff in a pending patent infringement lawsuit instituted in the U.S. District Court for the Southern District of New York (District court) entitled Sanofi-Synthelabo, Sanofi-Synthelabo, Inc. and Bristol-Myers Squibb Sanofi Pharmaceuticals Holding Partnership v. Apotex. The suit is based on U.S. Patent No. 4,847,265 (the ‘265 Patent), a composition of matter patent, which discloses and claims, among other things, the hydrogen sulfate salt of clopidogrel, a medicine made available in the U.S. by the Companies as PLAVIX*. Plaintiffs’ infringement position is based on Apotex’s filing of their Abbreviated New Drug Application (aNDA) with the FDA, seeking approval to sell generic clopidogrel bisulfate prior to the expiration of the composition of matter patent in 2011. Apotex has alleged that the patent is invalid and/or unenforceable.
As previously disclosed, in March 2006, the Company and Sanofi announced that they had executed a proposed settlement agreement (the March Agreement) with Apotex to settle the pending patent infringement lawsuit. In response to concerns expressed by the Federal Trade Commission (FTC) and state attorneys general, the parties modified the March Agreement (the Modified Agreement) in May 2006. In July 2006, the Companies announced that the Modified Agreement had failed to receive required antitrust clearance from the state attorneys general. On August 8, 2006, Apotex launched a generic version of clopidogrel bisulfate. On August 31, 2006, the District court issued a preliminary injunction ordering Apotex to halt sales of generic clopidogrel bisulfate, but not to recall product from its customers. On June 19, 2007, the District court issued an opinion and order upholding the validity and enforceability of the ‘265 Patent, maintaining the main patent protection for PLAVIX* in the U.S. until November 2011. The District court also ruled that Apotex’s generic clopidogrel bisulfate product infringed the ‘265 Patent and permanently enjoined Apotex from engaging in any activity that infringes the ‘265 Patent, including marketing its generic product in the U.S. until after the patent expires. The amount of damages will be set at a later time. Apotex’s appeal of the District court’s decision is pending before the U.S. Court of Appeals for the Federal Circuit with a hearing scheduled for March 2008. The District court has stayed certain antitrust counterclaims brought by Apotex pending the outcome of the appeal. Activities relating to the damages phase of the litigation are continuing.
As also previously disclosed, the Company’s U.S. territory partnership under its alliance with Sanofi is also a plaintiff in three additional pending patent infringement lawsuits against Dr. Reddy’s Laboratories, Inc. and Dr. Reddy’s Laboratories, LTD (Dr. Reddy’s), Teva Pharmaceuticals USA, Inc. (Teva) and Cobalt Pharmaceuticals Inc. (Cobalt), all related to the ‘265 Patent. A trial date for the action against Dr. Reddy’s has not been set. On January 14, 2008, Dr. Reddy’s received final approval of its aNDA. On January 24, 2008, the court entered an order that requires Dr. Reddy’s to give the Company 10 business days notice of its intent to launch. The patent infringement actions against Teva and Cobalt were stayed pending resolution of the Apotex litigation, and the parties to those actions agreed to be bound by the outcome of the litigation against Apotex, although Teva and Cobalt can appeal the outcome of the litigation.
 
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Note 22 LEGAL PROCEEDINGS AND CONTINGENCIES (continued)
 
Consequently, on July 12, 2007, the District court entered judgments against Cobalt and Teva and permanently enjoined Cobalt and Teva from engaging in any activity that infringes the ‘265 Patent until after the Patent expires. Cobalt and Teva have each filed an appeal. Each of Dr. Reddy’s, Teva and Cobalt have filed an aNDA with the FDA, and all exclusivity periods and statutory stay periods under the Hatch-Waxman Act have expired. Accordingly, final approval by the FDA would provide each company authorization to distribute a generic clopidogrel bisulfate product in the U.S., subject to various legal remedies for which the Companies may apply including injunctive relief and damages.
As previously disclosed, in March 2007, the Company was served with a Civil Investigative Demand by the FTC requesting documents and information related to the proposed settlement. In addition, as previously disclosed, in April 2007, the Company received a subpoena from the New York State Attorney General’s Office — Antitrust Bureau for documents related to the proposed settlement. The Company is cooperating fully with the investigations. It is not possible at this time reasonably to assess the outcomes of the investigations or their impact on the Company.
As also previously disclosed, the Company’s U.S. territory partnership under its alliance with Sanofi is a plaintiff in another pending patent infringement lawsuit instituted in the U.S. District Court for the District of New Jersey entitled Sanofi-Synthelabo, Sanofi-Synthelabo Inc. and Bristol-Myers Squibb Sanofi Pharmaceuticals Holding Partnership v. Watson Pharmaceuticals, Inc. and Watson Laboratories, Inc. (Watson). The suit was filed in October 2004 and was based on U.S. Patent No. 6,429,210 (the ‘210 Patent), which discloses and claims a particular crystalline or polymorph form of the hydrogen sulfate salt of clopidogrel, which is marketed as PLAVIX*. The case is in the discovery phase. In December 2005, the court permitted Watson to pursue its declaratory judgment counterclaim with respect to U.S. Patent No. 6,504,030. In January 2006, the Court approved the parties’ stipulation to stay this case pending the outcome of the trial in the Apotex matter. In April 2007, Pharmastar filed a request for inter partes reexamination of the ‘210 Patent. The U.S. Patent and Trademark Office granted this request in July of 2007. Thus, the ‘210 Patent is currently under reexamination.
It is not possible at this time reasonably to assess the outcomes of the appeal by Apotex of the District court’s decision, or the other PLAVIX* patent litigations or the timing of any renewed generic competition for PLAVIX* from Apotex or additional generic competition for PLAVIX* from other third-party generic pharmaceutical companies. However, if Apotex were to prevail in an appeal of the patent litigation, the Company would expect to face renewed generic competition for PLAVIX* from Apotex promptly thereafter. Loss of market exclusivity for PLAVIX* and/or sustained generic competition would be material to the Company’s sales of PLAVIX*, results of operations and cash flows, and could be material to the Company’s financial condition and liquidity. Additionally, it is not possible at this time reasonably to assess the amount of damages that could be recovered by the Company and Apotex’s ability to pay such damages in the event the Company prevails in Apotex’s appeal of the District court decision.
See “Antitrust Litigation”, “Shareholder Derivative Actions” and “Securities Litigation” below for a further discussion of certain other U.S. litigations relating to PLAVIX*.
PLAVIX* Litigation – International
PLAVIX – Canada (Apotex, Inc.)
As previously disclosed, Sanofi-Synthelabo and Sanofi-Synthelabo Canada Inc. instituted a prohibition action in the Federal Court of Canada against Apotex Inc. and the Minister of Health in response to a Notice of Allegation (NOA) from Apotex directed against Canadian Patent No. 1,336,777 (the ‘777 Patent) covering clopidogrel bisulfate. Apotex’s NOA indicated that it had filed an Abbreviated New Drug Submission (ANDS) for clopidogrel bisulfate tablets and that it sought approval (a Notice of Compliance) of that ANDS before the expiration of the ‘777 Patent, which is scheduled for August 12, 2012. Apotex’s NOA further alleged that the ‘777 Patent was invalid or not infringed. In March 2005, the Canadian Federal Court of Ottawa rejected Apotex’s challenge to the Canadian PLAVIX* patent and held that the asserted claims are novel, not obvious and infringed, and granted Sanofi’s application for an order of prohibition against the Minister of Health and Apotex. That order of prohibition precludes approval of Apotex’s ANDS until the patent expires in 2012, unless the Federal Court’s decision is reversed on appeal. Apotex filed an appeal, which the Canadian Federal Court of Appeal heard on December 12-13, 2006. In December 2006, the Federal Court of Appeal dismissed Apotex’s appeal and upheld the Federal Court’s issuance of the order of prohibition. In February 2007, Apotex filed leave to appeal this decision to the Supreme Court of Canada. In July 2007, the Supreme Court of Canada granted Apotex leave to appeal the decision of the Canadian Federal Court of Appeal. BIOTECanada, the Canadian Generic Pharmaceutical Association and Canada’s Research-Based Pharmaceutical Companies were granted leave to intervene. The oral hearing is scheduled for April 2008.
As also previously disclosed, in April 2007, Apotex filed a lawsuit in Canada in the Ontario Superior Court of Justice entitled Apotex Inc. and Apotex Corp. v. Sanofi-Aventis, Sanofi-Synthelabo Inc., Bristol-Myers Squibb Company, and Bristol-Myers Squibb Sanofi Pharmaceuticals Holding Partnership, seeking a payment of $60 million, plus interest related to the break-up of the proposed settlement agreement. Defendants filed motions to dismiss on the grounds of forum non conveniens and subject matter jurisdiction. The motions were granted on January 14, 2008.
 
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Note 22 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)
 
PLAVIX* – Canada (Cobalt)
As previously disclosed, Sanofi and Sanofi-Synthelabo Canada instituted a prohibition action in the Federal Court of Canada against Cobalt and the Minister of Health in response to a NOA from Cobalt directed against the ‘777 Patent and Canadian Patent No. 2,334,870 (the ‘870 Patent). Cobalt’s NOA indicated that it has filed an ANDS for clopidogrel bisulfate tablets and that it sought a Notice of Compliance for that ANDS before the expiration of the ‘777 and ‘870 Patents. Cobalt alleged that the ‘777 Patent was invalid and that the ‘870 Patent was invalid and not infringed. The case has been stayed pending the outcome of the Apotex appeal.
PLAVIX* – Korea
As previously disclosed, in June 2006, the Korean Intellectual Property Tribunal (KIPT) invalidated all claims of Sanofi’s Korean Patent No. 103,094, including claims directed to clopidogrel and pharmaceutically acceptable salts and to clopidogrel bisulfate, and Sanofi appealed. In January 2008, the Patent Court affirmed the KIPT decision. The Company and Sanofi are considering its options, including an appeal. Sanofi has also commenced infringement actions against generic pharmaceutical companies, several of which have launched a generic clopidogrel bisulfate product in Korea. It is not possible at this time reasonably to assess the outcome of these lawsuits or the impact on the Company.
PLAVIX* – Australia
As previously disclosed, Sanofi was notified that in August 2007, GenRx Proprietary Limited (GenRx) obtained regulatory approval of an application for clopidogrel bisulfate 75mg tablets in Australia. In August 2007, GenRx filed an application in the Federal Court of Australia seeking revocation of Sanofi’s Australian Patent No. 597784 (Case No. NSD 1639 of 2007). Sanofi filed counterclaims of infringement and sought an injunction. On September 21, 2007, the Australian court granted Sanofi’s injunction and scheduled a trial date for April 2008.
OTHER INTELLECTUAL PROPERTY LITIGATION
ABILIFY*
As previously disclosed, Otsuka has filed patent infringement actions against Teva, Barr Pharmaceuticals, Inc. (Barr), Sandoz Inc. (Sandoz), Synthon Laboratories, Inc (Synthon), Sun Pharmaceuticals (Sun) and Apotex relating to U.S. Patent No. 5,006,528, which covers aripiprazole and expires in October 2014. Aripiprazole is comarketed by the Company and Otsuka in the U.S. as ABILIFY*. The lawsuits are currently pending in the U.S. District Court for the District of New Jersey.
It is not possible at this time reasonably to assess the outcome of these lawsuits or their impact on the Company.
ERBITUX*
Yeda Litigation
In October 2003, Yeda Research and Development Company Ltd. (Yeda) filed suit against ImClone and Aventis Pharmaceuticals, Inc. in Federal court claiming that three individuals associated with Yeda should be named as inventors of U.S. Patent No. 6,217,866 (the ‘866 Patent), which covers the therapeutic combination of any EGFR—specific monoclonal antibody and anti-neoplastic agents, such as chemotherapeutic agents, for use in treatment of cancer. In September 2006, following trial the Court issued an opinion and order in which it held that three researchers at Yeda were the sole inventors of the subject matter of the ‘866 Patent, and giving complete ownership of the patent to Yeda. ImClone has appealed. ImClone also filed a declaratory judgment action in the District court. The complaint alleged that if the Yeda researchers remain sole inventors of the ‘866 Patent, the patent is invalid. Under its commercial agreement with ImClone, the Company pays a royalty to ImClone on sales of ERBITUX* that was not impacted by the Court’s decision.
Pursuant to a settlement agreement executed by ImClone, Sanofi and Yeda announced on December 7, 2007 to end worldwide litigation related to the ‘866 Patent, Yeda and Sanofi granted ImClone a worldwide license under the ‘866 Patent, and the parties agreed that Yeda is the sole owner of the ‘866 Patent in the U.S. and Yeda and Sanofi are co-owners of the ‘866 Patent foreign counterparts. The settlement agreement does not change ImClone’s worldwide royalty rate for ERBITUX* sales. Under its commercial agreement with ImClone, the Company pays a royalty to ImClone on sales of ERBITUX* that is not impacted by the settlement agreement.
 
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Yeda also has the right to license the patent to others. Yeda’s license of the patent to third parties could result in product competition for ERBITUX* that might not otherwise occur. It is too early to assess whether and to what extent any such competitive impact will occur or to quantify any such impact. However, Yeda has licensed the patent to Amgen Inc. (Amgen). Amgen received FDA approval to market an EGFR product that competes with ERBITUX*.
Abbott Laboratories
As previously disclosed, in February 2007, Abbott Laboratories (Abbott) filed suit against ImClone in the U.S. District Court for the District of Massachusetts alleging that ImClone’s manufacture and sale of ERBITUX* infringe U.S. Patent No. 5,665,578 (the ‘578 Patent), and seeking damages for that alleged infringement. Pursuant to settlement and sublicensing agreements executed by ImClone and Repligen Corporation (Repligen) announced on September 10, 2007, Repligen granted ImClone a royalty-free, irrevocable worldwide sublicense for the future use of other patented technology, including the ‘578 Patent, owned by Abbott and licensed to Repligen under an agreement between Abbott and Repligen. The Company’s commercial agreements with ImClone include provisions pursuant to which certain financial consequences to the Company resulting from the settlement and sublicensing agreements would be the responsibility of ImClone. The settlement and sublicensing agreements, however, do not end this lawsuit.
It is not possible at this time to assess the outcome of this lawsuit or the potential impact on the Company.
ORENCIA
In January 2006, Repligen and the Regents of the University of Michigan filed a complaint against the Company in the U.S. District Court for the Eastern District of Texas, Marshall Division. ORENCIA was launched in February 2006. The complaint alleges that the Company’s then-anticipated sales of ORENCIA will infringe U.S. Patent No. 6,685,541. Repligen has since amended the complaint to include ongoing and future sales of ORENCIA. A court-ordered mediation is scheduled for March 4, 2008, and the trial is scheduled to commence in April 2008.
In August 2006, Zymogenetics, Inc. filed a complaint against the Company in the U.S. District Court for the District of Delaware. The complaint alleges that the Company’s manufacture and sales of ORENCIA infringe U.S. Patents Nos. 5,843,725 and 6,018,026. The trial is now expected to commence in 2009.
PRAVACHOL
In December 2006, LEK D.D. (LEK), a Slovenian generic company that is wholly-owned by Novartis, filed suit against the Company and Watson in the U.S. District Court for the Eastern District of Texas in Marshall, Texas. LEK’s complaint alleges that the Company’s sale of PRAVACHOL and Watson’s sale of an authorized generic of PRAVACHOL infringe two patents of LEK. The patents are U.S. Patents Nos. 6,740,775, issued May 25, 2004 and 7,078,558, issued July 18, 2006. The Company filed an Answer to the Complaint in June 2007. The Company believes that it has a strong defense to this suit and intends to defend itself vigorously. The trial is scheduled to commence in August 2009.
It is not possible at this time reasonably to assess the outcome of these lawsuits or their impact on the Company.
GENERAL COMMERCIAL LITIGATION
Clayworth Litigation
As previously disclosed, the Company, together with a number of other pharmaceutical manufacturers, was named as a defendant in an action filed in California State Superior Court in Oakland, James Clayworth et al. v. Bristol-Myers Squibb Company, et al ., alleging that the defendants conspired to fix the prices of pharmaceuticals by agreeing to charge more for their drugs in the U.S. than they charge outside the U.S., particularly Canada, and asserting claims under California’s Cartwright Act and unfair competition law. The plaintiffs sought trebled monetary damages, injunctive relief and other relief. In December 2006, the Court granted the Company and the other manufacturers’ motion for summary judgment based on the pass-on defense, and judgment was then entered in favor of defendants. In January 2007, a notice of appeal with respect to the judgment was filed and remains pending. It is not possible at this time reasonably to assess the outcome of this lawsuit or its impact on the Company in the event plaintiffs are successful on appeal.
 
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RxUSA Wholesale Litigation
As previously disclosed, in July 2006, a complaint was filed by drug wholesaler RxUSA Wholesale, Inc. in the U.S. District Court for the Eastern District of New York against the Company, 15 other drug manufacturers, five drug wholesalers, two officers of defendant McKesson and a wholesale distribution industry trade group, RxUSA Wholesale, Inc. v. Alcon Labs., Inc., et al . The complaint alleges violations of Federal and New York antitrust laws, as well as various other laws. Plaintiff claims that defendants allegedly engaged in anti-competitive acts that resulted in the exclusion of plaintiff from the relevant market and seeks $586 million in damages before any trebling, and other relief. The Company, together with the other manufacturer defendants, filed a motion to dismiss the case in November 2006. That motion remains pending before the Court. It is not possible at this time reasonably to estimate the outcome of this lawsuit or the impact on the Company.
ANTITRUST LITIGATION
As previously disclosed, 18 lawsuits comprised of both individual suits and purported class actions have been filed against the Company in U.S. District Court, Southern District of Ohio, Western Division, by various plaintiffs, including pharmacy chains (individually and as assignees, in whole or in part, of certain wholesalers), various health and welfare benefit plans/funds and individual residents of various states. These lawsuits allege, among other things, that the purported settlement with Apotex of the patent infringement litigation violated the Sherman Act and related laws. Plaintiffs are seeking, among other things, permanent injunctive relief barring the Apotex settlement and/or monetary damages. The class actions filed on behalf of direct purchasers have been consolidated under the caption In re: Plavix Direct Purchaser Antitrust Litigation , and the class actions filed on behalf of indirect purchasers have been consolidated under the caption In re: Plavix Indirect Purchaser Antitrust Litigation . Amended complaints were filed on October 19, 2007. Defendants filed a consolidated motion to dismiss on December 11, 2007. It is not possible at this time reasonably to assess the outcome of these lawsuits or their impact on the Company.
SHAREHOLDER DERIVATIVE ACTIONS
On July 31, 2007, certain members of the Board of Directors, current and former officers and the Company were named in two derivative actions filed in the New York State Supreme Court, John Frank v. Peter Dolan, et al. (07-602580) and Donald Beebout v. Peter Dolan, et al. (07-602579) , and one derivative action filed in the federal district court, Steven W. Sampson v. James D. Robinson, III, et al. (07-CV-6890) . The complaints allege breaches of fiduciary duties for allegedly failing to disclose material information relating to efforts to settle the PLAVIX* patent infringement litigation with Apotex. Plaintiffs seek monetary damages on behalf of the Company, contribution and indemnification. By decision filed on December 13, 2007, the state court granted motions to dismiss the complaints, Frank and Beebout , relating to certain members of the Board of Directors, but did not dismiss the complaints as to the former officers. The Company filed a motion to dismiss in the federal district court action, Sampson , which is pending.
SECURITIES LITIGATION
In Re Bristol-Myers Squibb Co. Securities Litigation
As previously disclosed, in June and July 2007, two putative class action complaints, Minneapolis Firefighters’ Relief Assoc. v. Bristol-Myers Squibb Co., et al., 07 CV 5867 and Jean Lai v. Bristol-Myers Squibb Company, et al., were filed in the U.S. District for the Southern District of New York against the Company, the Company’s former Chief Executive Officer, Peter Dolan and current Chief Financial Officer, Andrew Bonfield. The complaints allege violations of securities laws for allegedly failing to disclose material information relating to efforts to settle the PLAVIX* patent infringement litigation with Apotex. On September 20, 2007, the Court dismissed the Lai case without prejudice, changed the caption of the case to In re Bristol-Myers Squibb, Co. Securities Litigation , and appointed Ontario Teachers’ Pension Plan Board as lead plaintiff. On October 15, 2007, Ontario Teachers’ Pension Plan Board filed an amended complaint making similar allegations as the earlier filed complaints, but no longer naming Andrew Bonfield as a defendant. Motions to dismiss have been filed.
The Company intends to defend itself vigorously in this litigation. It is not possible at this time to reasonably assess the outcome of these lawsuits, or the potential impact on the Company.
 
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PRICING, SALES AND PROMOTIONAL PRACTICES LITIGATION AND INVESTIGATIONS
As previously disclosed, the Company, together with a number of defendants, is a defendant in a number of private civil matters relating to its pricing practices. In addition, the Company, together with a number of other pharmaceutical manufacturers, has received subpoenas and other document requests from various government agencies seeking records relating to its pricing, sales, marketing practices and best price reporting.
On September 28, 2007, the Company, the Department of Justice (DOJ) and the Office of the U.S. Attorney for the District of Massachusetts finalized the previously disclosed agreement in principle to settle several investigations involving the Company’s drug pricing, sales and marketing activities. The settlement agreement, which provides for a civil resolution, resolves matters that have been actively investigated by and discussed with the DOJ and the U.S. Attorney for the District of Massachusetts over a number of years, including matters relating to: (1) the pricing for certain products sold several years ago by a subsidiary, which had been reimbursed by governmental health care programs; 2) financial relationships between that subsidiary and certain customers and other entities; 3) certain consulting programs; 4) the promotion of ABILIFY* for unapproved indications; 5) the calculation of certain Medicaid rebates for SERZONE (nefazodone hydrochloride); and 6) the pricing for certain of the Company’s products reimbursed by governmental health care programs. There will be no criminal charges against the Company with respect to those matters. Pursuant to the agreement, the Company agreed to pay $499 million plus interest to resolve the Federal and state claims, resulting in a total amount of approximately $516 million as of the settlement date. The Company has paid the federal portion of the global settlement, approximately $317 million plus interest. The state portion of the global settlement, approximately $182 million, plus interest, will not be disbursed unless and until the states approve the settlement. There can be no assurances that any or all states will approve the settlement. In connection with the settlement, the Company has entered into a five-year Corporate Integrity Agreement with the Office of the Inspector General of the Department of Health and Human Services. The settlement only covers those matters outlined above, and the DOJ, the U.S. Attorney for the District of Massachusetts and the states have indicated that they may pursue other matters outside the scope of the settlement, and in that event, such matters could result in the assertion of civil and/or criminal claims.
Also as previously disclosed, as a result of the agreement in principle, the Company had recorded aggregate reserves in the amount of $499 million plus interest for these matters. With payment of the federal portion of the global settlement now having been made, the remaining reserve at December 31, 2007 was $182 million plus interest. If certain states choose not to participate, the amount reserved may not reflect eventual losses.
It is not possible at this time reasonably to assess the outcome of any additional matters that the DOJ and the Office of the U.S. Attorney for the District of Massachusetts may pursue, or the potential impact on the Company.
Litigation
As previously disclosed, the Company, together with a number of other pharmaceutical manufacturers, is a defendant in private class actions, as well as suits brought by the attorneys general of numerous states, many New York counties, and the City of New York. In these actions, plaintiffs allege defendants caused the Average Wholesale Prices (AWPs) of their products to be inflated, thereby injuring government programs, entities and persons who reimbursed prescription drugs based on AWPs. Twelve state attorneys’ general suits are pending in federal and state courts around the country. A case in Alabama state court is scheduled to be the first to proceed to trial in February 2008. One set of class actions, a suit by the Arizona attorney general and several suits filed by New York Counties and the City of New York, have been consolidated in the U.S. District Court for the District of Massachusetts (AWP MDL). The Court in the AWP MDL has certified three classes of persons and entities who paid for or reimbursed for seven of the Company’s physician-administered drugs. In June 2007, in a non-jury trial in the AWP MDL, the Court found the Company liable for violations of Massachusetts’ consumer protection laws with respect to certain oncology drugs for certain years and awarded damages in the amount of $183 thousand for Class 3 (private third-party payors) and instructed the parties to apply the Court’s opinion to determine damages for Class 2 (Medigap insurers). In August, 2007, the Court found damages of $187 thousand for Class 2. The Company has appealed the June 2007 decision to the U.S. Court of Appeals for the First Circuit. As previously disclosed, in June 2007, the Company settled in principle the claims of Class 1 (Medicare Part B beneficiaries nationwide) for $13 million, plus half the costs of class notice up to a maximum payment of $1 million and the parties are finalizing the terms of the settlement. A hearing will be scheduled thereafter for preliminary approval of the Class 1 settlement.
The Company has recorded reserves of $14 million for these matters. In accordance with GAAP, the reserve reflects the Company’s estimate of probable loss with respect to these matters, assuming the settlement is finalized. If the settlement is not finalized, the amount reserved may not reflect eventual losses. It is not possible at this time reasonably to assess the outcome of the litigation matters described above, or their potential impact on the Company.
 
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PRODUCT LIABILITY LITIGATION
The Company is a party to various product liability lawsuits. In addition to lawsuits, the Company also faces unfiled claims involving other products. At this time, the Company does not believe that any of the on-going matters or the potential unfiled claims of which it is aware have the potential to result in a material effect on the Company’s financial results or operations.
ENVIRONMENTAL PROCEEDINGS
As previously reported, the Company is a party to several environmental proceedings and other matters, and is responsible under various state, Federal and foreign laws, including the Comprehensive Environmental Response, Compensation and Liability Act, (CERCLA), for certain costs of investigating and/or remediating contamination resulting from past industrial activity at the Company’s current or former sites or at waste disposal or reprocessing facilities operated by third parties.
CERCLA Matters
With respect to CERCLA matters for which the Company is responsible under various state, Federal and foreign laws, the Company typically estimates potential costs based on information obtained from the U.S. Environmental Protection Agency (EPA), or counterpart state agency and/or studies prepared by independent consultants, including the total estimated costs for the site and the expected cost-sharing, if any, with other “potentially responsible parties”, and the Company accrues liabilities when they are probable and reasonably estimable. As of December 31, 2007, the Company estimated its share of the total future costs for these sites to be approximately $69 million, recorded as other liabilities, which represents the sum of best estimates or, where no simple estimate can reasonably be made, estimates of the minimal probable amount among a range of such costs (without taking into account any potential recoveries from other parties, which are not currently expected).
Puerto Rico Air Emissions Civil Litigation
As previously disclosed, the Company is one of several defendants in a class action suit filed in Superior Court in Puerto Rico relating to air emissions from a government-owned and operated wastewater treatment facility. The Court certified the class on August 9, 2007 and on August 15, 2007 the parties executed a global settlement agreement, resolving all claims in the litigation. A hearing to approve the settlement was held on October 26, 2007. Under the terms of the settlement, certain measures, including capital improvements, will be implemented at the wastewater treatment facility to minimize the potential for future odor emissions. The Company’s share of the payment to plaintiffs will be approximately $700 thousand. On November 6, 2007, the court entered Final Judgment approving the settlement. This concludes the Company’s involvement in the litigation, except for the Company’s payment of its share of the cost of the capital improvements, which will be finalized in early 2008.
Passaic River (NJ) Remediation and Natural Resource Damages Claims
As previously disclosed, in September 2003, the New Jersey Department of Environmental Protection (NJDEP) issued an administrative enforcement Directive requiring the Company and other companies to perform an assessment of natural resource damages and to implement unspecified interim remedial measures to restore conditions in the Lower Passaic River (LPR). The Directive named the Company due to releases from a nearby bulk chemical reprocessing facility operated by a predecessor of McKesson Corp. Subsequently, the EPA issued a notice letter to numerous parties, but not the Company, requesting performance of a Remedial Investigation/Feasibility Study (RI/FS) of conditions in the LPR. Under a consent agreement with EPA in 2004, a group of these other parties committed to pay roughly half of the $20 million estimated for the RI/FS by EPA at that time. The EPA thereafter substantially increased its estimate of the scope and cost of the RI/FS and, as a result, the EPA agreed to allow the group to perform most of the remaining RI/FS tasks. By the group’s estimate, total costs to complete the RI/FS and related tasks now exceed $50 million. The group has negotiated an amended consent agreement with the EPA to conduct the remaining RI/FS work, which became effective in May 2007. As part of that deal, the Company and McKesson have bought out of remaining RI/FS tasks.
Separately, the Company has agreed to pay approximately $110 thousand towards RI/FS tasks previously funded by McKesson and work cooperatively going forward. In addition, in mid-2007 the EPA announced plans to seek implementation of “early-action” remedial measures to address the most highly-contaminated portions of the LPR while the RI/FS is being completed. The EPA has indicated it expects to select any such actions early in 2008. Also, a group of federal natural resource trustee agencies have proposed that the private party group enter into an agreement to assess natural resource damages in the LPR. The group expects to discuss the proposal with the trustees in the near future. The extent of any liability the Company may face for these and related requirements cannot yet be determined.
 
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North Brunswick Township Board of Education
As previously disclosed, in October 2003, the Company was contacted by counsel representing the North Brunswick, NJ Board of Education (BOE) regarding a site where waste materials from E.R. Squibb and Sons may have been disposed from the 1940’s through the 1960’s. Fill material containing industrial waste and heavy metals in excess of residential standards was discovered during an expansion project at the North Brunswick Township High School, as well as at a number of neighboring residential properties and adjacent public park areas. In January 2004, the NJDEP sent the Company and others an information request letter about possible waste disposal at the site, to which the Company responded in March 2004. The BOE and the Township, who are the current owners of the school property and the park, are conducting and jointly financing soil remediation work and ground water investigation work under a work plan approved by NJDEP, and have asked the Company to contribute to the cost. Due to financial constraints, in late 2004 the BOE asked the Company to contribute funds on an interim basis to assure uninterrupted performance of necessary site work. The Company continues to actively monitor the clean-up project, including its costs. To date, neither the school board nor the Township has asserted any claim against the Company. Instead, the Company and the local entities have negotiated an agreement to attempt to resolve the matter by mediation; a central component of the anticipated agreement is provision by the Company of interim funding to help defray cleanup costs. The agreement has been executed by all parties, and the Company has transmitted an initial interim funding payment in January 2008. The parties have recently commenced work to prepare for mediation, which is expected to conclude by mid-2008.
ODS Regulatory Compliance
As previously disclosed, the EPA is investigating industrial and commercial facilities throughout the U.S. that use refrigeration equipment containing ozone-depleting substances (ODS) and enforcing compliance with regulations governing the prevention, service and repair of leaks (ODS requirements). In 2004, the Company performed a voluntary corporate-wide audit at its facilities in the U.S. and Puerto Rico that use ODS-containing refrigeration equipment. The Company submitted an audit report to the EPA in November 2004, identifying potential violations of the ODS requirements at several of its facilities. In addition to the matters covered in the Company’s audit report letter to the EPA, the EPA previously sent the Company’s wholly-owned subsidiary, Mead Johnson, a request for information regarding compliance with ODS requirements at its facility in Evansville, Indiana. The Company responded to the request in June 2004, and, as a result, identified potential violations at the Evansville facility. The Company currently is in discussions with the EPA to resolve both the potential violations discovered during the audit and those identified as a result of the EPA request for information to the Evansville facility. If the EPA determines that the Evansville facility, or any other facilities, was, or is, in violation of applicable ODS requirements, the Company could be subject to penalties and/or be required to convert or replace refrigeration equipment to use non-ODS approved substitutes.
MACT Compliance—Puerto Rico Facilities (Barceloneta and Humacao)
As previously disclosed, in March 2005, the Company commenced a voluntary environmental audit of the Barceloneta and Humacao, Puerto Rico facilities to determine their compliance with EPA’s regulations regarding the maximum achievable control technology requirements for emissions of hazardous air pollutants from pharmaceuticals production (Pharmaceutical MACT). The Company submitted to EPA an audit report for the Humacao facility in June 2005 and for the Barceloneta facility in July 2005, which disclosed potential violations of the Pharmaceutical MACT requirements at both facilities. The Company and the EPA are currently in discussions regarding resolution of this matter.
WAGE & HOUR LITIGATION
As previously disclosed, two putative class action complaints have been filed against the Company by former sales representatives.
In Kin Fung, et al. v. Bristol-Myers Squibb Company, et al., (Case Number RG07333147), filed in June 2007 in the Superior Court of the State of California for the County of Alameda, the plaintiff alleges that the Company violated California wage and hour laws by, among other things, not paying overtime compensation to him and a putative class of similarly situated sales employees. Plaintiff filed an Amended Complaint on September 24, 2007 to add a cause of action for penalties under California Labor Code §2699, the Private Attorney General Act. California Labor Code §2699 allows a plaintiff to collect civil penalties for violations of any provision of the California Labor Code, 75% of which is collected by the Labor and Workforce Development Agency. California Labor Code §2699 has a one-year statute of limitations, and allows for the recovery of a penalty for each outstanding violation per pay period, and could be interpreted to require a penalty per employee per pay period. On January 4, 2008, the Court dismissed the Kin Fung matter in its entirety due to Mr. Fung’s assertion that he did not wish to participate as plaintiff in the matter.
In Beth Amendola v. Bristol-Myers Squibb Company, et al. (Docket No. 07-CV-6088), filed in June 2007 in the District court, the plaintiff alleges that the Company violated the federal Fair Labor Standards Act by, among other things, not paying overtime compensation to her and a putative class of similarly situated sales employees. The parties are currently engaged in preliminary discovery in the Amendola matter.
 
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The Company intends to vigorously defend itself in these lawsuits. As the above matters are in the very early stages of litigation, it is not possible at this time reasonably to assess the outcome of the litigation matters described above, but it is not expected that their outcome would be material to the Company’s results of operations and cash flows, or be material to its financial condition and liquidity.
OTHER PROCEEDINGS
SEC Germany Investigation
As previously disclosed, in October 2004, the SEC notified the Company that it is conducting an informal inquiry into the activities of certain of the Company’s German pharmaceutical subsidiaries and its employees and/or agents. On October 4, 2006, the SEC informed the Company that its inquiry is now formal. The SEC’s inquiry encompasses matters currently under investigation by the German prosecutor in Munich, Germany. The Company understands the inquiry and investigation concern potential violations of the Foreign Corrupt Practices Act and German law, respectively. The Company is cooperating with both the SEC and the German authorities. The Company has established an accrual which represents minimum expected probable losses with respect to the investigation by the German prosecutor. It is not possible at this time reasonably to assess the outcome of these investigations or their impact on the Company.
Bari, Italy Investigation
As previously disclosed, in January 2006, the Company was notified by the Prosecutor in the Bari region of Italy (Bari Prosecutor) that the Company was under investigation as a result of the activities of two of its employees in the region. The investigation also involved a number of doctors, pharmacists, pharmaceutical companies and their sales representatives. The main allegation was that the parties were engaged in a plan to defraud the National Health Service, and that the companies lacked appropriate compliance controls and/or processes and procedures to control the activities of their sales representatives. In February 2007, the Company and the Bari Prosecutor reached an agreement in principle to settle the matter. The agreement requires final approval by the Civil Court, and a final hearing in the matter should occur during 2008. The Company has paid an administrative fine in an amount which is not material to the Company.
ConvaTec – Italy Investigation
The Italian competition authorities investigated a complaint lodged by a hospital in the Ferrara region of Italy relating to an allegation that four medical device companies, including ConvaTec, boycotted tenders in 2003 and 2004 (the Ferrara tenders). ConvaTec responded to the allegations earlier this year. In May 2007, ConvaTec received a statement of objections from the Italian competition authorities, whereby the authorities alleged that four medical device companies, including ConvaTec, acted in a concerted manner with regard not only to the Ferrara tenders, but tenders or pricing discussions in three other regions and acted in such a way to prevent competition throughout Italy. A hearing on the matter was held in July 2007. In August 2007, the competition authorities issued their decision, and found that the four medical device companies had infringed Italian anti-trust law by not participating in the Ferrara tenders, and imposed a fine of €2,345,200 against ConvaTec. (As ConvaTec is a division of BMS Italy, the fine was imposed against BMS Italy). The fine is based on ConvaTec’s market share and turnover in 2004. The other companies also were fined, but the amounts were smaller. ConvaTec has appealed the decision to the Administrative Court. A hearing on the appeal is expected in early or mid 2008, with a decision likely to issue soon  thereafter.
Note 23 SUBSEQUENT EVENTS
In December 2007, the Company entered into a definitive agreement with Avista for the sale of its Medical Imaging business, for a purchase price of approximately $525 million in cash, subject to customary post-closing adjustments. The closing of the transaction was completed on January 7, 2008. The Company expects to recognize a pre-tax gain of approximately $20 million to $40 million ($30 million to $50 million loss net of tax) in the first quarter of 2008, subject to the post-closing adjustments.
On February 21, 2008, the Company completed the sale and leaseback of an administrative facility in Paris, France for approximately €155 million. The Company expects to record a gain, of which the majority will be deferred and will reduce future lease rental costs over the lease period.
 
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Note 24 SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED)

Dollars in Millions, except per share data	  	First Quarter	  	Second Quarter	  	Third Quarter	  	Fourth Quarter	 	  	Year	
2007: (6) 	  			  			  			  				  			
Net Sales	  	$	4,317	  	$	4,757	  	$	4,893	  	$	5,381	 	  	$	19,348	
Gross Margin	  	 	2,977	  	 	3,265	  	 	3,324	  	 	3,564	 	  	 	13,130	
Net Earnings/(Loss) from Continuing Operations (5)	  	 	643	  	 	650	  	 	808	  	 	(133	)	  	 	1,968	
Net Earnings from Discontinued Operations, net	  	 	47	  	 	56	  	 	50	  	 	44	 	  	 	197	
Net Earnings/(Loss)	  	 	690	  	 	706	  	 	858	  	 	(89	)	  	 	2,165	
Earnings per Common Share (1) :	  			  			  			  				  			
Basic:	  			  			  			  				  			
Net Earnings/(Loss) from Continuing Operations (5)	  	$	0.33	  	$	0.33	  	$	0.41	  	$	(0.07	)	  	$	1.00	
Net Earnings from Discontinued Operations, net	  	 	0.02	  	 	0.03	  	 	0.02	  	 	0.02	 	  	 	0.10	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	
Net Earnings/(Loss) per common share	  	$	0.35	  	$	0.36	  	$	0.43	  	$	(0.05	)	  	$	1.10	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	
Diluted (2) (3) (4) :	  			  			  			  				  			
Net Earnings/(Loss) from Continuing Operations (5)	  	$	0.33	  	$	0.33	  	$	0.41	  	$	(0.07	)	  	$	0.99	
Net Earnings from Discontinued Operations, net	  	 	0.02	  	 	0.03	  	 	0.02	  	 	0.02	 	  	 	0.10	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	
Net Earnings/(Loss) per common share	  	$	0.35	  	$	0.36	  	$	0.43	  	$	(0.05	)	  	$	1.09	

Dividends declared per common share	  	$	0.28	  	$	0.28	  	$	0.28	  	$	0.31	 	  	$	1.15	
						
Cash and cash equivalents	  	$	2,214	  	$	2,379	  	$	1,647	  	$	1,801	 	  	$	1,801	
Marketable securities	  	 	1,798	  	 	2,267	  	 	1,935	  	 	424	 	  	 	424	
						
2006: (6) 	  			  			  			  				  			
Net Sales	  	$	4,495	  	$	4,703	  	$	4,001	  	$	4,057	 	  	$	17,256	
Gross Margin	  	 	3,079	  	 	3,186	  	 	2,590	  	 	2,662	 	  	 	11,517	
Net Earnings/(Loss) from Continuing Operations (5)	  	 	665	  	 	621	  	 	306	  	 	(170	)	  	 	1,422	
Net Earnings from Discontinued operations, net	  	 	49	  	 	46	  	 	32	  	 	36	 	  	 	163	
Net Earnings/(Loss)	  	 	714	  	 	667	  	 	338	  	 	(134	)	  	 	1,585	
Earnings per Common Share (1) :	  			  			  			  				  			
Basic:	  			  			  			  				  			
Net Earnings/(Loss) from Continuing Operations (5)	  	$	0.34	  	$	0.32	  	$	0.16	  	$	(0.09	)	  	$	0.73	
Net Earnings from Discontinued Operations, net	  	 	0.02	  	 	0.02	  	 	0.01	  	 	0.02	 	  	 	0.08	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	
Net Earnings/(Loss) per common share	  	$	0.36	  	$	0.34	  	$	0.17	  	$	(0.07	)	  	$	0.81	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	
Diluted (2) (3) (4) :	  			  			  			  				  			
Net Earnings/(Loss) from Continuing Operations (5)	  	$	0.34	  	$	0.32	  	$	0.16	  	$	(0.09	)	  	$	0.73	
Net Earnings from Discontinued Operations, net	  	 	0.02	  	 	0.02	  	 	0.01	  	 	0.02	 	  	 	0.08	
	  	 	 	  	 	 	  	 	 	  	 	 	 	  	 	 	
Net Earnings/(Loss) per common share	  	$	0.36	  	$	0.34	  	$	0.17	  	$	(0.07	)	  	$	0.81	

Dividends declared per common share	  	$	0.28	  	$	0.28	  	$	0.28	  	$	0.28	 	  	$	1.12	
						
Cash and cash equivalents	  	$	2,477	  	$	2,602	  	$	2,834	  	$	2,018	 	  	$	2,018	
Marketable securities	  	 	2,804	  	 	2,755	  	 	2,671	  	 	1,995	 	  	 	1,995	

(1)	Earnings per share for the quarters may not add to the amounts for the year, as each period is computed on a discrete basis.	

(2)	Common equivalent shares excluded from the computation of diluted earnings per share, because the effect would be anti-dilutive, were as follows (in millions):	

 	  	First
Quarter	  	Second
Quarter	  	Third
Quarter	  	Fourth
Quarter	  	Year	
2007	  	116	  	85	  	84	  	185	  	107	
2006	  	165	  	147	  	146	  	174	  	164	
 
(3)	For the three months ended December 31, 2007 and 2006, as a result of the net loss, basic and diluted loss per share are equal.	

(4)	In 2007 and 2006, the 29 million weighted-average shares issuable, as well as $38 million and $35 million of interest expense, net of tax, on the conversion of convertible debt were not included in the diluted earnings per share calculation because they were anti-dilutive.	
 
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Note 24 SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED) (Continued)
 
(5)	The Company recorded the following items in 2007 and 2006 that affected the comparability of results:	

2007:	  	 	 	 	 	 	 	 	 	 	 	 	  	 	 	
Dollars in Millions	  	First
Quarter	 	 	Second
Quarter	 	 	Third
Quarter	 	 	Fourth
Quarter	 	  	Year	 	
Productivity Transformation Initiative:	  				 				 				 				  				
Downsizing and streamlining of worldwide operations	  	$	—  	 	 	$	—  	 	 	$	—  	 	 	$	145	 	  	$	145	 	
Accelerated depreciation and asset impairment	  	 	—  	 	 	 	—  	 	 	 	—  	 	 	 	110	 	  	 	110	 	
Process standardization implementation costs	  	 	—  	 	 	 	—  	 	 	 	—  	 	 	 	37	 	  	 	37	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
	  	 	—  	 	 	 	—  	 	 	 	—  	 	 	 	292	 	  	 	292	 	
Other:	  				 				 				 				  				
Litigation settlement	  	 	—  	 	 	 	14	 	 	 	—  	 	 	 	—  	 	  	 	14	 	
Insurance recovery	  	 	—  	 	 	 	—  	 	 	 	(11	)	 	 	—  	 	  	 	(11	)	
Product liability	  	 	—  	 	 	 	—  	 	 	 	5	 	 	 	10	 	  	 	15	 	
Upfront and milestone payments and acquired in-process research and development	  	 	80	 	 	 	17	 	 	 	60	 	 	 	235	 	  	 	392	 	
Auction rate securities impairment	  	 	—  	 	 	 	—  	 	 	 	—  	 	 	 	275	 	  	 	275	 	
Downsizing and streamlining of worldwide operations	  	 	37	 	 	 	7	 	 	 	—  	 	 	 	—  	 	  	 	44	 	
Accelerated depreciation, asset impairment and contract termination	  	 	16	 	 	 	13	 	 	 	17	 	 	 	54	 	  	 	100	 	
Gain on sale of properties and product assets	  	 	—  	 	 	 	(26	)	 	 	(247	)	 	 	(9	)	  	 	(282	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
	  	 	133	 	 	 	25	 	 	 	(176	)	 	 	857	 	  	 	839	 	
Income taxes on items above	  	 	(40	)	 	 	(5	)	 	 	82	 	 	 	(70	)	  	 	(33	)	
Change in estimate for taxes on a prior year item	  	 	(39	)	 	 	—  	 	 	 	—  	 	 	 	—  	 	  	 	(39	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
(Increase)/Decrease to Net Earnings from Continuing Operations	  	$	54	 	 	$	20	 	 	$	(94	)	 	$	787	 	  	$	767	 	

2006:	  	 	 	 	 	 	 	 	 	 	 	 	  	 	 	
 	  	First
Quarter	 	 	Second
Quarter	 	 	Third
Quarter	 	 	Fourth
Quarter	 	  	Year	 	
Litigation Matters:	  				 				 				 				  				
Pharmaceutical pricing and sales litigation	  	$	—  	 	 	$	—  	 	 	$	—  	 	 	$	353	 	  	$	353	 	
Product liability	  	 	—  	 	 	 	—  	 	 	 	11	 	 	 	—  	 	  	 	11	 	
Claim for damages	  	 	—  	 	 	 	—  	 	 	 	—  	 	 	 	13	 	  	 	13	 	
Commercial litigations	  	 	40	 	 	 	(14	)	 	 	(40	)	 	 	—  	 	  	 	(14	)	
Insurance recovery	  	 	(21	)	 	 	—  	 	 	 	(9	)	 	 	(7	)	  	 	(37	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
	  	 	19	 	 	 	(14	)	 	 	(38	)	 	 	359	 	  	 	326	 	
Other:	  				 				 				 				  				
Debt retirement costs	  	 	—  	 	 	 	—  	 	 	 	—  	 	 	 	220	 	  	 	220	 	
Accelerated depreciation, asset impairment and contract termination	  	 	50	 	 	 	21	 	 	 	72	 	 	 	43	 	  	 	186	 	
Upfront and milestone payments	  	 	18	 	 	 	—  	 	 	 	17	 	 	 	35	 	  	 	70	 	
Downsizing and streamlining of worldwide operations	  	 	1	 	 	 	3	 	 	 	2	 	 	 	53	 	  	 	59	 	
Gain on sale of product asset	  	 	(200	)	 	 	—  	 	 	 	—  	 	 	 	—  	 	  	 	(200	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
	  	 	(112	)	 	 	10	 	 	 	53	 	 	 	710	 	  	 	661	 	
Income taxes on items above	  	 	48	 	 	 	3	 	 	 	(5	)	 	 	(196	)	  	 	(150	)	
Minority interest, net of taxes	  	 	(13	)	 	 	—  	 	 	 	13	 	 	 	—  	 	  	 	—  	 	
Change in estimate for taxes on prior year items	  	 	—  	 	 	 	—  	 	 	 	39	 	 	 	—  	 	  	 	39	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
(Increase)/Decrease to Net Earnings from Continuing Operations	  	$	(77	)	 	$	13	 	 	$	100	 	 	$	514	 	  	$	550	 	

(6)	All financial information reflects the Medical Imaging business as discontinued operations, see “ – Note 5. Discontinued Operations and Assets Held for Sale.”	
 
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 Report of Independent Registered Public Accounting Firm
To the Board of Directors and Stockholders of
Bristol-Myers Squibb Company
We have audited the accompanying consolidated balance sheets of Bristol-Myers Squibb Company and subsidiaries (the “Company”) as of December 31, 2007 and 2006, and the related consolidated statements of earnings, comprehensive income and retained earnings, and cash flows for the years then ended. Our audits also included the financial statement schedule for the years ended December 31, 2007 and 2006 listed in the Index at Item 15. These financial statements and financial statement schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on the financial statements and financial statement schedule based on our audits. The consolidated financial statements of the Company for the year ended December 31, 2005, before the effects of the retrospective adjustments for the discontinued operations of the Bristol-Myers Squibb Medical Imaging (“MI”) business discussed in Note 5 to the consolidated financial statements, were audited by other auditors whose report, dated March 13, 2006, expressed an unqualified opinion on those statements.
We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.
In our opinion, such consolidated financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2007 and 2006, and the results of their operations and their cash flows for the years then ended, in conformity with accounting principles generally accepted in the United States of America. Also, in our opinion, such financial statement schedule for the years ended December 31, 2007 and 2006, when considered in relation to the basic consolidated financial statements taken as a whole, presents fairly, in all material respects, the information set forth therein.
We have also audited the retrospective adjustments to the 2005 consolidated financial statements for the operations of MI which were discontinued in 2007, as discussed in Note 5 to the consolidated financial statements. Our procedures included (1) obtaining the Company’s underlying accounting analysis prepared by management of the retrospective adjustments for discontinued operations and comparing the retrospectively adjusted amounts per the 2005 consolidated financial statements to such analysis, (2) comparing previously reported amounts to the previously issued consolidated financial statements for such year, (3) testing the mathematical accuracy of the accounting analysis, and (4) comparing the adjustments to retrospectively adjust the consolidated financial statements for discontinued operations to the Company’s supporting documentation. In our opinion, such retrospective adjustments are appropriate and have been properly applied. However, we were not engaged to audit, review or apply any procedures to the 2005 consolidated financial statements of the Company other than with respect to the retrospective adjustments and, accordingly, we do not express an opinion or any other form of assurance on the 2005 consolidated financial statements taken as a whole.
As discussed in Notes 1, 8, 17 and 21 to the consolidated financial statements, the Company adopted Financial Accounting Standards Board Interpretation (“FIN”) No. 48, Accounting for Uncertainty in Income Taxes – an interpretation of FASB Statement No. 109 , effective January 1, 2007, Statement of Financial Accounting Standards (“SFAS”) No. 123(R), Share-Based Payment , effective January 1, 2006, and SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans – an Amendment of FASB Statements No. 87, 88, 106, and 132(R) , effective December 31, 2006.
We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the Company’s internal control over financial reporting as of December 31, 2007, based on the criteria established in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated February 21, 2008 expressed an unqualified opinion on the Company’s internal control over financial reporting.

/s/ Deloitte & Touche LLP	
	
Deloitte & Touche LLP	
Parsippany, New Jersey	
February 21, 2008	
 
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Report of Independent Registered Public Accounting Firm
To the Board of Directors
and Stockholders of
Bristol-Myers Squibb Company:
In our opinion, the consolidated statements of earnings, comprehensive income and retained earnings, and cash flows for the year ended December 31, 2005, before the effects of the adjustments to retrospectively reflect the discontinued operations described in Note 5, present fairly, in all material respects, the results of operations and cash flows of Bristol-Myers Squibb Company and its subsidiaries for the year ended December 31, 2005, in conformity with accounting principles generally accepted in the United States of America (the 2005 consolidated financial statements before the effects of the adjustments discussed in Note 5 are not presented herein). In addition, in our opinion, the financial statement schedule for the year ended December 31, 2005, before the effects of the adjustments to retrospectively reflect the discontinued operations described in Note 1 to the financial statement schedule, presents fairly, in all material respects, the information set forth therein when read in conjunction with the related consolidated financial statements referred to above (the financial statement schedule for the year ended December 31, 2005 before the effects of the adjustments discussed in Note 1 to the financial statement schedule is not presented herein). These financial statements and financial statement schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements and financial statement schedule based on our audit. We conducted our audit, before the effects of the adjustments described above, of these statements in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.
We were not engaged to audit, review, or apply any procedures to the adjustments to retrospectively reflect the discontinued operations described in Note 5 to the financial statements and Note 1 to the financial statement schedule and accordingly, we do not express an opinion or any other form of assurance about whether such adjustments are appropriate and have been properly applied. Those adjustments were audited by other auditors.

/s/ PricewaterhouseCoopers LLP	
	
PricewaterhouseCoopers LLP	
Philadelphia, PA	
March 13, 2006	
 
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Item 9.	CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE.	
None.
 
Item 9A.	CONTROLS AND PROCEDURES.	
Evaluation of Disclosure Controls and Procedures
As of December 31, 2007, management carried out an evaluation, under the supervision and with the participation of its chief executive officer and chief financial officer, of the effectiveness of the design and operation of its disclosure controls and procedures as such term is defined under Exchange Act Rule 13a-15(e). Based on this evaluation, management has concluded that as of December 31, 2007, such disclosure controls and procedures were effective.
Management’s Report on Internal Control Over Financial Reporting
Management is responsible for establishing and maintaining adequate internal control over financial reporting. Under the supervision and with the participation of management, including the chief executive officer and chief financial officer, management assessed the effectiveness of internal control over financial reporting as of December 31, 2007 based on the framework in “Internal Control—Integrated Framework” issued by the Committee of Sponsoring Organizations of the Treadway Commission. Based on that assessment, management has concluded that the Company’s internal control over financial reporting was effective at December 31, 2007 to provide reasonable assurance regarding the reliability of its financial reporting and the preparation of its financial statements for external purposes in accordance with United States generally accepted accounting principles. Due to its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.
Deloitte & Touche LLP, an independent registered public accounting firm, has audited the Company’s financial statements included in this report on Form 10-K and issued its report on the effectiveness of the Company’s internal control over financial reporting as of December 31, 2007, which is included herein.
Changes in Internal Control Over Financial Reporting
There were no changes in the Company’s internal control over financial reporting during the quarter ended December 31, 2007 that have materially affected, or are reasonably likely to materially affect, the Company’s internal control over financial reporting.
 
Item 9B.	OTHER INFORMATION.	
None.
 
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Report of Independent Registered Public Accounting Firm
To the Board of Directors and Stockholders of
Bristol-Myers Squibb Company
We have audited the internal control over financial reporting of Bristol-Myers Squibb Company and subsidiaries (the “Company”) as of December 31, 2007, based on criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission. The Company’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting. Our responsibility is to express an opinion on the Company’s internal control over financial reporting based on our audit.
We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.
A company’s internal control over financial reporting is a process designed by, or under the supervision of, the company’s principal executive and principal financial officers, or persons performing similar functions, and effected by the company’s board of directors, management, and other personnel to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.
Because of the inherent limitations of internal control over financial reporting, including the possibility of collusion or improper management override of controls, material misstatements due to error or fraud may not be prevented or detected on a timely basis. Also, projections of any evaluation of the effectiveness of the internal control over financial reporting to future periods are subject to the risk that the controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.
In our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2007, based on the criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission.
We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated financial statements and financial statement schedule as of and for the year ended December 31, 2007 of the Company and our report dated February 21, 2008 expressed an unqualified opinion on those financial statements and financial statement schedule and included an explanatory paragraph regarding the Company’s adoption of Financial Accounting Standards Board Interpretation (“FIN”) No. 48, Accounting for Uncertainty in Income Taxes – an interpretation of FASB Statement No. 109 , effective January 1, 2007.

/s/ Deloitte & Touche LLP	
	
Deloitte & Touche LLP	
Parsippany, New Jersey	
February 21, 2008	
 
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PART III
 
Item 10.	DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.	
(a) Reference is made to the 2008 Proxy Statement to be filed on or about March 21, 2008 with respect to the Directors of the Registrant, which is incorporated herein by reference and made a part hereof in response to the information required by Item 10.
(b) The information required by Item 10 with respect to the Executive Officers of the Registrant has been included in Part IA of this Form 10-K in reliance on General Instruction G of Form 10-K and Instruction 3 to Item 401(b) of Regulation S-K.
 
Item 11.	EXECUTIVE COMPENSATION.	
Reference is made to the 2008 Proxy Statement to be filed on or about March 21, 2008 with respect to Executive Compensation, which is incorporated herein by reference and made a part hereof in response to the information required by Item 11.
 
Item 12.	SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS.	
Reference is made to the 2008 Proxy Statement to be filed on or about March 21, 2008 with respect to the security ownership of certain beneficial owners and management, which is incorporated herein by reference and made a part hereof in response to the information required by Item 12.
 
Item 13.	CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.	
Reference is made to the 2008 Proxy Statement to be filed on or about March 21, 2008 with respect to certain relationships and related transactions, which is incorporated herein by reference and made a part hereof in response to the information required by Item 13.
 
Item 14.	AUDITOR FEES.	
Reference is made to the 2008 Proxy Statement to be filed on or about March 21, 2008 with respect to auditor fees, which is incorporated herein by reference and made a part hereof in response to the information required by Item 14.
 
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 PART IV
 
Item 15.	EXHIBITS, FINANCIAL STATEMENT SCHEDULE, AND REPORTS ON FORM 8-K.	
(a)

 	 	 	  	Page
Number	
1.	 	Consolidated Financial Statements	  		
	 	Consolidated Statements of Earnings	  	85	
	 	Consolidated Statements of Comprehensive Income and Retained Earnings	  	86	
	 	Consolidated Balance Sheets	  	87	
	 	Consolidated Statements of Cash Flows	  	88	
	 	Notes to Consolidated Financial Statements	  	89-141	
	 	Reports of Independent Registered Public Accounting Firms	  	142-143	
2.	 	Financial Statement Schedule	  		
	 	    Valuation and Qualifying Accounts	  	156	
All other schedules not included with this additional financial data are omitted because they are not applicable or the required information is included in the financial statements or notes thereto.
3. Exhibit Index
The Exhibits listed below are identified by numbers corresponding to the Exhibit Table of Item 601 of Regulation S-K. The Exhibits designated by two asterisks (**) are management contracts or compensatory plans or arrangements required to be filed pursuant to Item 15. An asterisk (*) in the Page column indicates that the Exhibit has been previously filed with the Commission and is incorporated herein by reference. Unless otherwise indicated, all Exhibits are part of Commission File Number 1-1136.

Exhibit No.	  	Description	  	Page No.	
			
3a.	  	Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 3a to the Form 10-Q for the quarterly period ended June 30, 2005).	  	*	
			
3b.	  	Bylaws of Bristol-Myers Squibb Company, as amended as of February 11, 2008 (incorporated herein by reference to Exhibit 3.1 to Form 8-K dated February 11, 2008 and filed on February 15, 2008).	  	*	
			
4a.	  	Letter of Agreement dated March 28, 1984 (incorporated herein by reference to Exhibit 4 to Form 10-K for the fiscal year ended December 31, 1983).	  	*	
			
4b.	  	Indenture, dated as of June 1, 1993, between Bristol-Myers Squibb Company and JPMorgan Chase Bank (as successor trustee to The Chase Manhattan Bank (National Association)) (incorporated herein by reference to Exhibit 4.1 to the Form 8-K dated May 27, 1993, and filed on June 3, 1993).	  	*	
			
4c.	  	Form of 7.15% Debenture due 2023 of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 4.2 to the Form 8-K dated May 27, 1993, and filed on June 3, 1993).	  	*	
			
4d.	  	Form of 6.80% Debenture due 2026 of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 4e to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
			
4e.	  	Form of 6.875% Debenture due 2097 of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 4f to the Form 10-Q for the quarterly period ended September 30, 1997).	  	*	
			
4f.	  	Third Supplemental Indenture, dated August 18, 2003, between Bristol-Myers Squibb Company and JPMorgan Chase Bank, as Trustee, to the indenture dated June 1, 1993 (incorporated herein by reference to Exhibit 4k to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4g.	  	Form of 4.00% Senior Note due 2008 (incorporated herein by reference to Exhibit 4n to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4h.	  	Form of 5.25% Senior Note due 2013 (incorporated herein by reference to Exhibit 4o to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4i.	  	Indenture, dated October 1, 2003, between Bristol-Myers Squibb Company, as Issuer, and JPMorgan Chase Bank, as Trustee (incorporated herein by reference to Exhibit 4q to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4j.	  	Form of Floating Rate Convertible Senior Debenture due 2023 (incorporated herein by reference to Exhibit 4s to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4k.	  	Specimen Certificate of Common Stock (incorporated herein by reference to Exhibit 4s to the Form 10-K for the fiscal year ended December 31, 2003).	  	*	
 
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4l.	  	Specimen Certificate of Convertible Preferred Stock (incorporated herein by reference to Exhibit 4s to the Form 10-K for the fiscal year ended December 31, 2003).	  	*	
			
4m.	  	Form of Fourth Supplemental Indenture between Bristol-Myers Squibb Company and The Bank of New York, as Trustee, to the indenture dated June 1, 1993 (incorporated herein by reference to Exhibit 4r the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
4n.	  	Form of 5.875% Notes due 2036 (incorporated herein by reference to Exhibit 4s the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
4o.	  	Form of 4.375% Notes due 2016 (incorporated herein by reference to Exhibit 4t the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
4p.	  	Form of 4.625% Notes due 2021 (incorporated herein by reference to Exhibit 4u the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
10a.	  	$2,000,000,000 Five Year Competitive Advance and Revolving Credit Facility Agreement dated as of December 21, 2006 among Bristol-Myers Squibb Company, the borrowing subsidiaries, the lenders named in the agreement, Bank of America, N.A. as syndication agent, and JPMorgan Chase Bank and Citicorp North America, Inc., as administrative agents (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated December 21, 2006 and filed December 27, 2006).	  	*	
			
10b.	  	SEC Consent Order (incorporated herein by reference to Exhibit 10s to the Form 10-Q for the quarterly period ended September 30, 2004).	  	*	
			
10c.	  	General Contract of Indemnity dated August 17, 2006 between Bristol-Myers Squibb Company and Travelers Casualty and Surety Company of America (incorporated herein by reference to Exhibit 10bb to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
10d.	  	Registered Pledge and Master Security Agreement dated August 17, 2006 between Bristol-Myers Squibb Company and Travelers Casualty and Surety Company of America (incorporated herein by reference to Exhibit 10cc to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
10e.	  	Control Agreement dated August 18, 2006 among Bristol-Myers Squibb Company, Travelers Casualty and Surety Company of America and Smith Barney Inc. (incorporated herein by reference to Exhibit 10dd to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
10f.	  	Letter Agreement dated August 18, 2006 between Bristol-Myers Squibb Company and Travelers Casualty and Surety Company of America (incorporated herein by reference to Exhibit 10ee to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
**10g.	  	Bristol-Myers Squibb Company 1997 Stock Incentive Plan, effective as of May 6, 1997 and as amended effective July 17, 2002 (incorporated herein by reference to Exhibit 10a to the Form 10-Q for the quarterly period ended June 30, 2002).	  	*	
			
**10h.	  	Bristol-Myers Squibb Company 2002 Stock Incentive Plan, effective as of May 7, 2002 and as amended effective January 23, 2007 (incorporated herein by reference to Exhibit 10b to the Form 10-K for the fiscal year ended December 31, 2006).	  	*	
			
**10i.	  	Bristol-Myers Squibb Company 2007 Stock Aware and Incentive Plan, effective as of May 1, 2007 (incorporated herein by reference to Exhibit B to the 2007 Proxy Statement dated March 22, 2007).	  	*	
			
**10j.	  	Bristol-Myers Squibb Company TeamShare Stock Option Plan, as amended and restated effective September 10, 2002 (incorporated herein by reference to Exhibit 10c to the Form 10-K for the fiscal year ended December 31, 2002).	  	*	
			
**10k.	  	Form of Non-Qualified Stock Option Agreement under the 2002 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10s to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
 
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**10l.	  	Form of Non-Qualified Stock Option Agreement under the 2007 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10s to the Form 10-Q for the quarterly period ended March 31, 2007).	  	*	
			
**10m.	  	Form of Restricted Stock Award Agreement under the 2002 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10t to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
			
**10n.	  	Form of Performance Shares Agreement for the 2006-2008 Performance Cycle (incorporated herein by reference to Exhibit 10u to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
			
**10o.	  	Form of Performance Shares Agreement for the 2007-2009 Performance Cycle (incorporated herein by reference to Exhibit 10.1 to the Form 10-Q for the quarterly period ended June 30, 2007).	  	*	
			
**10p.	  	Form of Performance Shares Agreement for the 2008-2010 Performance Cycle (incorporated herein by reference to Exhibit 10.1 to the Form 10-Q for the quarterly period ended September 30, 2007).	  	*	
			
**10q.	  	Form of Restricted Stock Units Agreement under the 2002 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10v to the Form 10-K for the fiscal year ended December 31, 2006).	  	*	
			
**10r.	  	Form of Restricted Stock Units Agreement under the 2007 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10t to the Form 10-Q for the quarterly period ended March 31, 2007).	  	*	
			
**10s.	  	Bristol-Myers Squibb Company Performance Incentive Plan, as amended (as adopted, incorporated herein by reference to Exhibit 2 to the Form 10-K for the fiscal year ended December 31, 1978; as amended as of January 8, 1990, incorporated herein by reference to Exhibit 19b to the Form 10-K for the fiscal year ended December 31, 1990; as amended on April 2, 1991, incorporated herein by reference to Exhibit 19b to the Form 10-K for the fiscal year ended December 31, 1991; as amended effective January 1, 1994, incorporated herein by reference to Exhibit 10d to the Form 10-K for the fiscal year ended December 31, 1993; and as amended effective January 1, 1994, incorporated herein by reference to Exhibit 10d to the Form 10-K for the fiscal year ended December 31, 1994).	  	*	
			
**10t.	  	Bristol-Myers Squibb Company Executive Performance Incentive Plan (effective January 1, 1997 and incorporated herein by reference to Exhibit 10b to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
			
**10u.	  	Bristol-Myers Squibb Company Executive Performance Incentive Plan (effective January 1, 2003 and incorporated herein by reference to Exhibit D to the 2003 Proxy Statement dated April 4, 2003).	  	*	
			
**10v.	  	Bristol-Myers Squibb Company 2007 Senior Executive Performance Incentive Plan (effective May 1, 2007 and incorporated herein by reference to Exhibit C to the 2007 Proxy Statement dated March 22, 2007).	  	*	
			
**10w.	  	Benefit Equalization Plan of Bristol-Myers Squibb Company and its Subsidiary or Affiliated Corporations Participating in the Bristol-Myers Squibb Company Retirement Income Plan or the Bristol-Myers Squibb Puerto Rico, Inc. Retirement Income Plan, as amended (as amended and restated as of January 1, 1993, as amended effective October 1, 1993, incorporated herein by reference to Exhibit 10e to the Form 10-K for the fiscal year ended December 31, 1993; and as amended effective February 1, 1995, incorporated herein by reference to Exhibit 10e to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
 
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**10x.	  	Benefit Equalization Plan of Bristol-Myers Squibb Company and its Subsidiary or Affiliated Corporations Participating in the Bristol-Myers Squibb Company Savings and Investment Program, as amended and restated effective as of January 1, 1996 (incorporated herein by reference to Exhibit 10h to the Form 10-K for the fiscal year ended December 31, 2001).	  	*	
			
**10y.	  	Squibb Corporation Supplementary Pension Plan, as amended (as previously amended and restated, incorporated herein by reference to Exhibit 19g to the Form 10-K for the fiscal year ended December 31, 1991; as amended as of September 14, 1993, and incorporated herein by reference to Exhibit 10g to the Form 10-K for the fiscal year ended December 31, 1993).	  	*	
			
**10z.	  	Senior Executive Severance Plan, effective as of April 26, 2007 (incorporated herein by reference to Exhibit 10.2 to the Form 8-K dated April 24, 2007 and filed on April 27, 2007).	  	*	
			
**10aa.	  	Letter Agreement dated October 31, 2006 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated October 31, 2006 and filed November 3, 2006).	  	*	
			
**10bb.	  	Letter Agreement dated April 26, 2007 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated April 24, 2007 and filed on April 27, 2007).	  	*	
			
**10cc.	  	Aircraft Time Sharing Agreement dated as of July 31, 2007 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.2 to the Form 10-Q for the quarterly period ended June 30, 2007).	  	*	
			
**10dd.	  	Letter Agreement dated February 12, 2008 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated February 11, 2008 and filed on February 15, 2008.	  	*	
			
**10ee.	  	Letter Agreement effective September 20, 2005 and addendum effective October 31, 2005 between Lamberto Andreotti and the Company (incorporated herein by reference to Exhibit 10.2 to the Form 8-K dated December 5, 2006 and filed on December 11, 2006).	  	*	
			
**10ff.	  	Form of Agreement entered into between the Registrant and each of the named executive officers and certain other executives effective January 1, 2008 (filed herewith).	  	E-10-1	
			
**10gg.	  	Bristol-Myers Squibb Company Retirement Income Plan for Non-Employee Directors, as amended to March 5, 1996 (incorporated herein by reference to Exhibit 10k to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
			
**10hh.	  	Bristol-Myers Squibb Company 1987 Deferred Compensation Plan for Non-Employee Directors, as amended to January 10, 2006 (incorporated herein by reference to Exhibit 10l to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
			
**10ii.	  	Bristol-Myers Squibb Company Non-Employee Directors’ Stock Option Plan, as amended (as approved by the Stockholders on May 1, 1990, incorporated herein by reference to Exhibit 28 to Registration Statement No. 33-38587 on Form S-8; as amended May 7, 1991, incorporated herein by reference to Exhibit 19c to the Form 10-K for the fiscal year ended December 31, 1991), as amended January 12, 1999 (incorporated herein by reference to Exhibit 10m to the Form 10-K for the fiscal year ended December 31, 1998).	  	*	
			
**10jj.	  	Bristol-Myers Squibb Company Non-Employee Directors’ Stock Option Plan, as amended (as approved by the Stockholders on May 2, 2000, incorporated herein by reference to Exhibit A to the 2000 Proxy Statement dated March 20, 2000.)	  	*	
			
**10kk.	  	Squibb Corporation Deferral Plan for Fees of Outside Directors, as amended (as adopted, incorporated herein by reference to Exhibit 10e Squibb Corporation 1991 Form 10-K for the fiscal year ended December 31, 1987, File No. 1-5514; as amended effective December 31, 1991 incorporated herein by reference to Exhibit 10m to the Form 10-K for the fiscal year ended December 31, 1992).	  	*	
			
**10ll.	  	Restricted Stock Units Agreement with James D. Robinson III, effective as of June 15, 2005 and as amended on July 13, 2005 (incorporated herein by reference to Exhibit 10x to the Form 10-Q for the quarterly period ended June 30, 2005).	  	*	
			
**10mm.	  	Amendment to all of the Company’s plans, agreements, legal documents and other writings, pursuant to action of the Board of Directors on October 3, 1989, to reflect the change of the Company’s name to Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10v to the Form 10-K for the fiscal year ended December 31, 1989).	  	*	
			
12.	  	Statement re computation of ratios (filed herewith).	  	E-12-1	
			
21.	  	Subsidiaries of the Registrant (filed herewith).	  	E-21-1	
			
23a.	  	Consent of Deloitte & Touche LLP (filed herewith).	  	E-23-1	
			
23b.	  	Consent of PricewaterhouseCoopers LLP (filed herewith)	  	E-23-2	
			
31a.	  	Section 302 Certification Letter (filed herewith).	  	E-31-1	
			
31b.	  	Section 302 Certification Letter (filed herewith).	  	E-31-2	
			
32a.	  	Section 906 Certification Letter (filed herewith).	  	E-32-1	
			
32b.	  	Section 906 Certification Letter (filed herewith).	  	E-32-2	

*	Indicates, in this Form 10-K, brand names of products, which are registered trademarks not owned by the Company or its subsidiaries. ERBITUX is a trademark of ImClone Systems Incorporated; AVAPRO/AVALIDE (known in the EU as APROVEL/KARVEA), ISCOVER and PLAVIX are trademarks of Sanofi-Aventis.; ABILIFY is a trademark of Otsuka Pharmaceutical Co., Ltd.; TRUVADA is a trademark of Gilead Sciences, Inc.; EMSAM is a trademark of Somerset Pharmaceuticals, Inc.; BUFFERIN, EXCEDRIN and GLEEVEC are trademarks of Novartis AG; ATRIPLA is a trademark of Bristol-Myers Squibb and Gilead Sciences, LLC; DOVONEX is a trademark of Leo Pharma A/S; NORVIR is a trademark of Abbott Laboratories.	
 
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SIGNATURES
Pursuant to the requirements of Section 13 or 15 (d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.

BRISTOL-MYERS SQUIBB COMPANY (Registrant)	
By	 	/ S / J AMES M. C ORNELIUS	
	 	James M. Cornelius	
	 	Chairman of the Board and Chief Executive Officer	
	
Date: February 21, 2008	
Pursuant to the requirements of the Securities Exchange Act of 1934, this Report has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.

Signature	  	Title	 	Date	
			
/s/ J AMES M. C ORNELIUS
(James M. Cornelius)	  	Chairman of the Board and
Chief Executive Officer
(Principal Executive Officer)	 	February 21, 2008	
			
/s/ A NDREW R.J. B ONFIELD
(Andrew R.J. Bonfield)	  	Chief Financial Officer
(Principal Financial Officer)	 	February 21, 2008	
			
/S/ J OSEPH C. C ALDARELLA
(Joseph C. Caldarella)	  	Vice President and Controller
(Principal Accounting Officer)	 	February 21, 2008	
			
/s/ L EWIS B. C AMPBELL
(Lewis B. Campbell)	  	Director	 	February 21, 2008	
			
/s/ L OUIS J. F REEH
(Louis J. Freeh)	  	Director	 	February 21, 2008	
			
/s/ L AURIE H. G LIMCHER , M.D.
(Laurie H. Glimcher, M.D.)	  	Director	 	February 21, 2008	
			
/s/ M ICHAEL G ROBSTEIN
(Michael Grobstein)	  	Director	 	February 21, 2008	
			
/s/ L EIF J OHANSSON
(Leif Johansson)	  	Director	 	February 21, 2008	
			
/s/ A LAN J. L ACY
(Alan J. Lacy)	  	Director	 	February 21, 2008	
			
/s/ J AMES D. R OBINSON III
(James D. Robinson III)	  	Director	 	February 21, 2008	
			
/s/ V ICKI L. S ATO , P H .D.
(Vicki L. Sato, Ph.D.)	  	Director	 	February 21, 2008	
			
/s/ T OGO D. W EST , J R .
(Togo D. West, Jr.)	  	Director	 	February 21, 2008	
			
/s/ R. S ANDERS W ILLIAMS , M.D.
(R. Sanders Williams, M.D.)	  	Director	 	February 21, 2008	
 
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EXHIBIT INDEX
The Exhibits listed below are identified by numbers corresponding to the Exhibit Table of Item 601 of Regulation S-K. The Exhibits designated by two asterisks (**) are management contracts or compensatory plans or arrangements required to be filed pursuant to Item 15. An asterisk (*) in the Page column indicates that the Exhibit has been previously filed with the Commission and is incorporated herein by reference. Unless otherwise indicated, all Exhibits are part of Commission File Number 1-1136.

Exhibit No.	  	Description	  	Page No.	
			
3a.	  	Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 3a to the Form 10-Q for the quarterly period ended June 30, 2005).	  	*	
			
3b.	  	Bylaws of Bristol-Myers Squibb Company, as amended as of February 11, 2008 (incorporated herein by reference to Exhibit 3.1 to Form 8-K dated February 11, 2008 and filed on February 15, 2008).	  	*	
			
4a.	  	Letter of Agreement dated March 28, 1984 (incorporated herein by reference to Exhibit 4 to Form 10-K for the fiscal year ended December 31, 1983).	  	*	
			
4b.	  	Indenture, dated as of June 1, 1993, between Bristol-Myers Squibb Company and JPMorgan Chase Bank (as successor trustee to The Chase Manhattan Bank (National Association)) (incorporated herein by reference to Exhibit 4.1 to the Form 8-K dated May 27, 1993, and filed on June 3, 1993).	  	*	
			
4c.	  	Form of 7.15% Debenture due 2023 of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 4.2 to the Form 8-K dated May 27, 1993, and filed on June 3, 1993).	  	*	
			
4d.	  	Form of 6.80% Debenture due 2026 of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 4e to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
			
4e.	  	Form of 6.875% Debenture due 2097 of Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 4f to the Form 10-Q for the quarterly period ended September 30, 1997).	  	*	
			
4f.	  	Third Supplemental Indenture, dated August 18, 2003, between Bristol-Myers Squibb Company and JPMorgan Chase Bank, as Trustee, to the indenture dated June 1, 1993 (incorporated herein by reference to Exhibit 4k to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4g.	  	Form of 4.00% Senior Note due 2008 (incorporated herein by reference to Exhibit 4n to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4h.	  	Form of 5.25% Senior Note due 2013 (incorporated herein by reference to Exhibit 4o to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4i.	  	Indenture, dated October 1, 2003, between Bristol-Myers Squibb Company, as Issuer, and JPMorgan Chase Bank, as Trustee (incorporated herein by reference to Exhibit 4q to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4j.	  	Form of Floating Rate Convertible Senior Debenture due 2023 (incorporated herein by reference to Exhibit 4s to the Form 10-Q for the quarterly period ended September 30, 2003).	  	*	
			
4k.	  	Specimen Certificate of Common Stock (incorporated herein by reference to Exhibit 4s to the Form 10-K for the fiscal year ended December 31, 2003).	  	*	
 
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4l.	  	Specimen Certificate of Convertible Preferred Stock (incorporated herein by reference to Exhibit 4s to the Form 10-K for the fiscal year ended December 31, 2003).	  	*	
			
4m.	  	Form of Fourth Supplemental Indenture between Bristol-Myers Squibb Company and The Bank of New York, as Trustee, to the indenture dated June 1, 1993 (incorporated herein by reference to Exhibit 4r the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
4n.	  	Form of 5.875% Notes due 2036 (incorporated herein by reference to Exhibit 4s the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
4o.	  	Form of 4.375% Notes due 2016 (incorporated herein by reference to Exhibit 4t the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
4p.	  	Form of 4.625% Notes due 2021 (incorporated herein by reference to Exhibit 4u the Form 8-K dated November 20, 2006 and filed November 27, 2006).	  	*	
			
10a.	  	$2,000,000,000 Five Year Competitive Advance and Revolving Credit Facility Agreement dated as of December 21, 2006 among Bristol-Myers Squibb Company, the borrowing subsidiaries, the lenders named in the agreement, Bank of America, N.A. as syndication agent, and JPMorgan Chase Bank and Citicorp North America, Inc., as administrative agents (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated December 21, 2006 and filed December 27, 2006).	  	*	
			
10b.	  	SEC Consent Order (incorporated herein by reference to Exhibit 10s to the Form 10-Q for the quarterly period ended September 30, 2004).	  	*	
			
10c.	  	General Contract of Indemnity dated August 17, 2006 between Bristol-Myers Squibb Company and Travelers Casualty and Surety Company of America (incorporated herein by reference to Exhibit 10bb to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
10d.	  	Registered Pledge and Master Security Agreement dated August 17, 2006 between Bristol-Myers Squibb Company and Travelers Casualty and Surety Company of America (incorporated herein by reference to Exhibit 10cc to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
10e.	  	Control Agreement dated August 18, 2006 among Bristol-Myers Squibb Company, Travelers Casualty and Surety Company of America and Smith Barney Inc. (incorporated herein by reference to Exhibit 10dd to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
10f.	  	Letter Agreement dated August 18, 2006 between Bristol-Myers Squibb Company and Travelers Casualty and Surety Company of America (incorporated herein by reference to Exhibit 10ee to the Form 8-K dated August 31, 2006 and filed September 5, 2006).	  	*	
			
**10g.	  	Bristol-Myers Squibb Company 1997 Stock Incentive Plan, effective as of May 6, 1997 and as amended effective July 17, 2002 (incorporated herein by reference to Exhibit 10a to the Form 10-Q for the quarterly period ended June 30, 2002).	  	*	
			
**10h.	  	Bristol-Myers Squibb Company 2002 Stock Incentive Plan, effective as of May 7, 2002 and as amended effective January 23, 2007 (incorporated herein by reference to Exhibit 10b to the Form 10-K for the fiscal year ended December 31, 2006).	  	*	
			
**10i.	  	Bristol-Myers Squibb Company 2007 Stock Aware and Incentive Plan, effective as of May 1, 2007 (incorporated herein by reference to Exhibit B to the 2007 Proxy Statement dated March 22, 2007).	  	*	
			
**10j.	  	Bristol-Myers Squibb Company TeamShare Stock Option Plan, as amended and restated effective September 10, 2002 (incorporated herein by reference to Exhibit 10c to the Form 10-K for the fiscal year ended December 31, 2002).	  	*	
			
**10k.	  	Form of Non-Qualified Stock Option Agreement under the 2002 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10s to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
 
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**10l.	  	Form of Non-Qualified Stock Option Agreement under the 2007 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10s to the Form 10-Q for the quarterly period ended March 31, 2007).	  	*	
			
**10m.	  	Form of Restricted Stock Award Agreement under the 2002 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10t to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
			
**10n.	  	Form of Performance Shares Agreement for the 2006-2008 Performance Cycle (incorporated herein by reference to Exhibit 10u to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
			
**10o.	  	Form of Performance Shares Agreement for the 2007-2009 Performance Cycle (incorporated herein by reference to Exhibit 10.1 to the Form 10-Q for the quarterly period ended June 30, 2007).	  	*	
			
**10p.	  	Form of Performance Shares Agreement for the 2008-2010 Performance Cycle (incorporated herein by reference to Exhibit 10.1 to the Form 10-Q for the quarterly period ended September 30, 2007).	  	*	
			
**10q.	  	Form of Restricted Stock Units Agreement under the 2002 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10v to the Form 10-K for the fiscal year ended December 31, 2006).	  	*	
			
**10r.	  	Form of Restricted Stock Units Agreement under the 2007 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10t to the Form 10-Q for the quarterly period ended March 31, 2007).	  	*	
			
**10s.	  	Bristol-Myers Squibb Company Performance Incentive Plan, as amended (as adopted, incorporated herein by reference to Exhibit 2 to the Form 10-K for the fiscal year ended December 31, 1978; as amended as of January 8, 1990, incorporated herein by reference to Exhibit 19b to the Form 10-K for the fiscal year ended December 31, 1990; as amended on April 2, 1991, incorporated herein by reference to Exhibit 19b to the Form 10-K for the fiscal year ended December 31, 1991; as amended effective January 1, 1994, incorporated herein by reference to Exhibit 10d to the Form 10-K for the fiscal year ended December 31, 1993; and as amended effective January 1, 1994, incorporated herein by reference to Exhibit 10d to the Form 10-K for the fiscal year ended December 31, 1994).	  	*	
			
**10t.	  	Bristol-Myers Squibb Company Executive Performance Incentive Plan (effective January 1, 1997 and incorporated herein by reference to Exhibit 10b to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
			
**10u.	  	Bristol-Myers Squibb Company Executive Performance Incentive Plan (effective January 1, 2003 and incorporated herein by reference to Exhibit D to the 2003 Proxy Statement dated April 4, 2003).	  	*	
			
**10v.	  	Bristol-Myers Squibb Company 2007 Senior Executive Performance Incentive Plan (effective May 1, 2007 and incorporated herein by reference to Exhibit C to the 2007 Proxy Statement dated March 22, 2007).	  	*	
			
**10w.	  	Benefit Equalization Plan of Bristol-Myers Squibb Company and its Subsidiary or Affiliated Corporations Participating in the Bristol-Myers Squibb Company Retirement Income Plan or the Bristol-Myers Squibb Puerto Rico, Inc. Retirement Income Plan, as amended (as amended and restated as of January 1, 1993, as amended effective October 1, 1993, incorporated herein by reference to Exhibit 10e to the Form 10-K for the fiscal year ended December 31, 1993; and as amended effective February 1, 1995, incorporated herein by reference to Exhibit 10e to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
 
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**10x.	  	Benefit Equalization Plan of Bristol-Myers Squibb Company and its Subsidiary or Affiliated Corporations Participating in the Bristol-Myers Squibb Company Savings and Investment Program, as amended and restated effective as of January 1, 1996 (incorporated herein by reference to Exhibit 10h to the Form 10-K for the fiscal year ended December 31, 2001).	  	*	
			
**10y.	  	Squibb Corporation Supplementary Pension Plan, as amended (as previously amended and restated, incorporated herein by reference to Exhibit 19g to the Form 10-K for the fiscal year ended December 31, 1991; as amended as of September 14, 1993, and incorporated herein by reference to Exhibit 10g to the Form 10-K for the fiscal year ended December 31, 1993).	  	*	
			
**10z.	  	Senior Executive Severance Plan, effective as of April 26, 2007 (incorporated herein by reference to Exhibit 10.2 to the Form 8-K dated April 24, 2007 and filed on April 27, 2007).	  	*	
			
**10aa.	  	Letter Agreement dated October 31, 2006 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated October 31, 2006 and filed November 3, 2006).	  	*	
			
**10bb.	  	Letter Agreement dated April 26, 2007 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated April 24, 2007 and filed on April 27, 2007).	  	*	
			
**10cc.	  	Aircraft Time Sharing Agreement dated as of July 31, 2007 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.2 to the Form 10-Q for the quarterly period ended June 30, 2007).	  	*	
			
**10dd.	  	Letter Agreement dated February 12, 2008 between James M. Cornelius and Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10.1 to the Form 8-K dated February 11, 2008 and filed on February 15, 2008.	  	*	
			
**10ee.	  	Letter Agreement effective September 20, 2005 and addendum effective October 31, 2005 between Lamberto Andreotti and the Company (incorporated herein by reference to Exhibit 10.2 to the Form 8-K dated December 5, 2006 and filed on December 11, 2006).	  	*	
			
**10ff.	  	Form of Agreement entered into between the Registrant and each of the named executive officers and certain other executives effective January 1, 2008 (filed herewith).	  	E-10-1	
			
**10gg.	  	Bristol-Myers Squibb Company Retirement Income Plan for Non-Employee Directors, as amended to March 5, 1996 (incorporated herein by reference to Exhibit 10k to the Form 10-K for the fiscal year ended December 31, 1996).	  	*	
			
**10hh.	  	Bristol-Myers Squibb Company 1987 Deferred Compensation Plan for Non-Employee Directors, as amended to January 10, 2006 (incorporated herein by reference to Exhibit 10l to the Form 10-K for the fiscal year ended December 31, 2005).	  	*	
			
**10ii.	  	Bristol-Myers Squibb Company Non-Employee Directors’ Stock Option Plan, as amended (as approved by the Stockholders on May 1, 1990, incorporated herein by reference to Exhibit 28 to Registration Statement No. 33-38587 on Form S-8; as amended May 7, 1991, incorporated herein by reference to Exhibit 19c to the Form 10-K for the fiscal year ended December 31, 1991), as amended January 12, 1999 (incorporated herein by reference to Exhibit 10m to the Form 10-K for the fiscal year ended December 31, 1998).	  	*	
			
**10jj.	  	Bristol-Myers Squibb Company Non-Employee Directors’ Stock Option Plan, as amended (as approved by the Stockholders on May 2, 2000, incorporated herein by reference to Exhibit A to the 2000 Proxy Statement dated March 20, 2000.)	  	*	
			
**10kk.	  	Squibb Corporation Deferral Plan for Fees of Outside Directors, as amended (as adopted, incorporated herein by reference to Exhibit 10e Squibb Corporation 1991 Form 10-K for the fiscal year ended December 31, 1987, File No. 1-5514; as amended effective December 31, 1991 incorporated herein by reference to Exhibit 10m to the Form 10-K for the fiscal year ended December 31, 1992).	  	*	
			
**10ll.	  	Restricted Stock Units Agreement with James D. Robinson III, effective as of June 15, 2005 and as amended on July 13, 2005 (incorporated herein by reference to Exhibit 10x to the Form 10-Q for the quarterly period ended June 30, 2005).	  	*	
			
**10mm.	  	Amendment to all of the Company’s plans, agreements, legal documents and other writings, pursuant to action of the Board of Directors on October 3, 1989, to reflect the change of the Company’s name to Bristol-Myers Squibb Company (incorporated herein by reference to Exhibit 10v to the Form 10-K for the fiscal year ended December 31, 1989).	  	*	
			
12.	  	Statement re computation of ratios (filed herewith).	  	E-12-1	
			
21.	  	Subsidiaries of the Registrant (filed herewith).	  	E-21-1	
			
23a.	  	Consent of Deloitte & Touche LLP (filed herewith).	  	E-23-1	
			
23b.	  	Consent of PricewaterhouseCoopers LLP (filed herewith)	  	E-23-2	
			
31a.	  	Section 302 Certification Letter (filed herewith).	  	E-31-1	
			
31b.	  	Section 302 Certification Letter (filed herewith).	  	E-31-2	
			
32a.	  	Section 906 Certification Letter (filed herewith).	  	E-32-1	
			
32b.	  	Section 906 Certification Letter (filed herewith).	  	E-32-2	
 
155

Table of Contents
 SCHEDULE II
BRISTOL-MYERS SQUIBB COMPANY
VALUATION AND QUALIFYING ACCOUNTS

Description	 	Balance at
beginning
of period	 	Provisions for
bad debts,
charge-backs
& discounts	 	Bad debts
written
off/payments
for charge-backs
& discounts	 	 	Discontinued
operations	 	 	Balance at
end
of period	
Dollars in Millions	 	 	 	 	 	 	 	 	 	 	 	 	
Allowances for Charge-Backs, Discounts and Doubtful Accounts: (1)	 			 			 				 				 			
For the year ended December 31, 2007	 	$	150	 	$	951	 	$	(919	)	 	$	(2	)	 	$	180	
For the year ended December 31, 2006	 	 	207	 	 	956	 	 	(1,012	)	 	 	(1	)	 	 	150	
For the year ended December 31, 2005	 	 	221	 	 	1,429	 	 	(1,442	)	 	 	(1	)	 	 	207	

Description	  	Balance at
beginning
of period	  	Provisions for
valuation
allowance	  	Release of
valuation
allowance
/other	 	 	Balance at
end
of period	
Dollars in Millions	  	 	  	 	  	 	 	 	 	
Valuation Allowance on Deferred Tax Assets:	  			  			  				 			
For the year ended December 31, 2007	  	$	625	  	$	1,325	  	$	—  	 	 	$	1,950	
For the year ended December 31, 2006	  	 	559	  	 	189	  	 	(123	)	 	 	625	
For the year ended December 31, 2005	  	 	507	  	 	55	  	 	(3	)	 	 	559	

(1)	Amounts have been reclassified to give effect to discontinued operations. For further information on discontinued operations, see “Item 8. Financial Statements – Note 5. Discontinued Operations and Assets Held for Sale.”	
 
156

Exhibit 10ff
CHANGE-IN-CONTROL AGREEMENT
December 17, 2007
PERSONAL AND CONFIDENTIAL

«First_Name» «Last_Name»	
«Job_Title»	
«Company»	
«Address»	
Dear «First_Name»:
Bristol-Myers Squibb Company (the “Company”) considers it essential to the best interests of its stockholders to foster the continued employment of key management personnel. Our Board of Directors (the “Board”) recognizes that the possibility of a change in ownership or control of the Company may result in the departure or distraction of key personnel to the detriment of the Company and our stockholders. Therefore, the Board has determined to enter into this agreement with you (i) to encourage and reinforce your attention and dedication to your assigned duties without distraction in the face of the disruptive circumstances that can arise from a possible change in control of the Company, (ii) to enhance our ability to retain you in those circumstances, and (iii) to provide you with fair and reasonable protection from the risks of a change in ownership and control so that you will be in a position to help the Company complete a transaction that would be beneficial to stockholders. Accordingly, you and the Company agree as follows:
1. Term of Agreement and Protected Period.
(a) Term of Agreement . This Agreement shall be effective as of January 1, 2008 and shall continue in effect through December 31, 2008, and commencing on January 1, 2009, and each January 1 thereafter, this Agreement shall be automatically extended for one additional year unless, not later than December 1 of the year preceding the renewal date, either party to this Agreement has given notice to the other that the Agreement shall not be extended under this Section 1(a); provided, however , that if a Change in Control or Potential Change in Control (as defined below) have occurred during the term of this Agreement, this Agreement shall continue in effect until the later of 36 months beyond the month in which the latest Change in Control occurred or the next December 31 that is at least 18 months after the latest occurrence of a Potential Change in Control. The foregoing notwithstanding, this Agreement shall terminate upon your attaining your Retirement Date.
(b) Protected Period . The “Protected Period” is the period from the time of occurrence of a Change in Control until the end of the 36th month after the Change in Control, except that the introductory text to Section 4 provides that certain events occurring before a Change in Control shall be deemed to have occurred during the Protected Period.
2. Change in Control and Potential Change in Control .
(a) A “Change in Control” shall be deemed to have occurred if, during the term of this Agreement, on the earliest to occur of the following dates:
(i) The date any Person (as defined in Section 13(d)(3) of the Securities and Exchange Act) shall have become the direct or indirect beneficial owner of thirty percent (30%) or more of the then outstanding common shares of the Company;
(ii) The date of consummation of a merger or consolidation of the Company with any other corporation other than (i) a merger or consolidation which would result in the voting securities of the company outstanding immediately prior thereto continuing to represent at least fifty one percent (51%) of the combined voting power of the voting securities of the Company or the surviving entity outstanding immediately after such merger or consolidation, or (ii) a
 
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merger or consolidation effected to implement a recapitalization of the Company in which no Person acquires more than fifty percent (50%) of the combined voting power of the Company’s then outstanding securities;
(iii) The date the stockholders of the Company approve a plan of complete liquidation of the Company or an agreement for the sale or disposition by the Company of all or substantially all the Company’s assets;
(iv) The date there shall have been a change in the composition of the Board of Directors of the Company within a two (2) year period such that a majority of the Board does not consist of directors who were serving at the beginning of such period together with directors whose initial nomination for election by the Company’s stockholders or, if earlier, initial appointment to the Board was approved by the vote of two-thirds of the directors then still in office who were in office at the beginning of the two (2) year period together with the directors who were previously so approved.
The foregoing notwithstanding, a Change in Control shall not include any event, circumstance or transaction resulting from the actions of any entity or group which is affiliated with you, unless the event, circumstance or transaction is within six months following a Potential Change in Control which resulted from the action of an entity or group not affiliated with you. The term “Person” has the meaning given in Section 3(a)(9) of the Exchange Act, as modified and used in Sections 13(d) and 14(d) thereof; however, a Person shall not include (i) the Company or any of its subsidiaries, (ii) a trustee or other fiduciary holding securities under an employee benefit plan of the Company or any of its subsidiaries, (iii) an underwriter temporarily holding securities pursuant to an offering of such securities, or (iv) a corporation owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their ownership of stock of the Company.
(b) A “Potential Change in Control” shall be deemed to have occurred if, during the term of this Agreement:
(i) The Company enters into a written agreement, the consummation of which would result in a Change in Control; or
(ii) The Company or any Person publicly announces an intention to take or to consider taking actions which, if consummated, would constitute a Change in Control; or
(iii) Any Person who is or becomes the Beneficial Owner, directly or indirectly, of securities of the Company representing 10% or more of the combined voting power of the Company’s then outstanding securities (except, if the Beneficial Owner is an institutional investor eligible to file a Schedule 13G in respect of the Company under Rule 13d-1(b), this threshold shall be 15%), thereafter increases such Person’s beneficial ownership of such securities by 5% or more; or
(iv) The Board adopts a resolution to the effect that, for purposes of this Agreement, a Potential Change in Control has occurred.
3. Employee Covenants .
You agree that, subject to the terms and conditions of this Agreement, in the event of a Potential Change in Control, you will remain in the employ of the Company or a subsidiary until the date that is six months after the earliest Potential Change in Control, except your commitment will end upon (i) the occurrence of a Change in Control, (ii) your Termination by reason of death , (iii) your Termination by the Company for any reason, or (iv) any other Termination under which you become entitled to severance and benefits under Section 4(b) of this Agreement. A “Termination” means an event by which your employment relationship with the Company and all subsidiaries has ended, provided that a Termination will occur no earlier than the time at which you have had a “separation from service” within the meaning of Proposed Treasury Regulation § 1.409A-1(h)
 
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4. Termination and Resulting Compensation and Benefits . The Agreement provides no compensation or benefits in connection with Terminations which occur at times other than during the Protected Period, except that, if you are Terminated prior to a Change in Control by the Company without Cause at the direction of a Person who has entered into an agreement with the Company the consummation of which will constitute a Change in Control, or if you Terminate with Good Reason prior to a Change in Control (determined by treating a Potential Change in Control as a Change in Control in applying the definition of Good Reason) if the circumstance or event which constitutes Good Reason occurs at the direction of such Person, then your Termination shall be deemed to have been during the Protected Period and following a Change in Control and shall qualify for the compensation and benefits specified in Section 4(b).
(a) Termination by the Company for Cause, by You Without Good Reason, or by Reason of Death, and Failure to Perform Duties Due to Disability . If during the Protected Period you are Terminated by the Company for Cause, you voluntarily Terminate without Good Reason, Termination occurs due to your death, or you fail to perform your duties with the Company as a result of Disability, the Company will have no obligation to pay any compensation or benefits to you under this Agreement, but the following obligations will apply:
(i) In the case of failure to perform your duties due to Disability, you will be compensated on terms at least as favorable as those of the Company’s short-term and long-term disability plans as in effect immediately prior to the Change in Control;
(ii) For any such Termination, you will be paid your salary through the Date of Termination plus all other compensation and benefits payable through the Date of Termination under the terms of any compensation or benefit plan, program or arrangement maintained by the Company during such period. If any annual incentive compensation was potentially earnable by you by performance in a year that has been completed, and such year was completed at the date the Termination but the annual incentive compensation was not yet determined or not yet paid, the Company will determine the amount payable in good faith and with no exercise of negative discretion except as is consistent with the exercise of such negative discretion for other executives of the Company who have not Terminated (taking into account practice in prior years in determining such annual incentive awards); provided, however, that this sentence will not apply in the case of a Termination by the Company for Cause.
(iii) You will receive other compensation and benefits accrued and owing but not yet paid at the Date of Termination and any compensation and benefits as may be provided under the Company’s retirement, insurance and other compensation or benefit plans, programs and arrangements on terms at least as favorable as those in effect immediately prior to the Change in Control.
(b) Terminations Triggering Severance Compensation and Benefits . In lieu of any other severance compensation or benefits to which you may otherwise be entitled under any plan, program, policy or arrangement of the Company or any subsidiary, entitlement to which you hereby expressly waive, the Company will pay you the payments described in this Section 4(b) (the “Severance Payments”) upon Termination during the Protected Period and during the term of this Agreement, unless such termination is (i) by the Company for Cause, (ii) by reason of death, (iii) due to your failure to perform your duties with the Company as a result of Disability, or (iv) by you without Good Reason. The compensation and benefits provided under this Section 4(b) are as follows:
(i) The Company will pay you the amounts specified in Section 4(a)(ii).
(ii) In lieu of any further salary payments to you and in lieu of any severance benefit otherwise payable to you, the Company will pay you a lump sum severance payment, in cash, equal to 2.99 or, if less, the number of years, including fractions, from your Date of Termination until you reach your Retirement Date, times the sum of (i) the higher of your annual base salary in effect immediately prior to the occurrence of the event or circumstance upon which the Notice of Termination is based or your annual base salary in effect immediately prior to the Change in Control, and (ii) the aggregate amount of your target annual
 
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bonus opportunity for the year in which the Notice of Termination was given under the annual incentive plan applicable to you as in effect immediately prior to the occurrence of the event or circumstances giving rise to the Notice of Termination or, if greater, your target annual bonus under the applicable plan for the preceding year.
(iii) The Company will pay to you a lump sum amount, in cash, equal to the sum of (A) any incentive compensation which has been earned, allocated or awarded by you or to you for a completed calendar year or other measuring period preceding the Date of Termination but has not yet been paid (this shall not result, however, in duplication of payments under Section 4(b)(i) and 4(a)(ii), with any further service requirement for the vesting of such compensation deemed met as of the Date of Termination, and (B), in the case of any incentive award contingent upon performance (i.e., a contingency other than continued service), an amount equal to the pro rata portion of each authorized award or award opportunity for any performance measurement period that was in effect at the Date of Termination, calculated as to each such award assuming that any performance goal or measurement will have been achieved (for the entire performance period) at the target level (or actual results if available); provided, however, any additional forfeiture conditions in the nature of a “clawback” contained in any plan or award agreement shall continue to apply to any payment under clause (A) or (B), and shall be deemed your covenants to be performed following termination. For purposes of clause (B), the pro rata portion shall be determined based on the proportion of the performance period elapsed from the beginning of such period until the Date of Termination, and any service, vesting or other non-performance requirement relating to such an award, including a service period that would have extended after the performance period, will be deemed met; provided, however, that the payment authorized by Section 4(b)(iii)(B) will be limited if the terms of any award or other agreement specifically limit the payment under this agreement (referring clearly to this agreement or a predecessor change in control agreement).
(iv) In the case of restricted stock, restricted stock units, options, stock appreciation rights (“SARs”) and other equity awards, other than performance-based awards governed by Section 4(b)(iii) above, such awards shall be deemed fully vested and non-forfeitable (to the extent not previously vested and non-forfeitable) and restrictions on such awards shall automatically lapse as of the Date of Termination (subject to Section 4(d)), and options and SARs and other exercisable awards will be immediately exercisable in full at that date; provided, however, that (A) the enhanced rights and benefits specified in this Section 4(b)(iv) will be limited if and to the extent that the terms of any award or other agreement specifically limit such enhanced rights and benefits under this agreement (referring clearly to this agreement or a predecessor change-in-control agreement), (B), if minimum vesting requirements applicable to any award under the 2002 Stock Incentive Plan or other Company plan do not permit such accelerated vesting, the Company will make a cash payment to you equal to the fair market value (net of any exercise price) of such award at the Date of Termination, whereupon such award will be canceled; (C) any additional forfeiture conditions in the nature of a “clawback” contained in any plan or award agreement shall continue to apply, and shall apply to any payment under clause (B), and shall be deemed your covenants to be performed following termination; and (D) the acceleration of options and SARs provided for hereunder is subject to the limitations specified in Section 4(c).
(v) In addition to the retirement benefits to which you are entitled under the Bristol-Myers Squibb Company Retirement Income Plan (the “Retirement Plan”) and the Bristol-Myers Squibb Company Benefit Equalization Plan relating to the Retirement Plan (the “BEP”), or any successor plans thereto, the Company will pay you an additional amount (the “Additional Amount”) equal to the excess of
 
 	(x)	the actuarial equivalent present value of the retirement pension (determined as a straight life annuity commencing at Retirement Date) which you would have accrued under the terms of the Retirement Plan and BEP (without regard to any amendment to the Retirement Plan or BEP made subsequent to a Change in Control which is adverse to you), determined as if you (A) were fully vested thereunder, and (B) had accumulated (after the Date of Termination) 36	
 
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 	additional months of age and service credit thereunder at your highest annual rate of compensation (as such term is defined under the BEP) during the 12 months immediately preceding the Date of Termination (but in no event will you be deemed to have accumulated additional service credit in excess of the maximums taken into account under the Retirement Plan and BEP) (the “Additional Age/Service Credit”)	
over
 
 	(y)	the actuarial equivalent present value of the vested retirement pension (determined as a straight life annuity commencing at your Retirement Date) which you had then accrued pursuant to the respective provisions of the Retirement Plan and BEP (the BEP portion of such retirement pension being the “Base BEP Benefit”).	
The Base BEP Benefit and the Additional Amount will be paid as a cash lump sum following your separation of service and in accordance with Section 4(d) hereof. If you have not attained age 55 with ten years of service credit as of the Date of Termination (after taking into account the Additional Age/Service Credit), you will receive the payments under this Section 4(b)(v) as though you had attained age 55 with ten years of service credit as of the Date of Termination, and without actuarial reduction to reflect the fact that you have not attained age 55 with ten years of service as of the Date of Termination. For purposes of this Section 4(b)(v), “actuarial equivalent” will be determined using the same methods and assumptions utilized under the Retirement Plan immediately prior to the Date of Termination.
(vi) For a 36-month period after the Date of Termination (subject to Section 4(d)), the Company will arrange to provide you with life and health (including medical and dental) insurance benefits substantially similar to those which you are receiving immediately prior to the Notice of Termination (without giving effect to any reduction in such benefits subsequent to a Change in Control). Benefits otherwise receivable by you pursuant to this Section 4(b)(vi) will be reduced to the extent comparable benefits are actually received by or made available to you without greater cost to you than as provided by the Company during the 36-month period (or shorter period applicable under Section 4(d)) following your termination of employment (and any such benefits actually received by you will be reported to the Company by you); provided, however, that if the provision of any type of benefits for the shorter period applicable under Section 4(d) nevertheless would result in you being deemed to be in constructive receipt of income and subject to tax penalties under Section 409A of the Internal Revenue Code (the “Code”) with respect to those benefits before the time of your actual receipt of the goods or services constituting those benefits, the Company will make cash payments to you in lieu of providing those benefits for the 36-month period following termination. If payable, such payments will equal the Company’s cost of providing those benefits, with reductions (if applicable under the preceding sentence) for comparable benefits based on your circumstances through the end of the month prior to the date each such payment is to be made hereunder. Your first payment in lieu of those benefits, if payable, for the year of termination and for the subsequent year if the subsequent year has begun before the payment is due, will be made six months after your termination, with subsequent payments in lieu of those benefits due on the 15 th day of January in each year until payments in lieu of benefits for the full 36-month period have been made.
(vii) Following the 36-month period described in Section 4(b)(vi) (or any shorter period applicable under Section 4(b)(vi)), you will be immediately eligible to participate (although you may elect to defer commencement of such participation to such later date as you will determine) in the Company’s retiree medical plans, whether or not you have satisfied any age and service requirements then applicable. For purposes of determining the level of your participation thereunder, you will be deemed to have accumulated 36 months of additional age and service credit; it being understood that if your age and service credit (as augmented hereunder) do not satisfy the minimum requirements for eligibility, you will be eligible to participate at the level requiring the maximum contribution requirement by an eligible retiree.
 
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(viii) In addition to the vested amounts, if any, to which you are entitled under the Company’s Savings and Investment Program, including the Company’s Benefit Equalization Plan for the Savings and Investment Program, as of the Date of Termination, the Company will pay you a lump sum amount equal to the value of the unvested portion, if any, of the employer matching contributions credited to you under the Company’s Savings and Investment Program, including the Company’s Benefit Equalization Plan for the Savings and Investment Program (to the extent such unvested portion is forfeited as a result of your Termination).
(ix) The Company will provide you with (including reimbursements to you for) reasonable outplacement services consistent with past practices of the Company prior to the Change in Control.
(c) Excise Tax, Gross-Up and Related Provisions . In the event you become entitled to any amounts payable in connection with a Change in Control (whether or not such amounts are payable pursuant to this Agreement) (the “CiC Payments”), if any of such CiC Payments are subject to the tax (the “Excise Tax”) imposed by Section 4999 of the Code (or any similar federal, state or local tax that may hereafter be imposed), the Company shall pay to you at the time specified in Section 4(d) hereof an additional amount (the “Gross-Up Payment”) such that the net amount retained by you, after deduction of any Excise Tax on the Total Payments (as hereinafter defined) and any federal, state and local income tax (taking into account the loss of itemized deductions) and employment tax and Excise Tax upon the payment provided for by this Section 4(c), shall be equal to present value of the Total Payments. If any portion of the Total Payments would be subject to the imposition of the Excise Tax, and if a reduction of any compensation or benefit under Section 4(b) by an amount not exceeding 10% of the Safe Harbor Amount would avoid the imposition of the Excise Tax on you, payments and benefits payable pursuant to Section 4(b) of this Agreement shall be reduced to the extent necessary (but not more than 10% of the Safe Harbor Amount and only to the extent necessary) to result in no imposition of the Excise Tax on you. This cut-back provision shall apply to amounts and benefits payable hereunder which are designated in writing by you prior to the applicable payment date or, if no designation has been made, to payments and benefits hereunder as determined by the Company so as to minimize the amount of your compensation that is reduced (i.e., the payments that to the greatest extent are parachute payments shall be reduced to the extent authorized hereunder). “Safe Harbor Amount” shall mean one dollar less than 300% of the “base amount” as determined in accordance with Section 280G(b)(3) of the Code.
For purposes of determining whether any of the CiC Payments will be subject to the Excise Tax and the amount of such Excise Tax:
(i) The Severance Payments and any other payments or benefits received or to be received by you in connection with a Change in Control or your termination of employment (whether pursuant to the terms of this Agreement or any other plan, arrangement or agreement with the Company, any Person whose actions result in a Change in Control or any Person affiliated with the Company or such Person) (which together constitute the “Total Payments”) shall be treated as “parachute payments” within the meaning of Section 280G(b)(2) of the Code, and all “excess parachute payments” within the meaning of Section 280G(b)(1) of the Code shall be treated as subject to the Excise Tax, unless in the opinion of nationally-recognized tax counsel selected by the Company’s independent auditors and reasonably acceptable to you (the “Tax Counsel”), such payments or benefits (in whole or in part) do not constitute parachute payments, or such excess parachute payments (in whole or in part) represent reasonable compensation for services actually rendered within the meaning of Section 280G(b)(4) of the Code in excess of the base amount within the meaning of Section 280G(b)(3) of the Code, or are otherwise not subject to the Excise Tax;
(ii) The amount of the Total Payments which shall be treated as subject to the Excise Tax shall be equal to the lesser of (A) the total amount of the Total Payments and (B) the amount of excess parachute payments within the meaning of Section 280G(b)(1) of the Code (after applying Section 4(c)(i) above), provided, however, that no payment or benefit shall be treated as subject to the Excise Tax or as a parachute payment if you have effectively waived in writing, prior to the Date of Termination, your right to receive such payment or benefit; and
 
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(iii) The value of any non-cash benefits or any deferred payments or benefit shall be determined by the Tax Counsel in accordance with the principles of Sections 280G(d)(3) and (4) of the Code.
For purposes of determining the amount of the Gross-Up Payment, you shall be deemed to pay federal income taxes at the highest marginal rate of federal income taxation (taking into account the loss of itemized deductions) in the calendar year in which the Gross-Up Payment is to be made and state and local income taxes at the highest marginal rate of taxation in the state and locality of your residence on the Date of Termination, net of the maximum reduction in federal income taxes which could be obtained from deduction of such state and local taxes. In the event that the Excise Tax is subsequently determined to be less than the amount taken into account hereunder at the time of your Termination, you shall repay to the Company, within ten days after the amount of such reduction in Excise Tax is finally determined, the portion of the Gross-Up Payment attributable to such reduction (plus the portion of the Gross-Up Payment attributable to the Excise Tax and federal and state and local income tax imposed on the Gross-Up Payment being repaid by you to the extent that such repayment results in a reduction in Excise Tax and/or federal and state and local income tax deduction) plus interest on the amount of such repayment at the rate provided in Section 1274(b)(2)(B) of the Code. In the event that the Excise Tax is determined to exceed the amount taken into account hereunder at the time of the termination of your employment (including by reason of any payment the existence or amount of which cannot be determined at the time of the Gross-Up Payment), the Company shall make an additional gross-up payment in respect of such excess within ten days after the time that the amount of such excess is finally determined. In the event that the subsequent determinations as to the Excise Tax affect the calculations relating to the cut-back provisions, such amounts will be recalculated and the provisions of this Section 4(c) applied based on the revised calculations, with interest applied to any payments by either party at the rate provided in Section 1274(b)(2)(B) of the Code.
(d) Time of Payment . The payments provided for in Sections 4(b)(i), (ii), (iii), (iv), (v) and (viii) and Section 4(c) shall be made not later than the fifth day following the Date of Termination; provided, however , that if authorization of payment of such amount at that time or the actual payment of such amount at that time would trigger constructive receipt of taxation on such payment under Code Section 409A prior to the year of actual payment or trigger a tax penalty in connection with such payment under Code Section 409A, the payment will be on the date six months after the Date of Termination, together with interest on the unpaid amount at a rate equal to the short-term applicable federal rate (with semiannual compounding) established by the Internal Revenue Service under Section 1274(b)(2)(B) of the Internal Revenue Code and in effect at the date the amount would have been paid but for the delay hereunder; and provided further that, if the amount of such payments due on the fifth day following the Date of Termination cannot be finally determined on or before that payment date, the Company shall pay to you on such day an estimate, as determined in good faith by the Company, of the minimum amount of such payments and shall pay the remainder of such payments (together with interest at the rate provided in Section 1274(b)(2)(B) of the Code) as soon as the amount thereof can be determined but in no event later than the thirtieth day after the Date of Termination. In the event that the amount of the estimated payments exceeds the amount subsequently determined to have been due, you shall be obligated to repay such excess amount on the fifth business day after demand by the Company, together with interest at the rate provided in Section 1274(b)(2)(B) of the Code. At the time that payments are made under this Section, the Company will provide you with a written statement setting forth the manner in which such payments were calculated and the basis for such calculations including any opinions or other advice the Company received from Tax Counsel, outside counsel, auditors or consultants. The foregoing and other provisions of the Agreement notwithstanding, if any right to payment or other benefit hereunder would be deemed, under then applicable U.S. federal income tax laws and regulations, to be constructively received by you (and thus subject to income taxation) prior to the date such payment or benefit is payable hereunder, then (i) the distribution terms and your other rights to such payment or benefit shall be automatically modified to conform to the tax law requirements to ensure that you do not have such constructive receipt and, (ii), if no possible modification under clause (i) could preclude your constructive receipt of such payment or benefit, the payment or benefit will be paid as promptly as practicable on or after the date it would be deemed to have been constructively received by you. The period during which a specific type of benefit will be provided under Section 4(b)(vi)
 
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shall be reduced so that it extends from the Date of Termination until December 31 of the second calendar year following the Date of Termination if (i) providing such benefit for the 36-month period specified under Section 4(b)(vi) would result in you being deemed to be in constructive receipt of compensation and to tax penalties under Code Section 409A in respect of substantially all of such benefit, and (ii) the reduced benefit period provided under this sentence would avoid such constructive receipt and tax penalties.
(e) Notice . During the Protected Period, any purported termination of your employment by the Company or by you shall be communicated by written Notice of Termination to the other party hereto.
(f) Certain Definitions . Except as otherwise indicated in this Agreement, all definitions in this Section 4(f) shall be applicable during the Protected Period only.
(i) Cause “Cause” for termination by the Company of your employment, during the Protected Period, shall mean (A) the willful and continued failure by you to substantially perform your duties with the Company (other than any such failure resulting from your incapacity due to physical or mental illness or any such actual or anticipated failure after the issuance of a Notice of Termination for Good Reason by you) for a period of at least 30 consecutive days after a written demand for substantial performance is delivered to you by the Board, which demand specifically identifies the manner in which the Board believes that you have not substantially performed your duties, (B) the willful engaging by you in conduct which is demonstrably and materially injurious to the Company or its subsidiaries, monetarily or otherwise, or (C) you are convicted of, or have entered a plea of nolo contendere to, a felony. For purposes of clauses (A) and (B) of this definition, no act, or failure to act, on your part shall be deemed “willful” unless done, or omitted to be done, by you not in good faith and without reasonable belief that your act, or failure to act, was in the best interest of the Company. The foregoing notwithstanding, you will not be deemed to have been terminated for Cause unless and until there shall have been delivered to you a copy of the resolution duly adopted by the affirmative vote of not less than three-quarters (3/4) of the entire membership of the Board at a meeting of the Board (after reasonable notice to you and an opportunity for you, together with your counsel, to be heard before the Board) finding that, in the good faith opinion of the Board, you were guilty of conduct set forth above in this Section 3(f)(ii) and specifying the particulars thereof in detail.
(ii) Date of Termination . “Date of Termination” shall mean the date specified in the Notice of Termination which, in the case of a Termination by the Company (other than a Termination for Cause), shall not be less than 30 days from the date such Notice of Termination is given and, in the case of a Termination by you, shall not be less than 15 nor more than 60 days from the date such Notice of Termination is given.
(iii) Disability . “Disability” shall have the meaning stated in the Company’s short and long-term disability plans as in effect immediately prior to a Change in Control.
(iv) Good Reason . “Good Reason” for Termination of your employment will mean the occurrence, without your express written consent, of any one of the following unless, in the case of paragraph (A), (E), (F), (G), or (H) below, such circumstances are fully corrected prior to the Date of Termination:
(A) the assignment to you of any duties inconsistent with your status as an officer of the Company or a substantial adverse alteration in the nature or status of your responsibilities from those in effect immediately prior to the Change in Control;
(B) a reduction by the Company in your annual base salary or target annual incentive bonuses in effect immediately prior to the Change in Control or as the same may be increased from time to time;
 
E-10-1

(C) the relocation of the principal place of your employment to a location more than 50 miles from the location of such place of employment on the date of this Agreement; except for required travel on the Company’s business to an extent substantially consistent with your business travel obligations prior to the Change in Control or, if you have consented to such a relocation, the failure by the Company to provide you with all of the benefits of the Company’s relocation policy as in operation immediately prior to a Change in Control;
(D) the failure by the Company to pay to you any portion of your compensation or to pay to you any portion of an installment of deferred compensation under any deferred compensation program of the Company within seven days of the date such compensation is due;
(E) the failure by the Company to continue in effect any compensation or benefit plan which is material to your compensation and in which you participated immediately prior to the Change in Control, unless an equitable arrangement (embodied in an ongoing substitute or alternative plan) has been made with respect to such plan, or the failure by the Company to continue your participation therein (or in such substitute or alternative plan) on a basis not materially less favorable, both in terms of the amounts of benefits provided and the level of your participation relative to other participants, as existed at the time of the Change in Control;
(F) the failure by the Company to continue to provide you with benefits substantially similar to those enjoyed by you under any of the Company’s pension (including, without limitation, the Company’s Retirement Plan, BEP and the Company’s Savings and Investment Program, including the Company’s Benefit Equalization Plan for the Savings and Investment Program), life insurance, medical, health and accident, or disability plans in which you were participating at the time of the Change in Control, the taking of any action by the Company which would directly or indirectly materially reduce any of such benefits or deprive you of any material fringe benefit enjoyed by you at the time of the Change in Control, or the failure by the Company to provide you with the number of paid vacation days to which you are entitled on the basis of years of service with the Company in accordance with the Company’s normal vacation policy in effect at the time of the Change in Control; or
(G) the failure of the Company to obtain a satisfactory agreement from any successor to assume and agree to perform this Agreement, as contemplated in Section 8 hereof; or
(H) any purported termination of your employment that is not effected pursuant to a Notice of Termination satisfying the requirements of Section 4(f)(iv) hereof (and, if applicable, the requirements of Section 4(f)(ii) hereof), which purported termination shall not be effective for purposes of this Agreement.
Your continued employment shall not constitute consent to, or a waiver of rights with respect to, any act or failure to act constituting Good Reason hereunder. Notwithstanding the foregoing, the occurrence of an event that would otherwise constitute Good Reason hereunder shall cease to be an event constituting Good Reason if Notice of Termination is not timely provided to the Company by you within 120 days of the date that you first become aware (or reasonably should have become aware) of the occurrence of such event.
(v) Notice of Termination . “Notice of Termination” shall mean notice indicating the specific termination provision in this Agreement relied upon and setting forth in reasonable detail the facts and circumstances claimed to provide a basis for termination of your employment under the provision so indicated.
 
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(vi) Retirement Date . “Retirement Date” shall mean the later of (i) the Executive’s normal retirement date under the Retirement Plan and (ii) such other date for retirement by the Executive which has been approved by the Board with the consent of the Executive.
(g) Dispute Concerning Termination . If within 15 days after any Notice of Termination is given, or, if later, prior to the Date of Termination stated in such Notice, the party receiving such Notice notifies the other party that a dispute exists concerning the Termination, the Date of Termination shall be the date on which the dispute is finally resolved, either by mutual written agreement of the parties or by a final judgment, order or decree of a court of competent jurisdiction (which is no longer appealable); provided however , that the Date of Termination shall be extended by a notice of dispute only if such notice is given in good faith and the party giving such notice pursues the resolution of such dispute with reasonable diligence. In case of such a dispute, the Company shall continue to pay you the full compensation in effect when the Notice giving rise to the dispute was given (including salary) or, if greater, the full compensation in effect immediately prior to the Change in Control, and continue you as a participant, on a basis at least as favorable to you as in effect immediately prior to the Change in Control, in all compensation, benefit and insurance plans in which you were participating when such Notice was given, until the dispute is finally resolved. Amounts paid under this Section 4(g) are in addition to all other amounts due under this Agreement but without duplication under Section 4(a) or 4(b)(i) hereof, and shall not be offset against or reduce any other amounts due under this Agreement.
5. Mitigation . Except as provided in Section 4(b)(vi) hereof, you shall not be required to mitigate the amount of payments or benefits provided for under this Agreement by seeking other employment or otherwise, nor shall the amount of payment or benefit provided for under this Agreement be reduced by any compensation earned by you as the result of employment by another employer, by retirement benefits, by offset against any amount claimed to be owed by you to the Company, or otherwise.
6. Noncompetition and Related Covenants . In consideration for the payments and benefits provided by the Company under this Agreement, you shall execute, concurrent with the execution of this Agreement, a noncompetition agreement with the Company in the form attached to this Agreement as Exhibit A, which agreement provides that, for a one-year period following your termination of employment with the Company or any of its subsidiaries or affiliates, you will not engage in any competitive activity with the Company or any of its subsidiaries or affiliates. In addition, if you receive any payment or benefit pursuant to Section 4(b)(iv), the forfeiture conditions in the nature of a “clawback” applicable to the award or the related payment or benefit shall become covenants to be performed following termination. A portion of the payments and benefits under Section 4(b) shall be deemed compensation for your performance of the covenants referred to in this Section 6.
7. Costs of Proceedings . The Company shall pay all costs and expenses, including all reasonable attorneys’ fees and disbursements, of the Company and, at least monthly, you in connection with any legal proceedings, whether or not instituted by the Company or you, relating to the interpretation or enforcement of any provision of this Agreement; provided that if you instituted the proceeding and a finding (no longer subject to appeal) is entered that you instituted the proceeding in bad faith, you shall pay all of your costs and expenses, including attorneys’ fees and disbursements and reimburse the Company for any and all attorneys’ fees and disbursements the Company had paid on your behalf. The Company shall pay prejudgment interest on any money judgment obtained by you as a result of such proceeding, calculated at the prime rate of The Chase Manhattan Bank as in effect from time to time from the date that payment should have been made to you under this Agreement.
8. Miscellaneous .
(a) Successors . The Company shall require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all of the business and/or assets of the Company to expressly assume and agree to perform this Agreement in the same manner and to the same extent that the Company would be required to perform it if no such succession had taken place. As used in this Agreement, “Company” shall mean the Company as hereinbefore defined and any successor to its business and/or assets as aforesaid which assumes and agrees to perform this Agreement by operation of law, or otherwise.
 
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(b) Binding Agreement . This Agreement shall inure to the benefit of and be enforceable by you and your personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees and legatees. In the event of your death, all amounts otherwise payable to you hereunder shall, unless otherwise provided herein, be paid in accordance with the terms of this Agreement to your devisee, legatee or other designee or, if there is no such designee, to your estate.
(c) Notice . Notices and all other communications provided for in this Agreement shall be in writing and shall be deemed to have been duly given when (i) personally delivered or (ii) mailed by United States certified or registered mail, return receipt requested, postage prepaid, addressed to the respective addresses set forth on the first page of this Agreement; provided that all notice to the Company shall be directed to the attention of the Board with a copy to the General Counsel of the Company, or to such other address as either party may have furnished to the other in writing in accordance herewith, except that notice of change of address shall be effective only upon receipt.
(d) Modifications . Except as otherwise set forth in this Agreement, no provision of this Agreement may be modified, waived or discharged unless such waiver, modification or discharge is agreed to in writing and signed by you and such officer as may be designated by the Board. The Company may amend this Agreement without your written consent if such amendment would not materially and adversely affect your rights under this Agreement. No waiver by either party hereto at any time of any breach by the other party hereto of, or compliance with, any condition or provision of this Agreement to be performed by such other party shall be deemed a waiver of similar or dissimilar provisions or conditions at the time or at any prior or subsequent time.
(e) Governing Law . THE VALIDITY, INTERPRETATION, CONSTRUCTION AND PERFORMANCE OF THIS AGREEMENT SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO ITS CONFLICTS OF LAW PRINCIPLES.
(f) Tax Withholding and Compliance with Code Section 409A . Any payments provided for hereunder shall be paid net of any applicable withholding required under federal, state or local law. The parties hereto intend that, to the maximum extent practicable, the rights to payment hereunder shall not give rise to constructive receipt of compensation prior to payment or to tax penalties under Code Section 409A. Accordingly, the Company shall have no right to accelerate payments if and to the extent that such right or an actual acceleration would result in such constructive receipt or tax penalties under Code Section 409A, and provisions of this Agreement shall be interpreted and construed in a manner which complies with requirements of Section 409A so as to avoid such constructive receipt and tax penalties. The Company shall have the right to modify this Agreement to comply with Code Section 409A without obtaining your written consent.
(g) Surviving Obligations . The obligations of the Company and your obligations under this Agreement shall survive the expiration of this Agreement to the extent necessary to give effect to this Agreement.
(h) Validity . The invalidity or unenforceability of any provision of this Agreement shall not affect the validity or enforceability of any other provision of this Agreement, which shall remain in full force and effect.
(i) Counterparts . This Agreement may be executed in counterparts, each of which shall be deemed to be an original but all of which together will constitute one and the same instrument.
(j) Entire Agreement . This Agreement sets forth the entire agreement of the parties hereto in respect of the subject matter contained herein and during the term of this Agreement supersedes the provisions of all prior agreements (including any prior Change in Control Agreement between the parties), promises, covenants, arrangements, communications, representations or warranties, whether oral or written, by any officer, employee or representative of any party hereof with respect to the subject matter contained herein. No agreements or representations, oral or otherwise, express or
 
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implied, with respect to the subject matter hereof have been made by either party which are not expressly set forth in this Agreement. Notwithstanding anything to the contrary in this Agreement, the procedural provisions of this Agreement shall apply to all benefits payable as a result of a Change in Control (or other change in control) under any employee benefit plan, agreement, program, policy or arrangement of the Company.
If this letter sets forth our agreement on the subject matter hereof, kindly sign and return to the Company the enclosed copy of this letter, which will then constitute our agreement on this subject.

BRISTOL-MYERS SQUIBB COMPANY	
		
By:	 	 	
	 	[Name]	
	 	[Title]	

Agreed to this      day of December, 2007.	

«First_Name» «Last_Name»	
 
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EXHIBIT 12.
Computation of Earnings to Fixed Charges
Five-Year Ratio of Earnings to Fixed Charges:

Dollars in Millions	  	2007	 	 	2006	 	 	2005	 	 	2004	 	  	2003	 	
Earnings	  				 				 				 				  				
Earnings from continuing operations before minority interest and income taxes	  	$	3,534	 	 	$	2,400	 	 	$	4,304	 	 	$	4,210	 	  	$	4,529	 	
Less:	  				 				 				 				  				
Equity in net income of affiliates	  	 	524	 	 	 	474	 	 	 	334	 	 	 	273	 	  	 	151	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Income adjusted for equity income	  	 	3,010	 	 	 	1,926	 	 	 	3,970	 	 	 	3,937	 	  	 	4,378	 	
Add:	  				 				 				 				  				
Fixed charges	  	 	512	 	 	 	566	 	 	 	408	 	 	 	369	 	  	 	361	 	
Distributed income of equity investments	  	 	409	 	 	 	439	 	 	 	383	 	 	 	278	 	  	 	155	 	
Pre-tax losses of equity investees	  	 	12	 	 	 	10	 	 	 	9	 	 	 	3	 	  	 	40	 	
Less:	  				 				 				 				  				
Capitalized interest	  	 	(35	)	 	 	(18	)	 	 	(9	)	 	 	(10	)	  	 	(35	)	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Total Earnings	  	$	3,908	 	 	$	2,923	 	 	$	4,761	 	 	$	4,577	 	  	$	4,899	 	

Fixed Charges	  				 				 				 				  				
Interest and debt expense	  	$	422	 	 	$	498	 	 	$	349	 	 	$	310	 	  	$	277	 	
Capitalized interest	  	 	35	 	 	 	18	 	 	 	9	 	 	 	10	 	  	 	35	 	
One-third of rental expense (1)	  	 	55	 	 	 	50	 	 	 	50	 	 	 	49	 	  	 	49	 	
	  	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	  	 	 	 	
Total Fixed Charges	  	$	512	 	 	$	566	 	 	$	408	 	 	$	369	 	  	$	361	 	

Ratio of Earnings to Fixed Charges	  	 	7.63	 	 	 	5.16	 	 	 	11.67	 	 	 	12.40	 	  	 	13.57	 	

(1)	Rents included in the computation consist of one-third of rental expense which we believe to be a conservative estimate of an interest factor in our leases, which are not material.	
 
E-12-1

EXHIBIT 21
Subsidiaries of Bristol-Myers Squibb Company

2309 Realty Corporation	
3130827 CANADA INC.	
345 Park Corporation	
77 Wilson St., Corp.	
A.G. Medical Services, P.A.	
Adnexus, a Bristol-Myers Squibb R&D Company	
Allard Laboratories, Inc.	
Allard Labs Acquisition G.P.	
Allied Medical Services (UK) Ltd.	
AMCARE Limited	
Apothecon, Inc.	
Bioenhance Medicines, Inc.	
Blisa Acquisition G.P.	
Blisa, Inc.	
BMS Benelux Holdings B.V.	
BMS Bermuda Holdings Ltd.	
BMS Bermuda Nominees L.L.C.	
B-MS GeneRx	
BMS Holdings sarl	
BMS Holdings Spain, S.L.	
BMS International Insurance Company Limited	
BMS Investco SAS	
BMS Korea Holdings L.L.C.	
BMS Latin American Nominees L.L.C.	
BMS Luxembourg Partners, L.L.C.	
BMS Mexico Holdings L.L.C.	
BMS Mexico International Holdings, GmbH	
BMS Omega Bermuda Holdings Finance Ltd.	
BMS Pharmaceutical Korea Limited	
BMS Pharmaceuticals Asia Holdings B.V.	
BMS Pharmaceuticals Germany Holdings B.V.	
BMS Pharmaceuticals International Holdings Netherlands B.V.	
BMS Pharmaceuticals Korea Holdings B.V.	
BMS Pharmaceuticals Mexico Holdings B.V.	
BMS Pharmaceuticals Netherlands Holdings B.V.	
BMS Real Estate LLC	
BMS Spain Investments, Inc.	
BMS-Generiques SAS	
BMSIC Pharma-Handels Verwaltungs GmbH	
Boclaro Inc.	
Bristol (Iran) S.A. (Inactive)	
Bristol Caribbean, Inc.	
Bristol Foundation	
Bristol Iran Private Company Limited (Inactive)	
Bristol Laboratories Corporation	
Bristol Laboratories Inc.	
Bristol Laboratories International, S.A.	
Bristol Laboratories Medical Information Systems Inc.	
Bristol-Myers (Andes) L.L.C.	
Bristol-Myers (Private) Limited	
 
E-21-1

	
Bristol-Myers Barceloneta, Inc.	
Bristol-Myers Company (2001) Limited	
Bristol-Myers de Venezuela S.C.A.	
Bristol-Myers K. K.	
Bristol-Myers Middle East S.A.L.	
Bristol-Myers Overseas Corporation	
Bristol-Myers Squibb & Gilead Sciences, LLC	
Bristol-Myers Squibb (China) Investment Co., Ltd.	
Bristol-Myers Squibb (Hong Kong) Limited	
Bristol-Myers Squibb (Israel) Ltd.	
Bristol-Myers Squibb (Malaysia) Sendirian Berhad	
Bristol-Myers Squibb (NZ) Limited	
Bristol-Myers Squibb (Phil.) Inc.	
Bristol-Myers Squibb (Proprietary) Limited	
Bristol-Myers Squibb (Shanghai) Trading Co. Ltd.	
Bristol-Myers Squibb (Singapore) Pte. Limited	
Bristol-Myers Squibb (Taiwan) Ltd.	
Bristol-Myers Squibb (Thailand) Ltd.	
Bristol-Myers Squibb (West Indies) Ltd.	
Bristol-Myers Squibb A.E.	
Bristol-Myers Squibb Aktiebolag	
Bristol-Myers Squibb and Gilead Sciences Limited	
Bristol-Myers Squibb Antilles Holdings N.V.	
Bristol-Myers Squibb Argentina S. R. L.	
Bristol-Myers Squibb Auslandsbeteiligungs Holding, GmbH	
Bristol-Myers Squibb Australia Holding Pty. Ltd.	
Bristol-Myers Squibb Australia Pty. Ltd.	
Bristol-Myers Squibb B.V.	
Bristol-Myers Squibb Barceloneta Holdings, L.L.C.	
Bristol-Myers Squibb Belgium S.A.	
Bristol-Myers Squibb Biologics Company	
Bristol-Myers Squibb Bulgaria EOOD	
Bristol-Myers Squibb Business Services Limited	
Bristol-Myers Squibb Canada Co.	
Bristol-Myers Squibb Caribbean Company	
Bristol-Myers Squibb Caribbean Holdings, L.L.C.	
Bristol-Myers Squibb Cayman Ltd.	
Bristol-Myers Squibb de Colombia S.A.	
Bristol-Myers Squibb de Costa Rica Sociedad Anonima	
Bristol-Myers Squibb de Guatemala, S.A.	
Bristol-Myers Squibb de Mexico S. de R. L. de C.V.	
Bristol-Myers Squibb Delta Company Limited	
Bristol-Myers Squibb Delta Holdings, L.L.C.	
Bristol-Myers Squibb Denmark Filial of Bristol-Myers Squibb AB	
Bristol-Myers Squibb Dominicana, S.A.	
Bristol-Myers Squibb Ecuador Cia. Ltd.	
Bristol-Myers Squibb Eesti Aktsiaselts	
Bristol-Myers Squibb EMEA	
Bristol-Myers Squibb Europa PLC	
Bristol-Myers Squibb Europe Strategic Sourcing	
Bristol-Myers Squibb Export S.A. (Slovak Republic)	
 
E-21-1

	
Bristol-Myers Squibb Farmaceutica Portuguesa S.A.	
Bristol-Myers Squibb Farmaceutica S.A.	
Bristol-Myers Squibb Finance Company	
Bristol-Myers Squibb Finance Limited	
Bristol-Myers Squibb Foreign Sales Corporation	
Bristol-Myers Squibb Ges. m.b.H.	
Bristol-Myers Squibb GmbH & Co. KGaA	
Bristol-Myers Squibb Holding Germany GmbH & Co. KG	
Bristol-Myers Squibb Holdings 2002 Limited	
Bristol-Myers Squibb Holdings B.V.	
Bristol-Myers Squibb Holdings Germany Verwaltungs Gmbh	
Bristol-Myers Squibb Holdings Ireland Limited	
Bristol-Myers Squibb Holdings Limited	
Bristol-Myers Squibb Holdings Pharma Ltd. Liability Company	
Bristol-Myers Squibb Hungary Pharmaceutical Trading Kft	
Bristol-Myers Squibb Ilaclari, Inc.	
Bristol-Myers Squibb India Pvt. Ltd.	
Bristol-Myers Squibb Inlandsbeteiligungs Holding GmbH	
Bristol-Myers Squibb International Company	
Bristol-Myers Squibb International Corporation	
Bristol-Myers Squibb International Holdings Ireland Limited	
Bristol-Myers Squibb International Limited	
Bristol-Myers Squibb Investco, L.L.C.	
Bristol-Myers Squibb Ireland Finance Company	
Bristol-Myers Squibb K.K.	
Bristol-Myers Squibb Luxembourg International S.C.A.	
Bristol-Myers Squibb Luxembourg S.a.r.l.	
Bristol-Myers Squibb Manufacturing Company	
Bristol-Myers Squibb Manufacturing Holdings, Inc.	
Bristol-Myers Squibb MEA GmbH	
Bristol-Myers Squibb Norway Ltd.	
Bristol-Myers Squibb Pakistan (Pvt.) Ltd.	
Bristol-Myers Squibb Peru S.A.	
Bristol-Myers Squibb Pharma Belgium SPRL	
Bristol-Myers Squibb Pharma Company	
Bristol-Myers Squibb Pharma EEIG	
Bristol-Myers Squibb Pharma Holding Company, LLC	
Bristol-Myers Squibb Pharma Ventures Corporation	
Bristol-Myers Squibb Pharmaceuticals	
Bristol-Myers Squibb Pharmaceuticals Limited (England)	
Bristol-Myers Squibb Polska Sp. z o.o.	
Bristol-Myers Squibb Products S.A.	
Bristol-Myers Squibb Puerto Rico, Inc.	
Bristol-Myers Squibb Puerto Rico/Sanofi Pharmaceutical Partnership Puerto Rico	
Bristol-Myers Squibb S.A. (Switz)	
Bristol-Myers Squibb S.r.l.	
Bristol-Myers Squibb Sanofi Pharmaceuticals Holding Partnership	
Bristol-Myers Squibb Sanofi-Synthelabo Partnership	
Bristol-Myers Squibb Sanofi-Synthelabo Puerto Rico	
Bristol-Myers Squibb Sarl (France)	
Bristol-Myers Squibb Service Ltd.	
 
E-21-1

	
Bristol-Myers Squibb Services Sp. z o.o.	
Bristol-Myers Squibb Sigma Finance Ltd.	
Bristol-Myers Squibb Sp. z o.o.	
Bristol-Myers Squibb spol. s r.o.	
Bristol-Myers Squibb Superannuation Plan Pty. Ltd.	
Bristol-Myers Squibb Thai Ltd.	
Bristol-Myers Squibb Trustees Ltd.	
Bristol-Myers Squibb UPSA	
Bristol-Myers Squibb UPSA Tunisie	
Bristol-Myers Squibb Verwaltungs GmbH	
Bristol-Myers Squibb, S.A.	
Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership	
Britcair Limited	
Compania Bristol-Myers Squibb de Centro America	
Consorzio Industriale Servizi Ecologici - CI.S.ECO SpA	
ConvaTec Dominican Republic, Inc.	
ConvaTec Limited	
ConvaTec Praha spol. s r.o.	
Convatec Speciality Fibres Limited	
Convatec, S.L.	
Convatec-Produtos Medicos, Limitada	
E. R. Squibb & Sons (Andes) L.L.C.	
E. R. Squibb & Sons de Venezuela SCA	
E. R. Squibb & Sons Inter-American Corporation	
E. R. Squibb & Sons Limited	
E. R. Squibb & Sons, L.L.C.	
EWI Corporation	
Grove Insurance Company Ltd.	
Grove Products (Far East) Limited	
Heyden Farmaceutica Portugesa Limitada	
Iris Acquisition Corp.	
Laboratoires Convatec S.A.	
Laboratorios Upsa, Sociedad Limitada	
Lawrence Laboratories	
Linson Investments Limited	
Linson Pharma Co.	
Little Sycamore Limited	
Mead Johnson & Company	
Mead Johnson (Manufacturing) Jamaica Limited	
Mead Johnson A.E.B.E.	
Mead Johnson B.V.	
Mead Johnson de Mexico, S. de R.L. de C.V.	
Mead Johnson Farmaceutica Limitada	
Mead Johnson International Limited (Canada)	
Mead Johnson Jamaica Ltd.	
Mead Johnson Limited	
Mead Johnson Nutritionals (China) Ltd.	
Monarch Crown Corporation	
NOVACARE Limited	
O.o.o. Bristol-Myers Squibb	
O.o.o. Bristol-Myers Squibb Manufacturing	
Off Prescriptions Medicines Limited	
 
E-21-1

	
Oy Bristol-Myers Squibb (Finland) AB	
P.T. Bristol-Myers Squibb Indonesia Tbk.	
Princeton Pharmaceutical Products, Inc.	
Princeton Pharmaceuticals, S.L.	
Princeton-Produtos Farmaceuticos, LDA	
PT Mead Johnson Indonesia	
Route 22 Real Estate Holding Corporation	
Sanofi Pharma Bristol-Myers Squibb SNC	
Sino-American Shanghai Squibb Pharmaceuticals Limited	
SMC Holdings LLC	
Societe Francaise de Complements Alimentaires (S.O.F.C.A.)	
Sphinx Holdings Company, Inc.	
Squibb (Nigeria) Limited	
Squibb Development Limited	
Squibb Farmaceutica Portuguesa, Limitada	
Squibb Manufacturing Company	
Squibb Manufacturing, Inc.	
Squibb Middle East S.A.	
Squibb Overseas Investments, Inc.	
Squibb Properties, Inc.	
Squibb Surgicare Limited	
Swords Holdings II, Inc.	
Swords Laboratories	
Tri-Supply Limited	
Unterstuetzungskasse Bristol-Myers Squibb G.m.b.H.	
UPSA CONSEIL	
UPSA Generiques	
UPSA S.r.l	
Westwood-Intrafin, S.A.	
Westwood-Squibb Holdings, Inc.	
Westwood-Squibb Pharmaceuticals, Inc.	
 
E-21-1

EXHIBIT 23a.
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in Registration Statement Nos. 33-33682, 33-62496, 333-114107 and 333-117818 on Form S-3, and Nos. 33-30856, 33-38411, 33-38587, 33-44788, 333-47403, 33-52691, 33-30756-02, 33-58187, 333-02873, 333-65424, 333-107414 and 333-144893 on Form S-8, of our reports dated February 21, 2008, relating to (1) the 2007 and 2006 consolidated financial statements and financial statement schedule, and the retrospective adjustments to the 2005 consolidated financial statements of Bristol-Myers Squibb Company and subsidiaries (the “Company”) (which report expresses an unqualified opinion and includes an explanatory paragraph regarding the Company’s adoption of Financial Accounting Standards Board Interpretation (“FIN”) No. 48, Accounting for Uncertainty in Income Taxes - an interpretation of FASB Statement No. 109 , effective January 1, 2007, Statement of Financial Accounting Standards (“SFAS”) No. 123(R), Share-Based Payment , effective January 1, 2006, and SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans - an Amendment of FASB Statements No. 87, 88, 106, and 132(R), effective December 31, 2006) and (2) the effectiveness of the Company’s internal control over financial reporting as of December 31, 2007, appearing in this Annual Report on Form 10-K of the Company for the year ended December 31, 2007.

/s/ Deloitte & Touche LLP	
	
Parsippany, New Jersey	
February 21, 2008	
 
E-23-1

EXHIBIT 23b.
Consent of Independent Registered Public Accounting Firm
We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 33-30856, 33-38411, 33-38587, 33-44788, 333-47403, 33-52691, 33-30756-02, 33-58187, 333-02873, 333-65424 and 333-107414) and Form S-3 (Nos. 33-33682, 33-62496, 333-114107 and 333-117818) of Bristol-Myers Squibb Company of our report dated March 13, 2006 relating to the financial statements and financial statement schedule, which appears in this Form 10-K.

/s/ PricewaterhouseCoopers LLP	
	
PricewaterhouseCoopers LLP	
Philadelphia, PA	
February 21, 2008	
 
E-23-2

EXHIBIT 31a.
CERTIFICATIONS PURSUANT TO SECTION 302 OF
THE SARBANES-OXLEY ACT OF 2002
CERTIFICATION BY CHIEF EXECUTIVE OFFICER
I, James M. Cornelius, certify that:
1. I have reviewed this annual report on Form 10-K of Bristol-Myers Squibb Company;
2. Based on my knowledge, this annual report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this annual report;
3. Based on my knowledge, the financial statements, and other financial information included in this annual report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this annual report;
4. The registrant’s other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
 
 	a.	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this annual report is being prepared;	
 
 	b.	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;	
 
 	c.	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and	
 
 	d.	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting;	
5. The registrant’s other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of registrant’s board of directors (or persons performing the equivalent function):
 
 	a.	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting that are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and	
 
 	b.	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.	
Date: February 21, 2008

/s/ JAMES M. CORNELIUS	
James M. Cornelius	
Chief Executive Officer	
 
E-31-1

EXHIBIT 31b.
CERTIFICATION BY THE CHIEF FINANCIAL OFFICER
I, Andrew R.J. Bonfield, certify that:
1. I have reviewed this annual report on Form 10-K of Bristol-Myers Squibb Company;
2. Based on my knowledge, this annual report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this annual report;
3. Based on my knowledge, the financial statements, and other financial information included in this annual report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this annual report;
4. The registrant’s other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
 
 	a.	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this annual report is being prepared;	
 
 	b.	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;	
 
 	c.	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and	
 
 	d.	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting;	
5. The registrant’s other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of registrant’s board of directors (or persons performing the equivalent function):
 
 	a.	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting that are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and	
 
 	b.	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.	
Date: February 21, 2008

/s/ ANDREW R.J. BONFIELD	
Andrew R.J. Bonfield	
Chief Financial Officer	
 
E-31-2

EXHIBIT 32a.
Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as
Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
Pursuant to 18 U. S. C. Section 1350, I, James M. Cornelius, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2007 (the Report), as filed with the Securities and Exchange Commission on February 21, 2008, fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934, as amended, and that the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Bristol-Myers Squibb Company.

/s/ J AMES M. C ORNELIUS	
James M. Cornelius	
Chief Executive Officer
February 21, 2008	
 
E-32-1

EXHIBIT 32b.
Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as
Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
Pursuant to 18 U. S. C. Section 1350, I, Andrew R.J. Bonfield, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2007 (the Report), as filed with the Securities and Exchange Commission on February 21, 2008, fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934, as amended, and that the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Bristol-Myers Squibb Company.

/s/ A NDREW R.J. B ONFIELD	
Andrew R.J. Bonfield	
Chief Financial Officer	
February 21, 2008	
 
E-32-2